MAPK13
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Official Full Name
mitogen-activated protein kinase 13
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Background
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is closely related to p38 MAP kinase, both of which can be activated by proinflammatory cytokines and cellular stress. MAP kinase kinases 3, and 6 can phosphorylate and activate this kinase. Transcription factor ATF2, and microtubule dynamics regulator stathmin have been shown to be the substrates of this kinase. -
Synonyms
MAPK13; mitogen-activated protein kinase 13; PRKM13; p38delta; SAPK4; MAPK 13; MAP kinase 13; MAP kinase p38 delta; stress-activated protein kinase 4; mitogen-activated protein kinase p38 delta; MGC99536;
- Involved Pathway
- Protein Function
- Interacting Protein
- MAPK13 Related Research Area
- MAPK13 Related Signal Pathway
MAPK13 involved in several pathways and played different roles in them. We selected most pathways MAPK13 participated on our site, such as MAPK signaling pathway, Rap signaling pathway, FoxO signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with MAPK13 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| MAPK signaling pathway | Fasl;MAPK8;RASGRP3;NTRK1;MAPK6;FGF8;TRAF2;PPM1B;MAPK3 |
| Rap signaling pathway | HRAS;ARAP3;VAV2;ITGA2B;KITLG;PRKCB;PIK3CD;RAP1GAP;PGF |
| FoxO signaling pathway | ATM;ARAF;HOMER1B;AGAP2;RAG2;PRKAB2;AKT2L;MAPK3;FOXO3B |
| Sphingolipid signaling pathway | S1PR4;LASS1;MAPK13;RAC1;PPP2R2A;CERS2;PIK3CA;CERS5;MAPK10 |
| Adrenergic signaling in cardiomyocytes | PPP2R5EA;RAPGEF4;ATP2B1A;ATF4;PPP2R3A;PPP2R5E;CACNG2A;PPP1CB;PPP2R2CA |
| VEGF signaling pathway | VEGFA;MAP2K2A;RAF1B;MAP2K1;PRKCA;CDC42L2;SH2D2A;SRC;BADB |
| Osteoclast differentiation | TYK2;FOSB;TGFB2;CALCR;IL1A;NOX3;LILRB5;MAPK9;NCF2 |
| Signaling pathways regulating pluripotency of stem cells | INHBB;MAPK1;ACVR1B;ACVR1C;MAP2K1;PCGF3;MAP2K2;ZFHX3;WNT10B |
| Platelet activation | PLA2G4D;PPP1CC;ROCK1;ROCK2;BTK;PPP1R12A;NOS3;FGG;MYL12B |
| Toll-like receptor signaling pathway | TRAF6;RELA;MAPK9;CD86;NFKBIAA;CCL5;IFNA7;IL1B;TAB2 |
| NOD-like receptor signaling pathway | RIPK2;CASP5;MAP3K7;NAIP1;IKBKB;TAB3;TNF;CXCL2;CARD8 |
| RIG-I-like receptor signaling pathway | CXCL8B.3;NFKBIA;IFNA17;IL8L1;IL8L2;Ifna15;MAPK12B;MAPK13;DDX58 |
| T cell receptor signaling pathway | NCK1;LCP2;LAT;PAK7;IFNG;MAPK13;PLCG1;PAK6;CD3E |
| Fc epsilon RI signaling pathway | TNF;PLA2G4F;PLA2G4C;PIK3CG;FCER1A;PIK3R3;LCP2;MAPK9;PIK3R1 |
| TNF signaling pathway | PIK3R1;CX3CL1;BAG4;NFKBIA;FADD;NFKB1;CXCL10;CCL20;PGAM5 |
| Leukocyte transendothelial migration | CTNNA3;ROCK2;PECAM1;MYL5;JAM3;CLDN14;RAP1A;MMP9;ITGB2 |
