ITGA6

  • Official Full Name

    integrin, alpha 6

  • Overview

    The ITGA6 protein product is the integrin alpha chain alpha 6. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins. For example, alpha 6 may combine with beta 4 in the integrin referred to as TSP180, or with beta 1 in the integrin VLA-6. Integrins are known to participate in cell adhesion as well as cell-surface mediated signalling. Two transcript variants encoding different isoforms have been found for this gene.
  • Synonyms

    ITGA6; integrin, alpha 6; integrin alpha-6; CD49f; integrin alpha6B; CD49 antigen-like family member F; VLA-6; ITGA6B; FLJ18737; DKFZp686J01244;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rhesus Macaque
  • CHO
  • E.coli
  • HEK293
  • HEK293T
  • Human Cell
  • In Vitro Cell Free System
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • C
  • His
  • Flag
  • Flag|His
  • GST
  • His (Fc)
  • Avi
  • His|Avi
  • His|GST
  • Myc
  • DDK
  • Myc|DDK
  • N/A
  • N
  • His6ABP
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human ITGA6-4110H Active Recombinant Human ITGA6 CHO N/A
Human ITGA6&ITGB1-608H Active Recombinant Human ITGA6&ITGB1 CHO N/A
Human ITGA6-609H Active Recombinant Human ITGA6 CHO N/A
Human ITGA6-4111H Recombinant Human ITGA6, GST-tagged Wheat Germ GST 24 a.a. - 133 a.a.
Human ITGA6-4115H Recombinant Human ITGA6, flag & His tagged Human Cell Flag/His
Human ITGA6 & ITGB1-1878HCL Recombinant Human ITGA6 & ITGB1 cell lysate Human Cell N/A
Human ITGA6-5131HCL Recombinant Human ITGA6 293 Cell Lysate HEK293 N/A
Human ITGA6 & ITGB1-609H Recombinant Human ITGA6 & ITGB1 Protein, His-Avi-tagged, Biotinylated HEK293 His/Avi
Human ITGA6-2612H Recombinant Human ITGA6 Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human ITGA6-4315H Recombinant Human ITGA6 Protein (Met1-Arg938), C-His tagged Mammalian cells C-His Met1-Arg938
Human ITGA6-4314H Recombinant Human ITGA6 Protein (Met1-Ser1050), C-His tagged Mammalian cells C-His Met1-Ser1050
Human ITGA6-1218H Recombinant Human ITGA6 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human ITGA6 & ITGB1-102H Recombinant Human ITGA6 & ITGB1 protein, His-Avi-tagged HEK293 His-Avi lt contains Phe24-Gly1012 (P23229-2) acidic tail& GIn21-His 728 (P05556)basic tail design.
Human ITGA6 & ITGB4-610H Recombinant Human ITGA6 & ITGB4 protein, Flag/His-tagged HEK293 Flag/His ITGA6 (Met1-Ser1011) & ITGB4 (Met1-Ser710)
Human ITGA6-4995H Recombinant Human ITGA6 Protein Wheat Germ N/A
Human ITGA6-5725HF Recombinant Full Length Human ITGA6 Protein In Vitro Cell Free System 420 amino acids
Human ITGA6-3016H Recombinant Human ITGA6 protein, His-tagged E.coli His 477-690 aa
Human ITGA6-06H Recombinant Human ITGA6 Protein, N-His6ABP tagged E.coli N-His6ABP
Human ITGA6-2342H Recombinant Human ITGA6 Protein, His-tagged E.coli N-His Phe24-Asn478
Mouse Itga6-6767M Recombinant Mouse Itga6 protein, His & GST-tagged E.coli His/GST Glu903~Ala1073 (Accession # Q61739)
Mouse Itga6-1698M Recombinant Mouse Itga6 Protein, His-tagged E.coli N-His Phe24-Asn479
Mouse Itga6-3597M Recombinant Mouse Itga6 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse Itga6-1699M Recombinant Mouse Itga6 Protein, His-tagged E.coli N-His Arg480-Arg899
Rhesus Macaque ITGA6-2314R Recombinant Rhesus monkey ITGA6 Protein, His-tagged Mammalian Cell His
Rhesus Macaque ITGA6-2135R Recombinant Rhesus Macaque ITGA6 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque ITGA6-2135R-B Recombinant Rhesus Macaque ITGA6 Protein Pre-coupled Magnetic Beads HEK293
Chicken ITGA6-6841C Recombinant Chicken ITGA6 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • ITGA6 Related Articles
  • ITGA6 Related Research Area

