• Official Full Name

    MAP2K2 mitogen-activated protein kinase kinase 2

  • Background

    MEK (MAP Kinase Kinase) phosphorylates the MAP Kinase on both threonine and tyrosine residues of the activation motif TEY. MEK1 and MEK2 are activated by phosphorylation of two serine residues (Ser 218/222 in MEK1 and Ser 222/226 in MEK2). These phosphorylation sites are substrates of the Raf family of kinases.
  • Synonyms

    MAP2K2; mitogen-activated protein kinase kinase 2; PRKMK2; dual specificity mitogen-activated protein kinase kinase 2; MEK2; MAPK/ERK kinase 2; MAP kinase kinase 2; ERK activator kinase 2; mitogen-activated protein kinase kinase 2, p45; MKK2; MAPKK2; FLJ26075;
    • Type:
    • Recombinant Proteins
    • Cell & Tissue Lysates
    • Protein Pre-coupled Magnetic Beads
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rat
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Insect Cell
    • Insect Cells
    • Mammalian Cell
    • Sf9 Insect Cell
    • Tag :
    • GST
    • His
    • His (Fc)
    • Avi
    • His|MBP
    • Myc
    • DDK
    • Myc|DDK
    • N/A
    • No tag
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Chicken MAP2K2-6940C Recombinant Chicken MAP2K2 Mammalian Cell His
    Human MAP2K2-29202TH Recombinant Human MAP2K2 N/A
    Human MAP2K2-613HCL Recombinant Human MAP2K2 cell lysate Insect Cell N/A
    Human MAP2K2-968H Recombinant Human MAP2K2, GST tagged Insect Cell GST
    Human MAP2K2-1316H Recombinant Human Mitogen-Activated Protein Kinase Kinase 2, His-tagged E.coli His
    Human MAP2K2-15860H Recombinant Human MAP2K2, His-tagged E.coli His
    Human MAP2K2-350H Recombinant Human MAP2K2, GST-tagged, Active Sf9 Insect Cell GST
    Human MAP2K2-302H Recombinant Human MAP2K2 protein, His/MBP-tagged E.coli His/MBP
    Human MAP2K2-301H Recombinant Human MAP2K2 protein, His/MBP-tagged E.coli His/MBP
    Human MAP2K2-968HAF488 Recombinant Human MAP2K2 Protein, GST-tagged, Alexa Fluor 488 conjugated Insect Cells GST
    Human MAP2K2-253H Recombinant Human MAP2K2 Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human MAP2K2-0227H Recombinant Human MAP2K2 Protein (E55-V400), His tagged E.coli His
    Human MAP2K2-968HAF555 Recombinant Human MAP2K2 Protein, GST-tagged, Alexa Fluor 555 conjugated Insect Cells GST
    Human MAP2K2-1353H-B Recombinant Human MAP2K2 Protein Pre-coupled Magnetic Beads HEK293
    Human MAP2K2-4024H Recombinant Human MAP2K2 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human MAP2K2-968HAF647 Recombinant Human MAP2K2 Protein, GST-tagged, Alexa Fluor 647 conjugated Insect Cells GST
    Human MAP2K2-0226H Recombinant Human MAP2K2 Protein (E55-V400), Tag Free E.coli No tag
    Human MAP2K2-968HF Recombinant Human MAP2K2 Protein, GST-tagged, FITC conjugated Insect Cells GST
    Human MAP2K2-1353H Recombinant Human MAP2K2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
    Mouse Map2k2-8085M Recombinant Mouse Map2k2 protein, His-tagged E.coli His
    Mouse Map2k2-3921M Recombinant Mouse Map2k2 Protein, Myc/DDK-tagged HEK293T Myc/DDK
    Rat MAP2K2-3560R Recombinant Rat MAP2K2 Protein Mammalian Cell His
    Rat MAP2K2-3216R Recombinant Rat MAP2K2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
    Rat MAP2K2-3216R-B Recombinant Rat MAP2K2 Protein Pre-coupled Magnetic Beads HEK293
    • Involved Pathway
    • Protein Function
    • Interacting Protein
    • MAP2K2 Related Research Area