| Neurotrophin signaling pathway | ARHGDIG;SHC1;IRS1;RAP1B;TP73;SHC3;PIK3CG;GAB1;CDC42 |
| Retrograde endocannabinoid signaling | GRIA4;MAPK9;GNAO1;GNG2;PRKCG;GNAI1;GABRG2;GNAI2;GABRG3 |
| Dopaminergic synapse | GRIA1;GNAI3;GNAQ;PPP2R5D;CREB3L1;GRIN2A;KIF5B;GSK3B;GNG5 |
| Inflammatory mediator regulation of TRP channels | PLCB3;PIK3R5;PPP1CB;PPP1CA;PTGER2;CALML5;TRPA1;F2RL1;PRKACA |
| GnRH signaling pathway | CALM2;PLCB3;GNA11B;MAP3K2;MAP2K2B;HRASB;PRKCDA;ITPR3;PRKCD |
| Progesterone-mediated oocyte maturation | RAF1A;CDC25B;ADCY1B;CDC16;PRKACB;ANAPC2;ANAPC13;RAF1B;PIK3CB |
| Prolactin signaling pathway | SOCS7;SOCS5;RAF1;MAPK12;PIK3CB;KRAS;NFKB1;SLC2A2;TH |
| Amyotrophic lateral sclerosis (ALS) | TOMM40;BAD;GRIN2C;GPX1;BAX;DAXX;GRIA2;TP53;MAP2K6 |
| Epithelial cell signaling in Helicobacter pylori infection | IKBKB;GIT1;MAPK9;CXCR2;MAPK11;IL-8;ATP6V0A2;CCL5;ATP6V0D1 |
| Shigellosis | CTTN;RAC1;RIPK2;MAPK13;ROCK1;ELMO2;IKBKB;RELA;PFN2 |
| Salmonella infection | FOS;IL8L2;NOS2B;MAPK12A;RAC1B;IFNGR2;RHOGC;CCL4;TLR5 |
| Pertussis | CALM2;C2;LY96;MAPK9;IRAK1;CASP7;IRF1;C4A;C1R |
| Leishmaniasis | CYBA;ITGB2;ITGB2L;TGFB2;MAPK3;ITGB1;STAT1;ITGA4;HLA-DPB1 |
| Chagas disease (American trypanosomiasis) | TNFRSF1A;PPP2R2D;GNA15;C1QC;CCL3;C1QA;PIK3CG;PIK3R2;C1QB |
| Toxoplasmosis | PIK3CD;PDPK1;HLA-DMA;PIK3CB;LDLR;MAPK8;HLA-DQA1;LAMB3;HLA-DRA |
| Tuberculosis | ATP6V0A1;MAPK10;VDR;KSR1;CALM1;Ifna11;BCL10;NOS2;HLA-DRB1 |
| Hepatitis C | CLDN11;CLDN16;KRAS;IRF3;OAS1;PPP2CB;CLDN10;CLDN23;TP53 |
| Influenza A | IL1A;HLA-DMB;RSAD2;NXT1;IL-8;IL18;NLRX1;HLA-DRB5;TMPRSS2 |
| Epstein-Barr virus infection | POLR2L;PSMD6;FGR;PSMD12;TRADD;HSPA1L;MAP3K7;HLA-DQA2;PSMC5 |
| Proteoglycans in cancer | SOS1;PPP1R12C;PTK2;MAPK11;IGF2;CDC42;FZD2;TWIST2;FGFR1 |
MAPK13 has several biochemical functions, for example, ATP binding, MAP kinase activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MAPK13 itself. We selected most functions MAPK13 had, and list some proteins which have the same functions with MAPK13. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ATP binding | CDK5;Acsm2a;YTHDC2;ATP1A3A;HYOU1;RET;FARSB;TESK2;ABCG3 |
| MAP kinase activity | MAPK15;MAPK6;MAPK12A;MAPK4;NLK;MAPK7;NLK1;MAPK14;MAPK8B |
| protein binding | HOXA1;CDC26;PLUNC;TTR;LONP1;PSEN1;IL5RA;ZUFSP;ZNF26 |
| protein serine/threonine kinase activity | GRK7B;PRKD2;SBK3;OXSR1A;MAPKAPK2;CDK14;PSKH1;CAMK2D1;MLKL |
MAPK13 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MAPK13 here. Most of them are supplied by our site. Hope this information will be useful for your research of MAPK13.
PRKD1; FPR1; saicar; PKM; ATF2; MAPKAPK3; Pkd1; MAP3K4; GPX4; SMAD4; ANKLE2; AKIP1; pi3p
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