mgmt
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  • Official Full Name
  • O-6-methylguanine-DNA methyltransferase
  • Background
  • MGMT (O6 methylguanine DNA methyltransferase) is an enzyme that transfers methyl groups from O(6) methylguanine, and other methylated moities of DNA, to a cysteine residue in itself, thus repairing DNA damage caused by alkylation in a single step reaction. This is a suicide reaction as the enzyme is irreversibly inactivated. MGMT prevents mutagenesis and malignant transformation, and also provides resistance to chemotherapy with alkylating agents among cancer patients.
  • Synonyms
  • MGMT; O-6-methylguanine-DNA methyltransferase; methylated-DNA--protein-cysteine methyltransferase; methylguanine-DNA methyltransferase; O-6-methylguanine-DNA-alkyltransferase; O6-methylguanine-DNA methyltransferase; 6-O-methylguanine-DNA methyltransferase;
Cat.#:MGMT-1238HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human MGMT Protein, MYC/DDK-tagged
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Cat.#:MGMT-5304HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human MGMT Protein, GST-tagged
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Cat.#:MGMT-121HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human O-6-methylguanine-DNA Methyltransferase, His-tagged
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Cat.#:MGMT-28449THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MGMT protein, His-tagged
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Cat.#:MGMT-6958HTag:His
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human MGMT, His-tagged
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Cat.#:MGMT-9817MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse MGMT Protein
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Cat.#:Mgmt-2125RTag:His/GST
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Mgmt protein, His & GST-tagged
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Cat.#:MGMT-3674RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat MGMT Protein
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Cat.#:MGMT-2764RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey MGMT Protein, His-tagged
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Cat.#:MGMT-8138ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish MGMT
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Cat.#:MGMT-814HTag:T7
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human O-6-methylguanine-DNA Methyltransferase, T7-tagged
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Cat.#:MGMT-1109HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human MGMT cell lysate
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Involved Pathway

MGMT involved in several pathways and played different roles in them. We selected most pathways MGMT participated on our site, such as DNA Damage Reversal, DNA Repair, MGMT-mediated DNA damage reversal, which may be useful for your reference. Also, other proteins which involved in the same pathway with MGMT were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
DNA Damage Reversal
MGMT; ASCC2; ASCC3; ALKBH2; ASCC1; ALKBH3
DNA Repair
APITD1; PAXIP1; USP45; CHEK1; ASCC2; COPS8; GPS1; COPS3; USP43A; HUS1
MGMT-mediated DNA damage reversal
MGMT

Protein Function

MGMT has several biochemical functions, for example, DNA binding, DNA-methyltransferase activity, calcium ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MGMT itself. We selected most functions MGMT had, and list some proteins which have the same functions with MGMT. You can find most of the proteins on our site.
Function
Related Protein
Function DNA binding
Related Protein ZNF189; MIXL1; PQBP1; CEBPZ; RAD51D; TET2; MSXD; OLIG3; BBX; GTF2F2A
Function DNA-methyltransferase activity
Related Protein DNMT3AB; DNMT4; NDUFAF5; MGMT; METTL21A; RNMTL1B; DIMT1; PRDM13; PRDM11; RNMTL1A
Function calcium ion binding
Related Protein FBN1; MELK; PLA2G2F; FKBP7; PLCZ1; PLSCR4; DSG1A; THBS3; S100A10A; PON1
Function damaged DNA binding
Related Protein RBBP8; MPG; FEN1; NEIL2; DCLRE1C; TDG; TRP53; POLB; TP63; XRCC5
Function methylated-DNA-[protein]-cysteine S-methyltransferase activity
Related Protein MGMT
Function methyltransferase activity
Related Protein KIAA1456; TOMT; METTL17; SETDB1B; NSUN5; DIMT1; PRMT1; TRMT10B; PRDM6; PRMT10

Interacting Protein

MGMT has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MGMT here. Most of them are supplied by our site. Hope this information will be useful for your research of MGMT.
q81u00_bacan; ssdna_dcdgm

MGMT Related Articles

Stark, AM; Doukas, A; et al. Expression of DNA mismatch repair proteins MLH1, MSH2, and MSH6 in recurrent glioblastoma. NEUROLOGICAL RESEARCH 37:95-105(2015).
Olah, Z; Kalman, J; et al. Proteomic Analysis of Cerebrospinal Fluid in Alzheimer's Disease: Wanted Dead or Alive. JOURNAL OF ALZHEIMERS DISEASE 44:1303-1312(2015).