gata3

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gata3

Official Full Name GATA binding protein 3
Background This gene encodes a protein which belongs to the GATA family of transcription factors. The protein contains two GATA-type zinc fingers and is an important regulator of T-cell development and plays an important role in endothelial cell biology. Defects in this gene are the cause of hypoparathyroidism with sensorineural deafness and renal dysplasia. [provided by RefSeq, Nov 2009]
Synonyms GATA3; GATA binding protein 3; HDR; HDRS; trans-acting T-cell-specific transcription factor GATA-3; GATA-binding factor 3;
    • Species :
    • Chicken
    • Human
    • Mouse
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • Myc/DDK
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human GATA3-28477TH Recombinant Human GATA3 Wheat Germ N/A
    Human GATA3-2939H Recombinant Human GATA3 protein, GST-tagged E.coli GST
    Human GATA3-2940H Recombinant Human GATA3 protein, His-tagged E.coli His
    Human GATA3-2941H Recombinant Human GATA3 protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human GATA3-4747H Recombinant Human GATA3 Protein, GST-tagged Wheat Germ GST
    Human GATA3-6011HCL Recombinant Human GATA3 293 Cell Lysate HEK293 N/A
    Human GATA3-978H Recombinant Human GATA3 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Mouse Gata3-3161M Recombinant Mouse Gata3 Protein, Myc/DDK-tagged HEK293T Myc/DDK
    Mouse GATA3-6224M Recombinant Mouse GATA3 Protein Mammalian Cell His
    Chicken GATA3-1825C Recombinant Chicken GATA3 Mammalian Cell His
    Zebrafish GATA3-8812Z Recombinant Zebrafish GATA3 Mammalian Cell His

    gata3 involved in several pathways and played different roles in them. We selected most pathways gata3 participated on our site, such as Inflammatory bowel disease (IBD), which may be useful for your reference. Also, other proteins which involved in the same pathway with gata3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Inflammatory bowel disease (IBD) HLA-DPA1; MAF; TGFB3; STAT6; TBX21; TNF; IL23R; H2-AA; HLA-DQB1; TGFB2

    gata3 has several biochemical functions, for example, DNA binding, E-box binding, HMG box domain binding. Some of the functions are cooperated with other proteins, some of the functions could acted by gata3 itself. We selected most functions gata3 had, and list some proteins which have the same functions with gata3. You can find most of the proteins on our site.

    Function Related Protein
    DNA binding TXLNB; ZNF471; ZNF507; EZH2; RORAA; MUS81; EGR1; OLIG1; MTF1; TBPL1
    E-box binding TCF3; TCF4; TFAP4; ASCL1; ATOH8; TCF21; NEUROG1; PER1; TWIST1; ZEB1
    HMG box domain binding POU3F3; SP1; UTF1; HOXC4; MEOX1; DLX5; EGR2; OLIG2; CEBPA; GATA3
    RNA polymerase II core promoter sequence-specific DNA binding ZNF277; RBPJ; SMYD3; TFAP2A; PAX8; RREB1; RUNX2; H2AFZ; H2AFY; NFIL3
    RNA polymerase II regulatory region sequence-specific DNA binding PHOX2B; CUX1; ZNF561; ATF4B2; SOX13; PRDM12B; PLAGL1; TAL1; SP1; GATA6
    RNA polymerase II transcription factor binding TRP53; ID4; TBX20; ATF4; ZFPM2; GATA3; GATA2B; GATA2A; TOX2; T
    chromatin binding RAD51; HDAC7A; ATF2; TRP53; CBX4; ACTL6A; SOX9; PKN1; LRWD1; MITF
    core promoter proximal region sequence-specific DNA binding DMRT3A; DMRT2A; UHRF1; DMRTC1B; DMRT1; DMRT2B; CREBBP; ZFP516; KLF1; DMRT3
    core promoter sequence-specific DNA binding ZNF750; ZFP750; CREM; KLF10; ZFP932; ATF4; SOX1; ESR2; ZFHX3; REST
    enhancer sequence-specific DNA binding GATA5; KLF7B; FOXN4; TWIST1B; TBX19; GATA1; TFAP2B; YY1; LMO4; GATA2
    interleukin-2 receptor binding GATA3; TIMM50; Il2; IL21; ECM1
    nucleic acid binding transcription factor activity GATA3; SOX4
    protein binding COPS8; CSTF3; KCTD1; SUV420H2; HIST1H4J; UBXN8; ODF1; EPN1; XBP1; WDYHV1
    protein dimerization activity HER9; AHR2; SCXB; AHR1A; SLC4A11; SCXA; HIF1AL2; RIMKLB; MGAA; LYL1
    transcription coactivator activity NR1H3; PSMC3; SP4; NPM1; ABT1; MTDH; TDRD3; SETD3; VGLL2; RIPK3
    transcription factor activity, sequence-specific DNA binding PAX6; ATF7; PBX2; BACH1; RXRBB; CBL; SCML2; ZFP287; BACH1A; CTBP1
    transcription factor binding FOXA2; SUFU; PPARG; NCOR2; HDAC11; NKX3; PPP1R13L; HDAC5; ESR1; TAF1
    transcription regulatory region DNA binding KLF15; ATF3; CITED1; XRCC6; SP1; MLL1; FOS; ZFP821; TNF; BRD7
    transcription regulatory region sequence-specific DNA binding PER2; GATA1; HDAC1; HIF1AL; POU2F1; NFE2L2; NKX3-1; CREB3L3; BAHD1; NFE2
    transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding POU1F1; SIX2; Ar; BSX; CEBPZ; SIX1; PBX1; NDN; TFE3A; FOXK2
    transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding FOXF2; ALX4; SOHLH1; ESRRG; GATA2; GATA5; LMO2; SOHLH2; MAFF; CREBBP
    transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding E2F8; HHEX; POU4F2; ASCL1; KCNIP3; TFAP2C; ZBTB20; CTCF; HAND1; NFIL3-5
    zinc ion binding CXXC4; AGBL4; KDM5BA; MMEL1; PIAS4B; NR1D4B; RARAB; ZNFL1; PHF21B; FHL1A

    gata3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with gata3 here. Most of them are supplied by our site. Hope this information will be useful for your research of gata3.

    PSMA3; RARA; ESR1; SOX4; FOXC1; myc_human_gene; tff1_human_gene; GREB1; FOS; RARG; TAL1; STAT1

    McMullen, E; Samuelson, M; et al. GATA3 Is Frequently Expressed By Estrogen Receptor-Negative Breast Cancers: A Comparison of Two Commercially Available Monoclonal Antibodies. MODERN PATHOLOGY 28:56A-56A(2015).
    Wendroth, SM; Mentrikoski, MJ; et al. GATA3 expression in morphologic subtypes of breast carcinoma: a comparison with gross cystic disease fluid protein 15 and mammaglobin. ANNALS OF DIAGNOSTIC PATHOLOGY 19:6-9(2015).

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