MAP2K2

  • Official Full Name

    MAP2K2 mitogen-activated protein kinase kinase 2
  • Overview

    MEK (MAP Kinase Kinase) phosphorylates the MAP Kinase on both threonine and tyrosine residues of the activation motif TEY. MEK1 and MEK2 are activated by phosphorylation of two serine residues (Ser 218/222 in MEK1 and Ser 222/226 in MEK2). These phosphorylation sites are substrates of the Raf family of kinases.
  • Synonyms

    MAP2K2;mitogen-activated protein kinase kinase 2;PRKMK2;dual specificity mitogen-activated protein kinase kinase 2;MEK2;MAPK/ERK kinase 2;MAP kinase kinase 2;ERK activator kinase 2;mitogen-activated protein kinase kinase 2, p45;MKK2;MAPKK2;FLJ26075

Recombinant Proteins

  • Human
  • Rat
  • Chicken
  • Mouse
  • Insect Cells
  • E.coli
  • Sf9 Cells
  • Mammalian Cells
  • HEK293
  • Sf21 Cells
  • GST
  • His
  • Non
  • MBP
  • Avi
  • Fc
  • Flag
  • DDK
  • Myc
Cat.# Product name Source (Host) Species Tag Protein Length Price
MAP2K2-968HAF488 Recombinant Human MAP2K2 Protein, GST-tagged, Alexa Fluor 488 conjugated Insect Cells Human GST 624
MAP2K2-968HAF555 Recombinant Human MAP2K2 Protein, GST-tagged, Alexa Fluor 555 conjugated Insect Cells Human GST 624
MAP2K2-968HAF647 Recombinant Human MAP2K2 Protein, GST-tagged, Alexa Fluor 647 conjugated Insect Cells Human GST 624
MAP2K2-968HF Recombinant Human MAP2K2 Protein, GST-tagged, FITC conjugated Insect Cells Human GST 624
MAP2K2-1316H Recombinant Human Mitogen-Activated Protein Kinase Kinase 2, His-tagged E.coli Human His
MAP2K2-15860H Recombinant Human MAP2K2, His-tagged E.coli Human His 1-400aa
MAP2K2-29202TH Recombinant Human MAP2K2 Human Non Full L.
MAP2K2-301H Recombinant Human MAP2K2 protein, His/MBP-tagged E.coli Human His&MBP 1-171 aa
MAP2K2-302H Recombinant Human MAP2K2 protein, His/MBP-tagged E.coli Human His&MBP 262-400 aa
MAP2K2-350H Recombinant Human MAP2K2, GST-tagged, Active Sf9 Cells Human GST
MAP2K2-3560R Recombinant Rat MAP2K2 Protein Mammalian Cells Rat His
MAP2K2-6940C Recombinant Chicken MAP2K2 Mammalian Cells Chicken His
Map2k2-8085M Recombinant Mouse Map2k2 protein, His-tagged E.coli Mouse His Leu44~Ser313
MAP2K2-968H Recombinant Human MAP2K2 protein(Met1-Val400), GST-tagged Insect Cells Human GST Met1-Val400
MAP2K2-613HCL Recombinant Human MAP2K2 cell lysate Insect Cells Human Non
MAP2K2-0226H Recombinant Human MAP2K2 Protein (E55-V400), Tag Free E.coli Human Non E55-V400
MAP2K2-0227H Recombinant Human MAP2K2 Protein (E55-V400), His tagged E.coli Human His E55-V400
MAP2K2-1353H Recombinant Human MAP2K2 Protein, His (Fc)-Avi-tagged HEK293 Human Avi&Fc&His
MAP2K2-1353H-B Recombinant Human MAP2K2 Protein Pre-coupled Magnetic Beads HEK293 Human
MAP2K2-1645HFL Recombinant Full Length Human MAP2K2 Protein, C-Flag-tagged Mammalian Cells Human Flag Full L.
MAP2K2-253H Recombinant Human MAP2K2 Protein, MYC/DDK-tagged HEK293 Human DDK&Myc
MAP2K2-3216R Recombinant Rat MAP2K2 Protein, His (Fc)-Avi-tagged HEK293 Rat Avi&Fc&His
MAP2K2-3216R-B Recombinant Rat MAP2K2 Protein Pre-coupled Magnetic Beads HEK293 Rat
Map2k2-3921M Recombinant Mouse Map2k2 Protein, Myc/DDK-tagged HEK293 Mouse DDK&Myc
MAP2K2-4024H Recombinant Human MAP2K2 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293 Human DDK&Myc
MAP2K2-5003H Recombinant Human MAP2K2 Protein (Val86-Pro331), N-His tagged E.coli Human His Val86-Pro331
MAP2K2-5651HF Active Recombinant Full Length Human MAP2K2 Protein, GST-tagged Sf21 Cells Human GST Full L. 1-400