    MAP2K2 involved in several pathways and played different roles in them. We selected most pathways MAP2K2 participated on our site, such as MAPK signaling pathway, ErbB signaling pathway, Ras signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with MAP2K2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    ErbB signaling pathwayAREGB;PAK3;PLCG1;CBLC;RAF1A;MAPK1;PAK7;CDKN1BB;NCK2A
    Ras signaling pathwayCALML3;ABL1;GRIN2B;FGF12;SHOC2;TBK1;TEK;IGF1R;PAK1
    Rap signaling pathwayMLLT4;PDGFC;FGF20;GNAI2;Adcy4;FLT4;CALML3;FGF19;PRKCI
    cGMP-PKG signaling pathwayMYLK3;PPP3R1;PPP1R12A;PDE3A;PLN;ATP2A3;ITPR3;MAPK1;PPP3R2
    cAMP signaling pathwayPLD2;PIK3CB;GRIN2A;TSHR;GLP1R;PIK3R2;HTR1B;MC2R;VAV2
    HIF- signaling pathwayRPS6KB2;IGF1R;TCEB2;PIK3R1;INS1;BCL2;RELA;EPO;PRKCB
    FoxO signaling pathwayCAT;PLK1;SKP2;RAF1A;CDKN2B;INS2;INS;BRAF;FOXG1
    Sphingolipid signaling pathwayPLCB3;MAP2K1;PRKCB;PLCB1;PLD1;PPP2R5E;NRAS;ACER1;LOC100328615
    Phospholipase D signaling pathwayPPAP2A;PDGFB;PDGFRA;PRKCA;PDGFA;MAP2K2;PLD1;AGTR1B;INS2
    PIK-Akt signaling pathwayPPP2R5E;LAMB4;Il6ra;IL2RB;GHR;LAMB2;YWHAZ;PPP2R1B;TCL1B
    Vascular smooth muscle contractionRAF1;NPR1;PLA2G12B;BRAF;PLA2G2F;PPP1R12C;GNAQ;ARAF;PRKG1
    Signaling pathways regulating pluripotency of stem cellsID1;PCGF6;TBX3;WNT3A;ZFHX3;ZIC3;MAPK1;ACVR1C;ISL1
    Toll-like receptor signaling pathwayMAP2K6;IFNA1;IFNA12;FADD;LY96;IRAK4;RIPK1;TLR2-2;PIK3R3
    Natural killer cell mediated cytotoxicityPPP3R2;IFNA17;PLCG2;TNFRSF10B;RAF1;TNF;MAPK1;CD247;PPP3CB
    T cell receptor signaling pathwayNFATC2;IKBKB;NCK2;NFATC1;MUC1;CBL;TNF;Il2;MAPK12
    B cell receptor signaling pathwayDUSP6;AKT1;KRAS;BTK;LILRB3;GRB2;CD22;ACTR2;PIK3CD
    Fc epsilon RI signaling pathwayKRAS;PLA2G4A;RAF1;VAV2;LYN;MAP2K4;PLA2G4D;FCER1G;FYN
    Long-term potentiationITPR3;RPS6KA2;BRAF;RAP1B;GNAQ;MAPK1;GRM5;RPS6KA1;EP300
    Neurotrophin signaling pathwayMAP3K1;RPS6KA3;MAPK3;MAPK7;RIPK2;AKT2;RAPGEF1;SHC1;IKBKB
    Long-term depressionGRIA1;PLA2G4F;RYR1;PLA2G4A;GRM1;PRKCA;PPP2CA;GNA12;GNAZ
    Regulation of actin cytoskeletonARAF;DIAPH1;TMSB4X;MYL7;ITGA6B;CFL2;RAC1A;RHOAB;EZRB
    Insulin signaling pathwayPPP1R3CA;SOCS1A;GSK3B;MAP2K2B;PDPK1;SOCS4;MKNK2;LIPE;PCK2
    GnRH signaling pathwayCALM2B;GNA11A;MAPK12;PLCB3;GNA15.4;MAPK9;MAP2K6;CALM;GNRH1
    Estrogen signaling pathwayPIK3R3;HSPA8;FOS;MAP2K2;GNAS;GABBR1;CREB5;SHC1;PIK3CA
    Prolactin signaling pathwayAKT1;SOCS4;PIK3R1;MAPK8;SHC2;PIK3CD;GALT;SOS1;PPIB
    Thyroid hormone signaling pathwayATP1B1;MED13L;PRKCB;RHEB;PRKACG;KAT2A;ACTG1;PIK3CA;KAT2B
    Oxytocin signaling pathwayCAMK1;PRKCG;ELK1;PIK3CG;ITPR1;KRAS;PRKCA;NPR1;MEF2C
    Prion diseasesLOC100033925;C1QA;C7;CCL5;PRKACA;HSPA5;BAX;C6;MAP2K2
    Hepatitis BSTAT4;CCND1;MAP2K4;EGR2;TP53;Fasl;SMAD3;FADD;CCNE1
    Influenza AOAS3;IL1B;Ifna15;VDAC1;IRF7;IRAK4;BLB2;Fasl;HSPA1A
    Pathways in cancerGLI1;SMO;FIGF;GNG3;CCDC6;RALGDS;FN1;PIK3R2;BIRC7
    Proteoglycans in cancerFZD1;ERBB3;PRKCA;WNT6;KRAS;PTPN6;ITGAV;PXN;MAPK3
    MicroRNAs in cancerMET;CCNE1;HDAC4;Pdgfa&Pdgfb;PIK3R2;MTOR;PTEN;PDGFRA;ATM
    Renal cell carcinomaPDGFB;BRAF;CDC42;GAB1;PIK3R2;PAK3;ARAF;VHL;FLCN
    Endometrial cancerERBB2;CTNNA2;MAPK1;RAF1;MAPK3;FOXO3;GSK3B;GRB2;APC
    Prostate cancerIGF1;ARAF;CCND1;Ar;SRD5A2;PIK3CG;ACTL6B;CREB3L2;TP53
    Chronic myeloid leukemiaRUNX1;IKBKB;TGFB2;PIK3R2;CDK6;CCND1;TGFB3;SHC3;AKT1
    Acute myeloid leukemiaRUNX1T1;PIK3R3;PIK3R2;RELA;HRAS;NRAS;PIK3CA;ARAF;RPS6KB2
    Non-small cell lung cancerAKT1;AKT2;RARB;EML4;PLCG2;PDPK1;BAD;PIK3R5;MAP2K1
    Central carbon metabolism in cancerSCO2;PIK3CB;HRAS;ERBB2;G6PDX;PIK3R5;NTRK1;PDHA2;FGFR1
    Choline metabolism in cancerPIP5K1B;DGKG;SLC5A7;MAP2K2;PIK3CG;PDGFB;EGF;PIK3CD;PLA2G4A

