Recombinant Human O-6-methylguanine-DNA Methyltransferase, T7-tagged

• Cat.No.: MGMT-814H
• Product Overview: Recombinant MGMT protein, fused to T7-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques, 21646Da (207aa).

Specification

• Cat. No.: MGMT-814H
• Description: Methylated-DNA-protein-cysteine methyltransferase is an enzyme that in humans is encoded by the MGMT gene.
• Sequences of amino acids: MDKDCEMKRT TLDSPLGKLE LSGCEQGLHE IKLLGKGTSA ADAVEVPAPA AVLGGPEPLM QCTAWLNAYF HQPEAIEEEP VPALHHPVFQ QESFTRQVLW KLLKVVKFGE VISYQQLAAL AGNPKAARAV GGAMRGNPVP ILIPCHRVVC SSGAVGNYSG GLAVKEWLLA HEGHRLGKPG LGGSSGLAGA WLKGAGATSG SPPAGRN
• Formulation: 10 mM Tris. pH 8.0. 0.1% Triton X-100. 0.002% NaN3
• Purity: > 95% by SDS - PAGE
• Applications: MS. SDS

Gene Information

• Gene Name: MGMT O-6-methylguanine-DNA methyltransferase [Homo sapiens]
• Synonyms: MGMT; O-6-methylguanine-DNA methyltransferase; methylated-DNA-protein-cysteine methyltransferase; 6-O-methylguanine-DNA methyltransferase; methylguanine-DNA methyltransferase; O-6-methylguanine-DNA-alkyltransferase; EC2.1.1.63; O6-methylguanine-DNA methyltransferase
• Gene ID: 4255
• mRNA Refseq: NM_002412
• Protein Refseq: NP_002403
• MIM: 156569
• UniProt ID: P16455
• Chromosome Location: 10q26
• Pathway: Reactome Event: DNA Repair
• Function: DNA binding; DNA-methyltransferase activity; metal ion binding; methylated-DNA-[protein]-cystein S-methyltransferase activity; methyltransferase activity; transferase activity