Active Human Haptoglobin Reference Standard

• Cat.No.: HP-14H

Specification

• Description: Haptoglobin is a positive acute phase protein that binds free hemoglobin and removes it from the circulation to prevent kidney injury, and iron lossfollowing hemolysis. Three major haptoglobinphenotypes are known to exist (Hp 1-1, Hp 2-1,and Hp 2-2). Hp 1-1 is biologically the most effective in binding free hemoglobin and suppressing inflammatory responses associated with free hemoglobin. Hp 2-2 is biologically the least active, and Hp 2-1 is moderately active.
• Species: Human
• Form: Liquid
• Bio-activity: The level of Haptoglobin in the serum was quantified using ELISA.
• Usage: For research use only, not for diagnostic or therapeutic use.
• Quality Control Test: Generated from a human serum pool. This lot has been tested by standard laboratory procedures and found to be negative for HIV 1, HIV 2, Hepatitis B and Hepatitis C.
• Storage: Stored at -20 °C, 4 °C for less than seven days, frozen for greater than seven days.
• Concentration: 1.31 mg/ml
• Preservative: 0.1% sodium azide
• Tag: Non

Gene Information

• Gene Name: HP haptoglobin [ Homo sapiens ]
• Official Symbol: HP
• Synonyms: HP; haptoglobin; zonulin; binding peptide; haptoglobin alpha(1S)-beta; haptoglobin alpha(2FS)-beta; haptoglobin, beta polypeptide; haptoglobin, alpha polypeptide; BP; HPA1S; HP2ALPHA2; MGC111141
• Gene ID: 3240
• mRNA Refseq: NM_001126102
• Protein Refseq: NP_001119574
• MIM: 140100
• UniProt ID: P00738
• Chromosome Location: 16q22.2
• Pathway: amb2 Integrin signaling, organism-specific biosystem
• Function: catalytic activity; hemoglobin binding; serine-type endopeptidase activity

Reviews

07/02/2022

Its superior purity and stability ensure reliable and reproducible results, providing me with confidence in the integrity of my experiments.

01/18/2020

Its impeccable purity and stability ensure accurate and reproducible results, giving me confidence in the reliability of my research outcomes

07/07/2019

Whether I am investigating protein-protein interactions, studying enzymatic activity, or conducting protein structure analyses, the HP protein consistently delivers exceptional performance and accurate results.

Q&As

Can Haptoglobin levels be influenced by genetic factors?

Yes, genetic variations can affect Haptoglobin levels, and understanding these variations can be crucial for personalized medicine approaches.

How does Haptoglobin contribute to the body's defense against oxidative stress?

Haptoglobin acts as an antioxidant by binding to free hemoglobin, preventing the formation of reactive oxygen species that contribute to oxidative stress.

Are there any specific diseases where monitoring Haptoglobin is particularly crucial?

Conditions such as hemolytic anemias, infections, and chronic inflammatory diseases often require monitoring Haptoglobin levels for diagnostic and prognostic purposes.

How is the Haptoglobin test performed in a clinical setting?

The Haptoglobin test is usually conducted through a blood sample, and the serum or plasma is analyzed for Haptoglobin levels.

Can Haptoglobin be a diagnostic marker for conditions other than hemolysis and inflammation?

Yes, altered levels of Haptoglobin are associated with various conditions, including cardiovascular diseases, infections, and certain cancers.