HP
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Official Full Name
Haptoglobin
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Overview
As a result of hemolysis, hemoglobin is found to accumulate in the kidney and is secreted in the urine. Haptoglobin captures, and combines with free plasma hemoglobin to allow hepatic recycling of heme iron and to prevent kidney damage. Haptoglobin also acts as an Antimicrobial; Antioxidant, has antibacterial activity and plays a role in modulating many aspects of the acute phase response. Hemoglobin/haptoglobin complexes are rapidely cleared by the macrophage CD163 scavenger receptor expressed on the surface of liver Kupfer cells through an endocytic lysosomal degradation pathway. Uncleaved haptoglogin, also known as zonulin, plays a role in intestinal permeability, allowing intercellular tight junction disassembly, and controlling the equilibrium between tolerance and immunity to non-self antigens. -
Synonyms
BP; Haptoglobin alpha chain; Haptoglobin alpha(1S) beta; Haptoglobin alpha(2FS) beta; Haptoglobin beta chain; Haptoglobin, alpha polypeptide; Haptoglobin, beta polypeptide; HP; HP2 ALPHA2; HP2ALPHA2; HPA1S; HPT; MGC111141; Zonulin; MGC111141; hp2-alpha; Haptoglobin; binding peptide; haptoglobin alpha(1S)-beta HP2ALPHA2; haptoglobin alpha(2FS)-beta; haptoglobin, alpha polypeptide; haptoglobin, beta polypeptide;
- Recombinant Proteins
- Cell & Tissue Lysates
- Native Proteins
- Transfected Stable Cell Lines
- Protein Pre-coupled Magnetic Beads
- Bovine
- Canine
- Cat
- Cattle
- Dog
- Equine
- Goat
- Hp
- Human
- Monkey
- Mouse
- Pig
- Rabbit
- Rat
- Rhesus Macaque
- Acute phase serum
- Bovine Serum
- Canine Serum
- E.coli
- Feline/Cat Serum
- HEK293
- HEK293T
- Horse Serum
- Human Milk
- Human Plasma
- Human Red Blood Cells
- Human Serum
- In Vitro Cell Free System
- Mammalian Cell
- Mammalian cells
- Monkey Plasma
- Mouse Serum
- Porcine Serum
- Rabbit Plasma
- Rat Serum
- Solid medium
- Wheat Germ
- C
- His
- Myc
- DDK
- Flag
- GST
- His (Fc)
- Avi
- His|T7
- B2M
- MYC
- Myc|DDK
- N/A
- N
- SUMO
Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
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Human | HP-26197TH | Recombinant Human HP, His-tagged | E.coli | His | ||
Human | HP-5001H | Recombinant Human HP Protein, GST-tagged | Wheat Germ | GST | ||
Human | HP-13916H | Recombinant Human HP, GST-tagged | E.coli | GST | C-term-228a.a. | |
Human | HP-5101H | Recombinant Human HP, His-tagged | E.coli | His | ||
Human | HP-715H | Recombinant Human HP Protein, His-tagged | HEK293 | His | ||
Human | HP-5408HCL | Recombinant Human HP 293 Cell Lysate | HEK293 | N/A | ||
Human | HP-3738HF | Recombinant Full Length Human HP Protein, GST-tagged | In Vitro Cell Free System | GST | 281 amino acids | |
Human | HP-079H | Recombinant Human HP Protein, MYC/DDK-tagged, C13 and N15-labeled | HEK293 | C-Myc/DDK | ||
Human | HP-26196TH | Native Human HP | N/A | |||
Human | HP-14H | Active Human Haptoglobin Reference Standard | N/A | |||
Human | HP-1093H | Recombinant Human HP Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi | ||
