Recombinant Human KRT8 Protein, GST-tagged

• Cat.No.: KRT8-4835H
• Product Overview: Human KRT8 full-length ORF ( NP_002264.1, 1 a.a. - 483 a.a.) recombinant protein with GST-tag at N-terminal.

Specification

• Description: This gene is a member of the type II keratin family clustered on the long arm of chromosome 12. Type I and type II keratins heteropolymerize to form intermediate-sized filaments in the cytoplasm of epithelial cells. The product of this gene typically dimerizes with keratin 18 to form an intermediate filament in simple single-layered epithelial cells. This protein plays a role in maintaining cellular structural integrity and also functions in signal transduction and cellular differentiation. Mutations in this gene cause cryptogenic cirrhosis. [provided by RefSeq
• Source: Wheat Germ
• Species: Human
• Tag: GST
• Molecular Mass: 80.1 kDa
• AA Sequence: MSIRVTQKSYKVSTSGPRAFSSRSY TSGPGSRISSSSFSRVGSSNFRGGL GGGYGGASGMGGITAVTVNQSLLSP LVLEVDPNIQAVRTQEKEQIKTLNN KFASFIDKVRFLEQQNKMLETKWSL LQQQKTARSNMDNMFESYINNLRRQ LETLGQEKLKLEAELGNMQGLVEDF KNKYEDEINKRTEMENEFVLIKKDV DEAYMNKVELESRLEGLTDEINFLR QLYEEEIRELQSQISDTSVVLSMDN SRSLDMDSIIAEVKAQYEDIANRSR AEAESMYQIKYEELQSLAGKHGDDL RRTKTEISEMNRNISRLQAEIEGLK GQRASLEAAIADAEQRGELAIKDAN AKLSELEAALQRAKQDMARQLREYQ ELMNVKLALDIEIATYRKLLEGEES RLESGMQNMSIHTKTTSGYAGGLSS AYGGLTSPGLSYSLGSSFGSGAGSS SFSRTSSSRAVVVKKIETRDGKLVS ESSDVLPK
• Applications: Enzyme-linked Immunoabsorbent Assay
  Western Blot (Recombinant protein)
  Antibody Production
  Protein Array
• Notes: Best use within three months from the date of receipt of this protein.
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.

Gene Information

• Gene Name: KRT8 keratin 8 [ Homo sapiens ]
• Official Symbol: KRT8
• Synonyms: KRT8; keratin 8; keratin, type II cytoskeletal 8; CARD2; CK8; CYK8; K2C8; K8; KO; cytokeratin 8; cytokeratin-8; type-II keratin Kb8; CK-8
• Gene ID: 3856
• mRNA Refseq: NM_001256282
• Protein Refseq: NP_001243211
• MIM: 148060
• UniProt ID: P05787