Active Recombinant Human GDF6 Protein

• Cat.No.: GDF6-050H
• Product Overview: The mature recombinant human GDF-6 protein (336-455aa) without tag was expressed in E. coli.

Specification

• Species: Human
• Source: E.coli
• Protein Length: 336-455 a.a.
• Description: This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein is required for normal formation of some bones and joints in the limbs, skull, and axial skeleton. Mutations in this gene are associated with Klippel-Feil syndrome, microphthalmia, and Leber congenital amaurosis.
• Bio-activity: The ED50 as determined by its ability to induce alkaline phosphatase production by ATDC-5 chondrogenic cells is in the range of 2-3 ug/mL.
• Molecular Mass: 14 kDa
• Product-Related Proteins: 336-455
• Endotoxin: < 0.1 EU/μg of the protein as determined by the LAL method
• Purity: > 95 % as determined by SDS-PAGE
• Storage: At -80 centigrade. Avoid repeated freeze-thaw cycles.
• Storage Buffer: PBS

Gene Information

• Gene Name: GDF6 growth differentiation factor 6 [ Homo sapiens (human) ]
• Official Symbol: GDF6
• Synonyms: GDF6; growth differentiation factor 6; KFM; KFS; KFS1; KFSL; SGM1; BMP13; CDMP2; SYNS4; BMP-13; growth/differentiation factor 6; bone morphogenetic protein 13; growth/differentiation factor 16
• Gene ID: 392255
• mRNA Refseq: NM_001001557
• Protein Refseq: NP_001001557
• MIM: 601147
• UniProt ID: Q6KF10