MAP4K2 Protein


Home / Products / MAP4K2


Official Full Name mitogen-activated protein kinase kinase kinase kinase 2
Background The protein encoded by this gene is a member of the serine/threonine protein kinase family. Although this kinase is found in many tissues, its expression in lymphoid follicles is restricted to the cells of germinal centre, where it may participate in B-cell differentiation. This kinase can be activated by TNF-alpha, and has been shown to specifically activate MAP kinases. This kinase is also found to interact with TNF receptor-associated factor 2 (TRAF2), which is involved in the activation of MAP3K1/MEKK1.
Synonyms MAP4K2; mitogen-activated protein kinase kinase kinase kinase 2; RAB8IP; BL44; GCK; MEKKK 2; GC kinase; MEK kinase kinase 2; germinal center kinase; Rab8 interacting protein; rab8-interacting protein; MAPK/ERK kinase kinase kinase 2; germinal centre kinas
    • Species :
    • Human
    • Mouse
    • Zebrafish
    • Source :
    • HEK293
    • HEK293T
    • Human
    • Insect (sf21)
    • Insect Cell
    • Mammalian Cell
    • Tag :
    • GST
    • His
    • Myc/DDK
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human MAP4K2-1167H Recombinant Human MAP4K2, His & GST tagged Insect Cell His/GST
    Human MAP4K2-1263H Recombinant Human Mitogen-Activated Protein Kinase Kinase Kinase Kinase 2, His-tagged Insect Cell His
    Human MAP4K2-28743TH Recombinant Human MAP4K2 N/A
    Human MAP4K2-934H Recombinant Human MAP4K2, GST-tagged Human GST
    Mouse MAP4K2-9521M Recombinant Mouse MAP4K2 Protein Mammalian Cell His
    Zebrafish MAP4K2-3782Z Recombinant Zebrafish MAP4K2 Mammalian Cell His
    Human MAP4K2-626HCL Recombinant Human MAP4K2 cell lysate Insect Cell N/A
    Human MAP4K2-9444HF Recombinant Full Length Human MAP4K2 Protein, GST-tagged Insect (sf21) GST
    Human MAP4K2-387H Recombinant Human MAP4K2 Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human MAP4K2-452H Recombinant Human MAP4K2 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Mouse Map4k2-3933M Recombinant Mouse Map4k2 Protein, Myc/DDK-tagged HEK293T Myc/DDK

    MAP4K2 involved in several pathways and played different roles in them. We selected most pathways MAP4K2 participated on our site, such as MAPK signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with MAP4K2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    MAPK signaling pathway MAP4K3; CACNG8; FGF2; TGFBR1A; FLNC; MAP2K2; ELK1; FGF11; TGFBR1B; MAP2K5

    MAP4K2 has several biochemical functions, for example, ATP binding, MAP kinase kinase kinase kinase activity, mitogen-activated protein kinase kinase kinase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MAP4K2 itself. We selected most functions MAP4K2 had, and list some proteins which have the same functions with MAP4K2. You can find most of the proteins on our site.

    Function Related Protein
    MAP kinase kinase kinase kinase activity ALPK2; MAP4K3; MAP4K6; MAP4K5; MAP4K2; MAP4K1
    mitogen-activated protein kinase kinase kinase binding MAPK8IP3; STK38; MARVELD3; DUSP19; PPEF2; CDC42; MAP3K11; TCF3; MAPK9; TRAF2
    protein binding C9orf100; GTF3C4; HM13; KIAA1958; LZTFL1; PEX1; HDAC7A; MSN; MYL6; TPRKB
    protein serine/threonine kinase activity ALPK2; MAP2K3; TP53RK; OXSR1A; PSKH1; CPNE3; MAP2K4; IRAK3; STK39; LRRK2

    MAP4K2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MAP4K2 here. Most of them are supplied by our site. Hope this information will be useful for your research of MAP4K2.

    POT1; saicar; PKM; HSP90AB1; MAP3K1; MAP3K11; Map3k1; NACAD; XRCC6; HNRNPA2B1; SERPINA4; DEFB1; PRDX4; SNRNP35; linkable pd173955 analogue; bosutinib; imatinib; dasatinib

    Tan, L; Nomanbhoy, T; et al. Discovery of Type II Inhibitors of TGF beta-Activated Kinase 1 (TAK1) and Mitogen-Activated Protein Kinase Kinase Kinase Kinase 2 (MAP4K2). JOURNAL OF MEDICINAL CHEMISTRY 58:183-196(2015).
    Lau, KS; Zhang, TH; et al. BAY61-3606 Affects the Viability of Colon Cancer Cells in a Genotype-Directed Manner. PLOS ONE 7:-(2012).

    Q&As (0)

    Ask a Question for All BRAF Products

    Required fields are marked with *

    • Verification Code

    Related Services & Products

    Apply For A Coupon

    $50 OFF Your First Purchase

    Apply For a Coupon

    Enter your email here to subscribe.

    creative biomart inc.

    Easy access to products and services you need from our library via powerful searching tools.

    Follow Us

    Copyright © 2023 Creative BioMart. All Rights Reserved. Terms and Conditions | Privacy Policy