Recombinant Human KRT8, His-tagged
Cat.No. : | KRT8-145H |
Product Overview : | Recombinant human KRT8 protein, fused to His-tag at N-terminus, was expressed in E.coli. |
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Description : | This gene is a member of the type II keratin family clustered on the long arm of chromosome 12. Type I and type II keratins heteropolymerize to form intermediate-sized filaments in the cytoplasm of epithelial cells. The product of this gene typically dimerizes with keratin 18 to form an intermediate filament in simple single-layered epithelial cells. This protein plays a role in maintaining cellular structural integrity and also functions in signal transduction and cellular differentiation. Mutations in this gene cause cryptogenic cirrhosis. Alternatively spliced transcript variants have been found for this gene. |
Source : | E.coli |
Species : | Human |
Tag : | His |
Form : | Liquid. In 20mM Tris-HCl buffer (pH 8.0) containing 0.4M Urea, 10% glycerol |
Molecular Mass : | 56 kDa (506aa) |
Protein length : | 1-483aa |
AA Sequence : | MGSSHHHHHH SSGLVPRGSH MGSMSIRVTQ KSYKVSTSGP RAFSSRSYTS GPGSRISSSS FSRVGSSNFR GGLGGGYGGA SGMGGITAVT VNQSLLSPLV LEVDPNIQAV RTQEKEQIKT LNNKFASFID KVRFLEQQNK MLETKWSLLQ QQKTARSNMD NMFESYINNL RRQLETLGQE KLKLEAELGN MQGLVEDFKN KYEDEINKRT EMENEFVLIK KDVDEAYMNK VELESRLEGL TDEINFLRQL YEEEIRELQS QISDTSVVLS MDNSRSLDMD SIIAEVKAQY EDIANRSRAE AESMYQIKYE ELQSLAGKHG DDLRRTKTEI SEMNRNISRL QAEIEGLKGQ RASLEAAIAD AEQRGELAIK DANAKLSELE AALQRAKQDM ARQLREYQEL MNVKLALDIE IATYRKLLEG EESRLESGMQ NMSIHTKTTS GYAGGLSSAY GGLTSPGLSY SLGSSFGSGA GSSSFSRTSS SRAVVVKKIE TRDGKLVSES SDVLPK |
Purity : | > 90% by SDS - PAGE |
Applications : | SDS-PAGE |
Storage : | Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles. |
Concentration : | 1 mg/ml (determined by Bradford assay) |
Gene Name : | KRT8 keratin 8 [ Homo sapiens (human) ] |
Official Symbol : | KRT8 |
Synonyms : | KRT8; K8; KO; CK8; CK-8; CYK8; K2C8; CARD2; keratin 8; keratin, type II cytoskeletal 8; cytokeratin 8; cytokeratin-8; type-II keratin Kb8 |
Gene ID : | 3856 |
mRNA Refseq : | NM_002273 |
Protein Refseq : | NP_002264 |
MIM : | 148060 |
UniProt ID : | P05787 |
Chromosome Location : | 12q13 |
Pathway : | EGFR1 Signaling Pathway; Signaling mediated by p38-alpha and p38-beta |
Function : | protein binding; protein complex binding; scaffold protein binding |
Products Types
◆ Recombinant Protein | ||
KRT8-2988R | Recombinant Rat KRT8 Protein, His (Fc)-Avi-tagged | +Inquiry |
KRT8-4835H | Recombinant Human KRT8 Protein, GST-tagged | +Inquiry |
KRT8-1267H | Recombinant Human KRT8 Protein, His (Fc)-Avi-tagged | +Inquiry |
Krt8-1285M | Recombinant Mouse Krt8 Protein, MYC/DDK-tagged | +Inquiry |
KRT8-2563H | Recombinant Human KRT8 protein(101-480 aa), C-His-tagged | +Inquiry |
◆ Native Protein | ||
KRT8-177B | Native bovine KRT8 | +Inquiry |
◆ Lysates | ||
KRT8-4862HCL | Recombinant Human KRT8 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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