MAP2K2
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Official Full Name
MAP2K2 mitogen-activated protein kinase kinase 2
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Background
MEK (MAP Kinase Kinase) phosphorylates the MAP Kinase on both threonine and tyrosine residues of the activation motif TEY. MEK1 and MEK2 are activated by phosphorylation of two serine residues (Ser 218/222 in MEK1 and Ser 222/226 in MEK2). These phosphorylation sites are substrates of the Raf family of kinases. -
Synonyms
MAP2K2; mitogen-activated protein kinase kinase 2; PRKMK2; dual specificity mitogen-activated protein kinase kinase 2; MEK2; MAPK/ERK kinase 2; MAP kinase kinase 2; ERK activator kinase 2; mitogen-activated protein kinase kinase 2, p45; MKK2; MAPKK2; FLJ26075;
- Involved Pathway
- Protein Function
- Interacting Protein
- MAP2K2 Related Research Area
MAP2K2 involved in several pathways and played different roles in them. We selected most pathways MAP2K2 participated on our site, such as MAPK signaling pathway, ErbB signaling pathway, Ras signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with MAP2K2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| MAPK signaling pathway | PPP3R1;GADD45AB;SOS1;RAF1A;PPP3CC;PRKCB;RASA1;HSPA1B;CACNG1A |
| ErbB signaling pathway | AREGB;PAK3;PLCG1;CBLC;RAF1A;MAPK1;PAK7;CDKN1BB;NCK2A |
| Ras signaling pathway | CALML3;ABL1;GRIN2B;FGF12;SHOC2;TBK1;TEK;IGF1R;PAK1 |
| Rap signaling pathway | MLLT4;PDGFC;FGF20;GNAI2;Adcy4;FLT4;CALML3;FGF19;PRKCI |
| cGMP-PKG signaling pathway | MYLK3;PPP3R1;PPP1R12A;PDE3A;PLN;ATP2A3;ITPR3;MAPK1;PPP3R2 |
| cAMP signaling pathway | PLD2;PIK3CB;GRIN2A;TSHR;GLP1R;PIK3R2;HTR1B;MC2R;VAV2 |
| HIF- signaling pathway | RPS6KB2;IGF1R;TCEB2;PIK3R1;INS1;BCL2;RELA;EPO;PRKCB |
| FoxO signaling pathway | CAT;PLK1;SKP2;RAF1A;CDKN2B;INS2;INS;BRAF;FOXG1 |
| Sphingolipid signaling pathway | PLCB3;MAP2K1;PRKCB;PLCB1;PLD1;PPP2R5E;NRAS;ACER1;LOC100328615 |
| Phospholipase D signaling pathway | PPAP2A;PDGFB;PDGFRA;PRKCA;PDGFA;MAP2K2;PLD1;AGTR1B;INS2 |
| PIK-Akt signaling pathway | PPP2R5E;LAMB4;Il6ra;IL2RB;GHR;LAMB2;YWHAZ;PPP2R1B;TCL1B |
| Vascular smooth muscle contraction | RAF1;NPR1;PLA2G12B;BRAF;PLA2G2F;PPP1R12C;GNAQ;ARAF;PRKG1 |
| VEGF signaling pathway | MAPKAPK3;MAPK12B;NRAS;MAPK11;PIK3CA;SHC2;BADB;VEGFAB;MAPKAPK2A |
| Gap junction | MAPK1;TUBA3C;CSNK1DA;GNAI3;TUBB;PRKCBA;GNA11A;GRB2B;TUBA4A |
| Signaling pathways regulating pluripotency of stem cells | ID1;PCGF6;TBX3;WNT3A;ZFHX3;ZIC3;MAPK1;ACVR1C;ISL1 |
| Toll-like receptor signaling pathway | MAP2K6;IFNA1;IFNA12;FADD;LY96;IRAK4;RIPK1;TLR2-2;PIK3R3 |
| Natural killer cell mediated cytotoxicity | PPP3R2;IFNA17;PLCG2;TNFRSF10B;RAF1;TNF;MAPK1;CD247;PPP3CB |
| T cell receptor signaling pathway | NFATC2;IKBKB;NCK2;NFATC1;MUC1;CBL;TNF;Il2;MAPK12 |
| B cell receptor signaling pathway | DUSP6;AKT1;KRAS;BTK;LILRB3;GRB2;CD22;ACTR2;PIK3CD |
| Fc epsilon RI signaling pathway | KRAS;PLA2G4A;RAF1;VAV2;LYN;MAP2K4;PLA2G4D;FCER1G;FYN |
| Long-term potentiation | ITPR3;RPS6KA2;BRAF;RAP1B;GNAQ;MAPK1;GRM5;RPS6KA1;EP300 |
| Neurotrophin signaling pathway | MAP3K1;RPS6KA3;MAPK3;MAPK7;RIPK2;AKT2;RAPGEF1;SHC1;IKBKB |
| Long-term depression | GRIA1;PLA2G4F;RYR1;PLA2G4A;GRM1;PRKCA;PPP2CA;GNA12;GNAZ |
| Regulation of actin cytoskeleton | ARAF;DIAPH1;TMSB4X;MYL7;ITGA6B;CFL2;RAC1A;RHOAB;EZRB |
| Insulin signaling pathway | PPP1R3CA;SOCS1A;GSK3B;MAP2K2B;PDPK1;SOCS4;MKNK2;LIPE;PCK2 |
| GnRH signaling pathway | CALM2B;GNA11A;MAPK12;PLCB3;GNA15.4;MAPK9;MAP2K6;CALM;GNRH1 |
