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Official Full Name MAP2K2 mitogen-activated protein kinase kinase 2
Background MEK (MAP Kinase Kinase) phosphorylates the MAP Kinase on both threonine and tyrosine residues of the activation motif TEY. MEK1 and MEK2 are activated by phosphorylation of two serine residues (Ser 218/222 in MEK1 and Ser 222/226 in MEK2). These phosphorylation sites are substrates of the Raf family of kinases.
Synonyms MAP2K2; mitogen-activated protein kinase kinase 2; PRKMK2; dual specificity mitogen-activated protein kinase kinase 2; MEK2; MAPK/ERK kinase 2; MAP kinase kinase 2; ERK activator kinase 2; mitogen-activated protein kinase kinase 2, p45; MKK2; MAPKK2; FLJ26075;
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rat
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Insect Cell
    • Mammalian Cell
    • Sf9 Insect Cell
    • Tag :
    • GST
    • His
    • MBP
    • Myc/DDK
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human MAP2K2-1316H Recombinant Human Mitogen-Activated Protein Kinase Kinase 2, His-tagged E.coli His
    Human MAP2K2-15860H Recombinant Human MAP2K2, His-tagged E.coli His
    Human MAP2K2-253H Recombinant Human MAP2K2 Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human MAP2K2-29202TH Recombinant Human MAP2K2 N/A
    Human MAP2K2-301H Recombinant Human MAP2K2 protein, His/MBP-tagged E.coli His/MBP
    Human MAP2K2-302H Recombinant Human MAP2K2 protein, His/MBP-tagged E.coli His/MBP
    Human MAP2K2-350H Recombinant Human MAP2K2, GST-tagged, Active Sf9 Insect Cell GST
    Human MAP2K2-4024H Recombinant Human MAP2K2 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human MAP2K2-613HCL Recombinant Human MAP2K2 cell lysate Insect Cell N/A
    Human MAP2K2-968H Recombinant Human MAP2K2, GST tagged Insect Cell GST
    Mouse Map2k2-3921M Recombinant Mouse Map2k2 Protein, Myc/DDK-tagged HEK293T Myc/DDK
    Mouse Map2k2-8085M Recombinant Mouse Map2k2 protein, His-tagged E.coli His
    Rat MAP2K2-3560R Recombinant Rat MAP2K2 Protein Mammalian Cell His
    Chicken MAP2K2-6940C Recombinant Chicken MAP2K2 Mammalian Cell His

