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Official Full Name MAP2K2 mitogen-activated protein kinase kinase 2
Background MEK (MAP Kinase Kinase) phosphorylates the MAP Kinase on both threonine and tyrosine residues of the activation motif TEY. MEK1 and MEK2 are activated by phosphorylation of two serine residues (Ser 218/222 in MEK1 and Ser 222/226 in MEK2). These phosphorylation sites are substrates of the Raf family of kinases.
Synonyms MAP2K2; mitogen-activated protein kinase kinase 2; PRKMK2; dual specificity mitogen-activated protein kinase kinase 2; MEK2; MAPK/ERK kinase 2; MAP kinase kinase 2; ERK activator kinase 2; mitogen-activated protein kinase kinase 2, p45; MKK2; MAPKK2; FLJ26075;
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rat
    • Source :
    • E.coli
    • HEK293
    • Insect Cell
    • Mammalian Cell
    • Sf9 Insect Cell
    • Tag :
    • GST
    • His
    • MBP
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human MAP2K2-1316H Recombinant Human Mitogen-Activated Protein Kinase Kinase 2, His-tagged E.coli His
    Human MAP2K2-15860H Recombinant Human MAP2K2, His-tagged E.coli His
    Human MAP2K2-253H Recombinant Human MAP2K2 Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human MAP2K2-29202TH Recombinant Human MAP2K2 N/A
    Human MAP2K2-301H Recombinant Human MAP2K2 protein, His/MBP-tagged E.coli His/MBP
    Human MAP2K2-302H Recombinant Human MAP2K2 protein, His/MBP-tagged E.coli His/MBP
    Human MAP2K2-350H Recombinant Human MAP2K2, GST-tagged, Active Sf9 Insect Cell GST
    Human MAP2K2-613HCL Recombinant Human MAP2K2 cell lysate Insect Cell N/A
    Human MAP2K2-968H Recombinant Human MAP2K2, GST tagged Insect Cell GST
    Mouse Map2k2-8085M Recombinant Mouse Map2k2 protein, His-tagged E.coli His
    Rat MAP2K2-3560R Recombinant Rat MAP2K2 Protein Mammalian Cell His
    Chicken MAP2K2-6940C Recombinant Chicken MAP2K2 Mammalian Cell His

