MAP2K2

  • Official Full Name

    MAP2K2 mitogen-activated protein kinase kinase 2

  • Overview

    MEK (MAP Kinase Kinase) phosphorylates the MAP Kinase on both threonine and tyrosine residues of the activation motif TEY. MEK1 and MEK2 are activated by phosphorylation of two serine residues (Ser 218/222 in MEK1 and Ser 222/226 in MEK2). These phosphorylation sites are substrates of the Raf family of kinases.
  • Synonyms

    MAP2K2; mitogen-activated protein kinase kinase 2; PRKMK2; dual specificity mitogen-activated protein kinase kinase 2; MEK2; MAPK/ERK kinase 2; MAP kinase kinase 2; ERK activator kinase 2; mitogen-activated protein kinase kinase 2, p45; MKK2; MAPKK2; FLJ26075;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Human
  • Mouse
  • Rat
  • E.coli
  • HEK293
  • HEK293T
  • Insect (sf21)
  • Insect Cell
  • Insect Cells
  • Mammalian Cell
  • Mammalian cells
  • Sf21
  • Sf9 Insect Cell
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • His|MBP
  • Myc
  • DDK
  • Myc|DDK
  • N/A
  • N
  • No tag
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human MAP2K2-106HFL Active Recombinant Full Length Human MAP2K2 Protein, N-His-tagged Sf21 His Full Length
Human MAP2K2-107HFL Unactive Recombinant Full Length Human MAP2K2 Protein, N-His-tagged Sf21 His Full Length
Human MAP2K2-29202TH Recombinant Human MAP2K2 N/A
Human MAP2K2-1316H Recombinant Human Mitogen-Activated Protein Kinase Kinase 2, His-tagged E.coli His
Human MAP2K2-968H Recombinant Human MAP2K2 protein(Met1-Val400), GST-tagged Insect Cells N-GST Met1-Val400
Human MAP2K2-350H Recombinant Human MAP2K2, GST-tagged, Active Sf9 Insect Cell GST
Human MAP2K2-15860H Recombinant Human MAP2K2, His-tagged E.coli His 1-400aa
Human MAP2K2-301H Recombinant Human MAP2K2 protein, His/MBP-tagged E.coli His/MBP 1-171 aa
Human MAP2K2-302H Recombinant Human MAP2K2 protein, His/MBP-tagged E.coli His/MBP 262-400 aa
Human MAP2K2-613HCL Recombinant Human MAP2K2 cell lysate Insect Cell N/A
Human MAP2K2-1645HFL Recombinant Full Length Human MAP2K2 Protein, C-Flag-tagged Mammalian cells Flag
Human MAP2K2-968HAF555 Recombinant Human MAP2K2 Protein, GST-tagged, Alexa Fluor 555 conjugated Insect Cells GST 624
Human MAP2K2-968HAF488 Recombinant Human MAP2K2 Protein, GST-tagged, Alexa Fluor 488 conjugated Insect Cells GST 624
Human MAP2K2-5651HF Active Recombinant Full Length Human MAP2K2 Protein, GST-tagged Insect (sf21) GST 1-400
Human MAP2K2-0227H Recombinant Human MAP2K2 Protein (E55-V400), His tagged E.coli His E55-V400
Human MAP2K2-968HAF647 Recombinant Human MAP2K2 Protein, GST-tagged, Alexa Fluor 647 conjugated Insect Cells GST 624
Human MAP2K2-1353H-B Recombinant Human MAP2K2 Protein Pre-coupled Magnetic Beads HEK293
Human MAP2K2-0226H Recombinant Human MAP2K2 Protein (E55-V400), Tag Free E.coli No tag E55-V400
Human MAP2K2-968HF Recombinant Human MAP2K2 Protein, GST-tagged, FITC conjugated Insect Cells GST 624
Human MAP2K2-5003H Recombinant Human MAP2K2 Protein (Val86-Pro331), N-His tagged E.coli N-His Val86-Pro331
Human MAP2K2-1353H Recombinant Human MAP2K2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human MAP2K2-253H Recombinant Human MAP2K2 Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human MAP2K2-4024H Recombinant Human MAP2K2 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Mouse Map2k2-8085M Recombinant Mouse Map2k2 protein, His-tagged E.coli His Leu44~Ser313
Mouse Map2k2-3921M Recombinant Mouse Map2k2 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Rat MAP2K2-3560R Recombinant Rat MAP2K2 Protein Mammalian Cell His
Rat MAP2K2-3216R Recombinant Rat MAP2K2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat MAP2K2-3216R-B Recombinant Rat MAP2K2 Protein Pre-coupled Magnetic Beads HEK293
Chicken MAP2K2-6940C Recombinant Chicken MAP2K2 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

