Active Recombinant Mouse Growth Differentiation Factor 6
Cat.No. : | Gdf6-722M |
Product Overview : | Recombinant Mouse Gdf6protein was expressed in E. coli. Thr335-Arg454. |
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Cat. No. : | Gdf6-722M |
Description : | Gdf6, also known asbone morphogenetic protein 13 (BMP13) or cartilage-derived morphogeneticprotein 2 (CDMP2), is a member of the bone morphogenetic protein (BMP) familywhich belongs to the transforming growth factor β (TGFβ) superfamily. Themature Gdf6 with 120 amino acids is a homodimeric protein containing thecharacteristic seven conserved cysteine residues. Gdf5, Gdf6 and Gdf7, whichshare 80-86% identity, define a new subgroup within the BMP family. |
Source : | E. coli-derived. |
Form : | Lyophilized from a0.2 μm filtered solution in Acetonitrile and TFA with BSA as a carrier protein. |
N-terminalSequence : | Thr335 |
Molecular Weight : | 13.7 kDa |
Activity : | Measuredby its ability to induce alkaline phosphatase production by ATDC5 mousechondrogenic cells. Nakamura, K. et al. (1999) Exp. Cell Res. 250:351. The ED50for this effect is typically 4-16 μg/mL. |
Endotoxin Level : | <1.0 EUper 1 μg of the protein by the LAL method. |
Purity : | >97%,by SDS-PAGE under reducing conditions and visualized by silver stain. |
Reconstitution : | 300μg/mL in sterile 4 mM HCl that containing at least 0.1% human or bovine serumalbumin. |
Storage : | Use amanual defrost freezer and avoid repeated freeze-thaw cycles. 12 months fromdate of receipt, -20 to -70°C as supplied. 1 month, 2 to 8 °C under sterileconditions after reconstitution. 3 months, -20 to -70°C under sterileconditions after reconstitution. |
Tag : | Non |
Protein length : | Thr335-Arg454 |
Gene Name : | Gdf6 growth differentiationfactor 6 [ Mus musculus ] |
Official Symbol : | Gdf6 |
Synonyms : | Gdf6; growthdifferentiation factor 6; BMP13; GDF16; growth/differentiation factor 6;GDF-6; growth differentiation factor 16; growth/differentiation factor 16 |
Gene ID : | 242316 |
mRNA Refseq : | NM_013526 |
Protein Refseq : | NP_038554 |
UniProt ID : | P43028 |
Chromosome Location : | 4 A1; 4 |
Pathway : | TGF-beta signalingpathway |
Function : | cytokine activity;growth factor activity; protein homodimerization activity |
Products Types
◆ Recombinant Protein | ||
GDF6-277H | Recombinant Human GDF6 Protein, His-tagged | +Inquiry |
GDF6-106H | Recombinant Active Human GDF6 Protein, His-tagged(C-ter) | +Inquiry |
GDF6-188H | Active Recombinant Human GDF6 Protein (Thr336-Arg455), C-His tagged, Animal-free, Carrier-free | +Inquiry |
GDF6-2159R | Recombinant Rat GDF6 Protein, His (Fc)-Avi-tagged | +Inquiry |
Gdf6-278M | Recombinant Mouse Gdf6 Protein, His-tagged | +Inquiry |
◆ Lysates | ||
GDF6-5967HCL | Recombinant Human GDF6 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Customer Reviews (3)
Write a reviewGDF6 has low pollution, safety and health, and is suitable for long-term use.
These are very convenient to use, and the results are very good, I highly recommend them.
The quality is very good, the experimental effect is in line with expectations, will continue to use.
Q&As (6)
Ask a questionStudying the regulatory mechanism of GDF6 protein requires the comprehensive use of various experimental methods and techniques, such as gene knockout, transcriptome analysis, and protein-protein interaction.
GDF6 protein has a complex relationship with other proteins, and can interact with other proteins and participate in a variety of biochemical reactions.
Abnormal expression levels of GDF6 protein may indicate some diseases related to bone and cartilage development.
GDF6 protein is associated with some bone diseases, such as osteoporosis, poor fracture healing, etc.
The activity of GDF6 protein can be modulated in a variety of ways, including protein modification (e.g., phosphorylation), binding to ligands, interaction with cell surface receptors, etc.
There are currently no drugs that directly regulate the expression level of GDF6 protein, but some diseases related to GDF6 protein can be treated by regulating its activity or regulating its expression.
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