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Official Full Name 5-hydroxytryptamine (serotonin) receptor 5A, G protein-coupled
Background The neurotransmitter serotonin (5-hydroxytryptamine, 5-HT) has been implicated in a wide range of psychiatric conditions and also has vasoconstrictive and vasodilatory effects. The gene described in this record is a member of 5-hydroxytryptamine (serotonin) receptor family and encodes a multi-pass membrane protein that functions as a receptor for 5-hydroxytryptamine and couples to G-proteins. This protein has been shown to function in part through the regulation of intracellular Ca2+ mobilization.
Synonyms HTR5A; 5-hydroxytryptamine (serotonin) receptor 5A, G protein-coupled; 5 hydroxytryptamine (serotonin) receptor 5A; 5-hydroxytryptamine receptor 5A; 5 HT5A; 5-HT-5; 5-HT-5A; serotonin receptor 5A; 5-HT5A; MGC138226
    • Species :
    • Human
    • Mouse
    • Rat
    • Rhesus Macaque
    • Zebrafish
    • Source :
    • HEK293
    • HEK293T
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • MYC/DDK
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human HTR5A-2194H Recombinant Human HTR5A Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human HTR5A-2295H Recombinant Human HTR5A Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human HTR5A-26029TH Recombinant Human HTR5A Wheat Germ N/A
    Human HTR5A-5235H Recombinant Human HTR5A Protein, GST-tagged Wheat Germ GST
    Mouse Htr5a-1196M Recombinant Mouse Htr5a Protein, MYC/DDK-tagged HEK293T MYC/DDK
    Mouse HTR5A-7938M Recombinant Mouse HTR5A Protein Mammalian Cell His
    Rat HTR5A-2968R Recombinant Rat HTR5A Protein Mammalian Cell His
    Rhesus Macaque HTR5A-2176R Recombinant Rhesus monkey HTR5A Protein, His-tagged Mammalian Cell His
    Zebrafish HTR5A-6724Z Recombinant Zebrafish HTR5A Mammalian Cell His
    Kit-0999 Taurine Assay Kit (Colorimetric) N/A
    Kit-1358 HTR5A U2OS β-Arrestin GPCR Assay Kit N/A

    htr5a involved in several pathways and played different roles in them. We selected most pathways htr5a participated on our site, such as Calcium signaling pathway, Neuroactive ligand-receptor interaction, Serotonergic synapse, which may be useful for your reference. Also, other proteins which involved in the same pathway with htr5a were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Calcium signaling pathway P2RX3B; DRD5; RYR2; PPIFB; CACNA1D; ERBB4A; ORAI1B; HTR2C; MYLK2; DRD1A
    Neuroactive ligand-receptor interaction GRIA4A; P2RY2; SCTR; GALR3; TAAR7B; PTGFR; NPBWR2; TAAR10; NPFFR2.1; LHCGR
    Serotonergic synapse HRAS; HTR2B; GNAO1; PTGS1; HTR6; GNG12; KCNN2; PLCB2; GNB1; PLA2G4A

    htr5a has several biochemical functions, for example, serotonin receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by htr5a itself. We selected most functions htr5a had, and list some proteins which have the same functions with htr5a. You can find most of the proteins on our site.

    Function Related Protein
    serotonin receptor activity HTR3C; HTR2B; HTR1A; HTR4; HTR1B; HTR3B; HTR2C; HTR6; HTR3A; HTR3E

    htr5a has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with htr5a here. Most of them are supplied by our site. Hope this information will be useful for your research of htr5a.

    serotonin; lsd-lysergic acid diethylamide

    Thomsen, WJ; Grottick, AJ; et al. Lorcaserin, a novel selective human 5-Hydroxytryptamine(2C) agonist: In vitro and in vivo pharmacological characterization. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS 325:577-587(2008).
    Francken, BJB; Vanhauwe, JFM; et al. Reconstitution of human 5-hydroxytryptamine(5A) receptor-G protein coupling in E-coli and Sf9 cell membranes with membranes from Sf9 cells expressing mammalian G proteins. RECEPTORS & CHANNELS 7:303-318(2001).

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