    map2k2 involved in several pathways and played different roles in them. We selected most pathways map2k2 participated on our site, such as MAPK signaling pathway, ErbB signaling pathway, Ras signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with map2k2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    MAPK signaling pathway MAP2K2; MAPK14B; CACNB2; MAP2K2A; CACNA1BA; GNA12; PPP3R1; MAPK11; TGFB1; MAP2K5
    ErbB signaling pathway NRG2; GRB2A; PAK2; PAK2A; PTK2; NCK2A; PIK3CD; GSK3B; PAK7; AKT2
    Ras signaling pathway FGF10; PIK3CD; GRB2; PDGFRA; EFNA4; MRAS; FGF14; RASSF1; REL; GRIN2B
    Rap signaling pathway MAPK11; RAP1GAP; FGF1; Pdgfa&Pdgfb; VEGFC; PFN1; BCAR1; DOCK4; PARD6A; ITGB1
    cGMP-PKG signaling pathway RGS2; BDKRB2; KCNJ8; CALM1; PIK3R2; ATP1B2; CALM3; PDE2A; PLN; PRKG2
    cAMP signaling pathway BDNF; CALM2; RAF1; BAD; ARAP3; NFATC1; SUCNR1; AKT1; PTGER2; RAC2
    HIF- signaling pathway RBX1; PIK3R5; PIK3R2; NOX3; TLR4; AKT2; PIK3CB; MTOR; EP300; PDK1
    FoxO signaling pathway PIK3CB; NLK1; RAF1; MAPK10; PDPK1; MAPK9; CDKN2B; TGFBR1; CDKN1BB; FOXO1
    Sphingolipid signaling pathway RELA; BCL2; GNAI3; LASS4; TRP53; S1PR2; NOS3; SPTLC2; MAP3K5; RAF1
    Phospholipase D signaling pathway AVP; SHC1; GRM7; PIP5K1B; PIP5K1A; PIK3R2; GRM4; PIK3CG; KIT; INS
    PIK-Akt signaling pathway LAMC2; CCNE1; TCL1B; IL7; VEGFB; FGFR2; PKN1; GYS1; VEGFA; PPP2CA
    Vascular smooth muscle contraction AVPR1A; PRKCQ; ADORA2AA; PRKACB; GNA13A; PRKACA; CALD1B; ARHGEF12; NPR1; CALML5
    VEGF signaling pathway MAPK12A; PTGS2; SHC2; AKT1; PIK3CA; MAPK14A; PRKCBA; RAC1; SPHK2; MAP2K2A
    Gap junction Adcy4; PDGFAA; DRD2L; TUBA3C; DRD2B; ADCY1A; ITPR3; MAP3K2; GRB2A; PRKCB
    Signaling pathways regulating pluripotency of stem cells APC; AKT2; IGF1; ID1; PCGF5; FZD1; AXIN1; ACVR1B; FGFR4; LHX5
    Toll-like receptor signaling pathway MAPK1; PIK3R3; IKBKE; RAC1A; TLR4BB; SPP1; IRF5; IFNA16; IFNA13; PIK3R3A
    Natural killer cell mediated cytotoxicity KLRC1; KLRK1; GM-CSF; TNFSF10; FYN; BRAF; FCGR3A; Casp3; CD247; PTPN11
    T cell receptor signaling pathway IL4; IKBKG; RHOA; NFATC2; CD3D; PIK3R3; AKT2; FYN; MAP3K7; MAP2K1
    B cell receptor signaling pathway BCL10; CDK6; IKBKB; ARPC3; RAF1; CDK4; MAPK4; PPP3R2; INPPL1; PTPN18
    Fc epsilon RI signaling pathway PIK3CG; PIK3R1; PRKCA; MAP2K4; GAB2; PLA2G4D; PLA2G4F; GRB2; FCER1A; MAP2K6
    Long-term potentiation PRKACG; HRAS; PLCB2; CALM2; EP300; ITPR1; GRIN1; MAPK1; PPP1CC; MAPK3
    Neurotrophin signaling pathway MAP2K5; MAPK3; PIK3CB; GRB2; PIK3CD; NFKBIE; RPS6KA1; CAMK2B; CALM4; ARHGDIA
    Long-term depression GUCY1B3; GRIA1; IGF1; PLCB3; ITPR3; GNAO1; PLCB4; PRKCG; PRKCB; CRHR1
    Regulation of actin cytoskeleton PAK7; FGF11A; ROCK2; RAC1; PFN2L; MAP2K2; PIK3R3B; RAC3A; ARPC5LB; FGF8
    Insulin signaling pathway PPP1CAB; IKBKB; TRIP10; CALM3; SOCS2; RHOQ; FBP2; AKT3A; EIF4EA; PRKACBB
    GnRH signaling pathway PRKCDA; MAP2K2A; CAMK2B; CALM3A; PRKCB; PRKCD; MAP3K3; SRC; CALM1A; MAP2K4
    Estrogen signaling pathway PIK3R3; PLCB4; GNAI1; MMP2; CREB5; MAPK3; CALML3; GPR30; HSP90B1; GNAI3
    Melanogenesis GNAI2; PLCB3; CALM2A; WNT3A; CREB3L1; GNAO1A; TCF7L2; CALM4; WNT8B; RAF1
    Prolactin signaling pathway SIRPA; SOCS1; SHC1; SOCS4; GALT; SOCS3; HRAS; MAP2K1; ELF5; NEK3
    Thyroid hormone signaling pathway MTOR; MED17; ITGB3; ATP1B4; SLCO1C1; ATP2A2; RAF1; HIF1A; PDPK1; MED13
    Oxytocin signaling pathway CAMK1G; KRAS; CAMKK1; MYL6B; GNAQ; ELK1; CCND1; CACNA2D4; PRKAA1; RYR2
    Prion diseases IL1B; NCAM1; PRKACA; C8G; C1QB; PRNP; Hc; MAPK1; CASP12; ELK1
    Hepatitis B MAPK8; TLR3; NRAS; APAF1; CREB5; IRF7; IFNA7; SMAD3; STAT1; EP300
    Influenza A NLRP3; H2-AB1; CYCS; IFN-a; H2-AA; EIF2AK4; TNFRSF10C; MAPK3; IFNG; IL8L1
    Pathways in cancer GNG5; TP53; WNT16; BIRC3; FGF17; SMAD3; FGF22; PTEN; PTGER3; NKX3-1
    Proteoglycans in cancer SOS1; ACTB; FZD1; FAS; CD63; TGFB2; RDX; SLC9A1; FZD7; PIK3R3
    MicroRNAs in cancer SPRY2; PLAU; ZFPM2; DNMT3B; PTEN; ATM; CD44; MTOR; MARCKS; RDX
    Renal cell carcinoma SOS1; PDGFB; EP300; RAP1A; TCEB2; CDC42; PIK3R1; HIF1A; BRAF; NRAS
    Endometrial cancer PIK3CD; ILK; ARAF; RAF1; ERBB2; GRB2; TP53; PIK3R1; TRP53; ELK1
    Glioma PRKCA; PIK3R3; MAP2K1; AKT2; MDM2; MAPK1; IGF1R; CALM4; Pdgfa&Pdgfb; TRP53
    Prostate cancer SOS1; TGFA; PDGFD; HSP90AA1; PIK3R1; INS1; PIK3CD; INS; GSTP1; CCNE1
    Thyroid cancer MAPK1; TPR; TFG; CDH1; MAP2K2; CCDC6; NRAS; LEF1; TCF7L2; MAP2K1
    Melanoma FGF21; PIK3CA; MITF; FGF13; FGF4; RB1; PDGFRA; PDGFA; FGF12; HGF
    Bladder cancer RAF1; RB1; DAPK3; RASSF1; MMP1; CDK4; DAPK1; IL-8; RPS6KA5; CDH1
    Chronic myeloid leukemia GAB2; CTBP2; IKBKG; KRAS; SMAD4; NRAS; CBLB; MECOM; MDM2; MAPK1
    Acute myeloid leukemia PIK3CB; PIK3R2; LEF1; RELA; NFKB1; TCF7L2; CHUK; STAT5A; PML; RUNX1
    Non-small cell lung cancer CASP9; PIK3CG; PIK3R2; RARB; BAD; STK4; RXRG; MAPK1; HRAS; PLCG2
    Central carbon metabolism in cancer SCO2; SLC2A2; MAP2K1; ERBB2; GLS; KRAS; PIK3CA; HRAS; PIK3R1; IDH1
    Choline metabolism in cancer PIK3R5; Pdgfa&Pdgfb; PDGFD; PPAP2A; SLC44A2; EIF4EBP1; PLA2G4C; RAC1; WASF1; WASF2

