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Official Full Name inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
Background NFKB1 (MIM 164011) or NFKB2 (MIM 164012) is bound to REL (MIM 164910), RELA (MIM 164014), or RELB (MIM 604758) to form the NFKB complex. The NFKB complex is inhibited by I-kappa-B proteins (NFKBIA, MIM 164008, or NFKBIB, MIM 604495), which inactivate NF-kappa-B by trapping it in the cytoplasm. Phosphorylation of serine residues on the I-kappa-B proteins by kinases (IKBKA, MIM 600664, or IKBKB) marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NF-kappa-B complex. Activated NFKB complex translocates into the nucleus and binds DNA at kappa-B-binding motifs such as 5-prime GGGRNNYYCC 3-prime or 5-prime HGGARNYYCC 3-prime (where H is A, C, or T; R is an A or G purine; and Y is a C or T pyrimidine).
Synonyms IKBKB; IKK2; IKKB; NFKBIKB; FLJ33771; FLJ36218; FLJ38368; FLJ40509; IKK-beta; MGC131801; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta; inhibitor of nuclear factor kappa-B kinase subunit beta; IKK-B; I-kappa-B kinase 2; OTTHUMP00000225854; OTTHUMP00000225858; OTTHUMP00000225860; OTTHUMP00000225865; OTTHUMP00000225866; I-kappa-B-kinase beta; nuclear factor NF-kappa-B inhibitor kinase beta
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rhesus Macaque
    • Zebrafish
    • Source :
    • E. coli
    • E.coli
    • HEK293
    • HEK293T
    • Insect Cell
    • Mammalian Cell
    • S.frugiperda
    • Sf9 Insect Cell
    • Wheat Germ
    • Tag :
    • Flag
    • GST
    • His
    • T7
    • MYC/DDK
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human IKBKB-1027H Recombinant Human Inhibitor Of Kappa Light Polypeptide Gene Enhancer In B-Cells, Kinase Beta, GST-tagged Sf9 Insect Cell GST
    Human IKBKB-125H Recombinant Human IKBKB protein, GST-tagged Insect Cell GST
    Human IKBKB-14132H Recombinant Human IKBKB, GST-tagged E.coli GST
    Human IKBKB-1720H Recombinant Human IKBKB protein, His & GST-tagged E.coli His/GST
    Human IKBKB-2661H Recombinant Human IKBKB, GST-His Sf9 Insect Cell GST
    Human IKBKB-28877TH Recombinant Human IKBKB Wheat Germ N/A
    Human IKBKB-501H Recombinant Human IKBKB Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human IKBKB-53H Recombinant Human IKBKB protein, Flag-tagged, Biotinylated Insect Cell Flag
    Human IKBKB-760H Recombinant Human IKBKB, His-S S.frugiperda His
    Human IKBKB-849HCL Recombinant Human IKBKB cell lysate N/A
    Human IKBKB-87H Recombinant Human IKBKB Protein, His-tagged E. coli His
    Human IKBKB-88H Recombinant Human IKKB-beta, active Sf9 Insect Cell GST/His
    Human IKBKB-89H Recombinant Human IKB-beta E.coli GST
    Mouse Ikbkb-1232M Recombinant Mouse Ikbkb Protein, MYC/DDK-tagged HEK293T MYC/DDK
    Mouse Ikbkb-1721M Recombinant Mouse Ikbkb protein, His & T7-tagged E.coli His/T7
    Rhesus Macaque IKBKB-2225R Recombinant Rhesus monkey IKBKB Protein, His-tagged Mammalian Cell His
    Chicken IKBKB-3048C Recombinant Chicken IKBKB Mammalian Cell His
    Zebrafish IKBKB-6658Z Recombinant Zebrafish IKBKB Mammalian Cell His

