GATA3 Protein

GATA3

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GATA3

Official Full Name GATA binding protein 3
Background This gene encodes a protein which belongs to the GATA family of transcription factors. The protein contains two GATA-type zinc fingers and is an important regulator of T-cell development and plays an important role in endothelial cell biology. Defects in this gene are the cause of hypoparathyroidism with sensorineural deafness and renal dysplasia. [provided by RefSeq, Nov 2009]
Synonyms GATA3; GATA binding protein 3; HDR; HDRS; trans-acting T-cell-specific transcription factor GATA-3; GATA-binding factor 3;
    • Species :
    • Chicken
    • Human
    • Mouse
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Mamanlian cells
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • Flag
    • GST
    • His
    • Myc/DDK
    • Myc
    • DDK
    • N/A
    • N-His
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human GATA3-28477TH Recombinant Human GATA3 Wheat Germ N/A
    Human GATA3-2939H Recombinant Human GATA3 protein, GST-tagged E.coli GST
    Human GATA3-2940H Recombinant Human GATA3 protein, His-tagged E.coli His
    Human GATA3-2941H Recombinant Human GATA3 protein, MYC/DDK-tagged HEK293 Myc/DDK
    Mouse GATA3-6224M Recombinant Mouse GATA3 Protein Mammalian Cell His
    Chicken GATA3-1825C Recombinant Chicken GATA3 Mammalian Cell His
    Zebrafish GATA3-8812Z Recombinant Zebrafish GATA3 Mammalian Cell His
    Human GATA3-6011HCL Recombinant Human GATA3 293 Cell Lysate HEK293 N/A
    Human GATA3-2194H Recombinant Human GATA3 Protein, His-tagged E.coli N-His
    Human GATA3-5436HFL Recombinant Full Length Human GATA3 protein, Flag-tagged Mamanlian cells Flag
    Human GATA3-4747H Recombinant Human GATA3 Protein, GST-tagged Wheat Germ GST
    Human GATA3-978H Recombinant Human GATA3 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Mouse Gata3-3161M Recombinant Mouse Gata3 Protein, Myc/DDK-tagged HEK293T Myc/DDK

    GATA3 involved in several pathways and played different roles in them. We selected most pathways GATA3 participated on our site, such as Inflammatory bowel disease (IBD), which may be useful for your reference. Also, other proteins which involved in the same pathway with GATA3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Inflammatory bowel disease (IBD) TLR2; HLA-DQB1; IL23R; IFNGR1; TLR4; TGFB2; HLA-DMB; IL4; IL13; RELA

    GATA3 has several biochemical functions, for example, DNA binding, E-box binding, HMG box domain binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GATA3 itself. We selected most functions GATA3 had, and list some proteins which have the same functions with GATA3. You can find most of the proteins on our site.

    Function Related Protein
    DNA binding DEAF1; ADNP2; MTF2; TOP1; TFEC; MBD1B; Alb; ARHGEF38; HMGA1B; LHX1A
    E-box binding TAL1; ASCL1; BHLHE40; MYC; NEUROD1; MYOD1; SREBF2; LMO2; TFAP4; ARNTL
    HMG box domain binding PAX3; MEOX1; JUN; HHEX; UTF1; SP1; HOXC4; GATA3; DLX5; PRRX1
    RNA polymerase II core promoter sequence-specific DNA binding SOX11; NFIL3; NSD1; STAT5A; SMAD1; SMYD3; EP300; MTF1; RUNX2; RUVBL2
    RNA polymerase II regulatory region sequence-specific DNA binding GATA1A; FOXC1; SOHLH1; GATA1; ZBTB12.2; GATA2A; MYOG; DMRT1; ATF1; XBP1
    RNA polymerase II transcription factor binding ZFPM2; GSC; ANKRD1; SPOP; HCLS1; Ar; MKX; DHX9; GATA2B; PITX2
    chromatin binding PCGF2; RERE; ASF1A; GABPA; CHAF1A; HESX1; SOX9A; TRIM24; PDX1; ZFP143
    core promoter proximal region sequence-specific DNA binding SP3; ZFP516; CREBBP; DMRTA2; MEF2C; DMRTC2; SMAD3; MIXL1; DMRTC1B; DMRT1
    core promoter sequence-specific DNA binding SP1; NRIP1; TRP53; MEOX1; GATA3; ESR2; PPARG; PDX1; PROX1; SIRT1
    enhancer sequence-specific DNA binding KLF7B; KLF6A; YY1; HMGB2; TBX19; LDB1; MYT1; ISL1; FOXN4; GATA1
    interleukin-2 receptor binding ECM1; TIMM50; GATA3; Il2; IL21
    nucleic acid binding transcription factor activity SOX4; GATA3
    protein binding SRPK1; HOXA1; BRK1; LBP; CHN1; PPP1R37; H2-KE2; RHOH; NARG1; RBL2
    protein dimerization activity NCOA2; GPR139; MXI1; SOHLH2; MYCS; SCXA; HEY1; LYL1; POLR2J2; MITFB
    transcription coactivator activity SOX17; TAF12; PSMC3; ZSCAN1; WWC1; E4F1; MED27; ACTL6A; KAT2A; ASXL1
    transcription factor activity, sequence-specific DNA binding UBN2A; KCNA3; HSF2; SUPT6H; NFIL3-4; TFDP2; ZFP27; CREB3L3A; POU5F2; SKINT8
    transcription factor binding SOST; NKX2-5; CXXC5; JUND; INSIG2; NLK; FOXO4; KEAP1; AIP; FOXA1
    transcription regulatory region DNA binding TBX16; NKX3; GATA5; SMAD6; HDAC1; GRHL1; SOX6; RNF10; NR5A2; BCL11B
    transcription regulatory region sequence-specific DNA binding NR5A2; BAHD1; NFE2L1; ZNF658; KDM3A; FOXN1; NFE2L3; NFKB1; NKX3; SUV39H2
    transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding CAMTA1; ONECUT3; MEIS1; NR3C1; FLI1; CDX4; MIXL1; ESR1; NR6A1; TFAP2C
    transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding HOXD8; CREBBP; GATA1A; ATF3; RFX6; GATA2A; SLAMF7; REST; GATA2B; BHLHA15
    transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding YY1; POU4F2; ETS2; FOXO1; ATF7; NFE2L3; ZNF217; ESRRA; GATA1; NACC2
    zinc ion binding RNF34; AKT1S1; MDM2; Shh; PYGO2; LNX2A; PCGF5A; MID1; NR1I2; LIMK1

    GATA3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GATA3 here. Most of them are supplied by our site. Hope this information will be useful for your research of GATA3.

    PSMA3; RARA; ESR1; SOX4; FOXC1; myc_human_gene; tff1_human_gene; GREB1; FOS; RARG; TAL1; STAT1

    McMullen, E; Samuelson, M; et al. GATA3 Is Frequently Expressed By Estrogen Receptor-Negative Breast Cancers: A Comparison of Two Commercially Available Monoclonal Antibodies. MODERN PATHOLOGY 28:56A-56A(2015).
    Wendroth, SM; Mentrikoski, MJ; et al. GATA3 expression in morphologic subtypes of breast carcinoma: a comparison with gross cystic disease fluid protein 15 and mammaglobin. ANNALS OF DIAGNOSTIC PATHOLOGY 19:6-9(2015).

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