MAP2K2 Protein

September 27-30, 2022

Boston Convention and Exhibition Center

Booth #336

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MAP2K2

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MAP2K2

Official Full Name MAP2K2 mitogen-activated protein kinase kinase 2
Background MEK (MAP Kinase Kinase) phosphorylates the MAP Kinase on both threonine and tyrosine residues of the activation motif TEY. MEK1 and MEK2 are activated by phosphorylation of two serine residues (Ser 218/222 in MEK1 and Ser 222/226 in MEK2). These phosphorylation sites are substrates of the Raf family of kinases.
Synonyms MAP2K2; mitogen-activated protein kinase kinase 2; PRKMK2; dual specificity mitogen-activated protein kinase kinase 2; MEK2; MAPK/ERK kinase 2; MAP kinase kinase 2; ERK activator kinase 2; mitogen-activated protein kinase kinase 2, p45; MKK2; MAPKK2; FLJ26075;
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rat
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Insect (sf21)
    • Insect Cell
    • Insect Cells
    • Mammalian Cell
    • Sf9 Insect Cell
    • Tag :
    • GST
    • His
    • MBP
    • Myc/DDK
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human MAP2K2-1316H Recombinant Human Mitogen-Activated Protein Kinase Kinase 2, His-tagged E.coli His
    Human MAP2K2-15860H Recombinant Human MAP2K2, His-tagged E.coli His
    Human MAP2K2-29202TH Recombinant Human MAP2K2 N/A
    Human MAP2K2-301H Recombinant Human MAP2K2 protein, His/MBP-tagged E.coli His/MBP
    Human MAP2K2-302H Recombinant Human MAP2K2 protein, His/MBP-tagged E.coli His/MBP
    Human MAP2K2-350H Recombinant Human MAP2K2, GST-tagged, Active Sf9 Insect Cell GST
    Human MAP2K2-968H Recombinant Human MAP2K2, GST tagged Insect Cell GST
    Mouse Map2k2-8085M Recombinant Mouse Map2k2 protein, His-tagged E.coli His
    Rat MAP2K2-3560R Recombinant Rat MAP2K2 Protein Mammalian Cell His
    Chicken MAP2K2-6940C Recombinant Chicken MAP2K2 Mammalian Cell His
    Human MAP2K2-613HCL Recombinant Human MAP2K2 cell lysate Insect Cell N/A
    Human MAP2K2-5651HF Recombinant Full Length Human MAP2K2 Protein, GST-tagged Insect (sf21) GST
    Human MAP2K2-968HAF488 Recombinant Human MAP2K2 Protein, GST-tagged, Alexa Fluor 488 conjugated Insect Cells GST
    Human MAP2K2-968HAF555 Recombinant Human MAP2K2 Protein, GST-tagged, Alexa Fluor 555 conjugated Insect Cells GST
    Human MAP2K2-968HAF647 Recombinant Human MAP2K2 Protein, GST-tagged, Alexa Fluor 647 conjugated Insect Cells GST
    Human MAP2K2-968HF Recombinant Human MAP2K2 Protein, GST-tagged, FITC conjugated Insect Cells GST
    Human MAP2K2-253H Recombinant Human MAP2K2 Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human MAP2K2-4024H Recombinant Human MAP2K2 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Mouse Map2k2-3921M Recombinant Mouse Map2k2 Protein, Myc/DDK-tagged HEK293T Myc/DDK

