|Official Full Name||Haptoglobin|
|Background||As a result of hemolysis, hemoglobin is found to accumulate in the kidney and is secreted in the urine. Haptoglobin captures, and combines with free plasma hemoglobin to allow hepatic recycling of heme iron and to prevent kidney damage. Haptoglobin also acts as an Antimicrobial; Antioxidant, has antibacterial activity and plays a role in modulating many aspects of the acute phase response. Hemoglobin/haptoglobin complexes are rapidely cleared by the macrophage CD163 scavenger receptor expressed on the surface of liver Kupfer cells through an endocytic lysosomal degradation pathway. Uncleaved haptoglogin, also known as zonulin, plays a role in intestinal permeability, allowing intercellular tight junction disassembly, and controlling the equilibrium between tolerance and immunity to non-self antigens.|
|Synonyms||BP; Haptoglobin alpha chain; Haptoglobin alpha(1S) beta; Haptoglobin alpha(2FS) beta; Haptoglobin beta chain; Haptoglobin, alpha polypeptide; Haptoglobin, beta polypeptide; HP; HP2 ALPHA2; HP2ALPHA2; HPA1S; HPT; MGC111141; Zonulin; MGC111141; hp2-alpha; Haptoglobin; binding peptide; haptoglobin alpha(1S)-beta HP2ALPHA2; haptoglobin alpha(2FS)-beta; haptoglobin, alpha polypeptide; haptoglobin, beta polypeptide|
|Species||Cat.#||Product name||Source (Host)||Tag||Protein Length||Price|
HP involved in several pathways and played different roles in them. We selected most pathways HP participated on our site, such as Binding and Uptake of Ligands by Scavenger Receptors, Scavenging of heme from plasma, Vesicle-mediated transport, which may be useful for your reference. Also, other proteins which involved in the same pathway with HP were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
|Pathway Name||Pathway Related Protein|
|Binding and Uptake of Ligands by Scavenger Receptors||IGKC; CD163; NFX1; STAB2; COL1A2; APOBB.1; LOC479668; Alb; IGKV1-5; HYOU1|
|Scavenging of heme from plasma||AMBP; CD163; LOC479668; NFX1; HP; HPX|
|Vesicle-mediated transport||MYO1C; RALAA; GJB4; SEC23IP; RALAB; HIP1RB; FTH1B; AMBP; COPE; STXBP3|
|amb2 Integrin signaling||MST1R; HP; CYR61; ELANE; LPA; NIPAL1; MST1|
HP has several biochemical functions, for example, antioxidant activity, hemoglobin binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HP itself. We selected most functions HP had, and list some proteins which have the same functions with HP. You can find most of the proteins on our site.
|antioxidant activity||APOM; SELS; KDM3B; PRDX2; FABP1; HP; S100A9; CAT; APOA4; APOE|
|hemoglobin binding||CUBN; HPR; HBB; LRP2; AHSP; HP|
|protein binding||FAM20A; ATOX1; SIX4; LSM5; CCDC148; TIPRL; NTS; DTNA; TAF15; POLR2E|
|serine-type endopeptidase activity||PCSK4; HP; FURINB; KLK5; PRSS1; ST14; C1RA; PCSK5B; PRSS59.1; FURINA|
HP has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HP here. Most of them are supplied by our site. Hope this information will be useful for your research of HP.
APOE; APOA1; MIS12; WASL; TBL1X; GADD45G; TGM2; RPL11; GRB2; SMAD3; MVP; RBBP6