itga6

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itga6

Official Full Name integrin, alpha 6
Background The ITGA6 protein product is the integrin alpha chain alpha 6. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins. For example, alpha 6 may combine with beta 4 in the integrin referred to as TSP180, or with beta 1 in the integrin VLA-6. Integrins are known to participate in cell adhesion as well as cell-surface mediated signalling. Two transcript variants encoding different isoforms have been found for this gene.
Synonyms ITGA6; integrin, alpha 6; integrin alpha-6; CD49f; integrin alpha6B; CD49 antigen-like family member F; VLA-6; ITGA6B; FLJ18737; DKFZp686J01244
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rhesus Macaque
    • Source :
    • CHO
    • E.coli
    • HEK293
    • HEK293T
    • Human Cell
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • Flag/His
    • Flag
    • His
    • GST
    • Avi
    • His-Avi
    • Myc/DDK
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human ITGA6 & ITGB4-610H Recombinant Human ITGA6 & ITGB4 protein, Flag/His-tagged HEK293 Flag/His
    Human ITGA6 & ITGB1-102H Recombinant Human ITGA6 & ITGB1 protein, His-Avi-tagged HEK293 His-Avi
    Human ITGA6 & ITGB1-609H Recombinant Human ITGA6 & ITGB1 Protein, His-Avi-tagged, Biotinylated HEK293 His/Avi
    Human ITGA6-1218H Recombinant Human ITGA6 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Mouse Itga6-3597M Recombinant Mouse Itga6 Protein, Myc/DDK-tagged HEK293T Myc/DDK
    Human ITGA6 & ITGB1-1878HCL Recombinant Human ITGA6 & ITGB1 cell lysate Human Cell N/A
    Human ITGA6&ITGB1-608H Recombinant Human ITGA6&ITGB1 CHO N/A
    Human ITGA6-2612H Recombinant Human ITGA6 Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human ITGA6-4110H Recombinant Human ITGA6 CHO N/A
    Human ITGA6-4111H Recombinant Human ITGA6, GST-tagged Wheat Germ GST
    Human ITGA6-4115H Recombinant Human ITGA6, flag & His tagged Human Cell Flag/His
    Human ITGA6-4995H Recombinant Human ITGA6 Protein Wheat Germ N/A
    Human ITGA6-5131HCL Recombinant Human ITGA6 293 Cell Lysate HEK293 N/A
    Human ITGA6-609H Recombinant Human ITGA6 CHO N/A
    Mouse Itga6-6767M Recombinant Mouse Itga6 protein, His & GST-tagged E.coli His/GST
    Rhesus Macaque ITGA6-2314R Recombinant Rhesus monkey ITGA6 Protein, His-tagged Mammalian Cell His
    Chicken ITGA6-6841C Recombinant Chicken ITGA6 Mammalian Cell His

    itga6 involved in several pathways and played different roles in them. We selected most pathways itga6 participated on our site, such as PIK-Akt signaling pathway, Focal adhesion, ECM-receptor interaction, which may be useful for your reference. Also, other proteins which involved in the same pathway with itga6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    PIK-Akt signaling pathway RELA; PIK3CD; Il4ra; Ifna11; PPP2R5A; FGFR3; FLT1; FN1; RPTOR; IL4
    Focal adhesion ACTN3; COL27A1B; LAMB1A; RAP1AA; MLCK2; THBS4B; PAK3; ITGA9; TLN2A; RAC1
    ECM-receptor interaction ITGB6; LAMB2; ITGA1; THBS3; GP9; ITGB1B.2; TNW; COL5A2; CD47; ITGA6
    Cell adhesion molecules (CAMs) CLDN6; LRRC4C; SELL; PDCD1LG2; CLDN16; HLA-DQB1; CLDN9; CLDN5; NADL1.2; NLGN2
    Hematopoietic cell lineage CD38; IL9R; FLT3; ITGA3; CD1D; CD1E; TFRC; GP1BA; IL4R; KIT
    Regulation of actin cytoskeleton FGF19; ARHGEF4; ITGAL; ITGA6B; PPP1CA; HRAS; FGF18A; FGF6A; RHOAD; PDGFC
    Toxoplasmosis GNAI1; GNAI3; BIRC2; PPIF; Toxoplasma Gondii Dense Granule Protein 7; TNFRSF1A; NFKB1; MAPK13; HSPA6; GNAI2
    Pathways in cancer TRAF6; CASP9; FGF16; Adcy4; RXRB; TGFBR1; GNG2; Flt3l; PTEN; GNG4
    Small cell lung cancer NFKBIA; SKP2; LAMB4; BIRC8; ITGA3; PIAS2; PTEN; TRAF2; PIK3CD; TRAF1
    Hypertrophic cardiomyopathy (HCM) CACNB1; TPM1; ITGB1; ITGA2B; CACNG7; TGFB3; Itga10&Itgb1; LMNA; TGFB2; CACNG8
    Arrhythmogenic right ventricular cardiomyopathy (ARVC) CACNG7; ITGA2B; EMD; LMNA; PKP2; ITGA3; CACNB1; DES; TCF7L2; CTNNA3
    Dilated cardiomyopathy MYH7; ITGA10; CACNG2; ITGB8; ITGA2B; TGFB1; TPM1; PRKACB; ITGB7; CACNG1

    itga6 has several biochemical functions, for example, integrin binding, metal ion binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by itga6 itself. We selected most functions itga6 had, and list some proteins which have the same functions with itga6. You can find most of the proteins on our site.

    Function Related Protein
    integrin binding TSPAN4; COL4A3; LYN; GPNMB; FCER2; VWF; ESM1; CYR61; CD9; COL16A1
    metal ion binding ZNF74; ZDHHC3A; RHEBL1; SMYD4; ESYT3; CYP2X9; ACVRL1; ZNF219; CLEC7A; PRKAA1
    protein binding FASTK; CTRC; FAM125A; TSC2; HIST1H4C; HEY1; TRIM72; GIMAP5; ASNS; USP49

    itga6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with itga6 here. Most of them are supplied by our site. Hope this information will be useful for your research of itga6.

    ITGB4; PDIA3; ITGB1; 1-phosphatidyl-1d-myo-inositol 3,5-bisphosphate; Itgb1; CD9

    Landowski, TH; Gard, J; et al. Targeting Integrin alpha 6 Stimulates Curative-Type Bone Metastasis Lesions in a Xenograft Model. MOLECULAR CANCER THERAPEUTICS 13:1558-1566(2014).
    Kwon, J; Lee, TS; et al. Integrin alpha 6: A novel therapeutic target in esophageal squamous cell carcinoma. INTERNATIONAL JOURNAL OF ONCOLOGY 43:1523-1530(2013).

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