Human | HP-3049H | Recombinant Human HP protein | E.coli | N/A | 19-406aa | |
Human | HP-8153H | Native Human Serum Haptoglobin | Human Serum | N/A | ||
Human | HP-1891H | Recombinant Human HP Protein, MYC/DDK-tagged | HEK293 | Myc/DDK | ||
Human | HP-2717H | Recombinant Human HP Protein (Val19-Asn406), C-His tagged | Mammalian cells | C-His | Val19-Asn406 | |
Human | HP-820HFL | Recombinant Full Length Human HP Protein, C-Flag-tagged | Mammalian cells | Flag | ||
Human | HP-2718H | Recombinant Human HP Protein (Cys145-Asn406), N-His tagged | E.coli | N-His | Cys145-Asn406 | |
Human | HP-3048H | Recombinant Human HP protein, His-B2M-tagged | E.coli | His-B2M | 19-406aa | |
Human | HP-2719H | Recombinant Human HP Protein (Gln160-Glu405), N-His tagged | E.coli | N-His | Gln160-Glu405 | |
Human | HP-4387H | Native Human Haptoglobin | Human Plasma | N/A | ||
Human | HP-1093H-B | Recombinant Human HP Protein Pre-coupled Magnetic Beads | HEK293 | |||
Human | HP-200H | Native Human Haptoglobin | Human Plasma | N/A | ||
Human | Hb-197H | Native Human Hemoglobin | Human Red Blood Cells | N/A | ||
Human | HP-127H | Native Human Hemoglobin protein | Human Milk | N/A | Full length native Hemoglobin protein | |
Mouse | Hp-7754M | Recombinant Mouse Hp protein, His-tagged | E.coli | His | Ala118~Cys281 (Accession # Q61646) | |
Mouse | Hp-7755M | Recombinant Mouse Hp protein, His & T7-tagged | E.coli | His/T7 | Asp70~Arg332 (Accession # Q61646) | |
Mouse | Hp-134M | Native Mouse Haptoglobin | Mouse Serum | N/A | ||
Mouse | Hp-38M | Mouse Haptoglobin Reference Standard | N/A | |||
Mouse | HP-145M | Native Mouse Hemoglobin | Mouse Serum | N/A | Full length native Mouse Hemoglobin | |
Mouse | Hp-8155M | Native Mouse Serum Haptoglobin | Mouse Serum | N/A | ||
Mouse | Hp-1162M | Recombinant Mouse Hp Protein, MYC/DDK-tagged | HEK293T | MYC/DDK | ||
Rat | Hp-7758R | Recombinant Rat Hp protein, His & T7-tagged | E.coli | His/T7 | Ser70~Arg332 (Accession # P06866) | |
Rat | Hp-7757R | Recombinant Rat Hp protein, His-tagged | E.coli | His | Gly125~Gly297 (Accession # P06866) | |
Rat | HP-2895R | Recombinant Rat HP Protein | Mammalian Cell | His | ||
Rat | Hp-194R | Native Rat Haptoglobin | Rat Serum | N/A | ||
Rat | Hp-81R | Rat Haptoglobin Reference Standard | N/A | |||
Rat | HP-2550R-B | Recombinant Rat HP Protein Pre-coupled Magnetic Beads | HEK293 | |||
Rat | HP-957R | Recombinant Rat Haptoglobin Protein (Met1-Asn347), His-tagged | HEK293 | His | Met1-Asn347 | |
Rat | Hp-80R | Purified Rat Haptoglobin | N/A | |||
Rat | HP-2550R | Recombinant Rat HP Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi | ||
Rat | HP-5310R | Recombinant Rat HP protein, His-tagged | E.coli | His | 19-346aa | |
Monkey | HP-199M | Native Monkey Haptoglobin | Monkey Plasma | N/A | ||
Rabbit | HP-7759R | Recombinant Rabbit HP protein, His-tagged | E.coli | His | Phe21~Asp98 (Accession # P19007) | |
Rabbit | HP-7760R | Recombinant Rabbit HP protein, His & T7-tagged | E.coli | His/T7 | Val177~Lys342 (Accession # P19007) | |
Rabbit | HP-68R | Rabbit Haptoglobin Reference Standard | N/A | |||
Rabbit | HP-7761R | Native Rabbit Haptoglobin Protein | Acute phase serum | |||