    ikbkb involved in several pathways and played different roles in them. We selected most pathways ikbkb participated on our site, such as MAPK signaling pathway, Ras signaling pathway, Chemokine signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with ikbkb were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    MAPK signaling pathway FAS; JIP1; CASP3B; CACNG7A; TRP53; MAP4K1; PRKCBA; RPS6KA6; MAPT; CACNB4
    Ras signaling pathway INS2; PDGFRB; RAF1; GNG12; RIN1; PIK3R3; LOC608458; GNG5; RRAS2; PLA2G4D
    Chemokine signaling pathway CCL18; CCL21; NFKBIA; VAV2; GM2506; CXCL13; GM1987; CCR7; CXCL16; GRB2
    NF-kappa B signaling pathway LY96; UBE2I; TNF; VCAM1; PTGS2; MAP3K7; IRAK4; CCL21; TNFRSF13C; LTBR
    FoxO signaling pathway CCND2A; MAP2K2A; CDKN2D; ATM; FOXG1A; HRAS; IKBKB; PIK3R2; SKP2; CCNB2
    mTOR signaling pathway PIK3CA; EIF4E1B; CAB39L; RRAGCA; PTENA; PRKAA2; PRKCG; RPS6KA1; PDPK1B; RPS6KB1
    PIK-Akt signaling pathway PIK3R3; PPP2R5E; PDGFRA; PIK3CD; GNGT1; PPP2R5A; G6PC2; PCK2; RHEB; COL6A4
    Osteoclast differentiation ITGB3; IKBKB; AKT1; MAP3K14; NCF2; TNFRSF11B; AKT2; CSF1; MAPK11; FCGR2A
    Toll-like receptor signaling pathway PIK3CD; MAPK3; LY96; MAPK8B; RIPK1L; IKBKG; TAB2; TLR3; TMED7-TICAM2; PIK3R2
    NOD-like receptor signaling pathway MAPK8; NLRC4; MAPK12; PSTPIP1; HSP90AA1; BIRC3; IKBKB; NAIP6; IKBKG; LOC100033925
    RIG-I-like receptor signaling pathway TBKBP1; IL-8; TBK1; RIPK1L; IFNA10; AZI2; SIKE1; IL8L2; MAPK8; DHX58
    Cytosolic DNA-sensing pathway IFI202B; POLR3K; IFNA1; IFNA10; IFNA14; NFKBIAA; IFNA17; Ifna15; NFKBIB; IKBKG
    T cell receptor signaling pathway EVLB; LCK; SOS1; NFATC2; PIK3R3; PDCD1; NFKB1; CD8B1; NFATC3; PTPRC
    B cell receptor signaling pathway IFITM1; SLA2; CRKL; PPP3CB; PPP3CC; FOS; PDPK1A; CD81; HRAS; PIK3CA
    TNF signaling pathway ATF4; VCAM1; BAG4; TRAF2; TNF; LIF; CXCL2; SOCS3; CCL2; MAPK1
    Neurotrophin signaling pathway NTRK3; SHC4; PDPK1; MAP3K5; NFKB1; PSEN2; GSK3B; SHC1; RIPK2; IRS1
    Insulin signaling pathway PPP1R3DA; ACACA; AKT1; PRKAR2AA; MAP2K2; SHC3; ELK1; HRASA; EIF4EA; SOCS3
    Adipocytokine signaling pathway PPARGC1A; ACSL1B; ACSL5; ADIPOR1; PRKAA2; SLC2A1; AKT3A; NFKBIE; ADIPOQ; SLC2A1A
    Type II diabetes mellitus MAPK8; PRKCD; PIK3R3; INS1; PIK3R2; MAPK1; PKLR; INS; IKBKB; SLC2A2
    Insulin resistance RPS6KAL; SLC2A2; GSK3AA; SOCS3; PRKAG1; PPP1R3C; PRKCB; G6PC; PPARA; PDPK1
    Non-alcoholic fatty liver disease (NAFLD) NDUFS3; NDUFA12; RXRA; INSR; NDUFA9; NDUFA4L2; BAX; NDUFA11; COX7B2; NDUFAB1
    Epithelial cell signaling in Helicobacter pylori infection NOD1; ATP6V1D; ATP6V1A; TCIRG1; JAM3; CXCR2; MAPK10; TJP1; MAP3K14; ATP6V1B1
    Shigellosis WAS; IKBKG; RIPK2; WASF1; IKBKB; CD44; U2AF1L4; MAPK12; MAPK9; ITGB1
    Chagas disease (American trypanosomiasis) IL6; AKT1; C1QB; GNA11; GNAI2; TGFB3; PLCB2; CD3D; TGFBR1; PIK3CB
    Toxoplasmosis TLR4; MAPK12; TGFB1; LAMA1; SOCS1; TGFB2; MAPK13; Toxoplasma Gondii Microneme Protein MIC3; IFNG; IRGM1
    Hepatitis C Ifna11; IFN-a; PPP2CA; MAPK1; IFNA5; IKBKE; TBK1; IFNA7; IFNA10; NFKBIA
    Hepatitis B MAVS; YWHAZ; FOS; IRF7; STAT5A; MAP2K2; IFNA13; IFNA12; VDAC3; TBK1
    Influenza A HLA-DRB4; IKBKB; AGFG1; IFN-a; HLA-DMA; PIK3R3; ICAM1; MAPK1; IRF3; IFNA13
    HTLV-I infection IL2RB; WNT16; KRAS; PIK3R3; WNT2; ELK1; HLA-A; EP300; BUB3; MYBL2
    Herpes simplex infection BMA1; HLA-DRB3; EP300; JAK2A; OAS1B; IL1B; TLR3; CCL5; HMGN1; SRSF5B
    Epstein-Barr virus infection DDX58; POLR2J3; HDAC4; PIK3CG; FGR; TRADD; HSPA1L; PSMD13; HSPB2; POLR2E
    Pathways in cancer MAP2K1; RAC2; TGFB2; CYCS; Flt3l; ARAF; RARB; GNA11; BIRC2; FH1
    MicroRNAs in cancer ZFPM2; TGFB2; APC; ABCC1; SOCS1; TRIM71; KRAS; CYP24A1; IKBKB; GLS
    Pancreatic cancer ARHGEF6; AKT1; VEGFA; PIK3CB; RAC3; RALB; MAPK10; RB1; PIK3CA; MAPK9
    Prostate cancer MAP4K1; BAD; CCND1; INS1; BCL2; PIK3CG; TCF7; PDGFA; CREB3L3; IKBKG
    Chronic myeloid leukemia MAPK1; CBLB; MDM2; TP53; PTPN11; CRK; IKBKB; ARAF; BRAF; SHC4
    Acute myeloid leukemia MAP2K1; SPI1; STAT3; RPS6KB2; AKT1; RELA; STAT5A; AKT2; PIK3CB; RARA
    Small cell lung cancer ITGAV; BCL2; PIK3CB; LAMA1; CYCS; TRAF1; ITGA3; PTEN; BCL2L1; PIK3R2