    Involved Pathway

    MAP2K2 involved in several pathways and played different roles in them. We selected most pathways MAP2K2 participated on our site, such as MAPK signaling pathway,ErbB signaling pathway,Ras signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with MAP2K2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Renal cell carcinoma HRAS,RAPGEF1,VHL,AKT2,ARNT,KRAS,RAP1A,MET,PIK3CB,MAPK3
    Regulation of Actin Cytoskeleton PAK1,FGF3,MYH9,PPP1CC,ACTB1,PIP5K1BB,MAPK1,NCKAP1L,MYLK3,PFN2
    Non-small cell lung cancer KRAS,PRKCA,PIK3CG,HRAS,AKT2,PRKCG,FOXO3,ERBB2,BAD,BRAF
    Central carbon metabolism in cancer PIK3CA,PKM,PTEN,PFKL,GLS,PDHA2,C12orf5,PIK3CB,AKT2,MAPK1
    Glioma PRKCG,CALML5,CCND1,TP53,PIK3CG,CAMK2A,CALML3,HRAS,PIK3CB,PIK3R2
    MAPK signaling pathway FGF8A,TGFB1A,FGFR1A,HRASB,RRAS,ARRB2B,PAK1,MAX,JUND,HRASA
    Prion diseases LOC100033925,Hc,PRKACA,MAP2K1,C8B,CCL5,PRNP,CASP12,STIP1,PRKACB
    Thyroid cancer TRP53,LEF1,MAPK1,BRAF,NCOA4,TFG,RXRB,TCF7,PPARG,TPR
    Prolactin signaling pathway SHC1,SOCS5,SRC,MAPK10,MAPK12,SOCS3,SOCS4,LHCGR,CCND1,SIRPA

    Protein Function

    MAP2K2 has several biochemical functions, for example, ATP binding,MAP kinase kinase activity,PDZ domain binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MAP2K2 itself. We selected most functions MAP2K2 had, and list some proteins which have the same functions with MAP2K2. You can find most of the proteins on our site.

    Function Related Protein
    metal ion binding CENPT,FAM170A,ZNF695,CD209C,PFKL,MAP3K2,ZNF561,HARBI1,SH3RF3,ACVR1C
    MAP kinase kinase activity MAP2K6,MAP3K9,SBK3,LRRK2,MAP3K20,MAPK10,MAP3K14,MAP2K1,MAP2K3,MAP2K7
    protein serine/threonine kinase activator activity STRADA,CALM3,CAB39,CALM2,STK4,FAM20A,IGF2,LTF,ALS2,PARP16
    protein binding AP3S1,CCDC9,KIF27,PAX9,UBE2Z,PCBD1,USP37,KCNQ1,ARMC9,TELO2
    PDZ domain binding PTENB,CXADR,CIT,CXXC4,FZD8,ARHGEF16,GRIA1,SNTA1,LPAR2,CCDC88C
    protein tyrosine kinase activity TESK1,BTK,CLK3,JAK2A,BCR,ABL1,TESK2,BAZ1B,PTK2B,TEK
    protein serine/threonine kinase activity SRPK3,TSSK5,PAK4,MYLK4,PIK3CA,ADCK4,VRK1,NEK7,SRPK1,PSKH2
    scaffold protein binding KCNA5,NOS3,NLGN3,HOMER1,PDE4D,NLGN1,NLGN4X,KRT15,NLRP1,NOS1
    protein serine/threonine/tyrosine kinase activity RPS6KA2,DYRK3,DYRK4,AURKA,DYRK1AA,AKT1,AURKC,DSTYK,DYRK1B,CLK4

    Interacting Protein

    MAP2K2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MAP2K2 here. Most of them are supplied by our site. Hope this information will be useful for your research of MAP2K2.

    ARAF;RAF1;BRAF;CCNDBP1;COPS5

    Resources

    References

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