| Official Full Name | malic enzyme 3, NADP(+)-dependent, mitochondrial |
| Background | Malic enzyme catalyzes the oxidative decarboxylation of malate to pyruvate using either NAD+ or NADP+ as a cofactor. Mammalian tissues contain 3 distinct isoforms of malic enzyme: a cytosolic NADP(+)-dependent isoform, a mitochondrial NADP(+)-dependent isoform, and a mitochondrial NAD(+)-dependent isoform. This gene encodes a mitochondrial NADP(+)-dependent isoform. Multiple alternatively spliced transcript variants have been found for this gene, but the biological validity of some variants has not been determined. |
| Synonyms | ME3; malic enzyme 3, NADP(+)-dependent, mitochondrial; NADP-dependent malic enzyme, mitochondrial; malate dehydrogenase; pyruvic-malic carboxylase; malic enzyme, NADP+-dependent, mitochondrial; mitochondrial NADP(+)-dependent malic enzyme 3; NADP-ME; FLJ3 |
| Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
|---|
me3 involved in several pathways and played different roles in them. We selected most pathways me3 participated on our site, such as Carbon metabolism, Metabolic pathways, Pyruvate metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with me3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Carbon metabolism | SDHDB; ALDOCA; ENO3; CPS1; H6PD; PC; GPIB; SDHB; ESD; PGAM2 |
| Metabolic pathways | EXT1B; ENPP1; ATP6V0D1; ATP6AP1; NME6; PPAP2B; ADSSL1; NDUFC2; ENO3; GOT2A |
| Pyruvate metabolism | BRP44; LDHBA; LDHAL6B; ALDH2; HAGHL; ACOT12; ALDH9A1; PCK1; MDH2; ACAT2 |
me3 has several biochemical functions, for example, NAD binding, cofactor binding, malate dehydrogenase (decarboxylating) (NAD+) activity. Some of the functions are cooperated with other proteins, some of the functions could acted by me3 itself. We selected most functions me3 had, and list some proteins which have the same functions with me3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| NAD binding | IDH3B; CTBP2L; CYB5R3; PARP1; LDHA; GPD1C; AOX3; IDH3A; NDUFV1; AOX1 |
| cofactor binding | TKT; BIRC5; HACL1; PAH; DDO; C3; DAO; TYMS; PGAM2; LMO2 |
| malate dehydrogenase (decarboxylating) (NAD+) activity | ME1; ME2; ME3 |
| malate dehydrogenase (decarboxylating) (NADP+) activity | ME1; ME3 |
| malic enzyme activity | ME3; ME2; ME1; MDH1 |
| metal ion binding | ABLIM1A; GTSF1L; PLA2G2F; ADH8A; CYP2AA12; ZC3H11A; PDE7B; KLF12B; PVALB7; CYP2K19 |
| oxaloacetate decarboxylase activity | ME2; ME3; ME1; FAHD1 |
me3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with me3 here. Most of them are supplied by our site. Hope this information will be useful for your research of me3.
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