KRT8

  • Official Full Name

    keratin 8

  • Overview

    This gene is a member of the type II keratin family clustered on the long arm of chromosome 12. Type I and type II keratins heteropolymerize to form intermediate-sized filaments in the cytoplasm of epithelial cells. The product of this gene typically dimerizes with keratin 18 to form an intermediate filament in simple single-layered epithelial cells. This protein plays a role in maintaining cellular structural integrity and also functions in signal transduction and cellular differentiation. Mutations in this gene cause cryptogenic cirrhosis. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2012]
  • Synonyms

    KRT8; keratin 8; K8; KO; CK8; CK-8; CYK8; K2C8; CARD2; keratin, type II cytoskeletal 8; cytokeratin 8; cytokeratin-8; type-II keratin Kb8;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Native Proteins
  • Bovine
  • Human
  • Mouse
  • Rat
  • Rhesus Macaque
  • Zebrafish
  • bovine liver
  • E.coli
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Insect Cell
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • C
  • His
  • Flag
  • GST
  • His (Fc)
  • Avi
  • Myc
  • His|S
  • SUMO
  • MYC
  • DDK
  • Myc|DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human KRT8-144H Recombinant Human Keratin 8 E.coli N/A
Human KRT8-1247H Recombinant Human Keratin 8 E.coli N/A
Human KRT8-561H Recombinant Human keratin 8, His-tagged E.coli His
Human KRT8-178H Recombinant human KRT8 E.coli N/A
Human KRT8-145H Recombinant Human KRT8, His-tagged E.coli His 1-483aa
Human KRT8-4862HCL Recombinant Human KRT8 293 Cell Lysate HEK293 N/A
Human KRT8-42H Recombinant Human KRT8 Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human KRT8-4835H Recombinant Human KRT8 Protein, GST-tagged Wheat Germ GST
Human KRT8-1267H-B Recombinant Human KRT8 Protein Pre-coupled Magnetic Beads HEK293
Human KRT8-301413H Recombinant Human KRT8 protein, GST-tagged E.coli GST Glu11-Leu50
Human KRT8-3152H Recombinant Human KRT8 protein, His-SUMO-tagged E.coli His-SUMO 2-483aa
Human KRT8-6096HF Recombinant Full Length Human KRT8 Protein, GST-tagged In Vitro Cell Free System GST 483 amino acids
Human KRT8-85HFL Recombinant Full Length Human KRT8 Protein, C-Flag-tagged Mammalian cells Flag
Human KRT8-2236H Recombinant Human KRT8 protein, His&Myc-tagged Insect Cell His&Myc 1-483aa
Human KRT8-1267H Recombinant Human KRT8 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human KRT8-2112H Recombinant Human KRT8 Protein (Gln90-Gln236), His tagged E.coli His Gln90-Gln236
Human KRT8-2562H Recombinant Human KRT8 protein(71-410 aa), C-His-tagged E.coli C-His 71-410 aa
Human KRT8-2563H Recombinant Human KRT8 protein(101-480 aa), C-His-tagged E.coli C-His 101-480 aa
Mouse KRT8-8855M Recombinant Mouse KRT8 Protein Mammalian Cell His
Mouse KRT8-4941M-B Recombinant Mouse KRT8 Protein Pre-coupled Magnetic Beads HEK293
Mouse KRT8-4941M Recombinant Mouse KRT8 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Krt8-1285M Recombinant Mouse Krt8 Protein, MYC/DDK-tagged HEK293T MYC/DDK
Rat KRT8-3332R Recombinant Rat KRT8 Protein Mammalian Cell His
Rat Krt8-2124R Recombinant Rat Krt8 protein, His & S-tagged E.coli His/S Glu399~Lys483 (Accession # Q10758)
Rat Krt8-2123R Recombinant Rat Krt8 protein, His & S-tagged E.coli His/S Ile260~Glu398 (Accession # Q10758)
Rat KRT8-2988R-B Recombinant Rat KRT8 Protein Pre-coupled Magnetic Beads HEK293
Rat KRT8-2988R Recombinant Rat KRT8 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Bovine KRT8-177B Native bovine KRT8 bovine liver N/A
Rhesus Macaque KRT8-2448R Recombinant Rhesus monkey KRT8 Protein, His-tagged Mammalian Cell His
Rhesus Macaque KRT8-2269R-B Recombinant Rhesus Macaque KRT8 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque KRT8-2269R Recombinant Rhesus Macaque KRT8 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Zebrafish KRT8-10433Z Recombinant Zebrafish KRT8 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

KRT8 involved in several pathways and played different roles in them. We selected most pathways KRT8 participated on our site, such as EGFR1 Signaling Pathway, Signaling mediated by p38-alpha and p38-beta, which may be useful for your reference. Also, other proteins which involved in the same pathway with KRT8 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
EGFR1 Signaling PathwayTNK2;GRB10;MAP3K2;RGS5B;EEF1A1;CEACAM1;SH2D3C;KRT17;GRB14
Signaling mediated by p38-alpha and p38-betaKRT8;HBP1;USF1;GDI1

KRT8 has several biochemical functions, for example, protein binding, protein complex binding, scaffold protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by KRT8 itself. We selected most functions KRT8 had, and list some proteins which have the same functions with KRT8. You can find most of the proteins on our site.

Function Related Protein
protein bindingRAB27A;KLHL41;EPB41B;WASF1;DDB1;CCER1;HMOX2;RAB33A;DPH2
protein complex bindingRAP1A;ABI1;DRD1A;NDUFA4;RELA;NCK2;TRAF2;ERCC6;KHDRBS1
scaffold protein bindingADCY6;NCK2;GRID2;KCNH2;KCNQ1;NLGN3;TREM1;NLRP1;NLGN4X
structural molecule activityKRT39;NCR3LG1;MTAP7D3;CKI;BGLAP;KRT3;MATR3;KRT23;CLDN10B

KRT8 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with KRT8 here. Most of them are supplied by our site. Hope this information will be useful for your research of KRT8.

KRT18; CFTR; p27958-pro_0000037566

Research Area

Related articles

Zhou, Y; Hu, ZQ; et al. Genome-Wide Demethylation by 5-aza-2 '-Deoxycytidine Alters the Cell Fate of Stem/Progenitor Cells. STEM CELL REVIEWS AND REPORTS 11:87-95(2015).
Bunel, A; Jorssen, EP; et al. Individual bovine in vitro embryo production and cumulus cell transcriptomic analysis to distinguish cumulus-oocyte complexes with high or low developmental potential. THERIOGENOLOGY 83:228-237(2015).
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