MAPK13

  • Official Full Name

    mitogen-activated protein kinase 13

  • Overview

    The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is closely related to p38 MAP kinase, both of which can be activated by proinflammatory cytokines and cellular stress. MAP kinase kinases 3, and 6 can phosphorylate and activate this kinase. Transcription factor ATF2, and microtubule dynamics regulator stathmin have been shown to be the substrates of this kinase.
  • Synonyms

    MAPK13; mitogen-activated protein kinase 13; PRKM13; p38delta; SAPK4; MAPK 13; MAP kinase 13; MAP kinase p38 delta; stress-activated protein kinase 4; mitogen-activated protein kinase p38 delta; MGC99536;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Human
  • Mouse
  • E.coli
  • HEK293
  • HEK293T
  • Human
  • Insect Cell
  • Insect Cells
  • Sf9 Insect Cell
  • GST
  • His
  • SUMO
  • Myc
  • DDK
  • Myc|DDK
  • N/A
  • N
  • No tag
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human MAPK13-357H Active Recombinant Human MAPK13 protein, GST-tagged Insect Cells GST Met1-Leu365
Human MAPK13-374H Recombinant Human MAPK13, GST-tagged, Active Sf9 Insect Cell GST
Human MAPK13-48H Recombinant Human MAPK13, GST-tagged Sf9 Insect Cell GST
Human MAPK13-31379TH Recombinant Human MAPK13, His-tagged E.coli His 365 amino acids
Human MAPK13-737H Recombinant Human Mitogen-activated Protein Kinase 13 E.coli N/A
Human MAPK13-945H Recombinant Human MAPK13 protein, GST-tagged Insect Cells GST Met1-Leu365
Human MAPK13-1285H Recombinant Human Mitogen-Activated Protein Kinase 13, His-tagged Human His
Human MAPK13-31H Recombinant human biotinylated MAPK13, His-tagged E.coli His
Human MAPK13-31380TH Recombinant Human MAPK13 N/A
Human MAPK13-574HCL Recombinant Human MAPK13 cell lysate Insect Cell N/A
Human MAPK13-4999H Recombinant Human MAPK13 Protein (Tyr25-Phe308), N-His tagged E.coli N-His Tyr25-Phe308
Human MAPK13-383H Recombinant Human MAPK13 Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human MAPK13-2436H Recombinant Human MAPK13 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human MAPK13-1089H Recombinant Human MAPK13 Protein (S2-L365), GST tagged Insect Cell GST S2-L365
Human MAPK13-3205H Recombinant Human MAPK13 protein, His-SUMO-tagged E.coli His-SUMO 1-365aa
Human MAPK13-1297HF Active Recombinant Full Length Human MAPK13 Protein, GST-tagged E.coli GST 1-365
Human MAPK13-1088H Recombinant Human MAPK13 Protein (S2-L365), Tag Free Insect Cell No tag S2-L365
Mouse Mapk13-3940M Recombinant Mouse Mapk13 Protein, Myc/DDK-tagged HEK293T Myc/DDK
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource
  • MAPK13 Related Signal Pathway

