Recombinant Human MUC16 Protein, GST-tagged

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Recombinant Human MUC16 Protein, GST-tagged

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Cat.No. : MUC16-5748H
Product Overview : Human MUC16 partial ORF ( AAK74120.3, 1321 a.a. - 1415 a.a.) recombinant protein with GST-tag at N-terminal.
Description : This gene encodes a protein that is a member of the mucin family. Mucins are high molecular weight, O-glycosylated proteins that play an important role in forming a protective mucous barrier, and are found on the apical surfaces of the epithelia. The encoded protein is a membrane-tethered mucin that contains an extracellular domain at its amino terminus, a large tandem repeat domain, and a transmembrane domain with a short cytoplasmic domain. The amino terminus is highly glycosylated, while the repeat region contains 156 amino acid repeats unit that are rich in serines, threonines, and prolines. Interspersed within the repeats are Sea urchin sperm protein Enterokinase and Agrin (SEA) modules, leucine-rich repeats and ankyrin (ANK) repeats. These regions together form the ectodomain, and there is a potential cleavage site found near an SEA module close to the transmembrane domain. This protein is thought to play a role in forming a barrier, protecting epithelial cells from pathogens. Products of this gene have been used as a marker for different cancers, with higher expression levels associated with poorer outcomes. [provided by RefSeq, May 2017]
Source : Wheat Germ
Species : Human
Tag : GST
Molecular Mass : 36.19 kDa
AA Sequence : VSRTEVMPSS RTSIPGPAQS TMSLDISDEV VTRLSTSPIM TESAEITITT QTGYSLATSQ VTLPLGTSMT FLSGTHSTMS QGLSHSEMTN LMSRG
Applications : Enzyme-linked Immunoabsorbent Assay
Western Blot (Recombinant protein)
Antibody Production
Protein Array
Notes : Best use within three months from the date of receipt of this protein.
Storage : Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
Storage Buffer : 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Quality Control Testing: :

12.5% SDS-PAGE Stained with Coomassie Blue.

Gene Name : MUC16 mucin 16, cell surface associated [ Homo sapiens ]
Official Symbol : MUC16
Synonyms : MUC16; mucin 16, cell surface associated; mucin-16; CA125; FLJ14303; CA-125; MUC-16; CA125 ovarian cancer antigen; ovarian carcinoma antigen CA125; ovarian cancer-related tumor marker CA125;
Gene ID : 94025
mRNA Refseq : NM_024690
Protein Refseq : NP_078966
MIM : 606154
UniProt ID : Q8WXI7

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