| Estrogen signaling pathway | PIK3R3;HSPA8;FOS;MAP2K2;GNAS;GABBR1;CREB5;SHC1;PIK3CA |
| Melanogenesis | TYRP1;GNA15.4;GSK3B;KITLGA;POMC;GNAIA;KITLGB;FZD3B;POMCA |
| Prolactin signaling pathway | AKT1;SOCS4;PIK3R1;MAPK8;SHC2;PIK3CD;GALT;SOS1;PPIB |
| Thyroid hormone signaling pathway | ATP1B1;MED13L;PRKCB;RHEB;PRKACG;KAT2A;ACTG1;PIK3CA;KAT2B |
| Oxytocin signaling pathway | CAMK1;PRKCG;ELK1;PIK3CG;ITPR1;KRAS;PRKCA;NPR1;MEF2C |
| Prion diseases | LOC100033925;C1QA;C7;CCL5;PRKACA;HSPA5;BAX;C6;MAP2K2 |
| Hepatitis B | STAT4;CCND1;MAP2K4;EGR2;TP53;Fasl;SMAD3;FADD;CCNE1 |
| Influenza A | OAS3;IL1B;Ifna15;VDAC1;IRF7;IRAK4;BLB2;Fasl;HSPA1A |
| Pathways in cancer | GLI1;SMO;FIGF;GNG3;CCDC6;RALGDS;FN1;PIK3R2;BIRC7 |
| Proteoglycans in cancer | FZD1;ERBB3;PRKCA;WNT6;KRAS;PTPN6;ITGAV;PXN;MAPK3 |
| MicroRNAs in cancer | MET;CCNE1;HDAC4;Pdgfa&Pdgfb;PIK3R2;MTOR;PTEN;PDGFRA;ATM |
| Renal cell carcinoma | PDGFB;BRAF;CDC42;GAB1;PIK3R2;PAK3;ARAF;VHL;FLCN |
| Endometrial cancer | ERBB2;CTNNA2;MAPK1;RAF1;MAPK3;FOXO3;GSK3B;GRB2;APC |
| Glioma | AKT1;MAP2K1;CCND1;IGF1R;PIK3CD;PDGFRB;PIK3CG;KRAS;TGFA |
| Prostate cancer | IGF1;ARAF;CCND1;Ar;SRD5A2;PIK3CG;ACTL6B;CREB3L2;TP53 |
| Thyroid cancer | CCND1;HRAS;NCOA4;MAP2K2;RET;MAPK1;TCF7;KRAS;CDH1 |
| Melanoma | PDGFC;FGF4;FGF12;Fgf15;MET;MAP2K1;MAPK3;FGF13;KRAS |
| Bladder cancer | CCND1;RAF1;DAPK1;RASSF1;UPK3A;HBEGF;CXCL8;EGF;DAPK2 |
| Chronic myeloid leukemia | RUNX1;IKBKB;TGFB2;PIK3R2;CDK6;CCND1;TGFB3;SHC3;AKT1 |
| Acute myeloid leukemia | RUNX1T1;PIK3R3;PIK3R2;RELA;HRAS;NRAS;PIK3CA;ARAF;RPS6KB2 |
| Non-small cell lung cancer | AKT1;AKT2;RARB;EML4;PLCG2;PDPK1;BAD;PIK3R5;MAP2K1 |
| Central carbon metabolism in cancer | SCO2;PIK3CB;HRAS;ERBB2;G6PDX;PIK3R5;NTRK1;PDHA2;FGFR1 |
| Choline metabolism in cancer | PIP5K1B;DGKG;SLC5A7;MAP2K2;PIK3CG;PDGFB;EGF;PIK3CD;PLA2G4A |
MAP2K2 has several biochemical functions, for example, ATP binding, MAP kinase kinase activity, PDZ domain binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MAP2K2 itself. We selected most functions MAP2K2 had, and list some proteins which have the same functions with MAP2K2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ATP binding | ACTA2;Acsm2a;PRPS1;CLCN7;ABCB9;RPS6KB1B;KIF4;CAMKVB;PANK1B |
| MAP kinase kinase activity | ALPK2;MAPK10;MAP3K20;LRRK2;MAP2K7;MAPKAPK5;MAP2K2A;SBK3;MAP2K6 |
| PDZ domain binding | SLC22A12;ERC1;TGFBR3;GIPC1;PROSAPIP1;SLC9A3R2;SNTA1;SRR;PTEN |
| metal ion binding | ZNF256;NOX1;DNAJC21;ZNF701;ZNF319;RHOU;ZNF266;MPPED2;CYP27C1 |
| protein binding | TMEM31;GHRL;RANGAP1;NABP1;ELL;ARRB1;MFN2;ARPC4;RGS19 |
| protein complex scaffold | AXIN1;SLC9A1;SLC9A3R2;MPP7;C9orf142;DLG1;MAP2K2;CAV1;AKAP6 |
| protein serine/threonine kinase activator activity | MAP2K2;STK4;STRADA;CALM1;IGF2;FAM20A;SPRY2;ALS2;CALM3 |
| protein serine/threonine kinase activity | TNNI3K;VRK2;DAPK2;MAP3K12;RAF1;CAMKK1A;PRKCZ;PHKG2;GSK3B |
| protein serine/threonine/tyrosine kinase activity | AURKA;TESK1;DYRK1B;MAP2K2;TESK2;TNK2;DYRK3;AURKC;RPS6KA1 |
| protein tyrosine kinase activity | TNK2;SYK;Aatk;KIT;BMX;JAK2;NTRK3A;PTK2AB;ERBB4A |
| scaffold protein binding | NOS3;KCNA5;SHANK1;NLGN3;NLRP1;TREM2;CACNA1G;HOMER1;P2RY1 |
MAP2K2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MAP2K2 here. Most of them are supplied by our site. Hope this information will be useful for your research of MAP2K2.
ARAF; RAF1; BRAF; CCNDBP1; COPS5
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