Recombinant Human MAP4K2, GST-tagged

• Cat.No.: MAP4K2-934H
• Product Overview: Recombinant full-length human MAP4K2 was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag

Specification

• Species: Human
• Source: Human
• Tag: GST
• Description: MAP4K2 is a serine/threonine protein kinase that is activated by TNFμ and interacts with the TNF receptor-associated factor 2 (TRAF2). MAP4K2 is upstream of MAP kinases and particularly activates the SAPK pathway . Although MAP4K2 is found in many tissues, its expression in lymphoid follicles is restricted to the cells of germinal centre, where it may participate in B-cell differentiation. A mouse protein Rab8ip that has high homology to MAP4K2 can interact with the vesicular transport protein Rab8. Based on its interaction with Rab8, it is postulated that Rab8ip/MAP4K2 may modulate secretion in response to stress stimuli .
• Expression System: Sf9 insect cells using baculovirus
• Sequence: Full-length
• Purity: >80%
• Concentration: 0.1ug/ul
• Applications: Kinase Assay, Western Blot
• Molecular Weight: ~125 kDa
• Storage: Store product at -70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Gene Information

• Gene Name: MAP4K2 mitogen-activated protein kinase kinase kinase kinase 2 [ Homo sapiens ]
• Official Symbol: MAP4K2
• Synonyms: mitogen-activated protein kinase kinase kinase kinase 2; MAPK/ERK kinase kinase kinase 2; GCK; MEK kinase kinase 2; RAB8IP; MEKKK 2; BL44; EC 2.7.11.1; B lymphocyte serine/threonine-protein kinase; B lymphocyte serine/threonine protein kinase; Germinal center kinase; germinal centre kinase (GC kinase); Rab8-interacting protein; Rab8 interacting protein; GC kinase
• Gene ID: 5871
• mRNA Refseq: NM_004579
• Protein Refseq: NP_004570
• MIM: 603166
• UniProt ID: Q12851
• Chromosome Location: 11q13
• Pathway: Insulin Signaling; organism-specific biosystem; MAPK signaling pathway; conserved biosystem; TNF receptor signaling pathway
• Function: ATP binding; mitogen-activated protein kinase kinase kinase binding; nucleotide binding; protein binding; protein serine/threonine kinase activity; small GTPase regulator activity