ME3

  • Official Full Name

    malic enzyme 3, NADP(+)-dependent, mitochondrial

  • Overview

    Malic enzyme catalyzes the oxidative decarboxylation of malate to pyruvate using either NAD+ or NADP+ as a cofactor. Mammalian tissues contain 3 distinct isoforms of malic enzyme: a cytosolic NADP(+)-dependent isoform, a mitochondrial NADP(+)-dependent isoform, and a mitochondrial NAD(+)-dependent isoform. This gene encodes a mitochondrial NADP(+)-dependent isoform. Multiple alternatively spliced transcript variants have been found for this gene, but the biological validity of some variants has not been determined.

  • Synonyms

    ME3;malic enzyme 3, NADP(+)-dependent, mitochondrial;NADP-dependent malic enzyme, mitochondrial;malate dehydrogenase;pyruvic-malic carboxylase;malic enzyme, NADP+-dependent, mitochondrial;mitochondrial NADP(+)-dependent malic enzyme 3;NADP-ME;FLJ3

Recombinant Proteins

  • Human
  • Zebrafish
  • Mouse
  • E.coli
  • Mammalian Cells
  • HEK293
  • His
  • Non
  • Avi
  • Fc
Cat.# Product name Source (Host) Species Tag Protein Length Price
ME3-22H Recombinant Human ME3 Protein, His tagged E.coli Human His
ME3-5511Z Recombinant Zebrafish ME3 Mammalian Cells Zebrafish His
ME3-9673M Recombinant Mouse ME3 Protein Mammalian Cells Mouse His
ME3-4399HCL Recombinant Human ME3 293 Cell Lysate HEK293 Human Non
ME3-20H Recombinant Human ME3 Protein, C-6×His tagged E.coli Human His
ME3-2413H Recombinant Human ME3 Protein (24-590 aa), His-tagged E.coli Human His 24-590 aa
ME3-42H Recombinant Human ME3 Protein E.coli Human
ME3-5437M Recombinant Mouse ME3 Protein, His (Fc)-Avi-tagged HEK293 Mouse Avi&Fc&His
ME3-5437M-B Recombinant Mouse ME3 Protein Pre-coupled Magnetic Beads HEK293 Mouse

    Involved Pathway

    ME3 involved in several pathways and played different roles in them. We selected most pathways ME3 participated on our site, such as Carbon metabolism,Metabolic pathways,Pyruvate metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with ME3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Metabolic pathways CYP3A7-CYP3AP1,G6PCA.2,PLCE1,CD38,CYP4F14,CYP4A10,AMDHD1,GLS,ADC,B4GALNT1
    Carbon metabolism SHMT2,RPE,SDHC,ACSS2,PFKMB,TKT,GPIB,ACSS1,FBP1A,HK3
    Pyruvate metabolism MDH1,ACACB,PDP1,PKM,ACOT12,HAGHL,ALDH7A1,PDHA1A,GRHPRA,ACSS2L

    Protein Function

    ME3 has several biochemical functions, for example, NAD binding,cofactor binding,malate dehydrogenase (decarboxylating) (NAD+) activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ME3 itself. We selected most functions ME3 had, and list some proteins which have the same functions with ME3. You can find most of the proteins on our site.

    Function Related Protein
    cofactor binding WWOX,ACLYA,HIF1AN,ASNS,TYMS,LMO2,HACL1,TKT,PAH,PGAM2
    metal ion binding TESK1,TPH1A,RSAD1,RASA4,STEAP3,ZDHHC20A,FBXO40.1,ZXDB,ITGA1,BMX
    malate dehydrogenase (decarboxylating) (NADP+) activity ME1
    malate dehydrogenase (decarboxylating) (NAD+) activity ME2,ME1
    NAD binding ME1,GAPDHS,GRHPRB,GLYR1,AOX4,ME2,HSD3B4,DLD,PARP1,HIBADHB
    malic enzyme activity MDH1,ME1,ME2
    oxaloacetate decarboxylase activity ME1,ME2,FAHD1

    Interacting Protein

    ME3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ME3 here. Most of them are supplied by our site. Hope this information will be useful for your research of ME3.

    Resources

    References

    • Karimi-Aghcheh, R; Bok, JW; et al. Functional Analyses of Trichoderma reesei LAE1 Reveal Conserved and Contrasting Roles of This Regulator. G3-GENES GENOMES GENETICS 3:369-378(2013).
    • Barnetova, I; Vackova, I; et al. Dynamics of epigenetic remodeling in interspecies porcine zygotes. CZECH JOURNAL OF ANIMAL SCIENCE 57:83-94(2012).

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