|Official Full Name||integrin, alpha 6|
|Background||The ITGA6 protein product is the integrin alpha chain alpha 6. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins. For example, alpha 6 may combine with beta 4 in the integrin referred to as TSP180, or with beta 1 in the integrin VLA-6. Integrins are known to participate in cell adhesion as well as cell-surface mediated signalling. Two transcript variants encoding different isoforms have been found for this gene.|
|Synonyms||ITGA6; integrin, alpha 6; integrin alpha-6; CD49f; integrin alpha6B; CD49 antigen-like family member F; VLA-6; ITGA6B; FLJ18737; DKFZp686J01244|
|Species||Cat.#||Product name||Source (Host)||Tag||Protein Length||Price|
itga6 involved in several pathways and played different roles in them. We selected most pathways itga6 participated on our site, such as PIK-Akt signaling pathway, Focal adhesion, ECM-receptor interaction, which may be useful for your reference. Also, other proteins which involved in the same pathway with itga6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
|Pathway Name||Pathway Related Protein|
|PIK-Akt signaling pathway||RELA; PIK3CD; Il4ra; Ifna11; PPP2R5A; FGFR3; FLT1; FN1; RPTOR; IL4|
|Focal adhesion||ACTN3; COL27A1B; LAMB1A; RAP1AA; MLCK2; THBS4B; PAK3; ITGA9; TLN2A; RAC1|
|ECM-receptor interaction||ITGB6; LAMB2; ITGA1; THBS3; GP9; ITGB1B.2; TNW; COL5A2; CD47; ITGA6|
|Cell adhesion molecules (CAMs)||CLDN6; LRRC4C; SELL; PDCD1LG2; CLDN16; HLA-DQB1; CLDN9; CLDN5; NADL1.2; NLGN2|
|Hematopoietic cell lineage||CD38; IL9R; FLT3; ITGA3; CD1D; CD1E; TFRC; GP1BA; IL4R; KIT|
|Regulation of actin cytoskeleton||FGF19; ARHGEF4; ITGAL; ITGA6B; PPP1CA; HRAS; FGF18A; FGF6A; RHOAD; PDGFC|
|Toxoplasmosis||GNAI1; GNAI3; BIRC2; PPIF; Toxoplasma Gondii Dense Granule Protein 7; TNFRSF1A; NFKB1; MAPK13; HSPA6; GNAI2|
|Pathways in cancer||TRAF6; CASP9; FGF16; Adcy4; RXRB; TGFBR1; GNG2; Flt3l; PTEN; GNG4|
|Small cell lung cancer||NFKBIA; SKP2; LAMB4; BIRC8; ITGA3; PIAS2; PTEN; TRAF2; PIK3CD; TRAF1|
|Hypertrophic cardiomyopathy (HCM)||CACNB1; TPM1; ITGB1; ITGA2B; CACNG7; TGFB3; Itga10&Itgb1; LMNA; TGFB2; CACNG8|
|Arrhythmogenic right ventricular cardiomyopathy (ARVC)||CACNG7; ITGA2B; EMD; LMNA; PKP2; ITGA3; CACNB1; DES; TCF7L2; CTNNA3|
|Dilated cardiomyopathy||MYH7; ITGA10; CACNG2; ITGB8; ITGA2B; TGFB1; TPM1; PRKACB; ITGB7; CACNG1|
itga6 has several biochemical functions, for example, integrin binding, metal ion binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by itga6 itself. We selected most functions itga6 had, and list some proteins which have the same functions with itga6. You can find most of the proteins on our site.
|integrin binding||TSPAN4; COL4A3; LYN; GPNMB; FCER2; VWF; ESM1; CYR61; CD9; COL16A1|
|metal ion binding||ZNF74; ZDHHC3A; RHEBL1; SMYD4; ESYT3; CYP2X9; ACVRL1; ZNF219; CLEC7A; PRKAA1|
|protein binding||FASTK; CTRC; FAM125A; TSC2; HIST1H4C; HEY1; TRIM72; GIMAP5; ASNS; USP49|
itga6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with itga6 here. Most of them are supplied by our site. Hope this information will be useful for your research of itga6.
ITGB4; PDIA3; ITGB1; 1-phosphatidyl-1d-myo-inositol 3,5-bisphosphate; Itgb1; CD9