MAP4K2

  • Official Full Name

    mitogen-activated protein kinase kinase kinase kinase 2

  • Overview

    The protein encoded by this gene is a member of the serine/threonine protein kinase family. Although this kinase is found in many tissues, its expression in lymphoid follicles is restricted to the cells of germinal centre, where it may participate in B-cell differentiation. This kinase can be activated by TNF-alpha, and has been shown to specifically activate MAP kinases. This kinase is also found to interact with TNF receptor-associated factor 2 (TRAF2), which is involved in the activation of MAP3K1/MEKK1.
  • Synonyms

    MAP4K2; mitogen-activated protein kinase kinase kinase kinase 2; RAB8IP; BL44; GCK; MEKKK 2; GC kinase; MEK kinase kinase 2; germinal center kinase; Rab8 interacting protein; rab8-interacting protein; MAPK/ERK kinase kinase kinase 2; germinal centre kinas;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Zebrafish
  • HEK293
  • HEK293T
  • Human
  • Insect (sf21)
  • Insect Cell
  • Mammalian Cell
  • GST
  • His
  • His (Fc)
  • Avi
  • His|GST
  • Myc
  • DDK
  • Myc|DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human MAP4K2-28743TH Recombinant Human MAP4K2 N/A
Human MAP4K2-1167H Recombinant Human MAP4K2, His & GST tagged Insect Cell His/GST
Human MAP4K2-934H Recombinant Human MAP4K2, GST-tagged Human GST
Human MAP4K2-1263H Recombinant Human Mitogen-Activated Protein Kinase Kinase Kinase Kinase 2, His-tagged Insect Cell His
Human MAP4K2-626HCL Recombinant Human MAP4K2 cell lysate Insect Cell N/A
Human MAP4K2-452H Recombinant Human MAP4K2 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human MAP4K2-9444HF Active Recombinant Full Length Human MAP4K2 Protein, GST-tagged Insect (sf21) GST
Human MAP4K2-387H Recombinant Human MAP4K2 Protein, MYC/DDK-tagged HEK293 Myc/DDK
Mouse MAP4K2-9521M Recombinant Mouse MAP4K2 Protein Mammalian Cell His
Mouse Map4k2-3933M Recombinant Mouse Map4k2 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse MAP4K2-5338M Recombinant Mouse MAP4K2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse MAP4K2-5338M-B Recombinant Mouse MAP4K2 Protein Pre-coupled Magnetic Beads HEK293
Zebrafish MAP4K2-3782Z Recombinant Zebrafish MAP4K2 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • MAP4K2 Related Articles

MAP4K2 involved in several pathways and played different roles in them. We selected most pathways MAP4K2 participated on our site, such as MAPK signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with MAP4K2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
MAPK signaling pathwayNTF4;TAB2;MAPK10;MAP2K5;PRKACBB;ACVR1C;FGF18;DUSP16;ELK4

MAP4K2 has several biochemical functions, for example, ATP binding, MAP kinase kinase kinase kinase activity, mitogen-activated protein kinase kinase kinase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MAP4K2 itself. We selected most functions MAP4K2 had, and list some proteins which have the same functions with MAP4K2. You can find most of the proteins on our site.

Function Related Protein
ATP bindingDDX55;RPS6KA3;PRKACBB;TNK2;ERBB2;TGFBR2;CDK20;ADCY8;UPF1
MAP kinase kinase kinase kinase activityALPK2;MAP4K5;MAP4K6;MAP4K3;MAP4K1;MAP4K2
mitogen-activated protein kinase kinase kinase bindingPPEF2;MAPK8IP3;MAP2K1;MAPK9;TCF3;MAP3K11;MAPK1;CDC42;DUSP19
protein bindingXPO7;RECQL4;TNFAIP8L2;DNAJB9;SRPK3;JAG2;CALB1;MORN2;OGT
protein serine/threonine kinase activityTESK1;PAK2B;CSNK1E;PRKCHA;MAP3K12;NUAK1;RAF1;BMPR2A;PRKACBA

MAP4K2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MAP4K2 here. Most of them are supplied by our site. Hope this information will be useful for your research of MAP4K2.

POT1; saicar; PKM; HSP90AB1; MAP3K1; MAP3K11; Map3k1; NACAD; XRCC6; HNRNPA2B1; SERPINA4; DEFB1; PRDX4; SNRNP35; linkable pd173955 analogue; bosutinib; imatinib; dasatinib

Tan, L; Nomanbhoy, T; et al. Discovery of Type II Inhibitors of TGF beta-Activated Kinase 1 (TAK1) and Mitogen-Activated Protein Kinase Kinase Kinase Kinase 2 (MAP4K2). JOURNAL OF MEDICINAL CHEMISTRY 58:183-196(2015).
Lau, KS; Zhang, TH; et al. BAY61-3606 Affects the Viability of Colon Cancer Cells in a Genotype-Directed Manner. PLOS ONE 7:-(2012).
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