Recombinant Mouse Map4k2 Protein, Myc/DDK-tagged
| Cat.No. : | Map4k2-3933M |
| Product Overview : | Purified recombinant protein of mouse full-length mitogen-activated protein kinase kinase kinase kinase 2 (Map4k2), with C-terminal MYC/DDK tag, expressed in HEK293T cells. |
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- Gene Information
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| Description : | Serine/threonine-protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Acts as a MAPK kinase kinase kinase (MAP4K) and is an upstream activator of the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway and to a lesser extent of the p38 MAPKs signaling pathway. Required for the efficient activation of JNKs by TRAF6-dependent stimuli, including pathogen-associated molecular patterns (PAMPs) such as polyinosine-polycytidine (poly(IC)), lipopolysaccharides (LPS), lipid A, peptidoglycan (PGN), or bacterial flagellin. To a lesser degree, IL-1 and engagement of CD40 also stimulate MAP4K2-mediated JNKs activation. The requirement for MAP4K2/GCK is most pronounced for LPS signaling, and extends to LPS stimulation of c-Jun phosphorylation and induction of IL-8. Enhances MAP3K1 oligomerization, which may relieve N-terminal mediated MAP3K1 autoinhibition and lead to activation following autophosphorylation. Mediates also the SAP/JNK signaling pathway and the p38 MAPKs signaling pathway through activation of the MAP3Ks MAP3K10/MLK2 and MAP3K11/MLK3. May play a role in the regulation of vesicle targeting or fusion. |
| Source : | HEK293T |
| Species : | Mouse |
| Tag : | Myc/DDK |
| Molecular Mass : | 91.7 kDa |
| Purity : | > 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : | Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
| Storage : | Store at -80 centigrade after receiving vials. |
| Concentration : | >50 μg/mL as determined by microplate BCA method |
| Storage Buffer : | 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol. |
| Gene Name : | Map4k2 mitogen-activated protein kinase kinase kinase kinase 2 [ Mus musculus (house mouse) ] |
| Official Symbol : | Map4k2 |
| Synonyms : | MAP4K2; mitogen-activated protein kinase kinase kinase kinase 2; MEKKK 2; MEK kinase kinase 2; germinal center kinase; RAB8 interacting protein; rab8-interacting protein; MAPK/ERK kinase kinase kinase 2; mitogen activated protein kinase kinase kinase kinase 2; GCK; BL44; Rab8ip; AI385662; MGC143893; MGC143894 |
| Gene ID : | 26412 |
| mRNA Refseq : | NM_009006 |
| Protein Refseq : | NP_033032 |
| UniProt ID : | Q61161 |
Products Types
| ◆ Recombinant Protein | ||
| MAP4K2-5338M | Recombinant Mouse MAP4K2 Protein, His (Fc)-Avi-tagged | +Inquiry |
| MAP4K2-387H | Recombinant Human MAP4K2 Protein, MYC/DDK-tagged | +Inquiry |
| MAP4K2-3782Z | Recombinant Zebrafish MAP4K2 | +Inquiry |
| MAP4K2-1167H | Recombinant Human MAP4K2, His & GST tagged | +Inquiry |
| MAP4K2-9521M | Recombinant Mouse MAP4K2 Protein | +Inquiry |
| ◆ Lysates | ||
| MAP4K2-626HCL | Recombinant Human MAP4K2 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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