Recombinant Mouse Notch3 Protein, His&GST-tagged

• Cat.No.: Notch3-1839M
• Product Overview: Recombinant Mouse Notch3 Protein (Ala40-Thr273) with N-His&GST tag was expressed in E. coli.

Specification

• Description: Enables enzyme binding activity. Involved in Notch signaling pathway and positive regulation of smooth muscle cell proliferation. Acts upstream of or within several processes, including blood vessel morphogenesis; nervous system development; and regulation of transcription by RNA polymerase II. Located in nucleus and plasma membrane. Is expressed in several structures, including alimentary system; cardiovascular system; central nervous system; genitourinary system; and sensory organ. Used to study CADASIL 1 and acute lymphoblastic leukemia. Human ortholog(s) of this gene implicated in CADASIL 1; infantile myofibromatosis; and lateral meningocele syndrome. Orthologous to human NOTCH3 (notch receptor 3).
• Source: E. coli
• Species: Mouse
• Tag: N-His&GST
• Form: Freeze-dried powder
• Molecular Mass: Predicted Molecular Mass: 54.4 kDa
  Accurate Molecular Mass: 57 kDa
• Protein length: Ala40-Thr273
• Purity: > 90%
• Applications: Positive Control; Immunogen; SDS-PAGE; WB.
• Stability: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 centigrade for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
• Storage: Avoid repeated freeze/thaw cycles. Store at 2-8 centigrade for one month. Aliquot and store at -80 centigrade for 12 months.
• Storage Buffer: PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
• Reconstitution: Reconstitute in PBS or others.

Gene Information

• Gene Name: Notch3 Notch gene homolog 3 (Drosophila) [ Mus musculus (house mouse) ]
• Official Symbol: Notch3
• Synonyms: NOTCH3; Notch gene homolog 3 (Drosophila); neurogenic locus notch homolog protein 3; notch 3; N3; hpbk; AW229011
• Gene ID: 18131
• mRNA Refseq: NM_008716
• Protein Refseq: NP_032742
• UniProt ID: Q61982