    MAP2K2 has several biochemical functions, for example, ATP binding, MAP kinase kinase activity, PDZ domain binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MAP2K2 itself. We selected most functions MAP2K2 had, and list some proteins which have the same functions with MAP2K2. You can find most of the proteins on our site.

    Function Related Protein
    MAP kinase kinase activityALPK2;MAPK10;MAP3K20;LRRK2;MAP2K7;MAPKAPK5;MAP2K2A;SBK3;MAP2K6
    metal ion bindingZNF256;NOX1;DNAJC21;ZNF701;ZNF319;RHOU;ZNF266;MPPED2;CYP27C1
    protein bindingTMEM31;GHRL;RANGAP1;NABP1;ELL;ARRB1;MFN2;ARPC4;RGS19
    protein complex scaffoldAXIN1;SLC9A1;SLC9A3R2;MPP7;C9orf142;DLG1;MAP2K2;CAV1;AKAP6
    protein serine/threonine kinase activator activityMAP2K2;STK4;STRADA;CALM1;IGF2;FAM20A;SPRY2;ALS2;CALM3
    protein serine/threonine kinase activityTNNI3K;VRK2;DAPK2;MAP3K12;RAF1;CAMKK1A;PRKCZ;PHKG2;GSK3B
    protein serine/threonine/tyrosine kinase activityAURKA;TESK1;DYRK1B;MAP2K2;TESK2;TNK2;DYRK3;AURKC;RPS6KA1
    protein tyrosine kinase activityTNK2;SYK;Aatk;KIT;BMX;JAK2;NTRK3A;PTK2AB;ERBB4A
    scaffold protein bindingNOS3;KCNA5;SHANK1;NLGN3;NLRP1;TREM2;CACNA1G;HOMER1;P2RY1

    MAP2K2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MAP2K2 here. Most of them are supplied by our site. Hope this information will be useful for your research of MAP2K2.


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