LIN28A

  • Official Full Name

    lin-28 homolog A (C. elegans)

  • Overview

    Acts as a 'translational enhancer', driving specific mRNAs to polysomes and thus increasing the efficiency of protein synthesis. Its association with the translational machinery and target mRNAs results in an increased number of initiation events per molecule of mRNA and, indirectly, in stabilizing the mRNAs. Binds IGF2 mRNA, MYOD1 mRNA, ARBP/36B4 ribosomal protein mRNA and its own mRNA. Essential for skeletal muscle differentiation program through the translational up-regulation of IGF2 expression (By similarity). Acts as a suppressor of microRNA (miRNA) biogenesis by specifically binding the precursor let-7 (pre-let-7), a miRNA precursor. Acts by binding pre-let-7 and recruiting ZCCHC11/TUT4 uridylyltransferase, leading to the terminal uridylation of pre-let-7. Uridylated pre-let-7 miRNAs fail to be processed by Dicer and undergo degradation. Degradation of pre-let-7 in embryonic stem (ES) cells contributes to the maintenance of ES cells. In contrast, LIN28A down-regulation in neural stem cells by miR-125, allows the processing of pre-let-7. Specifically recognizes the 5'-GGAG-3' motif in the terminal loop of pre-let-7. Also recognizes and binds non pre-let-7 pre-miRNAs that contain the 5'-GGAG-3' motif in the terminal loop, leading to their terminal uridylation and subsequent degradation.
  • Synonyms

    LIN28A; lin-28 homolog A (C. elegans); CSDD1; LIN28; LIN-28; ZCCHC1; lin-28A; protein lin-28 homolog A; RNA-binding protein LIN-28; zinc finger, CCHC domain containing 1; zinc finger CCHC domain-containing protein 1;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • Human
  • Insect Cell
  • Mammalian Cell
  • Mammalian cells
  • Yeast
  • Arg
  • Flag
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • N/A
  • N
  • FLAG
  • TAT
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human PF4V1-257H Recombinant Human Lin-28 Homolog A (C. elegans), His-tagged Human His
Human LIN28A-1577H Recombinant Full Length Human LIN28A Protein, Tag Free E.coli
Human LIN28A-29947TH Recombinant Human LIN28A Protein E.coli TAT
Human LIN28A-8467H Recombinant Human LIN28A, His-tagged E.coli His
Human LIN28A-129H Recombinant Human LIN28A protein, Arginine-tagged E.coli Arg
Human LIN28A-4734HCL Recombinant Human LIN28A 293 Cell Lysate HEK293 N/A
Human LIN28A-643H Recombinant Human LIN28A Protein E.coli N/A
Human LIN28A-1405HFL Recombinant Full Length Human LIN28A Protein, C-Flag-tagged Mammalian cells Flag
Human LIN28A-3677H Recombinant Human LIN28A Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human LIN28A-1296H Recombinant Human LIN28A Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human LIN28A-4355H Recombinant Human LIN28A protein, His-tagged Insect Cell His 113-209aa
Human LIN28A-08H Recombinant Human LIN28A Protein (2-209), N-FLAG/Avi-tagged, Biotined HEK293 N-FLAG and Avi 2-209
Human LIN28A-01HFL Recombinant Full Length Human LIN28A Protein E.coli
Human LIN28A-1296H-B Recombinant Human LIN28A Protein Pre-coupled Magnetic Beads HEK293
Human LIN28A-1432H Recombinant Human LIN28A protein, His-tagged Yeast His 39-112aa
Mouse LIN28A-9112M Recombinant Mouse LIN28A Protein Mammalian Cell His
Mouse LIN28A-5089M-B Recombinant Mouse LIN28A Protein Pre-coupled Magnetic Beads HEK293
Mouse LIN28A-5089M Recombinant Mouse LIN28A Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Lin28a-3785M Recombinant Mouse Lin28a Protein, Myc/DDK-tagged HEK293T Myc/DDK
Zebrafish LIN28A-11314Z Recombinant Zebrafish LIN28A Mammalian Cell His
Chicken LIN28A-3254C Recombinant Chicken LIN28A Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • LIN28A Related Research Area

