GATA3
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Official Full Name
GATA binding protein 3
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Background
This gene encodes a protein which belongs to the GATA family of transcription factors. The protein contains two GATA-type zinc fingers and is an important regulator of T-cell development and plays an important role in endothelial cell biology. Defects in this gene are the cause of hypoparathyroidism with sensorineural deafness and renal dysplasia. [provided by RefSeq, Nov 2009] -
Synonyms
GATA3; GATA binding protein 3; HDR; HDRS; trans-acting T-cell-specific transcription factor GATA-3; GATA-binding factor 3;
- Involved Pathway
- Protein Function
- Interacting Protein
- GATA3 Related Articles
- GATA3 Related Research Area
GATA3 involved in several pathways and played different roles in them. We selected most pathways GATA3 participated on our site, such as Inflammatory bowel disease (IBD), which may be useful for your reference. Also, other proteins which involved in the same pathway with GATA3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Inflammatory bowel disease (IBD) | NFKB1;IL23R;TGFB3;HLA-DPA1;IL17A;TGFB2;HLA-DQA1;IL6;RORA |
GATA3 has several biochemical functions, for example, DNA binding, E-box binding, HMG box domain binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GATA3 itself. We selected most functions GATA3 had, and list some proteins which have the same functions with GATA3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| DNA binding | HMGA1;BBX;ZFP382;IKZF1;KDM5D;ZNF620;RXRGB;ZFP110;VPS72 |
| E-box binding | NEUROD1;AHR;ASCL1;ATOH8;ARNTL;TCF3;LMO2;MYC;PER1 |
| HMG box domain binding | HOXA3;PAX3;ALX4;EGR2;POU3F3;OLIG2;MEOX1;SP1;UTF1 |
| RNA polymerase II core promoter sequence-specific DNA binding | H3F3A;TP53;PAX8;NSD1;SOX8;H3F3B;SMAD5;RREB1;PAX6 |
| RNA polymerase II regulatory region sequence-specific DNA binding | ARID3A;ZNF773;FOXD3;CDX1B;ZNF549;KLF12;H2AFY;PKNOX2;SUV39H1 |
| RNA polymerase II transcription factor binding | CREBBP;DHX9;ANKRD1;TEAD3;GATA1;PITX2;TRP53;ID4;SPI1 |
| chromatin binding | OST4;JUN;MNT;TFAP2A;MED12;HDGFRP2;UBTFL;MEN1;POLA1 |
| core promoter proximal region sequence-specific DNA binding | DMRTA2;PAX2;DMRTC1B;DMRT2A;DMRT2;UHRF1;GATA3;DMRT3;DMRTC2 |
| core promoter sequence-specific DNA binding | CHD2;MEOX1;ESR1;PRMT5;NRIP1;TOP1;THRAP3;KLF10;REST |
| enhancer sequence-specific DNA binding | LMO4;LDB1;XBP1;TBX19;TWIST1B;HMGB2;MYT1;GATA1;GATA3 |
| interleukin-2 receptor binding | Il2;TIMM50;ECM1;GATA3;IL21 |
| nucleic acid binding transcription factor activity | GATA3;SOX4 |
| protein binding | IGHMBP2;NUP62;POC1A;KLRC2;TTLL6;BAX;CACNA2D1A;STAT5B;ANKZF1 |
| protein dimerization activity | NCOA3;NEUROG3;ACTN2;TCF3B;FERD3L;NEUROG1;MXD3;TWIST1B;ATOH1B |
| transcription coactivator activity | ELF3;NEUROD1;LPIN2;MED26;ESRRB;ECD;NR1I2;MED13;SUB1B |
| transcription factor activity, sequence-specific DNA binding | HOXC6;PPARD;BCL6;BUD31;TARDBP;ENO1;FLI1B;PLAG1;TFEB |
| transcription factor binding | SRY;ZBTB49;TP73;TRAPPC2;HHEX;UBE2I;TLE1;RBL1;IRF4 |
| transcription regulatory region DNA binding | SMARCA2;TBX16;ATF5;TFAP4;POU5F1;SALL3;RFX6;TAF9;CEBPA |
| transcription regulatory region sequence-specific DNA binding | PITX2;MKL1;NFE2L1A;NFE2;SIN3A;POU5F1;CREB3L3;NFE2L2A;HIF1AL |
| transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding | GMEB1;MYB;SFPI1;FUBP3;RUNX2;GABPA;EBF3A;PITX3;HEYL |
| transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding | FOXO3;GATA1A;HIF1A;CREBBP;RFX6;NKX2-5;REST;MAFB;TBX5 |
| transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding | PROX1A;ZFPM2A;MYPOP;SREBF2;NFIL3-6;PROX1B;NFIL3-4;IFI203;MLXIPL |
| zinc ion binding | MICALL2;MGRN1B;MLL5;MKRN1;ADH8A;NR1D4B;CAHZ;MORC2B;TRIM55A |
GATA3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GATA3 here. Most of them are supplied by our site. Hope this information will be useful for your research of GATA3.
PSMA3; RARA; ESR1; SOX4; FOXC1; myc_human_gene; tff1_human_gene; GREB1; FOS; RARG; TAL1; STAT1
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