Active Recombinant Human GDF6 Protein

Cat.No. : GDF6-050H
Product Overview : The mature recombinant human GDF-6 protein (336-455aa) without tag was expressed in E. coli.
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Description : This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein is required for normal formation of some bones and joints in the limbs, skull, and axial skeleton. Mutations in this gene are associated with Klippel-Feil syndrome, microphthalmia, and Leber congenital amaurosis.
Source : E. coli
Species : Human
Bio-activity : The ED50 as determined by its ability to induce alkaline phosphatase production by ATDC-5 chondrogenic cells is in the range of 2-3 ug/mL.
Molecular Mass : 14 kDa
Product-Related Proteins : 336-455
Endotoxin : < 0.1 EU/μg of the protein as determined by the LAL method
Purity : > 95 % as determined by SDS-PAGE
Storage : At -80 centigrade. Avoid repeated freeze-thaw cycles.
Storage Buffer : PBS
Protein length : 336-455
Gene Name : GDF6 growth differentiation factor 6 [ Homo sapiens (human) ]
Official Symbol : GDF6
Synonyms : GDF6; growth differentiation factor 6; KFM; KFS; KFS1; KFSL; SGM1; BMP13; CDMP2; SYNS4; BMP-13; growth/differentiation factor 6; bone morphogenetic protein 13; growth/differentiation factor 16
Gene ID : 392255
mRNA Refseq : NM_001001557
Protein Refseq : NP_001001557
MIM : 601147
UniProt ID : Q6KF10

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Customer Reviews (3)

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Reviews
12/04/2022

    GDF6 has low pollution, safety and health, and is suitable for long-term use.

    07/28/2022

      These are very convenient to use, and the results are very good, I highly recommend them.

      09/21/2021

        The quality is very good, the experimental effect is in line with expectations, will continue to use.

        Q&As (6)

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        How to study the regulatory mechanism of GDF6 protein? 07/10/2022

        Studying the regulatory mechanism of GDF6 protein requires the comprehensive use of various experimental methods and techniques, such as gene knockout, transcriptome analysis, and protein-protein interaction.

        What is the relationship between GDF6 protein and other proteins? 01/29/2022

        GDF6 protein has a complex relationship with other proteins, and can interact with other proteins and participate in a variety of biochemical reactions.

        Are there any diseases that might indicate abnormal GDF6 protein expression levels? 09/04/2021

        Abnormal expression levels of GDF6 protein may indicate some diseases related to bone and cartilage development.

        What diseases is GDF6 protein associated with? 07/13/2021

        GDF6 protein is associated with some bone diseases, such as osteoporosis, poor fracture healing, etc.

        How is the activity of GDF6 protein regulated? 04/03/2021

        The activity of GDF6 protein can be modulated in a variety of ways, including protein modification (e.g., phosphorylation), binding to ligands, interaction with cell surface receptors, etc.

        How can diseases be treated by regulating the expression level of GDF6 protein? 12/30/2020

        There are currently no drugs that directly regulate the expression level of GDF6 protein, but some diseases related to GDF6 protein can be treated by regulating its activity or regulating its expression.

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