    map2k2 involved in several pathways and played different roles in them. We selected most pathways map2k2 participated on our site, such as MAPK signaling pathway, ErbB signaling pathway, Ras signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with map2k2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    MAPK signaling pathway FGF21; RELB; MAP3K11; PDGFAB; FGF1A; PPM1B; FGF20B; FGF8A; PLA2G4A; CACNG8
    ErbB signaling pathway PAK1; PLCG2; MAPK9; SHC2; PTK2; PAK7; PIK3R1; BAD; BTC; ERBB3B
    Ras signaling pathway PLD1; PRKACA; AKT1; PDGFRB; GNG3; SHOC2; PLA2G12B; RASAL2; PDGFRA; PIK3R1
    Rap signaling pathway PRKCG; RAC3; PFN1; RAPGEF6; P2RY1; AKT2; RALB; FGF4; VAV2; MAP2K2
    cGMP-PKG signaling pathway VASP; NPR2; PIK3R1; NFATC3; PDE3B; PLCB1; NFATC4; PPP3R2; CALM2; MAPK3
    cAMP signaling pathway RRAS2; MAP2K1; GPR119; ATP1B3; PDE4C; HCN2; RAC3; PLN; GRIA3; PLCE1
    HIF- signaling pathway PGK1; PLCG1; NOS2; PFKFB3; PIK3R5; GAPDH; MKNK1; TEK; PLCG2; TIMP1
    FoxO signaling pathway IRS1; GADD45BA; FOXO6; HRASB; SGK2A; SKP2; KLF2B; INSRB; PRKAG1; IGF1
    Sphingolipid signaling pathway GNAI1; MS4A2; PRKCA; KRAS; PIK3CB; MAPK11; PPP2R1B; HRAS; SGMS1; PLD1
    Phospholipase D signaling pathway LPAR2; PIK3R1; GRM4; PIK3R3; INS1; RAF1; GRM3; LPAR6; AGTR1B; PDGFC
    PIK-Akt signaling pathway STK11; IL3RA; YWHAH; G6PC3; GNG5; GH1; FGFR2; FGF8; PRKAA2; ITGA9
    Vascular smooth muscle contraction PPP1CB; PLA2G5; MYL9A; CALML3; MYLK; PRKACB; ACTA2; PPP1R12A; GNAS; CYP4A12A
    VEGF signaling pathway PPP3CC; PTK2AB; MAP2K2B; PIK3R3B; AKT2; VEGFAA; SRC; PLA2G4C; PPP3R1; CDC42L
    Gap junction ITPR1; GNA11A; TUBB; CSNK1DB; PRKCA; Adcy4; TJP1; PRKCBA; RAF1B; RAF1A
    Signaling pathways regulating pluripotency of stem cells MAPK11; WNT4; TBX3; STAT3; ESRRB; MAP2K1; AKT1; PIK3R1; FZD1; SMAD4
    Toll-like receptor signaling pathway NFKBIAB; NFKBIAA; IFNA5; CXCL11; IL1B; IFNA7; MAPK1; MAPK13; CXCL8B.3; MAPK8A
    Natural killer cell mediated cytotoxicity IFNA21; PRKCA; Ifna11; IFNGR2; KLRD1; NCR3; GZMB; KIR2DS2; H60a; LCP2
    T cell receptor signaling pathway NFATC1; ZAP70; MAP2K1; PPP3CC; CBL; SLA1; CDC42; CD40LG; LAT; Il2
    B cell receptor signaling pathway FCGR2B; AKT1; PIK3R5; CMTM3; SOS1; NRAS; IGHM; NFKBIB; PIK3R3; GSK3B
    Fc epsilon RI signaling pathway IL3; MS4A2; MAP2K1; BTK; VAV3; LAT; KRAS; MAP2K6; PLA2G4B; RAC3
    Long-term potentiation PRKACG; PPP1R1A; CALM3; GRIN2D; CALM2; GRM5; CAMK4; MAP2K2; CALM1; CALM4
    Neurotrophin signaling pathway RPS6KA2; MAPKAPK2; NTF4; RAF1; MAPK1; PRDM4; PSEN1; ARHGDIB; SHC2; IRAK4
    Long-term depression GNAO1; PRKG2; GNA13; NOS1; MAPK3; GRIA3; GUCY1B3; GNAI1; PRKCB; MAP2K2
    Regulation of actin cytoskeleton PXNA; FGF12A; RAC1A; ITGA2B; ARPC5B; ACTN2B; FGF13B; MAP2K2A; FGF6; ARHGEF1
    Insulin signaling pathway PPP1CA; MAP2K2A; MTOR; CALM3; NRAS; PHKB; PHKA2; EIF4E2RS1; CALM1B; KRAS
    Estrogen signaling pathway FKBP4; GABBR2; GNAO1; SRC; CALM2; ITPR3; CALM3; SHC3; SHC2; MAP2K1
    Melanogenesis POMCA; GNA15.1; MITFA; FZD7; GNAS; POMC; ADCY1A; WNT5B; CALM1A; EP300
    Prolactin signaling pathway SOCS6; STAT5B; SIRPA; NEK3; RELA; GRB2; ESR2; PRL; SOCS5; IRF1
    Thyroid hormone signaling pathway KAT2A; HRAS; SLC16A2; ATP1B3; MED4; NRAS; ATP1A1; RCAN2; RHEB; BMP4
    Oxytocin signaling pathway PLCB2; RYR2; PIK3CD; PRKACG; PRKCA; PPP1R12B; PLCB4; MYLK4; PPP3R2; KCNJ14
    Prion diseases PRKACG; Hc; SOD1; PRKACA; CCL5; MAP2K1; MAP2K2; ELK1; NOTCH1; FYN
    Hepatitis B Fasl; IFNA16; SMAD3; IRF7; TBK1; MYD88; CCND1; STAT3; CCNA1; CYCS
    Influenza A NUP98; LOC100033925; BCL2L2-PABPN1; NLRX1; PIK3R1; PRSS1; HLA-DRB5; IRF9; NXF2; EP300
    Pathways in cancer GNA12; RXRG; FASLG; PRKCG; TCF7L2; LPAR2; TRAF1; CCNE2; NCOA4; LAMC2
    Proteoglycans in cancer WNT4; ROCK2; PRKCB; RDX; ITGAV; TNF; CBL; HPSE2; PRKCG; PIK3CB
    MicroRNAs in cancer KRAS; ERBB3; MMP16; RAF1; TGFB2; PTGS2; HNRNPK; ERBB2; PDGFA; CYP24A1
    Renal cell carcinoma BRAF; PIK3R3; PTPN11; PIK3CG; RBX1; PIK3CA; MAP2K2; ARAF; ARNT; RAC1
    Endometrial cancer ARAF; MAPK3; LEF1; CASP9; AKT2; BAD; AXIN2; MAP2K1; CTNNA2; PIK3CB
    Glioma PDGFA; CALM2; PTEN; AKT1; MAPK3; Pdgfa&Pdgfb; PIK3CA; PRKCA; MAPK1; PIK3R2
    Prostate cancer IKBKB; MAPK1; NDRG1; EP300; MAP2K1; FOXO1; NFKB1; CCND1; SPRY1; SMARCA4
    Thyroid cancer NTRK1; BRAF; TRP53; KRAS; LEF1; RET; CDH1; MAPK1; RXRB; CCND1
    Melanoma FGF22; FGF8; IGF1; PIK3R5; FGF2; FGF18; PTEN; FGFR1; AKT2; FGF13
    Bladder cancer THBS1; ERBB2; TYMP; RASSF1; CXCL8; MYC; UPK3A; E2F1; MMP9; EGF
    Chronic myeloid leukemia GAB2; RELA; PIK3R3; CCND1; NFKBIA; TP53; CRKL; CBLC; NFKB1; AKT1
    Acute myeloid leukemia CEBPA; CCND1; LEF1; RELA; RPS6KB2; IKBKG; EIF4EBP1; MAP2K1; NFKB1; PIK3CD
    Non-small cell lung cancer PRKCG; PLCG1; AKT1; STK4; RASSF5; PIK3CB; HRAS; EML4; CASP9; BRAF
    Central carbon metabolism in cancer NTRK3; PFKM; PFKP; HK1; MAP2K1; HRAS; PIK3CG; PDGFRA; PDHA1; PDHA2
    Choline metabolism in cancer PDGFRA; PPAP2B; MAPK10; HRAS; RAC3; SOS1; DGKB; LYPLA1; WASF2; HIF1A

