RAD51

  • Official Full Name

    RAD51 recombinase

  • Overview

    The protein encoded by this gene is a member of the RAD51 protein family. RAD51 family members are highly similar to bacterial RecA and Saccharomyces cerevisiae Rad51, and are known to be involved in the homologous recombination and repair of DNA. This protein can interact with the ssDNA-binding protein RPA and RAD52, and it is thought to play roles in homologous pairing and strand transfer of DNA. This protein is also found to interact with BRCA1 and BRCA2, which may be important for the cellular response to DNA damage. BRCA2 is shown to regulate both the intracellular localization and DNA-binding ability of this protein. Loss of these controls following BRCA2 inactivation may be a key event leading to genomic instability and tumorigenesis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2009]
  • Synonyms

    RAD51; RAD51 recombinase; RECA; BRCC5; MRMV2; HRAD51; RAD51A; HsRad51; HsT16930; DNA repair protein RAD51 homolog 1; RAD51 homolog A; RecA-like protein; recombination protein A; RecA, E. coli, homolog of; BRCA1/BRCA2-containing complex, subunit 5;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • Mammalian Cell
  • Mammalian cells
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • N/A
  • N
  • Sumo
  • Strep
  • Trx
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human RAD51-1121H Active Recombinant Human RAD51 E.coli N/A
Human RAD51-128H Active Recombinant Human RAD51, His-tagged E.coli His
Human RAD51-134H Recombinant Human RAD51 E.coli N/A
Human RAD51-01H Recombinant Human RAD51 (G151D) Mutation Protein, Trx/His-tagged E.coli His
Human RAD51-29581TH Recombinant Human RAD51 E.coli N/A
Human RAD51-29580TH Recombinant Human RAD51, His-tagged E.coli His
Human RAD51-2155H Recombinant Human RAD51, GST-tagged E.coli GST 1-242aa
Human RAD51-2556HCL Recombinant Human RAD51 293 Cell Lysate HEK293 N/A
Human RAD51-125H Recombinant Human RAD51 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Human RAD51-279HFL Recombinant Full Length Human RAD51 Protein, C-Flag-tagged Mammalian cells Flag
Human RAD51-101H Recombinant Huamn RAD51 Protein E.coli
Human RAD51-2789H Recombinant Human RAD51 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human RAD1-01H Recombinant Human RAD51 (G151D) Mutation Protein, Trx/His-tagged E.coli Trx/His
Human RAD51-03H Recombinant Human RAD51 Protein (G151D mutated), Sumo/His/Strep tagged E.coli Sumo/His/Strep
Human RAD1-02H Recombinant Human RAD51 (G151D) Mutation Protein E.coli
Human RAD51-6135H Recombinant Human RAD51 Protein (Val174-Asp339), N-His tagged E.coli N-His Val174-Asp339
Human RAD51-1851H Recombinant Human RAD51 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human RAD51-1851H-B Recombinant Human RAD51 Protein Pre-coupled Magnetic Beads HEK293
Mouse Rad51-5350M Recombinant Mouse Rad51 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Zebrafish RAD51-12414Z Recombinant Zebrafish RAD51 Mammalian Cell His
Chicken RAD51-6728C Recombinant Chicken RAD51 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

RAD51 involved in several pathways and played different roles in them. We selected most pathways RAD51 participated on our site, such as Homologous recombination, Fanconi anemia pathway, Pathways in cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with RAD51 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Homologous recombinationTOP3B;RAD54L;POLD2;MUS81;RAD52;RAD51;NBN;MRE11A;BRCA2
Fanconi anemia pathwayFANCE;FANCA;HER9;BRCA2;TOP3A;RMI2;FANCI;ZBTB32;POLI
Pathways in cancerCKS2;MSH6;WNT9B;IL-8;PIK3R3;PLCB2;MMP1A;PRKCG;FZD6
Pancreatic cancerMAPK1;BCL2L1;BRCA2;VEGFA;TP53;ARAF;PIK3CG;TGFBR2;MAPK9

RAD51 has several biochemical functions, for example, ATP binding, DNA polymerase binding, chromatin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by RAD51 itself. We selected most functions RAD51 had, and list some proteins which have the same functions with RAD51. You can find most of the proteins on our site.

