Active Recombinant Mouse Growth Differentiation Factor 6

Cat.No. : Gdf6-722M
Product Overview : Recombinant Mouse Gdf6protein was expressed in E. coli. Thr335-Arg454.
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Cat. No. : Gdf6-722M
Description : Gdf6, also known asbone morphogenetic protein 13 (BMP13) or cartilage-derived morphogeneticprotein 2 (CDMP2), is a member of the bone morphogenetic protein (BMP) familywhich belongs to the transforming growth factor β (TGFβ) superfamily. Themature Gdf6 with 120 amino acids is a homodimeric protein containing thecharacteristic seven conserved cysteine residues. Gdf5, Gdf6 and Gdf7, whichshare 80-86% identity, define a new subgroup within the BMP family.
Source : E. coli-derived.
Form : Lyophilized from a0.2 μm filtered solution in Acetonitrile and TFA with BSA as a carrier protein.
N-terminalSequence : Thr335
Molecular Weight : 13.7 kDa
Activity : Measuredby its ability to induce alkaline phosphatase production by ATDC5 mousechondrogenic cells. Nakamura, K. et al. (1999) Exp. Cell Res. 250:351. The ED50for this effect is typically 4-16 μg/mL.
Endotoxin Level : <1.0 EUper 1 μg of the protein by the LAL method.
Purity : >97%,by SDS-PAGE under reducing conditions and visualized by silver stain.
Reconstitution : 300μg/mL in sterile 4 mM HCl that containing at least 0.1% human or bovine serumalbumin.
Storage : Use amanual defrost freezer and avoid repeated freeze-thaw cycles. 12 months fromdate of receipt, -20 to -70°C as supplied. 1 month, 2 to 8 °C under sterileconditions after reconstitution. 3 months, -20 to -70°C under sterileconditions after reconstitution.
Tag : Non
Protein length : Thr335-Arg454
Gene Name : Gdf6 growth differentiationfactor 6 [ Mus musculus ]
Official Symbol : Gdf6
Synonyms : Gdf6; growthdifferentiation factor 6; BMP13; GDF16; growth/differentiation factor 6;GDF-6; growth differentiation factor 16; growth/differentiation factor 16
Gene ID : 242316
mRNA Refseq : NM_013526
Protein Refseq : NP_038554
UniProt ID : P43028
Chromosome Location : 4 A1; 4
Pathway : TGF-beta signalingpathway
Function : cytokine activity;growth factor activity; protein homodimerization activity

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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12/04/2022

    GDF6 has low pollution, safety and health, and is suitable for long-term use.

    07/28/2022

      These are very convenient to use, and the results are very good, I highly recommend them.

      09/21/2021

        The quality is very good, the experimental effect is in line with expectations, will continue to use.

        Q&As (6)

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        How to study the regulatory mechanism of GDF6 protein? 07/10/2022

        Studying the regulatory mechanism of GDF6 protein requires the comprehensive use of various experimental methods and techniques, such as gene knockout, transcriptome analysis, and protein-protein interaction.

        What is the relationship between GDF6 protein and other proteins? 01/29/2022

        GDF6 protein has a complex relationship with other proteins, and can interact with other proteins and participate in a variety of biochemical reactions.

        Are there any diseases that might indicate abnormal GDF6 protein expression levels? 09/04/2021

        Abnormal expression levels of GDF6 protein may indicate some diseases related to bone and cartilage development.

        What diseases is GDF6 protein associated with? 07/13/2021

        GDF6 protein is associated with some bone diseases, such as osteoporosis, poor fracture healing, etc.

        How is the activity of GDF6 protein regulated? 04/03/2021

        The activity of GDF6 protein can be modulated in a variety of ways, including protein modification (e.g., phosphorylation), binding to ligands, interaction with cell surface receptors, etc.

        How can diseases be treated by regulating the expression level of GDF6 protein? 12/30/2020

        There are currently no drugs that directly regulate the expression level of GDF6 protein, but some diseases related to GDF6 protein can be treated by regulating its activity or regulating its expression.

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