GATA3

  • Official Full Name

    GATA binding protein 3

  • Overview

    This gene encodes a protein which belongs to the GATA family of transcription factors. The protein contains two GATA-type zinc fingers and is an important regulator of T-cell development and plays an important role in endothelial cell biology. Defects in this gene are the cause of hypoparathyroidism with sensorineural deafness and renal dysplasia. [provided by RefSeq, Nov 2009]
  • Synonyms

    GATA3; GATA binding protein 3; HDR; HDRS; trans-acting T-cell-specific transcription factor GATA-3; GATA-binding factor 3;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mamanlian cells
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • Myc|DDK
  • N/A
  • N
  • SUMO
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human GATA3-2941H Recombinant Human GATA3 protein, MYC/DDK-tagged HEK293 Myc/DDK
Human GATA3-2939H Recombinant Human GATA3 protein, GST-tagged E.coli GST 1-262aa
Human GATA3-28477TH Recombinant Human GATA3 Wheat Germ N/A 98 amino acids
Human GATA3-2940H Recombinant Human GATA3 protein, His-tagged E.coli His 1-262aa
Human GATA3-6011HCL Recombinant Human GATA3 293 Cell Lysate HEK293 N/A
Human GATA3-978H Recombinant Human GATA3 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human GATA3-963H Recombinant Human GATA3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human GATA3-01H Recombinant Human GATA3 Protein, His-tagged E.coli N-His
Human GATA3-4747H Recombinant Human GATA3 Protein, GST-tagged Wheat Germ GST
Human GATA3-1052HFL Active Recombinant Full Length Human GATA3 Protein, C-Flag-tagged Mammalian cells Flag
Human GATA3-2194H Recombinant Human GATA3 Protein, His-tagged E.coli N-His Tyr229-Gly444
Human GATA3-2596H Recombinant Human GATA3 Protein (Met1-Gly443), N-His and SUMO tagged E.coli N-His and SUMO Met1-Gly443
Human GATA3-5436HFL Recombinant Full Length Human GATA3 protein, Flag-tagged Mamanlian cells Flag
Human GATA3-5467HF Recombinant Full Length Human GATA3 Protein, GST-tagged In Vitro Cell Free System GST 444 amino acids
Human GATA3-02H Recombinant Human GATA3 Protein, His-tagged E.coli N-His
Human GATA3-963H-B Recombinant Human GATA3 Protein Pre-coupled Magnetic Beads HEK293
Mouse GATA3-6224M Recombinant Mouse GATA3 Protein Mammalian Cell His
Mouse GATA3-3483M Recombinant Mouse GATA3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse GATA3-3483M-B Recombinant Mouse GATA3 Protein Pre-coupled Magnetic Beads HEK293
Mouse Gata3-3161M Recombinant Mouse Gata3 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Zebrafish GATA3-8812Z Recombinant Zebrafish GATA3 Mammalian Cell His
Chicken GATA3-1825C Recombinant Chicken GATA3 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

GATA3 involved in several pathways and played different roles in them. We selected most pathways GATA3 participated on our site, such as Inflammatory bowel disease (IBD), which may be useful for your reference. Also, other proteins which involved in the same pathway with GATA3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Inflammatory bowel disease (IBD)TLR2;HLA-DMB;Il23a; Il12b;STAT6;SMAD3;IFNGR2;IL21;Il4ra;IL23R

GATA3 has several biochemical functions, for example, DNA binding, E-box binding, HMG box domain binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GATA3 itself. We selected most functions GATA3 had, and list some proteins which have the same functions with GATA3. You can find most of the proteins on our site.