    ikbkb has several biochemical functions, for example, ATP binding, IkappaB kinase activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ikbkb itself. We selected most functions ikbkb had, and list some proteins which have the same functions with ikbkb. You can find most of the proteins on our site.

    Function Related Protein
    IkappaB kinase activity CHUK; IKBKB; IKBKE
    protein binding MAPK10; NDUFS3; SPRR2A; TBXA2R; PFKFB1; TCF3; TPT1; MAU2; FOXP3; DNAJC15
    protein heterodimerization activity ATF2; NR4A1; HIST1H4H; HIST1H4B; HIST1H2AI; RELA; TERF1; BCL2L1; H2BFWT; TIMELESS
    protein homodimerization activity NUDT16; VEGFB; APOE; MBL1; PYGL; ABP1; TARS; NKX2-5; CEBPE; NOS2
    protein kinase activity TNK2B; NLK; RASSF2; ERBB4A; CAD; BMPR1BB; ADRBK2; ERBB3B; CCL8; PANK1A
    protein kinase binding PRKAG2; SUFU; HDAC7A; CCND1; EMP2; WAS; SV2A; HCLS1; TPRKB; GOLGA2
    protein serine/threonine kinase activity IRAK4; TBK1; PAK6; NEK3; SLK; PRKD2; CAMK2A; MARK1; RPS6KA3B; HIPK2
    scaffold protein binding KRT15; PDE4D; CHUK; SRC; NCK2; KCNH2; NLRP1; NOS3; CACNA1H; ADCY6

    ikbkb has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ikbkb here. Most of them are supplied by our site. Hope this information will be useful for your research of ikbkb.


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