ITGA6 involved in several pathways and played different roles in them. We selected most pathways ITGA6 participated on our site, such as PIK-Akt signaling pathway, Focal adhesion, ECM-receptor interaction, which may be useful for your reference. Also, other proteins which involved in the same pathway with ITGA6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
PIK-Akt signaling pathwayGYS1;SYK;ITGA8;RPS6;THBS2;LAMB3;CREB3L1;ITGA9;SGK3
Focal adhesionPTK2AB;VCLA;COL1A1;FYNA;ITGB6;PDGFRA;ROCK2;LAMA5;PIK3CA
ECM-receptor interactionCD36;THBS1;COL6A4;GP6;COL11A2;SDC4;CD44;COL4A3;ITGA2
Cell adhesion molecules (CAMs)ALCAMA;HLA-G;CD34;CLDNJ;CDH2;NRXN1A;MHC2A;NFASC;NCAM2
Hematopoietic cell lineageGP9;IL5RA;CD3G;IL5;Itga10&Itgb1;CD8B1;IL1R2;CD1A;CD1D
Regulation of actin cytoskeletonRASSF7;VAV3;PTK2AB;RRAS2;FGF14;PFN2L;FGF11;ARHGEF1;FGF18A
ToxoplasmosisTLR4;XIAP;MAPK13;IFNGR2;CASP9;AKT1;LAMC2;TLR2;Toxoplasma Gondii Dense Granule Protein 7
Pathways in cancerTRAF1;CCNA1;RBX1;ITGB1;WNT7A;BMP2;IKBKB;VEGFA;RHOA
Small cell lung cancerPIK3CB;LAMB4;LAMB3;APAF1;CCNE2;LAMB2;FN1;ITGA2;CKS2
Hypertrophic cardiomyopathy (HCM)ITGB3;TGFB3;EMD;TTN;LAMA2;PRKAA1;Itga10&Itgb1;CACNA2D2;ITGA1
Arrhythmogenic right ventricular cardiomyopathy (ARVC)CACNA2D1;CACNG2;CACNA2D3;CDH2;TCF7;CACNB2;PKP2;SLC8A1;ITGA2B
Dilated cardiomyopathyPRKACB;MYBPC3;ACTB;ITGB3;CACNA2D3;DMD;EMD;ITGA4;DAG1

ITGA6 has several biochemical functions, for example, integrin binding, metal ion binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ITGA6 itself. We selected most functions ITGA6 had, and list some proteins which have the same functions with ITGA6. You can find most of the proteins on our site.

Function Related Protein
integrin bindingCOL4A3;Npnt;S1PR2;ITGB1BP2;JAM3;LAMA5;ITGB1BP1;CD9;SRC
metal ion bindingFHL3B;ENTPD7;ZNF395B;CBS;PRSS37;DEAF1;C1GALT1A;MTL5;ADAM1B
protein bindingKRIT1;DLL1;ARIH1;LPHN1;KHDC1B;WDR74;EPHB1;SNRPD3;RAPGEF4

ITGA6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ITGA6 here. Most of them are supplied by our site. Hope this information will be useful for your research of ITGA6.

ITGB4; PDIA3; ITGB1; 1-phosphatidyl-1d-myo-inositol 3,5-bisphosphate; Itgb1; CD9

Landowski, TH; Gard, J; et al. Targeting Integrin alpha 6 Stimulates Curative-Type Bone Metastasis Lesions in a Xenograft Model. MOLECULAR CANCER THERAPEUTICS 13:1558-1566(2014).
Kwon, J; Lee, TS; et al. Integrin alpha 6: A novel therapeutic target in esophageal squamous cell carcinoma. INTERNATIONAL JOURNAL OF ONCOLOGY 43:1523-1530(2013).
  • Q&As
  • Reviews

Q&As (6)

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How can I detect the expression level of ITGA6 protein? 01/02/2022

The expression level of ITGA6 protein can be detected by immunohistochemistry, western blotting, and real-time PCR.

What is the effect of aberrant expression of ITGA6 protein on the development and metastasis of cancer? 03/02/2021

Aberrant expression of ITGA6 protein can promote the adhesion and migration of cancer cells, thereby contributing to the development and metastasis of cancer. High expression of ITGA6 is often associated with the degree of malignancy and poor prognosis of the cancer.

What are the current challenges and controversies in the research on ITGA6 protein? 02/04/2021

There are some challenges and controversies in the current research on ITGA6 protein, including its specific mechanism of action in different diseases, its interaction with other molecules, and the optimal treatment. In addition, more clinical data is needed to validate the reliability of ITGA6 protein as a biomarker.

What are the potential applications of ITGA6 protein in drug discovery? 06/07/2020

Due to its critical role in a variety of diseases, ITGA6 protein may become an important target for drug discovery. Drugs targeting the ITGA6 protein may have the potential to treat diseases such as cancer, fibrotic diseases, and inflammatory diseases.

Is there a targeted therapy for the ITGA6 protein? 02/25/2020

At present, targeted therapies targeting ITGA6 protein are still in the research stage, and there are no drugs approved for clinical use. However, some studies are exploring the use of antibodies or small molecule inhibitors to block the function of ITGA6 to treat related diseases.

Can the expression level of ITGA6 protein be used as a biomarker for disease prognosis or treatment response? 02/18/2020

Some studies have shown that the expression level of ITGA6 protein can serve as a biomarker for the prognosis and treatment response of certain cancers. However, more studies are needed to verify its clinical application value.

Customer Reviews (3)

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Reviews
10/12/2021

    I've used this several times and their performance has been consistent and I've never had a problem.

    05/22/2021

      It is very suitable for crystallography research.

      05/05/2021

        It has good antigenicity and can induce a target immune response.

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