Function Related Protein
DNA bindingIRX5;ZNF566;HIST1H3A;NR5A5;UBN2A;HOXA13;HOXC12;NR4A1;HOXA3A
E-box bindingARNTL;GATA3;AHR;MYOD1;MYOG;ASCL1;NEUROG1;CLOCK;ARNTL2
HMG box domain bindingPAX3;HOXC4;GATA3;PRRX1;EGR2;JUN;CEBPA;HHEX;HOXA3
RNA polymerase II core promoter sequence-specific DNA bindingTFAP2B;NR4A2;YAP1;MTF1;SPI1;WBP2;EP300;RUVBL2;GATA1
RNA polymerase II regulatory region sequence-specific DNA bindingGATA2A;BCL6A;ARID5B;ATF2;FOXC1;TFAP2D;ZBTB16A;SKINT8;TRP53
RNA polymerase II transcription factor bindingTP53;SPOP;ZGLP1;KLF4;ZFPM2;ATF4;WWP2;GATA5;MKX
chromatin bindingKDM8;KLF14;GLI3;LDB2A;CENPB;SOX14;HMGB1A;WACA;TICRR
core promoter proximal region sequence-specific DNA bindingKLF4;CREBBP;DMRT1;PAX2;UHRF1;SP3;TFAP2A;ZFP516;DMRT2
core promoter sequence-specific DNA bindingCREM;PRMT5;CRY1;C1orf51;SOX9;SOHLH1;SOX1;MYOCD;PPARG
enhancer sequence-specific DNA bindingXBP1;KLF6A;GATA4;SOX9;ATF2;LMO4;TFAP2B;FOXN4;HMGB2
interleukin-2 receptor bindingECM1;TIMM50;Il2;GATA3;IL21
nucleic acid binding transcription factor activitySOX4;GATA3
protein bindingCDC7;AHNAK2;RFC2;MYOT;FLI1;HP1BP3;MYL12A;B4GALT7;TMPRSS15
protein dimerization activityMYCLB;SRFA;TCF23;MYCB;CLOCKB;MITFB;ASCL2;MSGN1;MITF
transcription coactivator activityFUS;RIPK3;BRCA1;POU2AF1;NCOA4;TFAP2A;CTBP2;CARM1;ABT1
transcription factor activity, sequence-specific DNA bindingETS2;ZFP354B;DMRTC2;SNAPC5;L3MBTL1;ZNF41;SLAMF7;ZNF189;KLF2
transcription factor bindingPURB;SIX2;NLK;NR0B2;HTT;MAPK9;PPP1R13B;RELA;RB1
transcription regulatory region DNA bindingDLX5;Arid4b;PRDM5;ERBB4;TP73;CTCFL;ZFP746;HHEX;SNCA
transcription regulatory region sequence-specific DNA bindingNR5A5;HDAC1;ZNF658;SOX4;BACH1B;ARNTL;NFE2L1A;SIN3A;HIF1AL
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific bindingETV2;PGR;SOX11;EBF2;MYOCD;SREBF1;WT1;NKX2-8;NFATC3
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific bindingLEF1;GATA1;ALX1;CSRNP3;CREB3L3;STAG2;MAFBA;NHLH1;TRPS1
transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific bindingPROX1B;NKX6-2;OVOL1;NKX3-2;CUX2;SNAI1;YY1;ASCL2;NFIL3-4
zinc ion bindingMT1G;DTX1;LIMS3L;APOBEC3C;RERE;DRP2;ZFAND5;TRIM43C;ZFP385C

GATA3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GATA3 here. Most of them are supplied by our site. Hope this information will be useful for your research of GATA3.

PSMA3; RARA; ESR1; SOX4; FOXC1; myc_human_gene; tff1_human_gene; GREB1; FOS; RARG; TAL1; STAT1

Research Area

Related articles

McMullen, E; Samuelson, M; et al. GATA3 Is Frequently Expressed By Estrogen Receptor-Negative Breast Cancers: A Comparison of Two Commercially Available Monoclonal Antibodies. MODERN PATHOLOGY 28:56A-56A(2015).
Wendroth, SM; Mentrikoski, MJ; et al. GATA3 expression in morphologic subtypes of breast carcinoma: a comparison with gross cystic disease fluid protein 15 and mammaglobin. ANNALS OF DIAGNOSTIC PATHOLOGY 19:6-9(2015).
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