RAD51
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Official Full Name
RAD51 recombinase
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Overview
The protein encoded by this gene is a member of the RAD51 protein family. RAD51 family members are highly similar to bacterial RecA and Saccharomyces cerevisiae Rad51, and are known to be involved in the homologous recombination and repair of DNA. This protein can interact with the ssDNA-binding protein RPA and RAD52, and it is thought to play roles in homologous pairing and strand transfer of DNA. This protein is also found to interact with BRCA1 and BRCA2, which may be important for the cellular response to DNA damage. BRCA2 is shown to regulate both the intracellular localization and DNA-binding ability of this protein. Loss of these controls following BRCA2 inactivation may be a key event leading to genomic instability and tumorigenesis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2009] -
Synonyms
RAD51; RAD51 recombinase; RECA; BRCC5; MRMV2; HRAD51; RAD51A; HsRad51; HsT16930; DNA repair protein RAD51 homolog 1; RAD51 homolog A; RecA-like protein; recombination protein A; RecA, E. coli, homolog of; BRCA1/BRCA2-containing complex, subunit 5;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Mouse
- Zebrafish
- E. coli
- E.coli
- HEK293
- HEK293T
- Mammalian Cell
- Mammalian cells
- Flag
- GST
- His
- His (Fc)
- Avi
- Myc
- DDK
- N/A
- N
- Sumo
- Strep
- Trx
- Involved Pathway
- Protein Function
- Interacting Protein
- RAD51 Related Articles
RAD51 involved in several pathways and played different roles in them. We selected most pathways RAD51 participated on our site, such as Homologous recombination, Fanconi anemia pathway, Pathways in cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with RAD51 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Homologous recombination | RAD52;POLD1;RAD54B;RPA4;SYCP3;XRCC2;MRE11A;SSBP1;RAD51L3 |
| Fanconi anemia pathway | FANCC;SLX1B;RAD51;RMI2;RPA4;USP36;TELO2;HER9;REV1 |
| Pathways in cancer | PDGFB;LAMA2;GNG2;RALGDS;WNT10B;SPI1;RASGRP3;WNT5B;GNA12 |
| Pancreatic cancer | IKBKG;MAPK8;TGFA;SMAD4;AKT2;TGFBR1;NFKB1;MAPK1;PIK3R3 |
RAD51 has several biochemical functions, for example, ATP binding, DNA polymerase binding, chromatin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by RAD51 itself. We selected most functions RAD51 had, and list some proteins which have the same functions with RAD51. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ATP binding | SNRKB;MYO1EB;CSNK2A2;NEK1;RUNX2;cka1;PAPSS1;ASS1;PFKMA |
| DNA polymerase binding | FANCI;CDK2AP1;FANCD2;ACD;RAD51;HMGB1;LONP1;PCNA;SMARCA4 |
| chromatin binding | CIC;NFIA;ATAD2;TFAP2A;RBPJ;SMC1A;ZMYND11;NKX2-5;DNAJC2 |
| double-stranded DNA binding | MCM10;NEIL3;RBMS1;MTERF;XRCC3;MTERFD3;XRCC5;ZNF638;AKAP8 |
| contributes_to endodeoxyribonuclease activity | RAD51B;RAD51L3;DMC1;RAD51L1;ERCC4;RAD51D;RAD51;XRCC2 |
| four-way junction DNA binding | RAD51L1;YY1;DMC1;RAD51;HMGB1;HMGB3;RAD51L3;HMGB2;MEN1 |
| identical protein binding | CLDN8;RPE;ADORA2A;GPR50;WAS;PPP1R13L;PHC2;CALCA;HOMER1 |
| protein C-terminus binding | DBNL;XRCC5;CACNA1B;GRIP1;AP2A1;FOXN3;KSR1;PEX5;SNX17 |
| protein binding | YIPF3;FAM103A1;SKP2;TTN;ENSA;NR5A1;RP9;METTL9;HSPA4L |
| recombinase activity | RAD51;DMC1;XRCC2;RAD51L3;RAD51D;RAD51B;RAD51L1;XRCC3;RAD51C |
| single-stranded DNA binding | RAD51L1;XRCC2;HNRNPK;FUBP1;SETMAR;PMS1;FBXO18;LONP1;POLR2GL |
| single-stranded DNA-dependent ATPase activity | DNA2;RAD18;RAD51 |
RAD51 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RAD51 here. Most of them are supplied by our site. Hope this information will be useful for your research of RAD51.
BRCA2
- Q&As
- Reviews
Q&As (7)
Ask a questionIn the HR pathway, RAD51 forms nucleoprotein filaments on single-stranded DNA, allowing it to search for and invade a homologous DNA sequence, facilitating accurate DNA repair.
Yes, RAD51 interacts with BRCA proteins, especially BRCA2. This interaction is crucial for the proper function of RAD51 in the HR pathway.
While mutations in RAD51 are rare, dysregulation of its function can contribute to genomic instability. Some mutations in RAD51 have been linked to increased cancer susceptibility.
RAD51 plays a central role in the DNA repair mechanism, specifically in homologous recombination (HR), where it facilitates the search for homology and strand pairing.
RAD51 is recruited to sites of DNA damage through interactions with various mediator proteins, including BRCA2, which helps load RAD51 onto single-stranded DNA regions.
Yes, RAD51's activity can be targeted therapeutically. Inhibiting RAD51 can sensitize cancer cells to DNA-damaging agents, making it a potential target in combination cancer therapies, especially for tumors with defective DNA repair pathways.
RAD51 has several paralogs, including RAD51B, RAD51C, RAD51D, XRCC2, and XRCC3. While they all play roles in HR, each has distinct functions and interactions, with some acting as mediators or stabilizers of RAD51's nucleoprotein filament.
Customer Reviews (4)
Write a reviewRAD51-134H, Rad51 works well.
User-friendly protocol included.
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Product met all specifications.
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