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Recombinant Human IKBKB protein, His & GST-tagged

Cat.No. : IKBKB-1720H
Product Overview : Recombinant Human IKBKB aa. (Asp246~Val528 (Accession # O14920)) fused with N-terminal His & GST tag was produced in E. coli cells.
  • Specification
  • Gene Information
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Description : The protein encoded by this gene phosphorylates the inhibitor in the inhibitor/NF-kappa-B complex, causing dissociation of the inhibitor and activation of NF-kappa-B. The encoded protein itself is found in a complex of proteins. Several transcript variants, some protein-coding and some not, have been found for this gene.
Source : E. coli
Species : Human
Tag : His & GST
Form : Freeze-dried powder
Molecular Mass : Predicted Molecular Mass: 62.3kDa
Protein length : Asp246~Val528 (Accession # O14920)
Endotoxin : <1.0EU per 1ug (determined by the LAL method)
Purity : >90%
Applications : SDS-PAGE; WB; ELISA; IP.
Stability : The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
Storage : Avoid repeated freeze/thaw cycles. Store at 2-8°C for one month. Aliquot and store at -80°C for 12 months.
Storage buffer : Supplied as lyophilized form in 20mM Tris, 150mM NaCl, pH8.0, containing 1mM EDTA, 1mM DTT, 0.01% sarcosyl, 5% trehalose, and preservative.
Reconstitution : Reconstitute in sterile ddH2O.
Isoelectric Point : 5.4
Gene Name : IKBKB inhibitor of nuclear factor kappa B kinase subunit beta [ Homo sapiens (human) ]
Official Symbol : IKBKB
Synonyms : IKBKB; inhibitor of nuclear factor kappa B kinase subunit beta; IKK2; IKKB; IMD15; NFKBIKB; IKK-beta; inhibitor of nuclear factor kappa-B kinase subunit beta; I-kappa-B kinase 2; I-kappa-B-kinase beta; IKK-B; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta; nuclear factor NF-kappa-B inhibitor kinase beta
Gene ID : 3551
mRNA Refseq : NM_001190720.2
Protein Refseq : NP_001177649.1
UniProt ID : O14920

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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How is IKBKB protein involved in inflammatory diseases? 02/24/2023

IKBKB protein is a key regulator of the NF-κB pathway, which plays a central role in the inflammatory response. Dysregulation of IKBKB can contribute to the development of inflammatory diseases.

Can dysregulation of IKBKB protein contribute to neurodegenerative diseases? 11/05/2020

Yes, dysregulation of IKBKB protein and the NF-κB pathway has been implicated in neuroinflammation and the pathogenesis of neurodegenerative diseases such as Alzheimer's and Parkinson's disease.

Is there any potential for targeting IKBKB protein in the treatment of autoimmune diseases? 08/21/2020

Yes, targeting IKBKB protein or the NF-κB pathway is being explored as a potential strategy for treating autoimmune diseases by modulating the inflammatory response.

How is IKBKB protein involved in the regulation of cell survival and apoptosis? 08/28/2019

IKBKB protein activates the NF-κB pathway, which can promote cell survival and inhibit apoptosis in response to various stimuli, making it a potential target for cancer therapy.

Can mutations in the IKBKB gene lead to human diseases? 12/23/2018

Yes, mutations in the IKBKB gene have been associated with immunodeficiency disorders and inflammatory diseases, highlighting the importance of IKBKB protein in immune system function.

Customer Reviews (3)

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Reviews
04/26/2020

    Their team of experts is readily available to assist you with any inquiries or challenges you may encounter during your experiments.

    09/24/2018

      Its purity and functional integrity guarantee optimal performance in a wide range of experimental applications.

      04/13/2016

        This protein, manufactured with utmost precision, provides reliable and consistent results, ensuring the accuracy and reproducibility of your research findings.

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