MGMT

  • Official Full Name

    O-6-methylguanine-DNA methyltransferase

  • Overview

    MGMT (O6 methylguanine DNA methyltransferase) is an enzyme that transfers methyl groups from O(6) methylguanine, and other methylated moities of DNA, to a cysteine residue in itself, thus repairing DNA damage caused by alkylation in a single step reaction. This is a suicide reaction as the enzyme is irreversibly inactivated. MGMT prevents mutagenesis and malignant transformation, and also provides resistance to chemotherapy with alkylating agents among cancer patients.
  • Synonyms

    MGMT; O-6-methylguanine-DNA methyltransferase; methylated-DNA--protein-cysteine methyltransferase; methylguanine-DNA methyltransferase; O-6-methylguanine-DNA-alkyltransferase; O6-methylguanine-DNA methyltransferase; 6-O-methylguanine-DNA methyltransferase;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • Rhesus Macaque
  • Zebrafish
  • E. coli
  • E.coli
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mammalian Cell
  • Mammalian cells
  • Sf9 Insect Cell
  • Wheat Germ
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • Strep
  • His|GST
  • Myc
  • DDK
  • Myc|DDK
  • N/A
  • No tag
  • T7
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human MGMT-121H Recombinant Human O-6-methylguanine-DNA Methyltransferase, His-tagged E.coli His
Human MGMT-6958H Recombinant Human MGMT, His-tagged Sf9 Insect Cell His Full length
Human MGMT-28449TH Recombinant Human MGMT protein, His-tagged E.coli His
Human MGMT-814H Recombinant Human O-6-methylguanine-DNA Methyltransferase, T7-tagged E.coli T7
Human MGMT-1109HCL Recombinant Human MGMT cell lysate N/A
Human MGMT-0597H Recombinant Human MGMT Protein (M1-N207), Tag Free E.coli No tag M1-N207
Human MGMT-5304H Recombinant Human MGMT Protein, GST-tagged Wheat Germ GST
Human MGMT-004H Recombinant Human MGMT Protein, His-tagged E.coli His
Human MGMT-1238H Recombinant Human MGMT Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human MGMT-0598H Recombinant Human MGMT Protein (M1-N207), His/Strep tagged E.coli His/Strep M1-N207
Human MGMT-6517HF Recombinant Full Length Human MGMT Protein, GST-tagged In Vitro Cell Free System GST 207 amino acids
Human MGMT-1408H-B Recombinant Human MGMT Protein Pre-coupled Magnetic Beads HEK293
Human MGMT-075H Recombinant Human MGMT Protein, His-tagged E. coli His
Human MGMT-4546H Recombinant Human MGMT Protein (Met1-Asn207), His tagged E.coli His Met1-Asn207
Human MGMT-1344HFL Recombinant Full Length Human MGMT Protein, C-Flag-tagged Mammalian cells Flag
Human MGMT-1408H Recombinant Human MGMT Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse MGMT-9817M Recombinant Mouse MGMT Protein Mammalian Cell His
Mouse MGMT-5541M-B Recombinant Mouse MGMT Protein Pre-coupled Magnetic Beads HEK293
Mouse Mgmt-4062M Recombinant Mouse Mgmt Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse MGMT-5541M Recombinant Mouse MGMT Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat MGMT-3674R Recombinant Rat MGMT Protein Mammalian Cell His
Rat Mgmt-2125R Recombinant Rat Mgmt protein, His & GST-tagged E.coli His/GST Met1~Gly2097 (Accession # P24528)
Rat MGMT-3330R Recombinant Rat MGMT Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat MGMT-3330R-B Recombinant Rat MGMT Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque MGMT-2764R Recombinant Rhesus monkey MGMT Protein, His-tagged Mammalian Cell His
Rhesus Macaque MGMT-2585R-B Recombinant Rhesus Macaque MGMT Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque MGMT-2585R Recombinant Rhesus Macaque MGMT Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Zebrafish MGMT-8138Z Recombinant Zebrafish MGMT Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • MGMT Related Articles
  • MGMT Related Research Area