    MAP2K2 involved in several pathways and played different roles in them. We selected most pathways MAP2K2 participated on our site, such as MAPK signaling pathway, ErbB signaling pathway, Ras signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with MAP2K2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    MAPK signaling pathway HSPB1; CACNB1; MAPK9; PRKCBB; PPP3R1B; FGF1B; MAP2K2; MAP2K4A; TRP53; CDC42L2
    ErbB signaling pathway CAMK2A; AKT1; GRB2; MAPK9; PTK2; MAPK8B; NCK2A; PIK3CA; GSK3AA; HBEGFA
    Ras signaling pathway PLD1; GNGT1; GNG13; Kitl; FGF13; PIK3R5; SHC3; KSR1; PDGFA; GNG7
    Rap signaling pathway P2RY1; BCAR1; PFN2; PDGFRA; IGF1R; RALB; ITGB2; FGF18; Pdgfa&Pdgfb; PDGFC
    cGMP-PKG signaling pathway NPR1; SRF; MEF2B; GUCY1B3; NPR2; ATP2B4; SLC25A31; CREB3L1; CALM3; PIK3CD
    cAMP signaling pathway CAMK2G; PAK1; TNNI3; MC2R; CAMK2D; GNAI1; GRIN1; OXTR; GLI1; GHRL
    HIF- signaling pathway MAPK3; NPPA; RELA; HIF1A; PIK3R5; SERPINE1; NOX3; NOX1; RPS6KB2; PDHA2
    FoxO signaling pathway GRM1; GRB2; PRKAG2A; CCNB3; EP300; IRS2; G6PC2; CDKN2D; MAPK14B; TGFB1
    Sphingolipid signaling pathway FCER1G; MAP2K2; MAPK9; PPP2CB; RHOA; PIK3R5; NOS3; ABCC1; HRAS; PPP2R2A
    Phospholipase D signaling pathway SHC1; PRKCA; PLD1; PIP5K1B; RRAS2; AKT2; INSR; PDGFC; ARF6; GRM1
    PIK-Akt signaling pathway LAMB4; NGF; PDGFA; LAMA5; PRL; MLST8; FGFR1; VEGFB; TNN; PHLPP1
    Vascular smooth muscle contraction CALD1B; PLA2G4AA; PRKACBB; CYP4A12A; ARHGEF11; MYLK3; PPP1R12C; PLA2G2F; KCNMB4; PRKCB
    VEGF signaling pathway RAC3A; AKT2; PRKCBB; PIK3R3; MAPK1; CDC42; MAP2K2B; PPP3CB; PLA2G4D; NRAS
    Gap junction MAP2K5; CSNK1DB; GRM1; CX43; PRKACG; PRKCBA; PRKACAB; GNAQ; GRB2B; RAF1B
    Signaling pathways regulating pluripotency of stem cells PCGF5; KLF4; ZFHX3; SMAD4; MAP2K1; RAF1; INHBE; PIK3R5; HOXB1; TBX3
    Toll-like receptor signaling pathway TLR4BB; TLR2-2; IL8L1; IFNA8; IFNB; IFNA2; IFNA10; TLR9; IRF3; AKT2
    Natural killer cell mediated cytotoxicity KLRC4-KLRK1; IFNA4; ULBP1; IFNGR2; ICAM2; PAK1; KLRA8; ITGB2L; TNFSF10; ULBP2
    T cell receptor signaling pathway PAK6; IFNG; PPP3CB; MUC1; LCK; CD8B; MAP2K2; MAP3K7; NCK2; PDPK1
    B cell receptor signaling pathway PTPN18; PIK3CG; ACTR2; PRKCB; MAPK1; PIK3R2; NEDD9; CDK2; ARPC1B; RELA
    Fc epsilon RI signaling pathway PLA2G4C; MAPK13; RAF1; GRB2; HRAS; MAP2K7; FCER1A; PIK3R2; PLA2G4F; GM-CSF
    Long-term potentiation CAMK4; RAP1A; GRIA1; MAPK1; NRAS; PLCB4; HRAS; PPP3R1; RAF1; RPS6KA2
    Neurotrophin signaling pathway RAC1; MATK; SHC2; PLCG1; BRAF; CAMK2B; PDPK1; IRAK1; SHC3; RAPGEF1
    Long-term depression MAPK1; RAF1; GNA11; MAPK3; PLA2G4D; IGF1; GUCY1B3; PLCB2; GNA12; PLA2G4C
    Regulation of actin cytoskeleton ITGB2L; WASF1; LIMK2; LIMK1; ROCK2; PAK2A; PTK2AA; ITGB1B.2; CHRM5B; MAP2K2
    Insulin signaling pathway INS2; INS1; SOCS1A; SOCS2; AKT2; ELK1; GYS2; SOCS3B; PYGB; PCK1
    GnRH signaling pathway PRKACB; CALM2B; PLCB4; MAPK13; MAP2K4; CDC42L; PLCB2; MMP14A; MAP2K2B; PRKACAA
    Estrogen signaling pathway CALM3; PIK3CD; HSPA1A; HSPA1L; CALM4; PRKACB; FKBP4; FOS; PRKCD; CALM1
    Melanogenesis DCT; WNT9B; FZD8; WNT3; PRKACA; GNAO1A; LEF1; PRKCB; WNT11R; CAMK2B
    Prolactin signaling pathway STAT3; SRC; SOCS3; ESR1; FOXO3; SOCS4; MAPK3; PIK3CA; SHC2; PRP2
    Thyroid hormone signaling pathway BAD; PIK3CA; PLCG2; KRAS; TBC1D4; MAP2K1; MED14; SLC16A2; ITGAV; TRP53
    Oxytocin signaling pathway Adcy4; NPR2; RYR2; PTGS2; PRKCA; GNAQ; CACNA2D3; CAMK1D; CALML5; GNAI3
    Prion diseases NCAM1; C8A; PRKACG; C6; C9; C8G; IL1A; MAP2K2; ELK1; IL1B
    Hepatitis B IFNA1; IFNB1; STAT4; STAT3; IL-8; IFN-a; PIK3CB; MAVS; IFNA21; CASP8
    Influenza A ICAM1; IFNA21; EIF2AK2; TNFRSF10B; CCL2; TNFRSF10A; PIK3R5; IFNA6; HLA-DRB5; RAE1
    Pathways in cancer SFPI1; WNT9B; WNT8A; PLD1; RALBP1; WNT9A; GNG7; IKBKG; FLT3; MMP2
    Proteoglycans in cancer FGF2; IGF1; ITGB3; RRAS2; PIK3CA; FGFR1; WNT3A; HRAS; PTPN6; NRAS
    MicroRNAs in cancer BCL2; RAF1; CCNE1; IRS1; CCNE2; DNMT3B; TNR; PRKCB; HRAS; CCNG1
    Renal cell carcinoma MAP2K2; FLCN; PTPN11; BRAF; FH1; TGFB2; TCEB1; MAPK3; TGFA; HRAS
    Endometrial cancer PIK3CB; MAPK1; HRAS; ERBB2; AKT1; TCF7; ARAF; LEF1; BRAF; RAF1
    Glioma PDGFA; PRKCG; CALM2; KRAS; CAMK2D; CCND1; CALM3; PRKCB; SHC2; MAPK3
    Prostate cancer SMARCD1; CCNE2; SPINK1; RB1; INS; SPRY1; RAF1; FGFR2; PIK3CB; PTEN
    Thyroid cancer MAP2K2; MAP2K1; MAPK3; NCOA4; RXRG; CDH1; PPARG; TP53; RET; MAPK1
    Melanoma MDM2; CCND1; FGFR1; PIK3CB; FGF22; IGF1; FGF5; PIK3R2; PDGFC; CDH1
    Bladder cancer MAP2K1; MYC; MMP1; KRAS; THBS1; FGFR3; E2F1; DAPK1; IL-8; HBEGF
    Chronic myeloid leukemia ARAF; MAPK3; AKT1; PTPN11; CCND1; CRKL; CBLC; ABL1; RAF1; PIK3R2
    Acute myeloid leukemia RPS6KB1; MAPK1; RUNX1; CEBPA; AKT3; MTOR; BAD; BRAF; MAP2K1; RAF1
    Non-small cell lung cancer PIK3R1; CCND1; TRP53; SOS1; FHIT; FOXO3; RASSF1; RARB; HRAS; PIK3R5
    Central carbon metabolism in cancer PGAM2; NTRK1; C12orf5; G6PD; PKM2; MTOR; PDGFRB; FLT3; GLS2; TRP53
    Choline metabolism in cancer GRB2; FOS; EGF; DGKD; WASF3; SP1; WASF2; RAC3; PLCG1; LYPLA1