LIN28A involved in several pathways and played different roles in them. We selected most pathways LIN28A participated on our site, such as Cardiac Progenitor Differentiation, Developmental Biology, Transcriptional regulation of pluripotent stem cells, which may be useful for your reference. Also, other proteins which involved in the same pathway with LIN28A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Cardiac Progenitor DifferentiationNOG;TBX20;NKX2;ROR2;LIN28B;BMP1;SIRPA;ZFP42;T
Developmental BiologyMED15;FGF18B;DPYSL4;EPHA4A;RASGRP4;ACTR3;ITSN1;MED7;FGFR1B
Transcriptional regulation of pluripotent stem cellsLIN28A;HIF3A;POU5F3;NR6A1;NR5A1;FOXD3;SALL4;TDGF1;PRDM14

LIN28A has several biochemical functions, for example, DNA binding, RNA binding, mRNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by LIN28A itself. We selected most functions LIN28A had, and list some proteins which have the same functions with LIN28A. You can find most of the proteins on our site.

Function Related Protein
DNA bindingDMRT2B;ZNF784;GSX1;DMRT2;RORCA;THAP7;ZNF131;POLR3D;PREB
RNA bindingDDX43;AKAP1B;HNRNPA1L2;THOC6;TEP1;ZMAT2;RBMX;SRSF9;PRDM14
mRNA bindingLUC7L2;ITM2B;ZFP36;FMR1;MRPL13;XPO5;SNRNP70;CELF1;CCDC55
miRNA bindingAGO1;DICER1;AGO3;POU5F1;TRIM71;AGO2;SOX2;TARBP2;MEF2C
protein bindingDUSP7;SUPT6H;TRDN;BPIFA2;KLC2;KCNIP2;CHMP5;EMG1;ITSN1
translation initiation factor bindingPOLR2G;EIF2B4;POLR2D;EIF3BA;EIF3C;POLR2GL;ZNF259;EIF2B5;LIN28A
zinc ion bindingS100A8;PHEX;PEX2;LNX2B;SIRT3;PPARD;MMP16;MT1;MGRN1B

LIN28A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with LIN28A here. Most of them are supplied by our site. Hope this information will be useful for your research of LIN28A.

ZCCHC11; pre-let-7a; ZDHHC17

  • Q&As
  • Reviews

Q&As (6)

Ask a question
What are the implications for assessing the role of LIN28A in disease? 05/25/2022

The role of LIN28A in disease can be assessed through in-depth analysis of the patient's genomic data and combined with the results of studies in cell and animal models. This can help doctors better understand the patient's condition and develop more effective treatment plans.

Which biomolecules can be used as molecular markers for LIN28A? 04/28/2022

Certain biomolecules can be used as molecular markers of LIN28A, such as mRNA or protein of LIN28A detected in biological samples such as blood and urine. These markers can be used for early diagnosis of disease, prognostic judgment, or monitoring of treatment efficacy.

How can LIN28A-related treatment strategies be considered in clinical practice? 01/25/2022

In clinical practice, treatment strategies related to LIN28A need to consider the patient's specific condition, genotype, and treatment goals. Doctors can develop a personalized treatment plan based on the patient's actual situation to improve the treatment effect and maximize the patient's quality of life. At the same time, long-term follow-up and studies are needed to assess the effectiveness and safety of treatment strategies.

How can I study the function of LIN28A experimentally? 01/06/2022

The function of LIN28A can be studied through cell models and animal models. For example, the expression of LIN28A can be manipulated by gene knockout or overexpression techniques and then observed for its effects on cell biology and animal behavior.

What are the treatment strategies for LIN28A? 03/17/2021

Therapeutic strategies for LIN28A include inhibiting its expression, modulating its activity, or using gene therapy. For example, some small molecule inhibitors can inhibit the activity of LIN28A, thereby treating some LIN28A-related diseases.

How can the relationship between LIN28A and disease be analyzed by bioinformatics methods? 07/22/2020

The effect of LIN28A on disease can be predicted by comparing the expression level, sequence, and structure in different disease tissues and normal tissues. This could help scientists better understand the role of LIN28A in disease.

Customer Reviews (3)

Write a review
Reviews
09/07/2023

    LIN28A is green and environmentally friendly, and has little harm to the human body.

    07/22/2021

      It is easy to adhere to the surface of the material, reducing the loss of reagents and reducing costs.

      04/25/2020

        The preparation cost is low and cost-effective.

        Ask a Question for All LIN28A Products

        Required fields are marked with *

        My Review for All LIN28A Products

        Required fields are marked with *

        logo

        FOLLOW US

        Terms and Conditions        Privacy Policy

        Copyright © 2024 Creative BioMart. All Rights Reserved.

        Contact Us

        • /

        Stay Updated on the Latest Bioscience Trends