Recombinant Mouse Itga2b Protein, Myc/DDK-tagged

• Cat.No.: Itga2b-3593M
• Product Overview: Purified recombinant protein of mouse full-length integrin alpha 2b (Itga2b), with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Description: Integrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. It recognizes the sequence R-G-D in a wide array of ligands. It recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha-IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial cell surface.
• Source: HEK293T
• Species: Mouse
• Tag: Myc/DDK
• Molecular Mass: 112.7 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Itga2b integrin alpha 2b [ Mus musculus (house mouse) ]
• Official Symbol: Itga2b
• Synonyms: ITGA2B; integrin alpha 2b; integrin alpha-IIb; GP IIb; alpha IIb; GPalpha IIb; platelet membrane glycoprotein IIb; platelet glycoprotein IIb of IIb/II Ia complex; CD41; CD41B; GpIIb; AI172977; alphaIIb
• Gene ID: 16399
• mRNA Refseq: NM_010575
• Protein Refseq: NP_034705
• UniProt ID: Q9QUM0