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Recombinant Human MUC16 Protein, His-tagged

Cat.No. : MUC16-127H
Product Overview : Recombinant Human MUC16(Arg21622~Ser21762) fused with His tag at N-terminal was expressed in E. coli.
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  • Gene Information
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Description : This gene encodes a protein that is a member of the mucin family. Mucins are high molecular weight, O-glycosylated proteins that play an important role in forming a protective mucous barrier, and are found on the apical surfaces of the epithelia. The encoded protein is a membrane-tethered mucin that contains an extracellular domain at its amino terminus, a large tandem repeat domain, and a transmembrane domain with a short cytoplasmic domain. The amino terminus is highly glycosylated, while the repeat region contains 156 amino acid repeats unit that are rich in serines, threonines, and prolines. Interspersed within the repeats are Sea urchin sperm protein Enterokinase and Agrin (SEA) modules, leucine-rich repeats and ankyrin (ANK) repeats. These regions together form the ectodomain, and there is a potential cleavage site found near an SEA module close to the transmembrane domain. This protein is thought to play a role in forming a barrier, protecting epithelial cells from pathogens. Products of this gene have been used as a marker for different cancers, with higher expression levels associated with poorer outcomes
Source : E. coli
Species : Human
Tag : His
Form : PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
Molecular Mass : 21.2kDa
Identity : Reconstitute in PBS or others
Protein length : Arg21622~Ser21762
Endotoxin : <1.0EU per 1µg (determined by the LAL method)
Purity : > 95%
Applications : Positive Control; Immunogen; SDS-PAGE; WB.
If bio-activity of the protein is needed, please check active protein
Stability : The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 centigrade for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
Storage : Avoid repeated freeze/thaw cycles. Store at 2-8 centigrade for one month. Aliquot and store at -80 centigrade for 12 months.
Reconstitution : Reconstitute in PBS or others
Gene Name : MUC16 mucin 16, cell surface associated [ Homo sapiens ]
Official Symbol : MUC16
Synonyms : MUC16; mucin 16, cell surface associated; mucin-16; CA125; FLJ14303; CA-125; MUC-16; CA125 ovarian cancer antigen; ovarian carcinoma antigen CA125; ovarian cancer-related tumor marker CA125;
Gene ID : 94025
mRNA Refseq : NM_024690
Protein Refseq : NP_078966
MIM : 606154
UniProt ID : Q8WXI7

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (7)

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How does MUC16 interact with other components of the epithelial barrier and immune system? 10/15/2022

MUC16 works with other mucins and immune components to maintain epithelial barrier function and immune responses.

How does MUC16 contribute to the formation of the mucosal barrier? 10/12/2022

It aids in forming the mucosal barrier, protecting against pathogens and mechanical damage.

What potential therapeutic applications arise from targeting MUC16 in cancer treatment? 08/02/2021

Targeting MUC16 in cancer therapy, especially in ovarian cancer, could be effective in inhibiting tumor growth and spread.

What is the impact of altered MUC16 activity on inflammatory and infectious diseases? 03/15/2021

Altered MUC16 activity can impact the body's defense against inflammation and infection.

What is the primary role of MUC16 in epithelial cell function? 05/03/2020

MUC16, a mucin protein, is essential for maintaining the protective mucous layer on epithelial surfaces.

What role does MUC16 play in cancer, particularly ovarian cancer? 02/15/2018

MUC16 is associated with cancer progression, particularly in ovarian cancer, where it may facilitate tumor growth and metastasis.

How do genetic variations in MUC16 affect its function in mucosal protection and cancer development? 04/03/2017

Genetic variations in MUC16 can lead to differences in mucosal integrity and potentially influence cancer susceptibility.

Customer Reviews (3)

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Reviews
07/28/2020

    Critical for decision-making. Supports our research endeavors.

    05/24/2018

      Expert service quality. Valuable for research integrity.

      06/05/2017

        Dependable partner in experiments. Consistent and trustworthy.

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