Recombinant Human NOTCH3 protein, His-Avi-tagged

• Cat.No.: NOTCH3-947H
• Product Overview: Human Notch 3 Protein is expressed from mammalian with His Tag and Avi Tag at the C-terminal. It contains Ala40-Glu467.

Specification

• Description: Human Notch-3 is part of the Notch family of type I transmembrane glycoproteins involved in a number of early-event developmental processes. The extracellular domain of Notch receptors interact with the extracellular domain of transmembrane ligands Jagged, Delta, and Serrate expressed on the surface of a neighboring cell. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs
• Source: HEK293
• Species: Human
• Tag: His-Avi
• Form: Supplied as 0.22um filtered solution in PBS (pH 7.4).
• Molecular Mass: The protein has a predicted MW of 47.7 Kda.
• Protein length: Ala40-Glu467
• Endotoxin: Less than 1EU per ug by the LAL method.
• Storage: The product should be stored at -70°C. Please do not repeated freeze-thaw cycles.

Gene Information

• Gene Name: NOTCH3
• Official Symbol: NOTCH3
• Synonyms: CADASIL; CASILneurogenic locus notch homolog protein 3; Notch (Drosophila) homolog 3; notch 3Notch homolog 3 (Drosophila); Notch homolog 3; Notch3; Notch-3
• Gene ID: 4854
• mRNA Refseq: NM_000435.3
• Protein Refseq: NP_000426.2
• MIM: 600276
• UniProt ID: Q9UM47