|Official Full Name||growth differentiation factor 6|
|Background||This gene encodes a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily of secreted signaling molecules. It is required for normal formation of some bones and joints in the limbs, skull, and axial skeleton. Mutations in this gene result in colobomata, which are congenital abnormalities in ocular development, and in Klippel-Feil syndrome (KFS), which is a congenital disorder of spinal segmentation.|
|Synonyms||GDF6; growth differentiation factor 6; growth/differentiation factor 6; BMP13; GDF-6; Klippel-Feil syndrome; Klip-Feil malformation; Klippel-Feil malformation; growth/differentiation factor 16; KFM; KFS; KFS1; KFSL; SGM1; CDMP2; MCOP4; SCDO4; MCOPCB6; MGC|
|Species||Cat.#||Product name||Source (Host)||Tag||Protein Length||Price|
GDF6 involved in several pathways and played different roles in them. We selected most pathways GDF6 participated on our site, such as TGF-beta signaling pathway, Hippo signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with GDF6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
|Pathway Name||Pathway Related Protein|
|TGF-beta signaling pathway||TGFB1; LTBP1; BMPR2B; BMP8A; TGFBR2; BMPR1BA; BMP8B; IFNG1-2; BMP7A; PITX2|
|Hippo signaling pathway||PARD6A; LLGL2; MOBKL1A; APC2; CTNNA2; TGFB2; FZD5; WNT7A; WNT3A; YWHAE|
GDF6 has several biochemical functions, for example, cytokine activity, growth factor activity, protein homodimerization activity. Some of the functions are cooperated with other proteins, some of the functions could acted by GDF6 itself. We selected most functions GDF6 had, and list some proteins which have the same functions with GDF6. You can find most of the proteins on our site.
|cytokine activity||Ifna11; THPO; CCL38A.5; IL37; IFNL3; FAM3C; TNF; IFNG1-1; IL3; Kitl|
|growth factor activity||CXCL1; NRG4; OSGIN1; CTGF; INHBAB; AMBN; FIGF; IL6; NENF; GPI1|
|protein homodimerization activity||SYT10; WHRN; TIMELESS; FGFR1; SNX9; MVD; CUL3; DAXX; ARID3A; ZHX2|
|transforming growth factor beta receptor binding||NDR1; USP15; GDF5; INHBA; GDF1; SMAD2; GDF7; GDF10B; BMP5; BMP6|
GDF6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GDF6 here. Most of them are supplied by our site. Hope this information will be useful for your research of GDF6.