Rabbit | HP-146R | Native Rabbit Hemoglobin | Rabbit Plasma | N/A | Full length native Rabbit Hemoglobin | |
Dog | HP-190C | Native Dog Haptoglobin | Canine Serum | N/A | ||
Bovine | HP-133B | Native Bovine Haptoglobin | Bovine Serum | N/A | ||
Bovine | HP-6B | Bovine Haptoglobin Reference Standard | N/A | |||
Canine | HP-75C | Native Canine Haptoglobin | Canine Serum | N/A | ||
Cat | HP-192F | Native Feline Haptoglobin | Feline/Cat Serum | N/A | ||
Cat | HP-9C | Cat Haptoglobin Reference Standard | N/A | |||
Cattle | HP-7752C | Recombinant Cattle HP protein, His & T7-tagged | E.coli | His/T7 | Val19~Gln155 (Accession # Q2TBU0) | |
Cattle | HP-7751C | Recombinant Cattle HP protein, His & T7-tagged | E.coli | His/T7 | Gly159~Leu329 (Accession # Q2TBU0) | |
Equine | HP-28H | Horse Haptoglobin Reference Standard | N/A | |||
Equine | HP-191E | Native Equine Haptoglobin | Horse Serum | N/A | ||
Goat | HP-2770G | Recombinant Goat HP Protein, His&SUMO-tagged | E.coli | N-His&SUMO | Val19-Asn401 | |
Hp | Hp-25 | Native Helicobacter pylori Antigen | Solid medium | |||
Rhesus Macaque | HP-2134R | Recombinant Rhesus monkey HP Protein, His-tagged | Mammalian Cell | His | ||
Rhesus Macaque | HP-1955R | Recombinant Rhesus Macaque HP Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi | ||
Rhesus Macaque | HP-1955R-B | Recombinant Rhesus Macaque HP Protein Pre-coupled Magnetic Beads | HEK293 | |||
Pig | HP-7756P | Recombinant Pig HP protein, His-tagged | E.coli | His | His123~Asp307 (Accession # Q8SPS7) | |
Pig | HP-193S | Native Swine Haptoglobin | Porcine Serum | N/A | ||
Pig | HP-61P | Pig Haptoglobin Reference Standard | N/A |
- Background
- Quality Guarantee
- Case Study
- Involved Pathway
- Protein Function
- Interacting Protein
- HP Related Articles
- HP Related Research Area
Fig1. Hp phenotype distribution affects the clinical value of Hp glycopeptides.
What is HP protein?
HP (Haptoglobin) is a protein coding gene which situated on the long arm of chromosome 16 at locus 16q22. This gene encodes a preproprotein which is processed to yield both alpha and beta chains, which subsequently combine as a tetramer to produce haptoglobin. Multiple transcript variants encoding different isoforms have been found for this gene. Haptoglobin protein is a secreted protein which is expressed by the liver and secreted in plasma. The Haptoglobin protein is consisted of 406 amino acids and its molecular mass is approximately 45.2 kDa.
What is the function of HP protein?
Haptoglobin is found to bind free plasma hemoglobin, which allows degradative enzymes to gain access to the hemoglobin, while at the same time preventing loss of iron through the kidneys and protecting the kidneys from damage by hemoglobin. Haptoglobin also acts as an antioxidant, has antibacterial activity, and plays a role in modulating many aspects of the acute phase response. The uncleaved form of allele alpha-2 (2-2), known as zonulin, plays a role in intestinal permeability, allowing intercellular tight junction disassembly, and controlling the equilibrium between tolerance and immunity to non-self antigens.
