me3 Protein, malic enzyme 3, NADP(+)-dependent, mitochondrial


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Official Full Name malic enzyme 3, NADP(+)-dependent, mitochondrial
Background Malic enzyme catalyzes the oxidative decarboxylation of malate to pyruvate using either NAD+ or NADP+ as a cofactor. Mammalian tissues contain 3 distinct isoforms of malic enzyme: a cytosolic NADP(+)-dependent isoform, a mitochondrial NADP(+)-dependent isoform, and a mitochondrial NAD(+)-dependent isoform. This gene encodes a mitochondrial NADP(+)-dependent isoform. Multiple alternatively spliced transcript variants have been found for this gene, but the biological validity of some variants has not been determined.
Synonyms ME3; malic enzyme 3, NADP(+)-dependent, mitochondrial; NADP-dependent malic enzyme, mitochondrial; malate dehydrogenase; pyruvic-malic carboxylase; malic enzyme, NADP+-dependent, mitochondrial; mitochondrial NADP(+)-dependent malic enzyme 3; NADP-ME; FLJ3
    • Species :
    • Human
    • Mouse
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • Mammalian Cell
    • Tag :
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human ME3-2413H Recombinant Human ME3 Protein (24-590 aa), His-tagged E.coli His
    Human ME3-4399HCL Recombinant Human ME3 293 Cell Lysate HEK293 N/A
    Mouse ME3-9673M Recombinant Mouse ME3 Protein Mammalian Cell His
    Zebrafish ME3-5511Z Recombinant Zebrafish ME3 Mammalian Cell His

    me3 involved in several pathways and played different roles in them. We selected most pathways me3 participated on our site, such as Carbon metabolism, Metabolic pathways, Pyruvate metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with me3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Carbon metabolism SDHDB; ALDOCA; ENO3; CPS1; H6PD; PC; GPIB; SDHB; ESD; PGAM2
    Metabolic pathways EXT1B; ENPP1; ATP6V0D1; ATP6AP1; NME6; PPAP2B; ADSSL1; NDUFC2; ENO3; GOT2A
    Pyruvate metabolism BRP44; LDHBA; LDHAL6B; ALDH2; HAGHL; ACOT12; ALDH9A1; PCK1; MDH2; ACAT2

    me3 has several biochemical functions, for example, NAD binding, cofactor binding, malate dehydrogenase (decarboxylating) (NAD+) activity. Some of the functions are cooperated with other proteins, some of the functions could acted by me3 itself. We selected most functions me3 had, and list some proteins which have the same functions with me3. You can find most of the proteins on our site.

    Function Related Protein
    cofactor binding TKT; BIRC5; HACL1; PAH; DDO; C3; DAO; TYMS; PGAM2; LMO2
    malate dehydrogenase (decarboxylating) (NAD+) activity ME1; ME2; ME3
    malate dehydrogenase (decarboxylating) (NADP+) activity ME1; ME3
    malic enzyme activity ME3; ME2; ME1; MDH1
    metal ion binding ABLIM1A; GTSF1L; PLA2G2F; ADH8A; CYP2AA12; ZC3H11A; PDE7B; KLF12B; PVALB7; CYP2K19
    oxaloacetate decarboxylase activity ME2; ME3; ME1; FAHD1

    me3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with me3 here. Most of them are supplied by our site. Hope this information will be useful for your research of me3.

    Karimi-Aghcheh, R; Bok, JW; et al. Functional Analyses of Trichoderma reesei LAE1 Reveal Conserved and Contrasting Roles of This Regulator. G3-GENES GENOMES GENETICS 3:369-378(2013).
    Barnetova, I; Vackova, I; et al. Dynamics of epigenetic remodeling in interspecies porcine zygotes. CZECH JOURNAL OF ANIMAL SCIENCE 57:83-94(2012).

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