    MAP2K2 has several biochemical functions, for example, ATP binding, MAP kinase kinase activity, PDZ domain binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MAP2K2 itself. We selected most functions MAP2K2 had, and list some proteins which have the same functions with MAP2K2. You can find most of the proteins on our site.

    Function Related Protein
    ATP binding MERTK; KIF25; ATP2B1; FGR; PANK1B; MCMDC2; RAF1B; EGFR; VRK2; PMVK
    MAP kinase kinase activity MAP2K2A; SBK3; MAP2K2B; MAP3K9; LRRK2; MAP3K20; MAPK14; MAP2K2; MAP2K6; PAK3
    PDZ domain binding GRIK2; LIN7C; GRM7; TGFBR3; PARK2; CADM1; ERC1; ARHGEF16; PTENA; SSTR2
    metal ion binding PRKRIR; SP3A; MBNL1; ZBTB26; GNAQ; ZBTB25; Amy1; ZNF800B; TRIM2A; MUT
    protein binding GSTK1; CCNF; HIST1H3C; NR2F2; ATE1; FAM131B; BTRC; YWHAE; ZNF473; C22orf28
    protein complex scaffold ISCU; MPP7; AKAP1; MAGI1B; TELO2; CNOT1; SLC9A3R2; DISC1; AKAP6; ITSN1
    protein serine/threonine kinase activator activity STRADA; IGF2; CALM3; CDK5R1; ALS2; STK3; PARP16; MAP2K1; STK4; CALM1
    protein serine/threonine kinase activity SIK2A; MAP3K12; PLK1; CSNK1DA; ACVR1; SMG1; TSSK6; ZAK; GM711; CSNK1G2B
    protein serine/threonine/tyrosine kinase activity RPS6KB1; AURKC; RPS6KA2; SGK1; CLK1; DYRK2; MAP2K1; AURKA; DYRK1B; TTK
    protein tyrosine kinase activity JAK2A; YES1; EPHA2A; NTRK3A; DYRK1A; JAK3; BMX; TTK; EPHB4A; EPHB4B
    scaffold protein binding CACNA1H; KRT15; CRIPT; GRIN2A; TREM2; PARK7; CACNA1G; IKBKB; KRT8; SCN5A

    MAP2K2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MAP2K2 here. Most of them are supplied by our site. Hope this information will be useful for your research of MAP2K2.

    ARAF; RAF1; BRAF; CCNDBP1; COPS5

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