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NR1I2

  • Official Full Name

    nuclear receptor subfamily 1, group I, member 2

  • Overview

    PXR (also known as orphan nuclear receptor PXR, pregnane X receptor, orphan nuclear receptor PAR1, and steroid and xenobiotic receptor (SXR)) is a member of the nuclear hormone receptor family, NR1 subfamily containing a zinc finger domain. Alternatively
  • Synonyms

    NR1I2; nuclear receptor subfamily 1, group I, member 2; nuclear receptor subfamily 1 group I member 2; BXR; ONR1; PAR2; PXR; SXR; pregnane X receptor; orphan nuclear receptor PXR; orphan nuclear receptor PAR1; steroid and xenobiotic receptor; pregnane X n;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • Rhesus Macaque
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Insect Cell
  • Mammalian Cell
  • Mammalian cells
  • Sf21 Insect Cell
  • Sf9 Insect Cell
  • Wheat Germ
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • His|GST
  • His|SUMO|Myc
  • Myc
  • DDK
  • N/A
  • No tag
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human NR1I2-1095H Active Recombinant Human Nuclear Receptor Subfamily 1, Group I, Member 2 Insect Cell N/A
Human NR1I2-1356H Recombinant Human NR1I2, His-tagged E.coli His C-term-378aa
Human NR1I2-1300H Recombinant Human NR1I2 Protein, His-SUMO/MYC-tagged E.coli His/SUMO/Myc
Human NR1I2-8489H Recombinant Human NR1I2, His-tagged Sf21 Insect Cell His
Human NR1I2-31269TH Recombinant Human NR1I2 N/A
Human NR1I2-1896H Recombinant Human NR1I2, Ligand Binding Domain E.coli N/A
Human NR1I2-107H Recombinant Human Pregnane X receptor LBD/Hsp90 complex, GST-tagged Sf9 Insect Cell GST
Human NR1I2-3718HCL Recombinant Human NR1I2 293 Cell Lysate HEK293 N/A
Human NR1I2-3925H Recombinant Human NR1I2 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human NR1I2-6073H Recombinant Human NR1I2 Protein, GST-tagged Wheat Germ GST
Human NR1I2-1114HFL Recombinant Human NR1I2 protein, His&Flag-tagged HEK293 His&Flag 1-434 aa
Human NR1I2-1537H Recombinant Human NR1I2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human NR1I2-6702HF Recombinant Full Length Human NR1I2 Protein, GST-tagged In Vitro Cell Free System GST 434 amino acids
Human NR1I2-0774H Recombinant Human NR1I2 Protein (S130-S434), His tagged E.coli His S130-S434
Human NR1I2-781HFL Recombinant Full Length Human NR1I2 Protein, C-Flag-tagged Mammalian cells Flag
Human NR1I2-5260H Recombinant Human NR1I2 Protein (Ser130-Ile431), His tagged E.coli His Ser130-Ile431
Human NR1I2-0773H Recombinant Human NR1I2 Protein (S130-S434), Tag Free E.coli No tag S130-S434
Human NR1I2-1537H-B Recombinant Human NR1I2 Protein Pre-coupled Magnetic Beads HEK293
Mouse NR1I2-10859M Recombinant Mouse NR1I2 Protein Mammalian Cell His
Mouse Nr1i2-1085M Recombinant Mouse Nr1i2 protein, His & GST-tagged E.coli His/GST Tyr205-Gly390 (Accession # O54915)
Mouse NR1I2-6181M Recombinant Mouse NR1I2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Nr1i2-4487M Recombinant Mouse Nr1i2 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse NR1I2-6181M-B Recombinant Mouse NR1I2 Protein Pre-coupled Magnetic Beads HEK293
Rat NR1I2-4065R Recombinant Rat NR1I2 Protein Mammalian Cell His
Rat Nr1i2-1086R Recombinant Rat Nr1i2 protein, His & GST-tagged E.coli His/GST Tyr246-Gly431 (Accession # Q9R1A7)
Rat NR1I2-3724R-B Recombinant Rat NR1I2 Protein Pre-coupled Magnetic Beads HEK293
Rat NR1I2-3724R Recombinant Rat NR1I2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque NR1I2-3093R Recombinant Rhesus monkey NR1I2 Protein, His-tagged Mammalian Cell His
Rhesus Macaque NR1I2-2912R Recombinant Rhesus Macaque NR1I2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque NR1I2-2912R-B Recombinant Rhesus Macaque NR1I2 Protein Pre-coupled Magnetic Beads HEK293
Zebrafish NR1I2-5691Z Recombinant Zebrafish NR1I2 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • NR1I2 Related Articles

