Recombinant Human Mitogen-Activated Protein Kinase Kinase Kinase Kinase 2, His-tagged

• Cat.No.: MAP4K2-1263H
• Product Overview: Recombinant human full length MAP4K2,His-tagged is expressed in Insect cells.

Specification

• Cat. No.: MAP4K2-1263H
• Description: MAP4K2 is an enzymethat in humans is encoded by the MAP4K2 gene. The protein encoded by thisgene is a member of the serine/threonine protein kinase family. Although thiskinase is found in many tissues, its expression in lymphoid follicles isrestricted to the cells of germinal centre, where it may participate inB-cell differentiation. This kinase can be activated by TNF-alpha, and hasbeen shown to specifically activate MAP kinases. This kinase is also found tointeract with TNF receptor-associated factor 2 (TRAF2), which is involved inthe activation of MAP3K1/MEKK1.
• Source: Insect cells
• Species: Human
• Form: Liquid in50 mM Tris, pH 7.5 + 150 mM NaCl + 0.5 mM EDTA + 0.02% Triton X-100 + 2 mMDTT + 50% glycerol.
• Molecular Weight: 95.6 kDa
• Concentration: 0.42mg/ml
• Specific Activity: 728 nmole of phosphate transferred tomyelin basic protein (MBP) per minute per mg of total protein at 30°C.Activity determined at a final protein concentration of 3.33 μg/ml.
• Storage: Stablefor 6 months in working aliquots at -80°C. Avoid repeated freeze-thaw cycles.
• OfficialSymbol: MAP4K2
• Function: ATP binding; mitogen-activatedprotein kinase kinase kinase binding; nucleotide binding; protein serine/tyreoninekinase activity; protein binding; small GTPase regulator activity

Gene Information

• Gene Name: MAP4K2 mitogen-activated protein kinase kinase kinase kinase2 [ Homo sapiens ]
• Synonyms: MAP4K2; mitogen-activated protein kinasekinase kinase kinase 2; RAB8IP; BL44; GCK; OTTHUMP00000042793; OTTHUMP00000069727;OTTHUMP00000069728; OTTHUMP00000199616; OTTHUMP00000199613; OTTHUMP00000199614;OTTHUMP00000199615; EC 2.7.11.1; B lymphocyte serine/threonine-protein kinase;Germinal center kinase; GC kinase; MAPK/ERK kinase kinase 2; MEK kinasekinase 2; MEKKK2; Rab8-interacting protein; B lymphocyte serine/threonine proteinkinase; germinal centre kinase (GC kinase); EC 2.7.11; Rab8 interactingprotein; Germinal centre kinase
• Gene ID: 5871
• mRNA Refseq: NM_004579
• Protein Refseq: NP_004570
• MIM: 603166
• UniProt ID: Q12851
• Chromosome Location: 11q13.1
• Pathway: MAPK signalingpathway; InsulinSignaling; TNF receptor signaling pathway