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Official Full Name integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)
Background ITGA2B encodes integrin alpha chain 2b. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. Alpha chain 2b undergoes post-translational cleavage to yield disulfide-linked light and heavy chains that join with beta 3 to form a fibronectin receptor expressed in platelets that plays a crucial role in coagulation. Mutations that interfere with this role result in thrombasthenia. In addition to adhesion, integrins are known to participate in cell-surface mediated signalling. [provided by RefSeq, Jul 2008]
Synonyms ITGA2B; integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41); GT; GTA; CD41; GP2B; HPA3; CD41B; GPIIb; BDPLT2; BDPLT16; integrin alpha-IIb; GPalpha IIb; platelet-specific antigen BAK; platelet membrane glycoprotein IIb; platelet fibrinogen receptor, alpha subunit;
    • Species :
    • Human
    • Mouse
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Human plasma
    • Mammalian Cell
    • Wheat Germ
    • Yeast
    • Tag :
    • GST
    • His
    • T7
    • Myc/DDK
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human ITGA2B-1425H Recombinant Human ITGA2B Protein (639-887 aa), His-tagged Yeast His
    Human ITGA2B-1586H Recombinant Human ITGA2B Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Mouse Itga2b-3593M Recombinant Mouse Itga2b Protein, Myc/DDK-tagged HEK293T Myc/DDK
    Human ITGA2B-10H Native Human GPIIbIIIa Human plasma N/A
    Human ITGA2B-174H Recombinant Human ITGA2B, GST-tagged E.coli GST
    Human ITGA2B-2615H Recombinant Human ITGA2B Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human ITGA2B-4999H Recombinant Human ITGA2B Protein, GST-tagged Wheat Germ GST
    Human ITGA2B-5758H Recombinant Human ITGA2B protein, His & T7-tagged E.coli His/T7
    Mouse ITGA2B-8348M Recombinant Mouse ITGA2B Protein Mammalian Cell His
    Zebrafish ITGA2B-1144Z Recombinant Zebrafish ITGA2B Mammalian Cell His

    itga2b involved in several pathways and played different roles in them. We selected most pathways itga2b participated on our site, such as Rap signaling pathway, PIK-Akt signaling pathway, Focal adhesion, which may be useful for your reference. Also, other proteins which involved in the same pathway with itga2b were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Rap signaling pathway FGF22; PRKCB; GNAI1; FGF16; PDGFA; RRAS; RASSF5; Fgf15; ITGB2L; KRAS
    PIK-Akt signaling pathway GNG8; INS1; TCL1; ITGA2; PPP2R1B; GNG13; MTCP1; ITGB5; RELA; PDGFRB
    Focal adhesion HRASB; RAF1A; ACTN3B; MAPK6; CAV1; FLT4; LAMB4; PDGFC; PTEN; PTK2
    ECM-receptor interaction COL3A1; COL4A1; LAMA2; LAMB3; GP5; GP1BA; ITGB3B; THBS3A; DAG1; ITGA4
    Platelet activation PLA2G4A; FGG; PLCG2; PRKCZ; MYLK; MYLK3; PIK3CB; PIK3CA; GP5; Adcy4
    Hematopoietic cell lineage FCER2; Il6ra; GP1BB; GM-CSF; CD1D2; GYPA; EPO; IL6R; CD1E; CD44
    Regulation of actin cytoskeleton ITGB7; FGF8; ARAF; MAP2K2; F2R; F2; PAK2B; ARHGEF7A; FGF1A; PPP1CA
    Pathways in cancer GNGT1; GNG12; TGFB1; ITGA6; PLEKHG5; SLC2A1; LAMC2; CSF1R; ITGA2; GNA12
    Small cell lung cancer PIK3CB; FN1; LAMA3; NFKBIA; ITGB1; PIAS2; BIRC2; LAMC2; BIRC3; TRAF1
    Hypertrophic cardiomyopathy (HCM) CACNB1; TNNC1; ITGB4; IL6; ACTC1; PRKAB1; LMNA; DES; ITGA2B; TPM4
    Arrhythmogenic right ventricular cardiomyopathy (ARVC) CACNA2D4; RYR2; ITGB3; LEF1; ITGA10; ACTN4; ITGA3; DSG2; Itga10&Itgb1; CACNG6
    Dilated cardiomyopathy ADRB1; ITGB6; CACNG6; ITGB7; ITGA9; MYL3; CACNG4; DES; ITGB8; CACNG8

    itga2b has several biochemical functions, for example, extracellular matrix binding, fibrinogen binding, identical protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by itga2b itself. We selected most functions itga2b had, and list some proteins which have the same functions with itga2b. You can find most of the proteins on our site.

    Function Related Protein
    extracellular matrix binding DCN; TGFBI; ITGAV; VEGFA; FBLN2; GPR56; DMP1; BGN; SPP1; VTN
    fibrinogen binding MFAP2; FBLN1; THBS1; ITGA2B
    identical protein binding SYT9; CEACAM16; APOA1; P2RX2; MYBPC3; MBIP; MAP3K11; TPRG1L; SNX1; DVL1
    metal ion binding ZFP593; CACNA2D3; MYCBP2; TPH1A; ITGA2B; EGR2B; NR5A5; MUL1B; BCL6AB; ZNF786
    protein binding PPP1R7; UBE2Q1; MTPAP; KRT4; RTN4RL2B; ATP1B2; ID4; TRPM6; GDF5; GDAP2

    itga2b has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with itga2b here. Most of them are supplied by our site. Hope this information will be useful for your research of itga2b.

    ITGB3; g3gu78_crigr

    Jin, Y; Wang, LM; et al. Differential expression of 5-HT-related genes in symptomatic pulmonary embolism patients. INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE 8:512-518(2015).
    Nishikawa, S; Arai, S; et al. Thrombopoietin/MPL signaling confers growth and survival capacity to CD41-positive cells in a mouse model of Evi1 leukemia. BLOOD 124:3587-3596(2014).

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