    map2k2 has several biochemical functions, for example, ATP binding, MAP kinase kinase activity, PDZ domain binding. Some of the functions are cooperated with other proteins, some of the functions could acted by map2k2 itself. We selected most functions map2k2 had, and list some proteins which have the same functions with map2k2. You can find most of the proteins on our site.

    Function Related Protein
    ATP binding DDX11; DHX29; HSPA1B; AK7; CCT3; EHD2; SEPHS1; UBE2QL1; ACTA1B; EPHA4B
    MAP kinase kinase activity MAPKAPK5; MAP3K14; LRRK2; MAP2K3; PAK3; MAP2K1; MAP3K9; SBK3; MAP2K2A; MAP2K6
    PDZ domain binding ATP2B1A; GNG5; SLC22A12; CXADR; EXOC4; SLC26A6; PSEN1; ADAM17; LIN7B; CXXC4
    metal ion binding RYBPA; PPM1BB; ZBTB8B; ACMSD; ZNF597; CYP2J6; VEPH1; ZBTB39; SNAI1B; ANKIB1A
    protein binding RHOA; S100P; SYF2; ZNF649; NFE2L1; LRRC26; ZNF792; ZEB1; GALR1; SOX17
    protein complex scaffold WWC2; CAV3; DISC1; ISCU; TELO2; DLG1; AKAP6; MAGI1; SLC9A3R2; MAGI3
    protein serine/threonine kinase activator activity PARP16; CDK5R1; CALM1; IGF2; CALM3; MAP2K2; FAM20A; CALM2; ALS2; STK4
    protein serine/threonine kinase activity OXSR1B; MAPKAPK5; SYK; ULK4; TGFBR1B; MAST2; PIK3CG; HIPK4; IRAK1; PRKACBB
    protein serine/threonine/tyrosine kinase activity DSTYK; CLK3; PRKAA2; DYRK4; AURKB; AKT1; AURKC; TNK2; AURKA; ACVR2B
    protein tyrosine kinase activity SYK; EGFR; CLK4; MAP2K2; TESK2; MAP3K11; FGFR2; PTK2; EPHB2; NTRK3A
    scaffold protein binding GRID2; MDM2; CASP8; KRT15; TREM2; KRT5; SRC; CACNA1G; MAP2K2; NOS1

    map2k2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with map2k2 here. Most of them are supplied by our site. Hope this information will be useful for your research of map2k2.


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