MGMT involved in several pathways and played different roles in them. We selected most pathways MGMT participated on our site, such as DNA Damage Reversal, DNA Repair, MGMT-mediated DNA damage reversal, which may be useful for your reference. Also, other proteins which involved in the same pathway with MGMT were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
DNA Damage ReversalASCC3;ALKBH2;ALKBH3;ASCC2;ASCC1;MGMT
DNA RepairRTEL1;INO80C;ASCC2;POLI;YY1;PPIE;CLSPN;TIMELESS;COPS3
MGMT-mediated DNA damage reversal

MGMT has several biochemical functions, for example, DNA binding, DNA-methyltransferase activity, calcium ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MGMT itself. We selected most functions MGMT had, and list some proteins which have the same functions with MGMT. You can find most of the proteins on our site.

Function Related Protein
DNA bindingZNF48;HOXB1A;ZNF367;POU3F2B;PROX1A;ZBTB25;TMF1;ZBP1;ZIM3
DNA-methyltransferase activityDIMT1;DNMT3AA;METTL7B;FAM86;RNMTL1A;MGMT;NDUFAF5;DNMT3AB;DNMT3B
calcium ion bindingS100A1;PCDHB10;S100A3;Npnt;EFHC2;CRELD2;EFCAB3;NCAN;ANXA5A
damaged DNA bindingTP63;POLI;FANCG;ERCC3;UNG;APEX1;TDG;MPG;APTX
methylated-DNA-[protein]-cysteine S-methyltransferase activity
methyltransferase activityC20orf7;PMT;ZCCHC4;TPMT.1;TRMT13;FAM86;METTL6;PRMT3;METTL4

MGMT has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MGMT here. Most of them are supplied by our site. Hope this information will be useful for your research of MGMT.

q81u00_bacan; ssdna_dcdgm

Stark, AM; Doukas, A; et al. Expression of DNA mismatch repair proteins MLH1, MSH2, and MSH6 in recurrent glioblastoma. NEUROLOGICAL RESEARCH 37:95-105(2015).
Olah, Z; Kalman, J; et al. Proteomic Analysis of Cerebrospinal Fluid in Alzheimer's Disease: Wanted Dead or Alive. JOURNAL OF ALZHEIMERS DISEASE 44:1303-1312(2015).
  • Q&As
  • Reviews

Q&As (5)

Ask a question
Can MGMT status be used to predict the response to other types of cancer treatments? 01/31/2022

Yes, MGMT status has implications beyond glioblastoma and can influence the response to various alkylating agents in different cancer types.

Can the MGMT protein be targeted for cancer prevention strategies? 03/24/2020

While direct targeting is challenging, understanding MGMT's role may lead to the development of preventive strategies, such as identifying high-risk individuals for regular screenings.

Is MGMT involved in resistance mechanisms to chemotherapy? 10/08/2018

Yes, MGMT expression can confer resistance to alkylating agents, making it an important factor in understanding and overcoming chemotherapy resistance.

How does MGMT repair DNA damage caused by environmental factors like radiation? 08/21/2018

MGMT repairs DNA damage by directly removing alkyl groups from the O6-position of guanine, which can be induced by exposure to radiation and certain chemicals.

How does MGMT status affect the choice of chemotherapy in glioblastoma patients? 04/25/2018

Glioblastoma patients with MGMT promoter methylation are more likely to benefit from alkylating agents like temozolomide.

Customer Reviews (3)

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Reviews
05/31/2021

    The MGMT protein is an exceptional protein solution that exceeds expectations in terms of quality and suitability for my experimental requirements.

    12/15/2018

      In addition to its outstanding quality, the MGMT protein comes with exceptional technical support from its manufacturer.

      03/07/2017

        I am confident that utilizing the MGMT protein will empower me to uncover crucial insights into cellular mechanisms with precision.

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