    map2k2 has several biochemical functions, for example, ATP binding, MAP kinase kinase activity, PDZ domain binding. Some of the functions are cooperated with other proteins, some of the functions could acted by map2k2 itself. We selected most functions map2k2 had, and list some proteins which have the same functions with map2k2. You can find most of the proteins on our site.

    Function Related Protein
    MAP kinase kinase activity MAP2K2A; MAP2K3; MAP2K2B; MAP2K1; MAP3K20; MAPK10; SBK3; MAP2K7; MAP2K2; MAP3K14
    PDZ domain binding SRR; ADRB1; DLC; CIT; ACOX1; SLC9A3; LRP2; ATP2B1; KIDINS220; GRIA1
    metal ion binding SMYD2A; ZFP143; PDLIM3B; ZNHIT6; TNFRSF11A; PTGS2; NUDT11; GNA15; STEAP1; ZNF726
    protein binding TMEM86B; MLLT1; TTC19; ARMC8; PPIL3; SSX2; C1GALT1C1; TLX2; CCDC94; C9orf116
    protein complex scaffold DLG1; ARRB2; MAP2K2; TELO2; MAGI3; GNB2L1; CAV2; WWC3; SLC9A1; MPP7
    protein serine/threonine kinase activator activity CALM2; FAM20A; PARP16; MAP2K1; ALS2; STK4; MAP2K2; STRADA; CALM1; CALM3
    protein serine/threonine kinase activity SBK3; MOS; MAPKAPK2; TRIO; GM4922; HUNK; ACVR2AA; NEK8; ACVR2B; OXSR1B
    protein serine/threonine/tyrosine kinase activity TESK2; AURKB; AKT1; DYRK4; DYRK1B; TNK2; RPS6KA2; DYRK3; RPS6KB1; CLK4
    protein tyrosine kinase activity EPHA2A; DYRK3; KITA; WEE2; TTK; EPHA4B; FGFR3; DYRK1A; LYN; FER
    scaffold protein binding SHANK1; CRIPT; NLGN4Y; CACNA1H; TREM2; KRT18; CAV2; KRT15; LRP4; ADCY6

    map2k2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with map2k2 here. Most of them are supplied by our site. Hope this information will be useful for your research of map2k2.


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