Recombinant Human MAP4K2, GST-tagged

Cat.No. : MAP4K2-934H
Product Overview : Recombinant full-length human MAP4K2 was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag
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Cat. No. : MAP4K2-934H
Description : MAP4K2 is a serine/threonine protein kinase that is activated by TNFμ and interacts with the TNF receptor-associated factor 2 (TRAF2). MAP4K2 is upstream of MAP kinases and particularly activates the SAPK pathway . Although MAP4K2 is found in many tissues, its expression in lymphoid follicles is restricted to the cells of germinal centre, where it may participate in B-cell differentiation. A mouse protein Rab8ip that has high homology to MAP4K2 can interact with the vesicular transport protein Rab8. Based on its interaction with Rab8, it is postulated that Rab8ip/MAP4K2 may modulate secretion in response to stress stimuli .
Expression System : Sf9 insect cells using baculovirus
Species : Human
Sequence : Full-length
Purity : >80%
Concentration : 0.1ug/ul
Applications : Kinase Assay, Western Blot
Molecular Weight : ~125 kDa
Storage : Store product at -70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Gene Name : MAP4K2 mitogen-activated protein kinase kinase kinase kinase 2 [ Homo sapiens ]
Official Symbol : MAP4K2
Synonyms : mitogen-activated protein kinase kinase kinase kinase 2; MAPK/ERK kinase kinase kinase 2; GCK; MEK kinase kinase 2; RAB8IP; MEKKK 2; BL44; EC; B lymphocyte serine/threonine-protein kinase; B lymphocyte serine/threonine protein kinase; Germinal center kinase; germinal centre kinase (GC kinase); Rab8-interacting protein; Rab8 interacting protein; GC kinase
Gene ID : 5871
mRNA Refseq : NM_004579
Protein Refseq : NP_004570
MIM : 603166
UniProt ID : Q12851
Chromosome Location : 11q13
Pathway : Insulin Signaling; organism-specific biosystem; MAPK signaling pathway; conserved biosystem; TNF receptor signaling pathway
Function : ATP binding; mitogen-activated protein kinase kinase kinase binding; nucleotide binding; protein binding; protein serine/threonine kinase activity; small GTPase regulator activity

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.


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