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Official Full Name growth differentiation factor 6
Background This gene encodes a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily of secreted signaling molecules. It is required for normal formation of some bones and joints in the limbs, skull, and axial skeleton. Mutations in this gene result in colobomata, which are congenital abnormalities in ocular development, and in Klippel-Feil syndrome (KFS), which is a congenital disorder of spinal segmentation.
Synonyms GDF6; growth differentiation factor 6; growth/differentiation factor 6; BMP13; GDF-6; Klippel-Feil syndrome; Klip-Feil malformation; Klippel-Feil malformation; growth/differentiation factor 16; KFM; KFS; KFS1; KFSL; SGM1; CDMP2; MCOP4; SCDO4; MCOPCB6; MGC
    • Species :
    • Human
    • Mouse
    • Rat
    • Source :
    • E. coli
    • E.coli
    • HEK293
    • Mammalian Cell
    • Tag :
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human GDF6-050H Recombinant Human GDF6 Protein E. coli
    Human GDF6-19H Recombinant Human Growth Differentiation Factor 6 E.coli N/A
    Human GDF6-277H Recombinant Human GDF6 Protein, His-tagged E.coli His
    Human GDF6-381H Recombinant Human GDF6 protein E.coli N/A
    Human GDF6-517H Recombinant Human GDF6 Mammalian Cell His
    Human GDF6-5967HCL Recombinant Human GDF6 293 Cell Lysate HEK293 N/A
    Mouse Gdf6-278M Recombinant Mouse Gdf6 Protein, His-tagged E.coli His
    Mouse Gdf6-722M Recombinant Mouse Growth Differentiation Factor 6 E.coli N/A
    Rat GDF6-2503R Recombinant Rat GDF6 Protein Mammalian Cell His

    GDF6 involved in several pathways and played different roles in them. We selected most pathways GDF6 participated on our site, such as TGF-beta signaling pathway, Hippo signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with GDF6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    TGF-beta signaling pathway TGFB1; LTBP1; BMPR2B; BMP8A; TGFBR2; BMPR1BA; BMP8B; IFNG1-2; BMP7A; PITX2
    Hippo signaling pathway PARD6A; LLGL2; MOBKL1A; APC2; CTNNA2; TGFB2; FZD5; WNT7A; WNT3A; YWHAE

    GDF6 has several biochemical functions, for example, cytokine activity, growth factor activity, protein homodimerization activity. Some of the functions are cooperated with other proteins, some of the functions could acted by GDF6 itself. We selected most functions GDF6 had, and list some proteins which have the same functions with GDF6. You can find most of the proteins on our site.

    Function Related Protein
    cytokine activity Ifna11; THPO; CCL38A.5; IL37; IFNL3; FAM3C; TNF; IFNG1-1; IL3; Kitl
    growth factor activity CXCL1; NRG4; OSGIN1; CTGF; INHBAB; AMBN; FIGF; IL6; NENF; GPI1
    protein homodimerization activity SYT10; WHRN; TIMELESS; FGFR1; SNX9; MVD; CUL3; DAXX; ARID3A; ZHX2
    transforming growth factor beta receptor binding NDR1; USP15; GDF5; INHBA; GDF1; SMAD2; GDF7; GDF10B; BMP5; BMP6

    GDF6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GDF6 here. Most of them are supplied by our site. Hope this information will be useful for your research of GDF6.

    Wendroth, SM; Mentrikoski, MJ; et al. GATA3 expression in morphologic subtypes of breast carcinoma: a comparison with gross cystic disease fluid protein 15 and mammaglobin. ANNALS OF DIAGNOSTIC PATHOLOGY 19:6-9(2015).
    Esser, JS; Rahner, S; et al. Fibroblast Growth Factor Signaling Pathway in Endothelial Cells Is Activated by BMPER to Promote Angiogenesis. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY 35:358-367(2015).


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