GATA3

  • Official Full Name

    GATA binding protein 3

  • Background

    This gene encodes a protein which belongs to the GATA family of transcription factors. The protein contains two GATA-type zinc fingers and is an important regulator of T-cell development and plays an important role in endothelial cell biology. Defects in this gene are the cause of hypoparathyroidism with sensorineural deafness and renal dysplasia. [provided by RefSeq, Nov 2009]
  • Synonyms

    GATA3; GATA binding protein 3; HDR; HDRS; trans-acting T-cell-specific transcription factor GATA-3; GATA-binding factor 3;
    • Type:
    • Recombinant Proteins
    • Cell & Tissue Lysates
    • Protein Pre-coupled Magnetic Beads
    • Species :
    • Chicken
    • Human
    • Mouse
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • In Vitro Cell Free System
    • Mamanlian cells
    • Mammalian Cell
    • Mammalian cells
    • Wheat Germ
    • Tag :
    • Flag
    • GST
    • His
    • His (Fc)
    • Avi
    • Myc
    • DDK
    • Myc|DDK
    • N/A
    • N
    • SUMO
    Species Cat.# Product name Source (Host) Tag Price
    Human GATA3-2941H Recombinant Human GATA3 protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human GATA3-2939H Recombinant Human GATA3 protein, GST-tagged E.coli GST
    Human GATA3-28477TH Recombinant Human GATA3 Wheat Germ N/A
    Human GATA3-2940H Recombinant Human GATA3 protein, His-tagged E.coli His
    Human GATA3-6011HCL Recombinant Human GATA3 293 Cell Lysate HEK293 N/A
    Human GATA3-978H Recombinant Human GATA3 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human GATA3-963H Recombinant Human GATA3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
    Human GATA3-01H Recombinant Human GATA3 Protein, His-tagged E.coli N-His
    Human GATA3-4747H Recombinant Human GATA3 Protein, GST-tagged Wheat Germ GST
    Human GATA3-1052HFL Active Recombinant Full Length Human GATA3 Protein, C-Flag-tagged Mammalian cells Flag
    Human GATA3-2194H Recombinant Human GATA3 Protein, His-tagged E.coli N-His
    Human GATA3-2596H Recombinant Human GATA3 Protein (Met1-Gly443), N-His and SUMO tagged E.coli N-His and SUMO
    Human GATA3-5436HFL Recombinant Full Length Human GATA3 protein, Flag-tagged Mamanlian cells Flag
    Human GATA3-5467HF Recombinant Full Length Human GATA3 Protein, GST-tagged In Vitro Cell Free System GST
    Human GATA3-02H Recombinant Human GATA3 Protein, His-tagged E.coli N-His
    Human GATA3-963H-B Recombinant Human GATA3 Protein Pre-coupled Magnetic Beads HEK293
    Mouse GATA3-6224M Recombinant Mouse GATA3 Protein Mammalian Cell His
    Mouse GATA3-3483M Recombinant Mouse GATA3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
    Mouse GATA3-3483M-B Recombinant Mouse GATA3 Protein Pre-coupled Magnetic Beads HEK293
    Mouse Gata3-3161M Recombinant Mouse Gata3 Protein, Myc/DDK-tagged HEK293T Myc/DDK
    Zebrafish GATA3-8812Z Recombinant Zebrafish GATA3 Mammalian Cell His
    Chicken GATA3-1825C Recombinant Chicken GATA3 Mammalian Cell His
    • Involved Pathway
    • Protein Function
    • Interacting Protein
    • GATA3 Related Articles
    • GATA3 Related Research Area

    GATA3 involved in several pathways and played different roles in them. We selected most pathways GATA3 participated on our site, such as Inflammatory bowel disease (IBD), which may be useful for your reference. Also, other proteins which involved in the same pathway with GATA3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Inflammatory bowel disease (IBD)NFKB1;IL23R;TGFB3;HLA-DPA1;IL17A;TGFB2;HLA-DQA1;IL6;RORA

    GATA3 has several biochemical functions, for example, DNA binding, E-box binding, HMG box domain binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GATA3 itself. We selected most functions GATA3 had, and list some proteins which have the same functions with GATA3. You can find most of the proteins on our site.