Function Related Protein
ATP bindingCDC34B;HSC70;TLK1A;HSPA5;PRKCHB;CLCN4-2;VPS4A;GLULA;PANK1
DNA polymerase bindingSMARCA4;RAD51;FANCD2;HMGB1;LONP1;CDK2AP1;ACD;FANCI;PCNA
chromatin bindingHMGXB4A;CALCOCO1;ZKSCAN3;TICRR;COQ7;RERE;SMARCE1;KDM5A;RBMX
double-stranded DNA bindingMTERF;RAD51D;NTHL1;HNRPDL;HES2;AKAP8;TRP63;IFI16;LSM14A
contributes_to endodeoxyribonuclease activityXRCC2;RAD51L3;RAD51;RAD51L1;ERCC4;RAD51D;DMC1;RAD51B
four-way junction DNA bindingRAD51L3;YY1;MEN1;HMGB1;DMC1;HMGB2;HMGB3;RAD51L1;RAD51
identical protein bindingALCAMA;PICK1;MICALL1;SOX10;EPS15;GLE1;GBP5;CALHM1;HOOK2
protein C-terminus bindingCAV3;VGLL3;SLC4A1;ZBTB16;PHB;CD2AP;YWHAB;BCL10;COIL
protein bindingASPSCR1;PDE4DIP;KIR2DL1;ITGA3;PSMB7;SHANK3;CDK17;GPRC5A;SALL1
recombinase activityRAD51L1;RBPJ;RAD51C;DMC1;RAD51L3;RAD51B;RAD51;XRCC2;RAD51D
single-stranded DNA bindingCNBPA;POLR2GL;PURA;TREX1;DDX11;NABP1A;ANXA1;RAD51B;HNRNPA1
single-stranded DNA-dependent ATPase activityRAD51;RAD18;DNA2

RAD51 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RAD51 here. Most of them are supplied by our site. Hope this information will be useful for your research of RAD51.

BRCA2

Research Area

Related articles

Liu, H; Yang, WF; et al. Nimotuzumab abrogates acquired radioresistance of KYSE-150R esophageal cancer cells by inhibiting EGFR signaling and cellular DNA repair. ONCOTARGETS AND THERAPY 8:509-518(2015).
Le Cigne, A; Menil-Philippot, V; et al. Transient expression of RAD51 in the late G2-phase is required for cell cycle progression in synchronous Physarum cells. GENES TO CELLS 19:755-765(2014).
  • Reviews
  • Q&As

Customer Reviews (4)

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Reviews
04/02/2024

    RAD51-134H, Rad51 works well.

    09/05/2022

      User-friendly protocol included.

      03/14/2022

        Affordable price, great value.

        01/03/2022

          Product met all specifications.

          Q&As (7)

          Ask a question
          How does RAD51 contribute to the homologous recombination (HR) repair pathway? 10/24/2021

          In the HR pathway, RAD51 forms nucleoprotein filaments on single-stranded DNA, allowing it to search for and invade a homologous DNA sequence, facilitating accurate DNA repair.

          Are there any known interactions between RAD51 and BRCA proteins? 05/02/2021

          Yes, RAD51 interacts with BRCA proteins, especially BRCA2. This interaction is crucial for the proper function of RAD51 in the HR pathway.

          Are there any diseases or conditions associated with RAD51 dysregulation or mutations? 10/17/2020

          While mutations in RAD51 are rare, dysregulation of its function can contribute to genomic instability. Some mutations in RAD51 have been linked to increased cancer susceptibility.

          What is the primary function of RAD51 in DNA repair mechanisms? 05/27/2020

          RAD51 plays a central role in the DNA repair mechanism, specifically in homologous recombination (HR), where it facilitates the search for homology and strand pairing.

          How is RAD51 recruited to sites of DNA damage? 06/01/2018

          RAD51 is recruited to sites of DNA damage through interactions with various mediator proteins, including BRCA2, which helps load RAD51 onto single-stranded DNA regions.

          Can RAD51 activity be targeted therapeutically in cancer treatments? 06/01/2018

          Yes, RAD51's activity can be targeted therapeutically. Inhibiting RAD51 can sensitize cancer cells to DNA-damaging agents, making it a potential target in combination cancer therapies, especially for tumors with defective DNA repair pathways.

          How does RAD51's function compare to that of its paralogs, like RAD51B, RAD51C, etc.? 05/09/2018

          RAD51 has several paralogs, including RAD51B, RAD51C, RAD51D, XRCC2, and XRCC3. While they all play roles in HR, each has distinct functions and interactions, with some acting as mediators or stabilizers of RAD51's nucleoprotein filament.

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