• Official Full Name

    5-hydroxytryptamine (serotonin) receptor 5A, G protein-coupled

  • Overview

    The neurotransmitter serotonin (5-hydroxytryptamine, 5-HT) has been implicated in a wide range of psychiatric conditions and also has vasoconstrictive and vasodilatory effects. The gene described in this record is a member of 5-hydroxytryptamine (serotonin) receptor family and encodes a multi-pass membrane protein that functions as a receptor for 5-hydroxytryptamine and couples to G-proteins. This protein has been shown to function in part through the regulation of intracellular Ca2+ mobilization.
  • Synonyms

    HTR5A; 5-hydroxytryptamine (serotonin) receptor 5A, G protein-coupled; 5 hydroxytryptamine (serotonin) receptor 5A; 5-hydroxytryptamine receptor 5A; 5 HT5A; 5-HT-5; 5-HT-5A; serotonin receptor 5A; 5-HT5A; MGC138226;

  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Assay Kits
  • Homo sapiens (Human)
  • Human
  • Mouse
  • Mus musculus (Mouse)
  • Rat
  • Rattus norvegicus (Rat)
  • Rhesus Macaque
  • Zebrafish
  • E.coli
  • E.coli expression system
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • MYC
  • Myc|DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human HTR5A-26029TH Recombinant Human HTR5A Wheat Germ N/A 357 amino acids
Human HTR5A-301334H Recombinant Human HTR5A protein, GST-tagged E.coli GST Gly182-Arg282
Human HTR5A-5699HF Recombinant Full Length Human HTR5A Protein, GST-tagged In Vitro Cell Free System GST 357 amino acids
Human HTR5A-2194H Recombinant Human HTR5A Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human HTR5A-5235H Recombinant Human HTR5A Protein, GST-tagged Wheat Germ GST
Human HTR5A-2295H Recombinant Human HTR5A Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human HTR5A-242HF Recombinant Full Length Human HTR5A Protein In Vitro Cell Free System 357 amino acids
Mouse HTR5A-7938M Recombinant Mouse HTR5A Protein Mammalian Cell His
Mouse HTR5A-4379M Recombinant Mouse HTR5A Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse HTR5A-4379M-B Recombinant Mouse HTR5A Protein Pre-coupled Magnetic Beads HEK293
Mouse Htr5a-1196M Recombinant Mouse Htr5a Protein, MYC/DDK-tagged HEK293T MYC/DDK
Rat HTR5A-2968R Recombinant Rat HTR5A Protein Mammalian Cell His
Rat HTR5A-2623R-B Recombinant Rat HTR5A Protein Pre-coupled Magnetic Beads HEK293
Rat HTR5A-2623R Recombinant Rat HTR5A Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Homo sapiens (Human) RFL32294HF Recombinant Full Length Human 5-Hydroxytryptamine Receptor 5A(Htr5A) Protein, His-Tagged E.coli expression system His Full Length (1-357)
Mus musculus (Mouse) RFL28430MF Recombinant Full Length Mouse 5-Hydroxytryptamine Receptor 5A(Htr5A) Protein, His-Tagged E.coli expression system His Full Length (1-357)
Rattus norvegicus (Rat) RFL17417RF Recombinant Full Length Rat 5-Hydroxytryptamine Receptor 5A(Htr5A) Protein, His-Tagged E.coli expression system His Full Length (1-357)
Rhesus Macaque HTR5A-2176R Recombinant Rhesus monkey HTR5A Protein, His-tagged Mammalian Cell His
Rhesus Macaque HTR5A-1997R Recombinant Rhesus Macaque HTR5A Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque HTR5A-1997R-B Recombinant Rhesus Macaque HTR5A Protein Pre-coupled Magnetic Beads HEK293
Zebrafish HTR5A-6724Z Recombinant Zebrafish HTR5A Mammalian Cell His
Kit-1358 HTR5A U2OS β-Arrestin GPCR Assay Kit N/A
Kit-0999 Taurine Assay Kit (Colorimetric) N/A
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

HTR5A involved in several pathways and played different roles in them. We selected most pathways HTR5A participated on our site, such as Calcium signaling pathway, Neuroactive ligand-receptor interaction, Serotonergic synapse, which may be useful for your reference. Also, other proteins which involved in the same pathway with HTR5A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Neuroactive ligand-receptor interactionGALR3;LEPB;GRIA3;CHRNA2;GABRB2;ADRA2DB;PTGER4A;HTR6;EDNRAA
Serotonergic synapseGNB1;HTR3E;ALOX8;CYP2C39;CYP4X1;TRPC1;HTR4;TPH1;CYP2D26

HTR5A has several biochemical functions, for example, serotonin receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by HTR5A itself. We selected most functions HTR5A had, and list some proteins which have the same functions with HTR5A. You can find most of the proteins on our site.

Function Related Protein
serotonin receptor activityHTR5AL;HTR1D;HTR1AA;HTR2C;HTR7;HTR1E;HTR3B;HTR2A;HTR3C

HTR5A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HTR5A here. Most of them are supplied by our site. Hope this information will be useful for your research of HTR5A.

serotonin; lsd-lysergic acid diethylamide

Gene Family


Research Area

Related articles

Thomsen, WJ; Grottick, AJ; et al. Lorcaserin, a novel selective human 5-Hydroxytryptamine(2C) agonist: In vitro and in vivo pharmacological characterization. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS 325:577-587(2008).
Francken, BJB; Vanhauwe, JFM; et al. Reconstitution of human 5-hydroxytryptamine(5A) receptor-G protein coupling in E-coli and Sf9 cell membranes with membranes from Sf9 cells expressing mammalian G proteins. RECEPTORS & CHANNELS 7:303-318(2001).
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