Recombinant Human Lin-28 Homolog A (C. elegans), His-tagged

• Cat.No.: PF4V1-257H
• Product Overview: CXCL4 Variant-1 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 77 amino acids and having a molecular mass of 8.7 kDa. The CXCL4 Variant-1 is fused to 6xHis tag at N-Terminus and purified by standard chromatogrpahy techniques.

Specification

• Cat. No.: PF4V1-257H
• Description: Platelet factor-4 is a 70-amino acid protein that is released from the alpha-granules of activated platelets and binds with high affinity to heparin. Its major physiologic role appears to be neutralization of heparin-like molecules on the endothelial surface of blood vessels, thereby inhibiting local antithrombin III activity and promoting coagulation. As a strong chemoattractant for neutrophils and fibroblasts, PF4 probably has a role in inflammation and wound repair. Oncostatin-A is a member of the CXC chemocinfamily. Human PF4 is used for the proof of heparin-induced thrombocytopenia. Furthermore it is used as an inhibitor in the angiogenesis during tumor therapy.
• Source: Human
• Host: Escherichia Coli
• Form: The protein was lyophilized without additives.
• Purity: Greater than 95.0% as determined by SDS-PAGE.
• Physical Appearance: Sterile Filtered white lyophilized powder.
• Amino acid sequence: MHHHHHHEAE EDGDLQCLCV KTTSQVRPRH ITSLEVIKAG PHCPTAQLIA TLKNGRKICL DLQALLYKKI IKEHLES.
• Storage: Human CXCL4 although stable at 25°C 1 week, should be stored desiccated below -18°C. Please prevent freeze-thaw cycles.
• Pathways: Cell surface interactions at the vascular wall; Chemokine signaling pathway; Common Pathway; Cytokine-cytokine receptor interaction; Formation of Fibrin Clot (Clotting Cascade); Hemostasis

Gene Information

• Gene Name: PF4V1 platelet factor 4 variant 1 [ Homo sapiens ]
• Official Symbol: PF4V1
• Synonyms: PF4V1; platelet factor 4 variant 1; PF4A; CXCL4L1; CXCL4V1; PF4-ALT; SCYB4V1; platelet factor 4 variant; PF4alt; PF4var1; OTTHUMP00000160680; C-X-C motif chemokine 4; platelet factor 4, variant 1 (PF4-like); PF4var1; C-X-C motif chemokine 4 variant
• Gene ID: 5197
• mRNA Refseq: NM_002620
• Protein Refseq: NP_002611
• MIM: 173461
• UniProt ID: P10720
• Chromosome Location: 4q12-q21
• Function: chemokine activity; heparin binding