• Official Full Name

    interleukin 26

  • Background

    Interleukin 26 (IL-26) is a homodimer cytokine belonging to the IL-10 family that is expressed in certain herpesvirus-transformed T cells but IL-26 induces rapid phosphorylation of the transcription factors STAT1 and STAT3,Which enhance IL-10 and IL-8 secretion and as expression of the CD54 molecule on the surface of epithelial cells. IL-26's function in human disease is unknown, however research has found that IL-26 expression is up-regulated in active Crohn's disease, and therefore may play an active role along with Th17 cells in various autoimmune diseases.
  • Synonyms

    IL26; interleukin 26; interleukin-26; AK155; IL 26; IL-26;
    • Type:
    • Recombinant Proteins
    • Cell & Tissue Lysates
    • Species :
    • Human
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • Mammalian Cell
    • Wheat Germ
    • Yeast
    • Tag :
    • GST
    • His
    • His(C
    • ter)
    • His|B2M
    • Trx
    • N/A
    • N
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human IL26-5208H Recombinant Human IL26 Protein, GST-tagged Wheat Germ GST
    Human IL26-2174H Recombinant Human IL26 Protein (22-171 aa), His-tagged Yeast His
    Human IL26-2446H Recombinant Human IL26 Protein (22-171 aa), His-B2M-tagged E.coli His/B2M
    Human IL26-5230HCL Recombinant Human IL26 293 Cell Lysate HEK293 N/A
    Human IL26-4327H Recombinant Human IL26 protein, His-Trx-tagged E.coli His-Trx
    Human IL26-1674H Recombinant Human IL26 Protein, His&GST-tagged E.coli N-His&GST
    Human IL26-184H Recombinant Active Human IL26 Protein, His-tagged(C-ter) E.coli His(C-ter)
    Zebrafish IL26-61Z Recombinant Zebrafish IL26 Protein, His-tagged E.coli His
    Zebrafish IL26-2932Z Recombinant Zebrafish IL26 Mammalian Cell His
    • Involved Pathway
    • Protein Function
    • Interacting Protein
    • IL26 Related Articles
    • IL26 Related Research Area

    IL26 involved in several pathways and played different roles in them. We selected most pathways IL26 participated on our site, such as Cytokine-cytokine receptor interaction, which may be useful for your reference. Also, other proteins which involved in the same pathway with IL26 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Cytokine-cytokine receptor interactionIFNE;IFNPHI1;IL3RA;TGFB2;Il2;CXCR2;Ccl27a;IL2RG;AMHR2

    IL26 has several biochemical functions, for example, cytokine activity. Some of the functions are cooperated with other proteins, some of the functions could acted by IL26 itself. We selected most functions IL26 had, and list some proteins which have the same functions with IL26. You can find most of the proteins on our site.

    Function Related Protein
    cytokine activityCCL38A.5;IL36A;INHBE;IFNB;IL17A/F1;EDN1;CMTM3;LIF;GDF10B

    IL26 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IL26 here. Most of them are supplied by our site. Hope this information will be useful for your research of IL26.

    Skepner, J; Ramesh, R; et al. Pharmacologic Inhibition of ROR gamma t Regulates Th17 Signature Gene Expression and Suppresses Cutaneous Inflammation In Vivo. JOURNAL OF IMMUNOLOGY 192:2564-2575(2014).
    Brand, S; et al. Crohn's disease: Th1, Th17 or both? The change of a paradigm: new immunological and genetic insights implicate Th17 cells in the pathogenesis of Crohn's disease. GUT 58:1152-1167(2009).
    • Q&As
    • Reviews

    Q&As (6)

    Ask a question
    How to detect the level of Il26 in vivo? 06/11/2022

    The level of Il26 in vivo can be detected by enzyme-linked immunosorbent assay and flow cytometry.

    What is the role of Il26 in inflammatory response? 06/03/2022

    Il26 can mediate the inflammatory response, regulating it by attracting immune cells and enhancing inflammation.

    Can recombinant Il26 be used in laboratory animals? 01/14/2022

    Il26 can be used for laboratory animal studies.

    What is the role of Il26 in cell signal transduction pathway? 11/30/2020

    It can mediate cell growth and differentiation through JAK-STAT signal transduction pathway.

    How to optimize the production process of Il26? 06/26/2020

    The production process of Il26 can be optimized by optimizing the transformation system, improving the culture conditions and optimizing the purification process.

    How to design drugs that target Il26? 11/21/2019

    Drugs targeting Il26 can be designed through computer simulation, drug screening and molecular modification.

    Customer Reviews (3)

    Write a review

      Animal models are used to evaluate the biological function of IL-26 protein, and its effects and side effects are evaluated by observing its effects on immune response, inflammation, disease, etc., in mice or rats. -


        Techniques such as ELISA or flow cytometry can be used to detect IL-26 concentrations in body fluids or cells. -


          The molecular weight, composition and stability of IL-26 protein can be determined by western blotting and mass spectrometry. -

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