MAPK13 involved in several pathways and played different roles in them. We selected most pathways MAPK13 participated on our site, such as MAPK signaling pathway, Rap signaling pathway, FoxO signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with MAPK13 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
MAPK signaling pathwayFGF13B;NFKB2;MAP2K7;FLNA;NFATC3;PLA2G4AA;BDNF;MAP2K4A;MAP3K2
Rap signaling pathwayRHOA;FGF4;PDGFD;FGF20;FGFR2;PLCB2;ANGPT2;PLCE1;CALM1
FoxO signaling pathwayTGFB1A;TGFBR1;GADD45B;MAPK12B;PRKAB2;IRS2;FOXG1;PRKAA1;BCL6A
Sphingolipid signaling pathwayRELA;SGMS2;MS4A2;MAP2K1;PIK3CD;SPHK1;SGPP1;ROCK2;PRKCZ
Adrenergic signaling in cardiomyocytesFXYD2;CACNA1D;PRKACAA;TNNC1;SCN1BA;SCN1B;CACNG8;TNNT2A;ATP1A4
VEGF signaling pathwayAKT2;VEGFA;PRKCBB;MAPK14A;MAP2K2;PTK2;PLA2G4A;HRASB;PPP3R1
Osteoclast differentiationPIK3R1;CYBB;PIK3CB;FCGR3A;PIK3R5;IFNGR1;IFNGR2;FCGR3B;IFNAR1
Signaling pathways regulating pluripotency of stem cellsPCGF5;TBX3;ACVR2A;WNT6;STAT3;BMP2;KRAS;GRB2;AXIN2
Platelet activationPLCB2;PRKCI;GNAI3;GNAI1;GP1BB;F2RL3;ITGA2B;FYN;BTK
Toll-like receptor signaling pathwayCD14;IFNA12;IFNA2;MAPK12;MYD88;CCL4L1;MAP2K2;PIK3CD;RAC1
NOD-like receptor signaling pathwayBIRC3;HSP90AA1.1;SUGT1;CXCL1;IL8L2;IL8L1;PSTPIP1;MAP3K7;CARD18
RIG-I-like receptor signaling pathwayDDX3;FADD;NLRX1;IKBKG;IFNA14;CASP8;IFNA10;IFNE;IFNA3
T cell receptor signaling pathwayIl2;NFKBIB;MAPK9;CARD11;MAP3K7;PPP3CA;CD8A;MAP2K1;NFATC2
Fc epsilon RI signaling pathwayMAPK11;PLA2G4F;PLCG2;LYN;MAPK3;PIK3R3;VAV2;HRAS;MAPK10
TNF signaling pathwayITCH;MAP2K7;TRAF1;ATF4;RIPK1;DNM1L;MAP2K4;MAP3K7IP3;CASP8
Leukocyte transendothelial migrationRAP1B;CLDN6;PXN;BCAR1;PIK3R2;CLDN5;ROCK1;CD99;ARHGAP35
Neurotrophin signaling pathwayNTF4;ATF4;CALM1;RPS6KA6;PLCG1;GAB1;CALML3;CALML5;NFKB1
Retrograde endocannabinoid signalingGNB1;MAPK1;GABRA4;GABRB1;SLC17A8;GNB2;ITPR3;GABRP;MAPK8
Dopaminergic synapsePPP2CA;AKT2;GNG4;KIF5B;GNG7;PPP2R2B;PPP1CB;KCNJ9;PRKCG
Inflammatory mediator regulation of TRP channelsTRPM8;HTR2B;CYP2C70;TRPV1;PIK3R1;ACCN4;PPP1CB;BDKRB1;ASIC3
GnRH signaling pathwayMMP14A;CACNA1DA;GRB2;GNRHR;PRKCB;MAPK13;MAP2K6;RAF1B;CAMK2B1
Progesterone-mediated oocyte maturationPRKACB;ANAPC13;RPS6KA6;CDC25A;PIK3R2;PIK3R3A;AKT2L;PDE3B;INSB
Prolactin signaling pathwaySTAT5B;PIK3R2;INS2;AKT2;SOCS6;MAPK11;GALT;PRL;PPIB
Amyotrophic lateral sclerosis (ALS)MAPK14;ALS2;TNFRSF1B;BID;PPP3R2;GRIA2;MAP3K5;NEFM;TOMM40L
Epithelial cell signaling in Helicobacter pylori infectionATP6V1F;TCIRG1;NOD1;ATP6V1D;RELA;MAP3K14;MAPK11;ATP6V0B;ATP6V0D1
ShigellosisATG5;PFN1;ACTG1;IKBKG;U2AF1L4;MAPK12;WAS;ITGB1;BTRC
Salmonella infectionMAPK10;DYNC1I2A;MAPK8;WASF1;IFNGR1;PFN2L;CASPA;PFN2;PKN1
PertussisC5;Il23a;C4BPB;CASP1;CALM4;ITGA5;CXCL6;TNF;FOS
LeishmaniasisPTPN6;MARCKSL1;FCGR3A;HLA-DQA1;TNF;ITGB1;NFKBIB;MAPK1;FOS
Chagas disease (American trypanosomiasis)NFKB1;RELA;C1QC;GNAO1;MYD88;SERPINE1;C1QA;CFLAR;GNAI2
ToxoplasmosisITGA6;LDLR;Toxoplasma Gondii Microneme Protein MIC3;MAPK12;PIK3CA;CD40;LAMB1;TNFRSF1A;HLA-DMA
TuberculosisPPP3R1;TLR4;CD14;CD209B;CALM4;APAF1;FCGR3A;IL10RA;IFNA6
Hepatitis CSTAT2;OCLN;TNFRSF1A;OAS3;CLDN23;IFNA7;IRF9;OAS2;PDPK1
Influenza ANXF3;PIK3CA;SOCS3;HSPA1B;IFNA8;PABPN1;IFNGR1;MAP2K6;AKT2
Epstein-Barr virus infectionTRADD;HLA-DRA;POLR2H;POLR3E;HLA-DRB3;Fcer2a;POLR2J2;NEDD4;MDM2
Proteoglycans in cancerANK1;CCND1;PRKACB;TGFB1;IGF2;ITGA5;CAMK2G;AKT2;PLCG1

MAPK13 has several biochemical functions, for example, ATP binding, MAP kinase activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MAPK13 itself. We selected most functions MAPK13 had, and list some proteins which have the same functions with MAPK13. You can find most of the proteins on our site.

Function Related Protein
ATP bindingSGK3;ABCB9;HIPK3B;ATP6V1A;CSNK1DA;KIFC2;LONP1;ATAD3A;DMC1
MAP kinase activityMAPK8B;MAPK14A;MAPK15;MAPK6;MAPK12B;MAPK12A;MAPK3;MAPK14B;NLK2
protein bindingPAXIP1;FAM124B;SLC39A13;FOSL1;WHRN;BLOC1S6;DTX3;DPM2;PC
protein serine/threonine kinase activityIRAK4;CAMKK1B;ACVR2AA;PIM1;TGFBR1;SPEG;SRPK2;GSK3A;SRPK1

MAPK13 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MAPK13 here. Most of them are supplied by our site. Hope this information will be useful for your research of MAPK13.

PRKD1; FPR1; saicar; PKM; ATF2; MAPKAPK3; Pkd1; MAP3K4; GPX4; SMAD4; ANKLE2; AKIP1; pi3p

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