Recombinant Human MAP4K2, GST-tagged
| Cat.No. : | MAP4K2-934H |
| Product Overview : | Recombinant full-length human MAP4K2 was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag |
- Specification
- Gene Information
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| Cat. No. : | MAP4K2-934H |
| Description : | MAP4K2 is a serine/threonine protein kinase that is activated by TNFμ and interacts with the TNF receptor-associated factor 2 (TRAF2). MAP4K2 is upstream of MAP kinases and particularly activates the SAPK pathway . Although MAP4K2 is found in many tissues, its expression in lymphoid follicles is restricted to the cells of germinal centre, where it may participate in B-cell differentiation. A mouse protein Rab8ip that has high homology to MAP4K2 can interact with the vesicular transport protein Rab8. Based on its interaction with Rab8, it is postulated that Rab8ip/MAP4K2 may modulate secretion in response to stress stimuli . |
| Expression System : | Sf9 insect cells using baculovirus |
| Species : | Human |
| Sequence : | Full-length |
| Purity : | >80% |
| Concentration : | 0.1ug/ul |
| Applications : | Kinase Assay, Western Blot |
| Molecular Weight : | ~125 kDa |
| Storage : | Store product at -70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles. |
| Gene Name : | MAP4K2 mitogen-activated protein kinase kinase kinase kinase 2 [ Homo sapiens ] |
| Official Symbol : | MAP4K2 |
| Synonyms : | mitogen-activated protein kinase kinase kinase kinase 2; MAPK/ERK kinase kinase kinase 2; GCK; MEK kinase kinase 2; RAB8IP; MEKKK 2; BL44; EC 2.7.11.1; B lymphocyte serine/threonine-protein kinase; B lymphocyte serine/threonine protein kinase; Germinal center kinase; germinal centre kinase (GC kinase); Rab8-interacting protein; Rab8 interacting protein; GC kinase |
| Gene ID : | 5871 |
| mRNA Refseq : | NM_004579 |
| Protein Refseq : | NP_004570 |
| MIM : | 603166 |
| UniProt ID : | Q12851 |
| Chromosome Location : | 11q13 |
| Pathway : | Insulin Signaling; organism-specific biosystem; MAPK signaling pathway; conserved biosystem; TNF receptor signaling pathway |
| Function : | ATP binding; mitogen-activated protein kinase kinase kinase binding; nucleotide binding; protein binding; protein serine/threonine kinase activity; small GTPase regulator activity |
Products Types
| ◆ Recombinant Protein | ||
| Map4k2-3933M | Recombinant Mouse Map4k2 Protein, Myc/DDK-tagged | +Inquiry |
| MAP4K2-5338M | Recombinant Mouse MAP4K2 Protein, His (Fc)-Avi-tagged | +Inquiry |
| MAP4K2-387H | Recombinant Human MAP4K2 Protein, MYC/DDK-tagged | +Inquiry |
| MAP4K2-28743TH | Recombinant Human MAP4K2 | +Inquiry |
| MAP4K2-1167H | Recombinant Human MAP4K2, His & GST tagged | +Inquiry |
| ◆ Lysates | ||
| MAP4K2-626HCL | Recombinant Human MAP4K2 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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