MAP2K2 involved in several pathways and played different roles in them. We selected most pathways MAP2K2 participated on our site, such as MAPK signaling pathway, ErbB signaling pathway, Ras signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with MAP2K2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
MAPK signaling pathwayHSPA8;STMN1B;CACNA2D1A;MAPK7;GRB2A;CASP3A;MAPK11;PPP3R1;MEF2CA
ErbB signaling pathwayELK1;CAMK2B;ARAF;BAD;MAP2K4B;MAPK1;ERBB3A;PLCG2;PAK6
Ras signaling pathwayRAF1;MAPK9;MAPK10;NGF;PLA1A;GNB2;NF1;FGF7;ABL2
Rap signaling pathwayRAP1B;FGF18;AKT2;FGF16;FGF19;CALM1;NGF;PLCB2;VEGFC
cGMP-PKG signaling pathwayIRS4;AGTR1B;AKT2;GTF2IRD1;ATP1A1;ITPR3;VDAC1;PPP3CB;SLC8A2
cAMP signaling pathwayPRKACA;GRIN2C;CREB3L3;GNAI1;ATP2B4;HHIP;PTGER3;GLI3;CALM4
HIF- signaling pathwayANGPT4;PRKCB;INS1;NPPA;PDK1;ALDOA;IGF1;PLCG2;HK1
FoxO signaling pathwayKLF2;G6PC3;MAPK8;PRKAA1;MAPK14B;MAPK12;MAPK12A;PLK1;SGK2B
Sphingolipid signaling pathwayPRKCE;PPP2R1B;SGPP2;MAPK13;PRKCG;MAPK1;GNAI1;OPRD1;PDPK1
Phospholipase D signaling pathwayPTGFR;CXCR2;PLCB4;DGKD;DGKZ;SHC3;FCER1G;SHC4;SPHK1
PIK-Akt signaling pathwayItga10&Itgb1;MCL1;YWHAE;PPP2R5B;TCL1;FGFR3;YWHAH;GNB2;PKN3
Vascular smooth muscle contractionPPP1R14AA;PRKCBA;CALML3;CALD1B;CALML5;PRKCE;GNA11A;CACNA1SB;CYP4A12A
VEGF signaling pathwaySPHK1;RAC1A;VEGFAB;PIK3R3A;AKT2L;PXNA;VEGFA;PPP3CA;PLA2G4D
Gap junctionPLCB3;GJD2;TUBA7L;TUBA8L3;PDGFAA;GNA15.4;DRD2A;TUBB5;GRB2
Signaling pathways regulating pluripotency of stem cellsSMAD1;AKT1;FZD8;APC;FGFR1;SKIL;BMP4;SMAD5;WNT5B
Toll-like receptor signaling pathwayMYD88;MAP2K1;TOLLIP;IKBKG;PIK3R3A;TLR3;IFNA5;MAP3K7;FOS
Natural killer cell mediated cytotoxicityKRAS;KIR3DL2;TNFRSF10A;LCP2;HLA-A;SHC3;CD244;KIR2DL1;FCGR3
T cell receptor signaling pathwayMUC1;CDC42;GRAP2;IKBKB;CD40LG;PAK6;IL5;NFKBIA;VAV2
B cell receptor signaling pathwayRAC1;MAPK1;CMTM3;PIK3R1;HDAC5;CRK;INPPL1;NEDD9;ARPC4
Fc epsilon RI signaling pathwayPDPK1;RAC1;AKT1;BTK;LAT;AKT2;RAC2;PIK3CG;GAB2
Long-term potentiationPPP1CC;PLCB4;GRIN2C;CAMK2B;MAPK3;MAPK1;ARAF;PRKCA;PPP3CC
Neurotrophin signaling pathwayMAP2K7;GRB2;KIDINS220;AKT2;MAPK7;SORT1;MAPK9;FASLG;MAPK11
Long-term depressionIGF1R;GRM1;MAPK1;PPP1R17;PRKG1;GNAQ;PLCB4;CRHR1;GUCY1A3
Regulation of actin cytoskeletonRHOA;ROCK2;PTK2AA;FGF13B;PAK7;F2;ITGA6B;INS;RAF1A
Insulin signaling pathwayRAF1B;PPP1CC;IRS1;GRB2A;PYGL;ACACB;SHC3;MAP2K2B;RPS6KB1B
GnRH signaling pathwayGNRHR;MAPK12;MAPK14A;CDC42L2;PRKCBB;GNRHR4;CALML3;CAMK2G1;MAPK11
Estrogen signaling pathwayCREB3L2;GABBR1;PLCB4;PRKACG;KCNJ5;GRM1;GNAI2;SHC3;MAP2K1
MelanogenesisADCY1B;PRKCA;WNT8B;WNT1;FZD3;FZD7;KITA;WNT8A;CREB3L3L
Prolactin signaling pathwayMAPK1;SHC3;SOCS2;PRLR;INS2;PIK3R1;PIK3CB;CSN2;PRP2
Thyroid hormone signaling pathwayDIO3;WNT4;ATP1A3;SLC9A1;NOTCH3;KRAS;PLCB4;PRKCB;CASP9
Oxytocin signaling pathwayCALM3;GUCY1B3;PPP1CB;PIK3R2;FOS;PLCB1;RGS2;PPP3R1;CAMK1G
Prion diseasesC8B;LAMC1;MAP2K1;LOC100033925;C5;IL1B;PRNP;MAPK3;STIP1
Hepatitis BSTAT5A;EGR3;FAS;IFNA14;NFKB1;FADD;CREB3L3;TIRAP;IFNA13
Influenza ANLRP3;IL1A;HLA-DRA;FURIN;PIK3CB;TNFRSF10B;MAP2K1;Fasl;HLA-DQA2
Pathways in cancerFOXO1;GLI3;RAC2;PTGER3;RXRB;NCOA4;WNT9B;KIT;MMP2
Proteoglycans in cancerWNT8A;SMO;LUM;CAV3;WNT7B;WNT11;ROCK1;FASLG;TGFB2
MicroRNAs in cancerPRKCE;SPRY2;Casp3;UBE2I;RHOA;BMPR2;RAF1;WNT3A;STMN1
Renal cell carcinomaPAK3;FLCN;RAF1;AHA-1;TGFB3;PIK3R5;PIK3R2;AKT1;VHL
Endometrial cancerTRP53;CDH1;PIK3CA;PIK3CD;MLH1;AXIN2;TCF7;KRAS;ELK1
GliomaCAMK2B;CALM1;MTOR;RB1;PLCG2;SHC2;PDGFB;PIK3CB;PIK3R2
Prostate cancerGSK3B;TCF7L2;NKX3-1;FOXA1;INS1;IGF1R;TP53;IKBKG;SRD5A2
Thyroid cancerRET;HRAS;MAPK3;RXRG;MAPK1;PAX8;TRP53;MAP2K1;BRAF
MelanomaPTEN;PIK3CB;HGF;FGFR1;FGF19;PIK3CA;CDH1;HRAS;FGF12
Bladder cancerMYC;MMP9;TYMP;CCND1;IL-8;CDK4;ERBB2;MMP2;ARAF
Chronic myeloid leukemiaRAF1;CRK;HRAS;MAPK3;MECOM;CDK6;TGFBR2;PIK3CB;IKBKB
Acute myeloid leukemiaRARA;EIF4EBP1;STAT5A;MYC;MAPK1;PIM2;STAT5B;HRAS;AKT2
Non-small cell lung cancerRXRG;MAP2K2;BAD;PIK3R1;RXRB;RASSF5;CASP9;TRP53;MAPK3
Central carbon metabolism in cancerPGAM1;PIK3R2;HKDC1;AKT1;MAPK1;NTRK1;PIK3CG;MAPK3;RET
Choline metabolism in cancerTSC2;WASL;DGKQ;TAE1;MAP2K2;MAPK9;CHKA;WASF3;MAPK10