NR1I2 involved in several pathways and played different roles in them. We selected most pathways NR1I2 participated on our site, such as Drug Induction of Bile Acid Pathway, Gene Expression, Generic Transcription Pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with NR1I2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Drug Induction of Bile Acid PathwayNR1I3;ABCC2;SLC51B;CYP7A1;NR1I2;SLCO1B1
Gene ExpressionCOX16;ZNF180;RDBP;NR4A2A;SUPT4H1;ZNF500;DGCR8;ZNF740;HNRNPA0A
Generic Transcription PathwaySKIA;ZNF582;MED16;ZNF671;ZNF689;ZNF649;TACO1;NRBF2B;ZNF41
Nuclear Receptor transcription pathwayRARAB;NR2C1;NR1I3;ESR2B;RARGA;RORAA;RXRBB;NR0B1;VDRB
Nuclear ReceptorsRARG;NR1I2;NR4A2A;ROR1;NR2E1;NR2C2;NR1H3;VDRB;NR2F2
Nuclear receptors in lipid metabolism and toxicityVDRB;CYP24A1;CYP27B1;ABCC2;RARG;NR1I3;RARGA;NR1I2;CYP26A1

NR1I2 has several biochemical functions, for example, RNA polymerase II regulatory region sequence-specific DNA binding, RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding, drug binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NR1I2 itself. We selected most functions NR1I2 had, and list some proteins which have the same functions with NR1I2. You can find most of the proteins on our site.

Function Related Protein
RNA polymerase II regulatory region sequence-specific DNA bindingMYOD1;BCL6A;TAL1;MSX1;MEF2C;RXRB;BARX1;NR1D1;ZFY2
RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA bindingAHR2;NR1I2;HNF4G;NR2E3;NR2F6;ESRRA;PTGER3;NR4A1;RORA
drug bindingDRD4;FASN;SFRP1;GABRA1;PPARG;CHRNA3;CHRNB4;GSTP2;TOP2A
protein bindingSUN1;ZNF649;ADRB1;BAG2;FAM46D;NCAM1A;OTUB2;HSP90B1;OSTC
steroid hormone receptor activityESRRB;RARG;OR51E2;NR1D4B;RORC;RORCB;RARAB;NR0B2A;PPARDB
transcription coactivator activitySTIL;GRIP1;CARM1;TBPL1;ECD;SMARCA4;POU2AF1;GTF2F1;LPIN1
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific bindingMYF5;GATA4;EAF2;MYOCD;RAD21;MAFK;GRHL2;CREB3L4;BARX1
zinc ion bindingZCCHC3;LMO7B;RBBP6;PEG10;VDRB;RARAA;TRIM13;ING5B;MUL1A

NR1I2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NR1I2 here. Most of them are supplied by our site. Hope this information will be useful for your research of NR1I2.

HSP90AB1; pxr-re_consensus_dna-probe; Sirt1; Ppargc1a; FGR; MAPK7; NFATC4; ATP6AP1; TFAP2C; SDF4; cp2c8_human_dr5-site_dna-probe

Huang, Q; Xue, JL; et al. NR4A1 is associated with chronic low-grade inflammation in patients with type 2 diabetes. EXPERIMENTAL AND THERAPEUTIC MEDICINE 8:1648-1654(2014).
Xiao, SS; Zhou, YH; et al. CD44 affects the expression level of FOS-like antigen 1 in cervical cancer tissues. MOLECULAR MEDICINE REPORTS 9:1667-1674(2014).
  • Q&As
  • Reviews

Q&As (5)

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Are there any diseases associated with dysregulation of NR1I2? 01/13/2022

Dysregulation of NR1I2 has been implicated in certain liver diseases and metabolic disorders, where impaired drug metabolism may contribute to disease progression.

How does NR1I2 influence the efficacy of chemotherapy drugs? 06/05/2021

NR1I2 can influence the metabolism of chemotherapy drugs, affecting their bioavailability and efficacy in cancer treatment.

Are there any drugs that specifically target NR1I2 for therapeutic purposes? 06/09/2020

Some drugs are designed to modulate NR1I2 activity for therapeutic purposes, aiming to enhance or inhibit its function based on the clinical context.

How does NR1I2 respond to xenobiotic exposure? 10/30/2019

NR1I2 is activated in response to xenobiotic exposure, leading to the upregulation of enzymes involved in detoxification and elimination of foreign substances.

Can genetic variations in NR1I2 influence drug response? 04/18/2017

Yes, genetic variations in NR1I2 can lead to inter-individual differences in drug metabolism, potentially impacting drug efficacy and safety.

Customer Reviews (3)

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Reviews
02/22/2023

    Their experienced team is dedicated to resolving any issues or challenges I may encounter during my experiments, providing prompt and effective solutions.

    03/02/2022

      The NR1I2 protein is renowned for its exceptional quality, making it a perfect match for my experimental requirements.

      10/22/2016

        In addition to its high-quality attributes, the manufacturer of the NR1I2 protein offers exemplary technical support.

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