MAP3K4 involved in several pathways and played different roles in them. We selected most pathways MAP3K4 participated on our site, such as MAPK signaling pathway, GnRH signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with MAP3K4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name |
Pathway Related Protein |
| MAPK signaling pathway |
ARR3A; MAPK1; ATF4B1; ECSIT; TRAF2; FGF8; FGFR1; ARRB2A; RPS6KA3B; BRAF |
| GnRH signaling pathway |
CGNRH-R; PRKCBA; MAPK1; MAPK10; PLCB2; GNRHR1; MAPK9; GNA15.1; MAPK14B; MAPK12A |
MAP3K4 has several biochemical functions, for example, ATP binding, MAP kinase kinase kinase activity, kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by MAP3K4 itself. We selected most functions MAP3K4 had, and list some proteins which have the same functions with MAP3K4. You can find most of the proteins on our site.
| Function |
Related Protein |
| ATP binding |
UBA2; DDR2; DMPK; HSPE1; ATP6V1B2; TXK; SGK2B; TIMM44; CPS1; AXL |
| MAP kinase kinase kinase activity |
RAF1; MAP3K14; MAP3K2; ALPK2; ZAK; TAOK2; MAP3K1; KIAA1804; TAOK3; MAP3K12 |
| kinase activity |
AKT2L; FGFR1B; AKT1; CAMK2G1; CCL3; ACVR2AA; CKBA; WNK2; CDK5R1B; ITPK1A |
| metal ion binding |
SMPD4; LMO7B; MKRN4; KEX2; PAK3; ZNF443; ZBTB4; ZBED6; ZNF354A; DNMT3L |
| nucleotide binding |
RBM39B; INSRB; RPS24; CLK4B; SLKA; UMPS; HNRNPA1L2; CELF6; TGFBR1A; KDRL |
| protein binding |
HDAC3; SNRPD1; SRGAP2; BRD7; DMD; TAS2R16; LAPTM4B; ETS1; NEU4; CD72 |
| protein kinase activity |
NRBP2; STK24; INSRA; DYRK1B; ABL2; PDK2; GUCY2F; PTK2AB; KITB; CSNK1DB |
| protein serine/threonine kinase activity |
PSKH1; PHKG1A; NIM1; MAP2K2A; EIF2AK3; STK11; ULK1; MAPK8A; ATM; GRK7B |
| transferase activity |
PHKG1B; AKT2L; MGAT4C; BMPR1BB; PLAUB; LTK; CD38; SULT3ST3; ST3GAL2L; HS3ST3B1B |
MAP3K4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MAP3K4 here. Most of them are supplied by our site. Hope this information will be useful for your research of MAP3K4.
Aslani, F; Schuppe, HC; et al. Targeting high mobility group box protein 1 ameliorates testicular inflammation in experimental autoimmune orchitis. HUMAN REPRODUCTION 30:417-431(2015).
Chang, CH; Wang, Y; et al. Extensive crosslinking of CD22 by epratuzumab triggers BCR signaling and caspase-dependent apoptosis in human lymphoma cells. MABS 7:199-211(2015).