MAP2K2 has several biochemical functions, for example, ATP binding, MAP kinase kinase activity, PDZ domain binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MAP2K2 itself. We selected most functions MAP2K2 had, and list some proteins which have the same functions with MAP2K2. You can find most of the proteins on our site.

Function Related Protein
ATP bindingABCD2;ABCA5;AK5;CLK1;LATS2;PYGL;DGKAA;DCK;DYRK1B
MAP kinase kinase activityMAPK14;MAP2K2A;LRRK2;MAP3K14;MAPKAPK5;MAP2K7;MAP2K2;MAP2K2B;MAP2K3
PDZ domain bindingSDC2;ERC1;GRASP;NLGN1;ACCN3;GRIA1;Apba1;GJA1;SLC26A6
metal ion bindingLIMS2;PPM1L;PPM1BB;ZFP583;NDUFS7;PPAT;KLF9;PLAG1;METAP1D
protein bindingCDH5;CLOCKA;AIRE;CLC;RNF20;RPL27A;HSPB6;OPRM1;F11R
protein complex scaffoldSMARCD1;SLC9A1;HOMER1;SLC9A3R2;C9orf142;MPP7;WWC3;PKP2;ARRB2
protein serine/threonine kinase activator activitySTK3;CALM3;MAP2K2;SPRY2;IGF2;CALM1;PARP16;STRADA;FAM20A
protein serine/threonine kinase activityNEK7;CAMK2G1;cka1;IRAK1;TP53RK;GRK7B;SMOK3A;ROCK2A;MAPK1
protein serine/threonine/tyrosine kinase activityPRKAA2;SGK1;ACVR2B;AURKA;CLK2;AKT1;DYRK1AA;RPS6KB1;RPS6KA2
protein tyrosine kinase activityPTK2AB;JAK2;KITB;SHC1;PTK2AA;FGR;DYRK3;BMX;JAK3
scaffold protein bindingKCNQ1;SHANK3;GRIN2A;SRC;KRT18;PANX1;CRIPT;CHUK;NLGN4Y

MAP2K2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MAP2K2 here. Most of them are supplied by our site. Hope this information will be useful for your research of MAP2K2.

ARAF; RAF1; BRAF; CCNDBP1; COPS5

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