HP Related Diseases
Mutations in this gene and/or its regulatory regions cause ahaptoglobinemia or hypohaptoglobinemia. This gene has also been linked to diabetic nephropathy, the incidence of coronary artery disease in type 1 diabetes, Crohns disease, inflammatory disease behavior, primary sclerosing cholangitis, susceptibility to idiopathic Parkinsons disease, and a reduced incidence of Plasmodium falciparum malaria.
High Purity
Fig1. SDS-PAGE (HP-079H) (PROTOCOL for western blot)
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Fig2. SDS-PAGE (Hp-7758R)
Case Study 1: Emily Kate Mewborn, 2023
Fig1. Haptoglobin genotype structures and weights. Abbreviations: kd, kilodaltons.
Case Study 2: J. F. Vélez-Pinto, 2023
Fig2. Specific ELISA of the more relevant parameters in peritoneal sepsis.
Fig1. The molecules associated with Aβ production in dogs with epilepsy.
Fig2. Schematic summarizes putative mode of action of iron uptake and metabolism mechanisms in iron-laden MCs at chronic active MS lesion rims.
HP involved in several pathways and played different roles in them. We selected most pathways HP participated on our site, such as Binding and Uptake of Ligands by Scavenger Receptors, Scavenging of heme from plasma, Vesicle-mediated transport, which may be useful for your reference. Also, other proteins which involved in the same pathway with HP were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Binding and Uptake of Ligands by Scavenger Receptors | APOBB.1;COL1A2;LOC479668;NFX1;HP;SPARC;STAB2;APOA1B;SAA1 |
Scavenging of heme from plasma | LOC479668;NFX1;AMBP;HP;HPX;CD163 |
Vesicle-mediated transport | HP;LOC479668;AP3S1;NECAP1;YIPF6;HSPH1;CX27.5;NAPB;CTAGE5 |
amb2 Integrin signaling | MST1;LPA;CYR61;ELANE;MST1R;HP;NIPAL1 |
HP has several biochemical functions, for example, antioxidant activity, hemoglobin binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HP itself. We selected most functions HP had, and list some proteins which have the same functions with HP. You can find most of the proteins on our site.
Function | Related Protein |
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antioxidant activity | TRP53INP1;S100A9;APOM;APOE;FAM213AA;KDM3B;PRDX2;PRDX6;FABP1 |
hemoglobin binding | LRP2;HP;CUBN;AHSP;HPR;HBB |
protein binding | STARD3;LGALS2;TPT1;NDEL1;YAP1;TUFM;LDHB;KRTAP10-11;MBD3 |
serine-type endopeptidase activity | PCSK7;ST14;CLPP;PRSS46;DPP4;ELA2;PRSS33;CTRC;ELA2L |
HP has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HP here. Most of them are supplied by our site. Hope this information will be useful for your research of HP.
APOE; APOA1; MIS12; WASL; TBL1X; GADD45G; TGM2; RPL11; GRB2; SMAD3; MVP; RBBP6
- Q&As
- Reviews
Q&As (5)
Ask a questionYes, genetic variations can affect Haptoglobin levels, and understanding these variations can be crucial for personalized medicine approaches.
Haptoglobin acts as an antioxidant by binding to free hemoglobin, preventing the formation of reactive oxygen species that contribute to oxidative stress.
Conditions such as hemolytic anemias, infections, and chronic inflammatory diseases often require monitoring Haptoglobin levels for diagnostic and prognostic purposes.
The Haptoglobin test is usually conducted through a blood sample, and the serum or plasma is analyzed for Haptoglobin levels.
Yes, altered levels of Haptoglobin are associated with various conditions, including cardiovascular diseases, infections, and certain cancers.
Customer Reviews (3)
Write a reviewIts superior purity and stability ensure reliable and reproducible results, providing me with confidence in the integrity of my experiments.
Its impeccable purity and stability ensure accurate and reproducible results, giving me confidence in the reliability of my research outcomes
Whether I am investigating protein-protein interactions, studying enzymatic activity, or conducting protein structure analyses, the HP protein consistently delivers exceptional performance and accurate results.
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