Recombinant Human Growth Differentiation Factor 6

• Cat.No.: GDF6-19H
• Product Overview: Recombinant HumanGDF6 produced inE.coliwas a 27.0kDa homodimeric disulfide-linked protein consisting of two 120 amino acid polypeptide chains.This 27.5kDa protein is obtained by proteolytic processing of a biologically inactive precursor protein of 97.7kDa.

Specification

• Species: Human
• Source: E.coli
• Tag: Non
• Description: BMP-13 is expressed in hypertrophic chondrocytes during embryonic development of long bones. Continued postnatal expression of BMP-13 in articular cartilage suggests that it plays a regulatory role in the growth and maintenance of articular cartilage. Adenovirus-mediated BMP-13 gene transfer to rabbit bone marrow stem cells have been reported to augment periosteal repair of osteochondral defects. The functional form of BMP-13/CDMP-2 is a disulfide-linked homodimer of two 120 amino acid polypeptide chains.
• Purity: >95% by SDS-PAGE.
• Endotoxin Level: <0.1ng/μg of BMP-13.
• Stabilizer: None.
• Formulation: Lyophilized.
• Biologically Activity: The ED₅₀was determined by its ability to induce alkaline phosphatase production by ATDC-5 chondrogenic cells in the range of 2.0-3.0μg/ml.
• Reconstitution: The human BMP-13 should be reconstituted in water to a concentration of 0.1-1.0mg/ml. This solution can be diluted in water or other buffer solutions or stored at -20°C.
• Stability: The lyophilized protein is stable for a few weeks at room temperature, but best stored at -20°C. Reconstituted human BMP-13 should be stored in working aliquots at -20°C. Avoid repeated freeze-thaw cycles.

Gene Information

• Gene Name: GDF6 growth differentiation factor 6 [ Homo sapiens ]
• Synonyms: GDF6; growth differentiation factor 6; KFSL; KFS; GDF16; SGM1; BMP13; CDMP2; MCOP4; SCDO4; MGC158100; MGC158101; Growth/differentiation factor 6; Growth/differentiation factor 16
• Gene ID: 392255
• mRNA Refseq: NM_001001557.2
• Protein Refseq: NP_001001557.1
• MIM: 601147
• UniProt ID: Q6KF10
• Chromosome Location: 8q22.1
• Pathway: Cytokine-cytokine receptor interaction; TGF-beta signaling pathway
• Function: cytokine activity; growth factor activity