GDF6

  • Official Full Name

    growth differentiation factor 6

  • Overview

    This gene encodes a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily of secreted signaling molecules. It is required for normal formation of some bones and joints in the limbs, skull, and axial skeleton. Mutations in this gene result in colobomata, which are congenital abnormalities in ocular development, and in Klippel-Feil syndrome (KFS), which is a congenital disorder of spinal segmentation.
  • Synonyms

    GDF6; growth differentiation factor 6; growth/differentiation factor 6; BMP13; GDF-6; Klippel-Feil syndrome; Klip-Feil malformation; Klippel-Feil malformation; growth/differentiation factor 16; KFM; KFS; KFS1; KFSL; SGM1; CDMP2; MCOP4; SCDO4; MCOPCB6; MGC;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • E. coli
  • E.coli
  • HEK293
  • Mammalian Cell
  • C
  • His
  • His (Fc)
  • Avi
  • His(C
  • ter)
  • N/A
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • GDF6 Related Articles
  • GDF6 Related Gene Family
  • GDF6 Related Research Area

GDF6 involved in several pathways and played different roles in them. We selected most pathways GDF6 participated on our site, such as TGF-beta signaling pathway, Hippo signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with GDF6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
TGF-beta signaling pathwayPITX2;RHOAB;INHBC;TGFB1A;ACVR2B;TGIF1;ID3;BAMBIB;THBS1
Hippo signaling pathwayAREG;LLGL1;PPP1CA;NKD1;WNT9A;ID2;ITGB2L;PPP2R1A;FRMD6

GDF6 has several biochemical functions, for example, cytokine activity, growth factor activity, protein homodimerization activity. Some of the functions are cooperated with other proteins, some of the functions could acted by GDF6 itself. We selected most functions GDF6 had, and list some proteins which have the same functions with GDF6. You can find most of the proteins on our site.

Function Related Protein
cytokine activityBMP5;IL36G;BMP7;GPR19;LFT1;IFNA7;SCGB3A1;IFNB;TSLP
growth factor activityIGF2;FGF14;JAG2;FGF11;FGF3;PDGFAB;BTC;COL20A1;GH1
protein homodimerization activityXPA;BMP4;TIMELESS;IMPA1;BARD1;HSPB6;LRP4;MZF1;FGFR2
transforming growth factor beta receptor bindingGDF15;BMP8A;GDF11;TGFBRAP1;GDF7;BMP6;BMP15;FKBP1A;GDF6

GDF6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GDF6 here. Most of them are supplied by our site. Hope this information will be useful for your research of GDF6.

Wendroth, SM; Mentrikoski, MJ; et al. GATA3 expression in morphologic subtypes of breast carcinoma: a comparison with gross cystic disease fluid protein 15 and mammaglobin. ANNALS OF DIAGNOSTIC PATHOLOGY 19:6-9(2015).
Esser, JS; Rahner, S; et al. Fibroblast Growth Factor Signaling Pathway in Endothelial Cells Is Activated by BMPER to Promote Angiogenesis. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY 35:358-367(2015).
TGF
  • Q&As
  • Reviews

Q&As (6)

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How to study the regulatory mechanism of GDF6 protein? 07/10/2022

Studying the regulatory mechanism of GDF6 protein requires the comprehensive use of various experimental methods and techniques, such as gene knockout, transcriptome analysis, and protein-protein interaction.

What is the relationship between GDF6 protein and other proteins? 01/29/2022

GDF6 protein has a complex relationship with other proteins, and can interact with other proteins and participate in a variety of biochemical reactions.

Are there any diseases that might indicate abnormal GDF6 protein expression levels? 09/04/2021

Abnormal expression levels of GDF6 protein may indicate some diseases related to bone and cartilage development.

What diseases is GDF6 protein associated with? 07/13/2021

GDF6 protein is associated with some bone diseases, such as osteoporosis, poor fracture healing, etc.

How is the activity of GDF6 protein regulated? 04/03/2021

The activity of GDF6 protein can be modulated in a variety of ways, including protein modification (e.g., phosphorylation), binding to ligands, interaction with cell surface receptors, etc.

How can diseases be treated by regulating the expression level of GDF6 protein? 12/30/2020

There are currently no drugs that directly regulate the expression level of GDF6 protein, but some diseases related to GDF6 protein can be treated by regulating its activity or regulating its expression.

Customer Reviews (3)

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Reviews
12/04/2022

    GDF6 has low pollution, safety and health, and is suitable for long-term use.

    07/28/2022

      These are very convenient to use, and the results are very good, I highly recommend them.

      09/21/2021

        The quality is very good, the experimental effect is in line with expectations, will continue to use.

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