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Recombinant Mouse Itga6 protein, His & GST-tagged

Cat.No. : Itga6-6767M
Product Overview : Recombinant Mouse Itga6 aa. (Glu903~Ala1073 (Accession # Q61739)) fused with N-terminal His & GST tag was produced in E. coli cells.
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  • Gene Information
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Description : This gene encodes a protein that is a member of the integrin superfamily. Integrins are transmembrane receptors involved cell adhesion and signaling, and they are subdivided based on the heterodimer formation of alpha and beta chains. This protein has been shown to heterodimerize with beta 4 to bind laminin and to form the main component of hemidesmosomes, which mediate attachment of epithelia to basement membranes. In mouse, deficiency of this gene is associated with absence of hemidesmosomes, severe skin blistering, and early post-natal death. In humans mutations of this gene are associated with epidermolysis bullosa. Alternative splicing results in multiple transcript variants that encode different protein isoforms.
Source : E. coli
Species : Mouse
Tag : His & GST
Form : Freeze-dried powder
Molecular Mass : Predicted Molecular Mass: 52.0kDa.
Protein length : Glu903~Ala1073 (Accession # Q61739)
Endotoxin : <1.0EU per 1ug (determined by the LAL method)
Purity : >95%
Characteristic : The isoelectric point is 8.4.
Applications : SDS-PAGE; WB; ELISA; IP.
Stability : The thermal stability is described by the loss rate of the target protein. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. (Referring from China Biological Products Standard, which was calculated by the Arrhenius equation.) The loss of this protein is less than 5% within the expiration date under appropriate storage condition.
Storage : Avoid repeated freeze/thaw cycles. Store at 2-8°C for one month. Aliquot and store at -80°C for 12 months.
Storage buffer : Supplied as lyophilized form in PBS, pH7.4, containing 5% sucrose, 0.01% sarcosyl.
Reconstitution : Reconstitute in sterile PBS, pH7.2-pH7.4.
Gene Name : Itga6 integrin alpha 6 [ Mus musculus (house mouse) ]
Official Symbol : Itga6
Synonyms : Cd49f; VLA-6; AI115430; 5033401O05Rik; CD49 antigen-like family member F; integrin alpha-6
Gene ID : 16403
mRNA Refseq : NM_001277970.1
Protein Refseq : NP_001264899.1
UniProt ID : Q61739

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (6)

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How can I detect the expression level of ITGA6 protein? 01/02/2022

The expression level of ITGA6 protein can be detected by immunohistochemistry, western blotting, and real-time PCR.

What is the effect of aberrant expression of ITGA6 protein on the development and metastasis of cancer? 03/02/2021

Aberrant expression of ITGA6 protein can promote the adhesion and migration of cancer cells, thereby contributing to the development and metastasis of cancer. High expression of ITGA6 is often associated with the degree of malignancy and poor prognosis of the cancer.

What are the current challenges and controversies in the research on ITGA6 protein? 02/04/2021

There are some challenges and controversies in the current research on ITGA6 protein, including its specific mechanism of action in different diseases, its interaction with other molecules, and the optimal treatment. In addition, more clinical data is needed to validate the reliability of ITGA6 protein as a biomarker.

What are the potential applications of ITGA6 protein in drug discovery? 06/07/2020

Due to its critical role in a variety of diseases, ITGA6 protein may become an important target for drug discovery. Drugs targeting the ITGA6 protein may have the potential to treat diseases such as cancer, fibrotic diseases, and inflammatory diseases.

Is there a targeted therapy for the ITGA6 protein? 02/25/2020

At present, targeted therapies targeting ITGA6 protein are still in the research stage, and there are no drugs approved for clinical use. However, some studies are exploring the use of antibodies or small molecule inhibitors to block the function of ITGA6 to treat related diseases.

Can the expression level of ITGA6 protein be used as a biomarker for disease prognosis or treatment response? 02/18/2020

Some studies have shown that the expression level of ITGA6 protein can serve as a biomarker for the prognosis and treatment response of certain cancers. However, more studies are needed to verify its clinical application value.

Customer Reviews (3)

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Reviews
10/12/2021

    I've used this several times and their performance has been consistent and I've never had a problem.

    05/22/2021

      It is very suitable for crystallography research.

      05/05/2021

        It has good antigenicity and can induce a target immune response.

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