Recombinant Human MAP4K2 Protein, Myc/DDK-tagged, C13 and N15-labeled

Cat.No. : MAP4K2-452H
Product Overview : MAP4K2 MS Standard C13 and N15-labeled recombinant protein (NP_004570) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells.
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Description : The protein encoded by this gene is a member of the serine/threonine protein kinase family. Although this kinase is found in many tissues, its expression in lymphoid follicles is restricted to the cells of germinal centre, where it may participate in B-cell differentiation. This kinase can be activated by TNF-alpha, and has been shown to specifically activate MAP kinases. This kinase is also found to interact with TNF receptor-associated factor 2 (TRAF2), which is involved in the activation of MAP3K1/MEKK1. Alternative splicing results in multiple transcript variants.
Source : HEK293
Species : Human
Tag : Myc/DDK
Molecular Mass : 91.4 kDa
AA Sequence : MALLRDVSLQDPRDRFELLQRVGAG TYGDVYKARDTVTSELAAVKIVKLD PGDDISSLQQEITILRECRHPNVVA YIGSYLRNDRLWICMEFCGGGSLQE IYHATGPLEERQIAYVCREALKGLH HLHSQGKIHRDIKGANLLLTLQGDV KLADFGVSGELTASVAKRRSFIGTP YWMAPEVAAVERKGGYNELCDVWAL GITAIELGELQPPLFHLHPMRALML MSKSSFQPPKLRDKTRWTQNFHHFL KLALTKNPKKRPTAEKLLQHPFTTQ QLPRALLTQLLDKASDPHLGTPSPE DCELETYDMFPDTIHSRGQHGPAER TPSEIQFHQVKFGAPRRKETDPLNE PWEEEWTLLGKEELSGSLLQSVQEA LEERSLTIRSASEFQELDSPDDTMG TIKRAPFLGPLPTDPPAEEPLSSPP GTLPPPPSGPNSSPLLPTAWATMKQ REDPERSSCHGLPPTPKVHMGACFS KVFNGCPLRIHAAVTWIHPVTRDQF LVVGAEEGIYTLNLHELHEDTLEKL ISHRCSWLYCVNNVLLSLSGKSTHI WAHDLPGLFEQRRLQQQVPLSIPTN RLTQRIIPRRFALSTKIPDTKGCLQ CRVVRNPYTGATFLLAALPTSLLLL QWYEPLQKFLLLKNFSSPLPSPAGM LEPLVLDGKELPQVCVGAEGPEGPG CRVLFHVLPLEAGLTPDILIPPEGI PGSAQQVIQVDRDTILVSFERCVRI VNMQGEPTATLAPELTFDFPIETVV CLQDSVLAFWSHGMQGRSLDTNEVT QEITDETRIFRVLGAHRDIILESIP TDNPEAHSNLYILTGHQSTYTRTRP LEQKLISEEDLAANDILDYKDDDDK V
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Stability : Stable for 3 months from receipt of products under proper storage and handling conditions.
Storage : Store at -80 centigrade. Avoid repeated freeze-thaw cycles.
Concentration : 50 μg/mL as determined by BCA
Storage Buffer : 100 mM glycine, 25 mM Tris-HCl, pH 7.3.
SDS-PAGE:
Gene Name : MAP4K2 mitogen-activated protein kinase kinase kinase kinase 2 [ Homo sapiens (human) ]
Official Symbol : MAP4K2
Synonyms : MAP4K2; mitogen-activated protein kinase kinase kinase kinase 2; RAB8IP; BL44; GCK; MEKKK 2; GC kinase; MEK kinase kinase 2; germinal center kinase; Rab8 interacting protein; rab8-interacting protein; MAPK/ERK kinase kinase kinase 2; germinal centre kinase (GC kinase); B lymphocyte serine/threonine protein kinase; b lymphocyte serine/threonine-protein kinase;
Gene ID : 5871
mRNA Refseq : NM_004579
Protein Refseq : NP_004570
MIM : 603166
UniProt ID : Q12851

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