GATA3
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Official Full Name
GATA binding protein 3 -
Overview
This gene encodes a protein which belongs to the GATA family of transcription factors. The protein contains two GATA-type zinc fingers and is an important regulator of T-cell development and plays an important role in endothelial cell biology. Defects in this gene are the cause of hypoparathyroidism with sensorineural deafness and renal dysplasia. [provided by RefSeq, Nov 2009] -
Synonyms
GATA3;GATA binding protein 3;HDR;HDRS;trans-acting T-cell-specific transcription factor GATA-3;GATA-binding factor 3
Recombinant Proteins
- Human
- Chicken
- Mouse
- Zebrafish
- E.coli
- Mammalian Cells
- Wheat Germ
- HEK293
- In Vitro Cell Free System
- GST
- His
- Non
- DDK
- Myc
- Flag
- SUMO
- Avi
- Fc
Involved Pathway
GATA3 involved in several pathways and played different roles in them. We selected most pathways GATA3 participated on our site, such as Inflammatory bowel disease (IBD), which may be useful for your reference. Also, other proteins which involved in the same pathway with GATA3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Inflammatory bowel disease (IBD) | IL23,STAT1,RORC,RELA,HLA-DQB1,IFNG,TGFB1,NFKB1,NFATC1,IFNGR2 |
Protein Function
GATA3 has several biochemical functions, for example, DNA binding,E-box binding,HMG box domain binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GATA3 itself. We selected most functions GATA3 had, and list some proteins which have the same functions with GATA3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding | PRDM1,SPI1,YY1,KLF16,ZFP746,ATF3,HES1,ZKSCAN3,HOXA2,ESRRA |
| transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding | PHOX2B,JUN,BARHL2,HIF1A,AKNA,PITX1,SOX9,CREB1,FOXJ2,TTC6 |
| HMG box domain binding | HOXC4,EGR2,PRRX1,POU3F3,HOXA3,MEOX1,UTF1,JUN,PAX3,SP1 |
| zinc ion binding | ING5A,ZNRF2B,LIN28B,TRIM109,TRAIP,ISL1,TRIM45,TRIM69,RNF135,DTX3L |
| transcription regulatory region DNA binding | HDAC1,XRCC5,TFAP2A,WNT5A,TCF7,GFI1,ZFP335,HIVEP3,CEBPA,KLF11 |
| transcription factor activity, sequence-specific DNA binding | CEBP1,ZNF548,ZNF490,ZGPAT,FOXN4,NKX3-1,LZTS1,CREB1B,FOXJ1A,RORA |
| DNA binding | MEF2C,POLR2J,RORAB,NR6A1A,POLG,ASCL1,NR4A2,SPTY2D1,BEND5,CERS4A |
| RNA polymerase II transcription factor binding | GSK3B,SFPI1,MIXL1,GATA2,KDM1A,T,TOX2,SPOP,MEF2A,GATA1A |
| RNA polymerase II regulatory region sequence-specific DNA binding | H2AFY,SOX13,ZNF773,ATF4B1,SP1,ARID3A,FOXD3,BARX1,PKNOX2,AEBP1 |
Interacting Protein
GATA3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GATA3 here. Most of them are supplied by our site. Hope this information will be useful for your research of GATA3.
PSMA3;RARA;ESR1;SOX4;FOXC1;myc_human_gene;tff1_human_gene;GREB1;FOS;RARG;TAL1;STAT1
Resources
Research Area
Tumor SuppressorsMultiple Sclerosis and Myelin Related Molecules
Transcription Factors in the Akt Pathway
Hematopoietic Stem Cell Transcription Factors and Regulators
Pluripotent Stem Cell Transcription Factors
gamma delta T Cells
Natural Killer T (NKT) Cells
T Follicular Helper (Tfh) Cells
Th2 Cells
Related Services
Related Products
References
- McMullen, E; Samuelson, M; et al. GATA3 Is Frequently Expressed By Estrogen Receptor-Negative Breast Cancers: A Comparison of Two Commercially Available Monoclonal Antibodies. MODERN PATHOLOGY 28:56A-56A(2015).
- Wendroth, SM; Mentrikoski, MJ; et al. GATA3 expression in morphologic subtypes of breast carcinoma: a comparison with gross cystic disease fluid protein 15 and mammaglobin. ANNALS OF DIAGNOSTIC PATHOLOGY 19:6-9(2015).
