MUC16

  • Official Full Name

    mucin 16, cell surface associated

  • Overview

    CA-125 (cancer antigen 125 or carbohydrate antigen 125) also known as mucin 16 or MUC16 is a protein that in humans is encoded by the MUC16 gene. MUC16 is a member of the mucin family glycoproteins. CA-125 has found application as a tumor marker or biomarker that may be elevated in the blood of some patients with specific types of cancers, or other benign conditions. MUC16 (CA125) is a serum marker that is used routinely in gynecologic practice to monitor patients with ovarian cancer. It is a mullerian duct differentiation antigen that is overexpressed in epithelial ovarian cancer cells and secreted into the blood, although its expression is not entirely confined to ovarian cancer. Most biochemical studies have concluded that MUC16 is a high molecular mass glycoprotein, although estimates of its size range from 200?to 2000?kDa with smaller “subunits” being described by some investigators.
  • Synonyms

    MUC16; mucin 16, cell surface associated; CA125; mucin-16; CA-125; MUC-16; CA125 ovarian cancer antigen; ovarian carcinoma antigen CA125; ovarian cancer-related tumor marker CA125; FLJ14303; Igovomab; Indimacis-125; 171656-50-1; Abagovomab; 792921-10-9;

  • Native Proteins
  • Recombinant Proteins
  • Human
  • Mouse
  • Rhesus macaque
  • CHO
  • E.coli
  • HEK293
  • HEK293 cells
  • Human Ascites Fluid
  • Human Cell
  • Insect Cell
  • Wheat Germ
  • Avi|Fc
  • C
  • Fc
  • Avi
  • His
  • Fc\Avi
  • GST
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human CDA002 Active Native Human MUC16 Protein Human Ascites Fluid N/A
Human MUC16-10H Recombinant Human MUC16 protein(Asp12783-Ser13467), His-tagged HEK293 C-His Asp12783-Ser13467
Human MUC16-1H Native Human MUC16 protein Human Ascites Fluid N/A
Human MUC16-9382H Recombinant Human MUC16 protein, His-tagged Insect Cell His
Human MUC16-42H Active Recombinant Human MUC16 Protein, His-tagged CHO His
Human MUC16-704H Recombinant Human MUC16 (Q72L) Protein, His-tagged E.coli His
Human MUC16-127H Recombinant Human MUC16 Protein, His-tagged E.coli His Arg21622~Ser21762
Human MUC16-02H Recombinant Human MUC16 Protein, His-tagged HEK293 His
Human MUC16-01H Recombinant Human MUC16 Protein, His tagged HEK293 His
Human MUC16-5333H Recombinant Human MUC16 Protein (13360-14347), His tagged E.coli His 13360-14347
Human MUC16-437H Recombinant Human MUC16 protein, His-Avi-tagged HEK293 His-Avi It contains Gly12660-Met12923.
Human MUC16-200H Recombinant Human MUC16 Protein, Fc\Avi-tagged Human Cell Fc\Avi
Human MUC16-1206H Recombinant Human MUC16 protein, His-tagged E.coli His 12660-12923aa
Human MUC16-5748H Recombinant Human MUC16 Protein, GST-tagged Wheat Germ GST
Human MUC16-1245H Recombinant Human MUC16 protein, His-tagged E.coli His Leu13633~His13754
Human MUC16-0066H Recombinant Human MUC16 Protein HEK293 cells
Human MUC16-0273H Active Recombinant Human MUC16 protein, His-tagged HEK293 His Pro13810-Pro14451
Human MUC16-43H Active Recombinant Human MUC16 Protein, Fc-Avi-tagged, Biotinylated HEK293 Avi/Fc
Human MUC16-5334H Recombinant Human MUC16 Protein (Met13360-Gln14347), N-His tagged E.coli N-His Met13360-Gln14347
Human MUC16-2978H Recombinant Human MUC16 protein, Fc-Avi-tagged, Biotinylated HEK293 Fc-Avi Pro 13810-Pro 14451
Human MUC16-030H Recombinant Human MUC16 Protein, Gly12660-Met12923, C-His-Avi tagged, Biotinylated HEK293 C-His-Avi Gly12660-Met12923
Human MUC16-28H Recombinant Human MUC16 Protein, C-Fc-Avi tagged, Biotinylated Human Cell C-Fc-Avi Gly12660-Met12923
Human MUC16-2979H Active Recombinant Human MUC16 protein, Fc-Avi-tagged, Biotinylated HEK293 Fc-Avi Gly 12660-Met 12923
Mouse Muc16-128M Recombinant Mouse Muc16 Protein, His-tagged E.coli His Thr2~Gln258
Rhesus macaque MUC16-2975R Active Recombinant Rhesus macaque MUC16 protein, His-tagged HEK293 His Gly 12664-Val 12920
Rhesus macaque MUC16-2977R Active Recombinant Rhesus macaque MUC16 protein, His-tagged HEK293 His Pro 13647-Pro 14291
  • Other Resource

MUC16 involved in several pathways and played different roles in them. We selected most pathways MUC16 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with MUC16 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein

MUC16 has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by MUC16 itself. We selected most functions MUC16 had, and list some proteins which have the same functions with MUC16. You can find most of the proteins on our site.

Function Related Protein

MUC16 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MUC16 here. Most of them are supplied by our site. Hope this information will be useful for your research of MUC16.

Research Area

Related articles

Sasaki, A; Akita, K; et al. Difference in mesothelin- binding ability of serum CA125 between patients with endometriosis and epithelial ovarian cancer. INTERNATIONAL JOURNAL OF CANCER 136:1985-1990(2015).
Ricardo, S; Marcos-Silva, L; et al. Detection of glyco-mucin profiles improves specificity of MUC16 and MUC1 biomarkers in ovarian serous tumours. MOLECULAR ONCOLOGY 9:503-512(2015).
  • Q&As
  • Reviews

Q&As (7)

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How does MUC16 interact with other components of the epithelial barrier and immune system? 10/15/2022

MUC16 works with other mucins and immune components to maintain epithelial barrier function and immune responses.

How does MUC16 contribute to the formation of the mucosal barrier? 10/12/2022

It aids in forming the mucosal barrier, protecting against pathogens and mechanical damage.

What potential therapeutic applications arise from targeting MUC16 in cancer treatment? 08/02/2021

Targeting MUC16 in cancer therapy, especially in ovarian cancer, could be effective in inhibiting tumor growth and spread.

What is the impact of altered MUC16 activity on inflammatory and infectious diseases? 03/15/2021

Altered MUC16 activity can impact the body's defense against inflammation and infection.

What is the primary role of MUC16 in epithelial cell function? 05/03/2020

MUC16, a mucin protein, is essential for maintaining the protective mucous layer on epithelial surfaces.

What role does MUC16 play in cancer, particularly ovarian cancer? 02/15/2018

MUC16 is associated with cancer progression, particularly in ovarian cancer, where it may facilitate tumor growth and metastasis.

How do genetic variations in MUC16 affect its function in mucosal protection and cancer development? 04/03/2017

Genetic variations in MUC16 can lead to differences in mucosal integrity and potentially influence cancer susceptibility.

Customer Reviews (3)

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07/28/2020

    Critical for decision-making. Supports our research endeavors.

    05/24/2018

      Expert service quality. Valuable for research integrity.

      06/05/2017

        Dependable partner in experiments. Consistent and trustworthy.

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