IKBKB
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Official Full Name
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta -
Overview
NFKB1 (MIM 164011) or NFKB2 (MIM 164012) is bound to REL (MIM 164910), RELA (MIM 164014), or RELB (MIM 604758) to form the NFKB complex. The NFKB complex is inhibited by I-kappa-B proteins (NFKBIA, MIM 164008, or NFKBIB, MIM 604495), which inactivate NF-kappa-B by trapping it in the cytoplasm. Phosphorylation of serine residues on the I-kappa-B proteins by kinases (IKBKA, MIM 600664, or IKBKB) marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NF-kappa-B complex. Activated NFKB complex translocates into the nucleus and binds DNA at kappa-B-binding motifs such as 5-prime GGGRNNYYCC 3-prime or 5-prime HGGARNYYCC 3-prime (where H is A, C, or T; R is an A or G purine; and Y is a C or T pyrimidine). -
Synonyms
IKBKB;IKK2;IKKB;NFKBIKB;FLJ33771;FLJ36218;FLJ38368;FLJ40509;IKK-beta;MGC131801;inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta;inhibitor of nuclear factor kappa-B kinase subunit beta;IKK-B;I-kappa-B kinase 2;OTTHUMP00000225854;OTTHUMP00000225858;OTTHUMP00000225860;OTTHUMP00000225865;OTTHUMP00000225866;I-kappa-B-kinase beta;nuclear factor NF-kappa-B inhibitor kinase beta
Recombinant Proteins
- Human
- Rhesus macaque
- Chicken
- Zebrafish
- Mouse
- E.coli
- Sf9 Cells
- Insect Cells
- Mammalian Cells
- Wheat Germ
- HEK293
- S.frugiperda
- Yeast
- In Vitro Cell Free System
- GST
- His
- Non
- DDK
- Myc
- Flag
- Avi
- Fc
- T7
Involved Pathway
IKBKB involved in several pathways and played different roles in them. We selected most pathways IKBKB participated on our site, such as MAPK signaling pathway,Ras signaling pathway,Chemokine signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with IKBKB were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Acute myeloid leukemia | PIK3R1,PIM2,MAP2K1,SOS1,PIK3R5,KRAS,FLT3,PIM1,MYC,RAF1 |
| Hepatitis B | FAS,RAF1,IFNA21,CREB3L2,APAF1,IFNA13,IL-8,MAP2K2,STAT2,KRAS |
| MAPK signaling pathway | PDGFAB,CACNB1,FGF2,HRASB,MAX,MAPK8B,NFKB2,FGF18A,PRKACAA,MAPK6 |
| NOD-like receptor signaling pathway | CXCL1,MAPK1,NFKBIAB,PSTPIP1A,TRIP6,CCL5,PSTPIP1,PYCARD,IL-8,HSP90AB1 |
| Apoptosis | TNFRSF10C,PIK3CA,PIK3R1,SATB1,CASP9,PIK3CD,AKT2,TNFRSF10D,CAPN2A,PRKAR2B |
| NF-kappa B signaling pathway | TRAF2,LAT,GM13304,GADD45B,PTGS2,XIAP,PLAU,MYD88,MAP3K14,LTBR |
| Type II diabetes mellitus | SLC2A4,PKM,SOCS2,TNF,MAPK3,IRS2,IRS4,ADIPOQ,CACNA1G,PIK3R3 |
| PIK-Akt signaling pathway | COL4A1,LPAR6,GNG2,IFNA17,MAPK3,SYK,RAF1,ITGA2,LAMC2,FGF4 |
| Osteoclast differentiation | PIK3CG,SYK,NCF2,PPP3CB,LCK,LILRB4,IFNG,CALCR,FCGR3B,FOSL1 |
Protein Function
IKBKB has several biochemical functions, for example, ATP binding,IkappaB kinase activity,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IKBKB itself. We selected most functions IKBKB had, and list some proteins which have the same functions with IKBKB. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein heterodimerization activity | SMAD4,IRAK3,PPP1CBL,HIST1H4L,HIST1H2BL,TAL1,CAPN2,MAFA,SRY,RXRA |
| protein homodimerization activity | CREB3,CARD8,UGT1A6B,PRPS2,SEPT12,SLC16A1,PVRL2L,S100A5,DLK2,CADM1B |
| ATP binding | MAP3K4,KATNA1,POMK,AK2,P2RY2,MAP2K4B,STRADB,CKB,ACSM2,UBE2L3 |
| protein serine/threonine kinase activity | AURKA,ERN2,ACVR2A,ROCK1,PBK,PKN1B,DAPK3,VPRBP,HUNK,MTOR |
| protein binding | DBF4B,JAM3B,DNAJC28,ANGPT1,IGSF1,MEP1B,TLX1,SLIT2,FOXK1,TH1L |
| IkappaB kinase activity | CHUK,IKBKE |
| protein kinase activity | STK35L,MAP2K4,ANKK1,CDK5,STK24,PRKDC,MAP3K12,CSNK1E,IGF1RA,CSF1RA |
| scaffold protein binding | DLG4,VIM,KRT8,MDM2,PANX1,NCK2,NLRP1,TREM1,KRT15,PARK7 |
| protein kinase binding | ADRA2A,KCNA5,KAT2B,PARK2,ZBTB4,JTB,CD36,PRKAB1,SFN,FOXM1 |
Interacting Protein
IKBKB has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IKBKB here. Most of them are supplied by our site. Hope this information will be useful for your research of IKBKB.
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