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Recombinant Human MUC16 protein, His-tagged

Cat.No. : MUC16-9382H
Product Overview : Recombinant Human MUC16(aa 12055-12535) fused with His tag was expressed in Insect cells.
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  • Gene Information
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Description : CA-125 is a tumor marker has been shown to be elevated in the blood of some patients with specific types of cancers, or other benign conditions. CA-125 is best known for its role as a biomarker for ovarian but elevated levels have also been associated with endometrial, fallopian tube, lung, breast, and gastrointestinal cancer. CA-125 also known as mucin 16 or MUC16 is a protein that in humans is encoded by the MUC16 gene. MUC16 is a member of the mucin family glycoproteins.
Source : Insect cells
Species : Human
Tag : His
Form : Liquid. In 1X PBS.
Molecular Mass : ~75 kDa
Purity : ≥90% (SDS-PAGE)
Applications : WB; in vitro Assay
Storage : Short Term Storage: +4 centigrade;Long Term Storage: -20 centigrade.Avoid freeze/thaw cycles.
Reconstitution : Soluble in 1X PBS or water
Gene Name : MUC16 mucin 16, cell surface associated [ Homo sapiens ]
Official Symbol : MUC16
Synonyms : MUC16; mucin 16, cell surface associated; mucin-16; CA125; FLJ14303; CA-125; MUC-16; CA125 ovarian cancer antigen; ovarian carcinoma antigen CA125; ovarian cancer-related tumor marker CA125;
Gene ID : 94025
mRNA Refseq : NM_024690
Protein Refseq : NP_078966
MIM : 606154
UniProt ID : Q8WXI7
Chromosome Location : 19p13.2
Pathway : Metabolism of proteins, organism-specific biosystem; O-linked glycosylation of mucins, organism-specific biosystem; Post-translational protein modification, organism-specific biosystem; Termination of O-glycan biosynthesis, organism-specific biosystem;
Function : protein binding;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (7)

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How does MUC16 interact with other components of the epithelial barrier and immune system? 10/15/2022

MUC16 works with other mucins and immune components to maintain epithelial barrier function and immune responses.

How does MUC16 contribute to the formation of the mucosal barrier? 10/12/2022

It aids in forming the mucosal barrier, protecting against pathogens and mechanical damage.

What potential therapeutic applications arise from targeting MUC16 in cancer treatment? 08/02/2021

Targeting MUC16 in cancer therapy, especially in ovarian cancer, could be effective in inhibiting tumor growth and spread.

What is the impact of altered MUC16 activity on inflammatory and infectious diseases? 03/15/2021

Altered MUC16 activity can impact the body's defense against inflammation and infection.

What is the primary role of MUC16 in epithelial cell function? 05/03/2020

MUC16, a mucin protein, is essential for maintaining the protective mucous layer on epithelial surfaces.

What role does MUC16 play in cancer, particularly ovarian cancer? 02/15/2018

MUC16 is associated with cancer progression, particularly in ovarian cancer, where it may facilitate tumor growth and metastasis.

How do genetic variations in MUC16 affect its function in mucosal protection and cancer development? 04/03/2017

Genetic variations in MUC16 can lead to differences in mucosal integrity and potentially influence cancer susceptibility.

Customer Reviews (3)

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Reviews
07/28/2020

    Critical for decision-making. Supports our research endeavors.

    05/24/2018

      Expert service quality. Valuable for research integrity.

      06/05/2017

        Dependable partner in experiments. Consistent and trustworthy.

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