    Function Related Protein
    DNA bindingHMGA1;BBX;ZFP382;IKZF1;KDM5D;ZNF620;RXRGB;ZFP110;VPS72
    E-box bindingNEUROD1;AHR;ASCL1;ATOH8;ARNTL;TCF3;LMO2;MYC;PER1
    HMG box domain bindingHOXA3;PAX3;ALX4;EGR2;POU3F3;OLIG2;MEOX1;SP1;UTF1
    RNA polymerase II core promoter sequence-specific DNA bindingH3F3A;TP53;PAX8;NSD1;SOX8;H3F3B;SMAD5;RREB1;PAX6
    RNA polymerase II regulatory region sequence-specific DNA bindingARID3A;ZNF773;FOXD3;CDX1B;ZNF549;KLF12;H2AFY;PKNOX2;SUV39H1
    RNA polymerase II transcription factor bindingCREBBP;DHX9;ANKRD1;TEAD3;GATA1;PITX2;TRP53;ID4;SPI1
    chromatin bindingOST4;JUN;MNT;TFAP2A;MED12;HDGFRP2;UBTFL;MEN1;POLA1
    core promoter proximal region sequence-specific DNA bindingDMRTA2;PAX2;DMRTC1B;DMRT2A;DMRT2;UHRF1;GATA3;DMRT3;DMRTC2
    core promoter sequence-specific DNA bindingCHD2;MEOX1;ESR1;PRMT5;NRIP1;TOP1;THRAP3;KLF10;REST
    enhancer sequence-specific DNA bindingLMO4;LDB1;XBP1;TBX19;TWIST1B;HMGB2;MYT1;GATA1;GATA3
    interleukin-2 receptor bindingIl2;TIMM50;ECM1;GATA3;IL21
    nucleic acid binding transcription factor activityGATA3;SOX4
    protein bindingIGHMBP2;NUP62;POC1A;KLRC2;TTLL6;BAX;CACNA2D1A;STAT5B;ANKZF1
    protein dimerization activityNCOA3;NEUROG3;ACTN2;TCF3B;FERD3L;NEUROG1;MXD3;TWIST1B;ATOH1B
    transcription coactivator activityELF3;NEUROD1;LPIN2;MED26;ESRRB;ECD;NR1I2;MED13;SUB1B
    transcription factor activity, sequence-specific DNA bindingHOXC6;PPARD;BCL6;BUD31;TARDBP;ENO1;FLI1B;PLAG1;TFEB
    transcription factor bindingSRY;ZBTB49;TP73;TRAPPC2;HHEX;UBE2I;TLE1;RBL1;IRF4
    transcription regulatory region DNA bindingSMARCA2;TBX16;ATF5;TFAP4;POU5F1;SALL3;RFX6;TAF9;CEBPA
    transcription regulatory region sequence-specific DNA bindingPITX2;MKL1;NFE2L1A;NFE2;SIN3A;POU5F1;CREB3L3;NFE2L2A;HIF1AL
    transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific bindingGMEB1;MYB;SFPI1;FUBP3;RUNX2;GABPA;EBF3A;PITX3;HEYL
    transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific bindingFOXO3;GATA1A;HIF1A;CREBBP;RFX6;NKX2-5;REST;MAFB;TBX5
    transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific bindingPROX1A;ZFPM2A;MYPOP;SREBF2;NFIL3-6;PROX1B;NFIL3-4;IFI203;MLXIPL
    zinc ion bindingMICALL2;MGRN1B;MLL5;MKRN1;ADH8A;NR1D4B;CAHZ;MORC2B;TRIM55A

    GATA3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GATA3 here. Most of them are supplied by our site. Hope this information will be useful for your research of GATA3.

    PSMA3; RARA; ESR1; SOX4; FOXC1; myc_human_gene; tff1_human_gene; GREB1; FOS; RARG; TAL1; STAT1

    McMullen, E; Samuelson, M; et al. GATA3 Is Frequently Expressed By Estrogen Receptor-Negative Breast Cancers: A Comparison of Two Commercially Available Monoclonal Antibodies. MODERN PATHOLOGY 28:56A-56A(2015).
    Wendroth, SM; Mentrikoski, MJ; et al. GATA3 expression in morphologic subtypes of breast carcinoma: a comparison with gross cystic disease fluid protein 15 and mammaglobin. ANNALS OF DIAGNOSTIC PATHOLOGY 19:6-9(2015).
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