IL26

  • Official Full Name

    interleukin 26

  • Overview

    Interleukin 26 (IL-26) is a homodimer cytokine belonging to the IL-10 family that is expressed in certain herpesvirus-transformed T cells but IL-26 induces rapid phosphorylation of the transcription factors STAT1 and STAT3,Which enhance IL-10 and IL-8 secretion and as expression of the CD54 molecule on the surface of epithelial cells. IL-26's function in human disease is unknown, however research has found that IL-26 expression is up-regulated in active Crohn's disease, and therefore may play an active role along with Th17 cells in various autoimmune diseases.
  • Synonyms

    IL26; interleukin 26; interleukin-26; AK155; IL 26; IL-26;

  • Cell & Tissue Lysates
  • Recombinant Proteins
  • Human
  • Zebrafish
  • E.coli
  • HEK293
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • Yeast
  • C
  • His
  • GST
  • His(C
  • ter)
  • His|B2M
  • Trx
  • N/A
  • N
  • MBP
  • Avi
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human IL26-5230HCL Recombinant Human IL26 293 Cell Lysate HEK293 N/A
Human IL26-5208H Recombinant Human IL26 Protein, GST-tagged Wheat Germ GST
Human IL26-2174H Recombinant Human IL26 Protein (22-171 aa), His-tagged Yeast His 22-171 aa
Human IL26-5746HF Recombinant Full Length Human IL26 Protein, GST-tagged In Vitro Cell Free System GST 171 amino acids
Human IL26-3564H Recombinant Human IL26 Protein (Lys22-Gln171), C-His tagged E.coli C-His Lys22-Gln171
Human IL26-2446H Recombinant Human IL26 Protein (22-171 aa), His-B2M-tagged E.coli His/B2M 22-171 aa
Human IL26-1674H Recombinant Human IL26 Protein, His&GST-tagged E.coli N-His&GST Lys24-His112
Human IL26-4327H Recombinant Human IL26 protein, His-Trx-tagged E.coli His-Trx 22-171aa
Human IL26-252H Active Recombinant Human IL26 Protein (Lys22-Gln171), C-His tagged, Animal-free, Carrier-free E.coli C-His Lys22-Gln171
Human IL26-184H Recombinant Active Human IL26 Protein, His-tagged(C-ter) E.coli His(C-ter)
Human IL26-6432H Recombinant Human IL26 protein(22-171aa), MBP&His-Avi-tagged, Biotinylated E.coli N-MBP&C-His-Avi 22-171aa
Zebrafish IL26-2932Z Recombinant Zebrafish IL26 Mammalian Cell His
Zebrafish IL26-61Z Recombinant Zebrafish IL26 Protein, His-tagged E.coli His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

IL26 involved in several pathways and played different roles in them. We selected most pathways IL26 participated on our site, such as Cytokine-cytokine receptor interaction, which may be useful for your reference. Also, other proteins which involved in the same pathway with IL26 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Cytokine-cytokine receptor interactionKITLGA;CXCL10;TNFRSF17;BMPR1A;CSF3;IFNA21;PF4V1;GM2506;TGFB1A

IL26 has several biochemical functions, for example, cytokine activity. Some of the functions are cooperated with other proteins, some of the functions could acted by IL26 itself. We selected most functions IL26 had, and list some proteins which have the same functions with IL26. You can find most of the proteins on our site.

Function Related Protein
cytokine activityINHBAB;IL22;TGFB1A;TNFSF13;GDF6;INHBE;SPP1;BMP2;CCL38.1

IL26 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IL26 here. Most of them are supplied by our site. Hope this information will be useful for your research of IL26.

Research Area

Related articles

Skepner, J; Ramesh, R; et al. Pharmacologic Inhibition of ROR gamma t Regulates Th17 Signature Gene Expression and Suppresses Cutaneous Inflammation In Vivo. JOURNAL OF IMMUNOLOGY 192:2564-2575(2014).
Brand, S; et al. Crohn's disease: Th1, Th17 or both? The change of a paradigm: new immunological and genetic insights implicate Th17 cells in the pathogenesis of Crohn's disease. GUT 58:1152-1167(2009).
  • Reviews
  • Q&As

Customer Reviews (3)

Write a review
Reviews
12/11/2022

    The background is clean and non-immunogenic.

    06/03/2021

      Expression is very high and can be easily detected.

      07/04/2020

        Yield is very high and can meet a lot of my needs.

        Q&As (6)

        Ask a question
        How to detect the level of Il26 in vivo? 06/11/2022

        The level of Il26 in vivo can be detected by enzyme-linked immunosorbent assay and flow cytometry.

        What is the role of Il26 in inflammatory response? 06/03/2022

        Il26 can mediate the inflammatory response, regulating it by attracting immune cells and enhancing inflammation.

        Can recombinant Il26 be used in laboratory animals? 01/14/2022

        Il26 can be used for laboratory animal studies.

        What is the role of Il26 in cell signal transduction pathway? 11/30/2020

        It can mediate cell growth and differentiation through JAK-STAT signal transduction pathway.

        How to optimize the production process of Il26? 06/26/2020

        The production process of Il26 can be optimized by optimizing the transformation system, improving the culture conditions and optimizing the purification process.

        How to design drugs that target Il26? 11/21/2019

        Drugs targeting Il26 can be designed through computer simulation, drug screening and molecular modification.

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