IL26
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Official Full Name
interleukin 26
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Background
Interleukin 26 (IL-26) is a homodimer cytokine belonging to the IL-10 family that is expressed in certain herpesvirus-transformed T cells but IL-26 induces rapid phosphorylation of the transcription factors STAT1 and STAT3,Which enhance IL-10 and IL-8 secretion and as expression of the CD54 molecule on the surface of epithelial cells. IL-26's function in human disease is unknown, however research has found that IL-26 expression is up-regulated in active Crohn's disease, and therefore may play an active role along with Th17 cells in various autoimmune diseases. -
Synonyms
IL26; interleukin 26; interleukin-26; AK155; IL 26; IL-26;
| Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
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| Human | IL26-5208H | Recombinant Human IL26 Protein, GST-tagged | Wheat Germ | GST |
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| Human | IL26-2174H | Recombinant Human IL26 Protein (22-171 aa), His-tagged | Yeast | His |
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| Human | IL26-2446H | Recombinant Human IL26 Protein (22-171 aa), His-B2M-tagged | E.coli | His/B2M |
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| Human | IL26-5230HCL | Recombinant Human IL26 293 Cell Lysate | HEK293 | N/A |
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| Human | IL26-4327H | Recombinant Human IL26 protein, His-Trx-tagged | E.coli | His-Trx |
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| Human | IL26-1674H | Recombinant Human IL26 Protein, His&GST-tagged | E.coli | N-His&GST |
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| Human | IL26-184H | Recombinant Active Human IL26 Protein, His-tagged(C-ter) | E.coli | His(C-ter) |
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| Zebrafish | IL26-61Z | Recombinant Zebrafish IL26 Protein, His-tagged | E.coli | His |
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| Zebrafish | IL26-2932Z | Recombinant Zebrafish IL26 | Mammalian Cell | His |
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- Involved Pathway
- Protein Function
- Interacting Protein
- IL26 Related Articles
- IL26 Related Research Area
IL26 involved in several pathways and played different roles in them. We selected most pathways IL26 participated on our site, such as Cytokine-cytokine receptor interaction, which may be useful for your reference. Also, other proteins which involved in the same pathway with IL26 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Cytokine-cytokine receptor interaction | IFNE;IFNPHI1;IL3RA;TGFB2;Il2;CXCR2;Ccl27a;IL2RG;AMHR2 |
IL26 has several biochemical functions, for example, cytokine activity. Some of the functions are cooperated with other proteins, some of the functions could acted by IL26 itself. We selected most functions IL26 had, and list some proteins which have the same functions with IL26. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| cytokine activity | CCL38A.5;IL36A;INHBE;IFNB;IL17A/F1;EDN1;CMTM3;LIF;GDF10B |
IL26 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IL26 here. Most of them are supplied by our site. Hope this information will be useful for your research of IL26.
- Q&As
- Reviews
Q&As (6)
Ask a questionThe level of Il26 in vivo can be detected by enzyme-linked immunosorbent assay and flow cytometry.
Il26 can mediate the inflammatory response, regulating it by attracting immune cells and enhancing inflammation.
Il26 can be used for laboratory animal studies.
It can mediate cell growth and differentiation through JAK-STAT signal transduction pathway.
The production process of Il26 can be optimized by optimizing the transformation system, improving the culture conditions and optimizing the purification process.
Drugs targeting Il26 can be designed through computer simulation, drug screening and molecular modification.
Customer Reviews (3)
Write a reviewAnimal models are used to evaluate the biological function of IL-26 protein, and its effects and side effects are evaluated by observing its effects on immune response, inflammation, disease, etc., in mice or rats. -
Techniques such as ELISA or flow cytometry can be used to detect IL-26 concentrations in body fluids or cells. -
The molecular weight, composition and stability of IL-26 protein can be determined by western blotting and mass spectrometry. -
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