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Active Recombinant Human RAD51, His-tagged

Cat.No. : RAD51-128H
Product Overview : Active Recombinant Human RAD51, fused with His tag, was expressed in E.coli.
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Source : E.coli
Species : Human
Tag : His
Form : Lyophilized from sterile PBS, 0.01% SKL, pH 7.4, 5% Trehalose, 5% Mannitol.
Bio-activity : The EC50 of the RAD51 is 16.3607ug/ml in the presence of 1ug of RAD51 antibody.
Molecular Mass : The protein has a calculated MW of 41 kDa.
AA Sequence : MGSSHHHHHHSSGLVPRGSHMASMT GGQQMGRGSEFAMQMQLEANADTSV EEESFGPQPISRLEQCGINANDVKK LEEAGFHTVEAVAYAPKKELINIKG ISEAKADKILAEAAKLVPMGFTTAT EFHQRRSEIIQITTGSKELDKLLQG GIETGSITEMFGEFRTGKTQICHTL AVTCQLPIDRGGGEGKAMYIDTEGT FRPERLLAVAERYGLSGSDVLDNVA YARAFNTDHQTQLLYQASAMMVESR YALLIVDSATALYRTDYSGRGELSA RQMHLARFLRMLLRLADEFGVAVVI TNQVVAQVDGAAMFAADPKKPIGGN IIAHASTTRLYLRKGRGETRICKIY DSPCLPEAEAMFAINADGVGDAKD
Endotoxin : < 1.0 EU per μg protein as determined by the LAL method.
Purity : > 90% as determined by SDS-PAGE.
Storage : Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Reconstitution : It is recommended that sterile water be added to the vial to prepare a stock solution of 0.25 mg/ml. Centrifuge the vial at 4℃ before opening to recover the entire contents.
Gene Name : RAD51 RAD51 homolog (RecA homolog, E. coli) (S. cerevisiae) [ Homo sapiens ]
Official Symbol : RAD51
Synonyms : RAD51; RAD51 homolog (RecA homolog, E. coli) (S. cerevisiae); RECA; BRCC5; HRAD51; RAD51A; HsRad51; HsT16930; RAD51 homolog protein; RecA-like protein; RAD51D; recombination protein A; RecA, E. coli, homolog of DNA repair protein RAD51 homolog 1; BRCA1/BRCA2-containing complex, subunit 5; RAD51L3; hRAD51; RAD51 (S. cerevisiae) homolog (E coli RecA homolog)
Gene ID : 5888
mRNA Refseq : NM_002875
Protein Refseq : NP_002866
MIM : 179617
UniProt ID : Q06609

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (7)

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How does RAD51 contribute to the homologous recombination (HR) repair pathway? 10/24/2021

In the HR pathway, RAD51 forms nucleoprotein filaments on single-stranded DNA, allowing it to search for and invade a homologous DNA sequence, facilitating accurate DNA repair.

Are there any known interactions between RAD51 and BRCA proteins? 05/02/2021

Yes, RAD51 interacts with BRCA proteins, especially BRCA2. This interaction is crucial for the proper function of RAD51 in the HR pathway.

Are there any diseases or conditions associated with RAD51 dysregulation or mutations? 10/17/2020

While mutations in RAD51 are rare, dysregulation of its function can contribute to genomic instability. Some mutations in RAD51 have been linked to increased cancer susceptibility.

What is the primary function of RAD51 in DNA repair mechanisms? 05/27/2020

RAD51 plays a central role in the DNA repair mechanism, specifically in homologous recombination (HR), where it facilitates the search for homology and strand pairing.

How is RAD51 recruited to sites of DNA damage? 06/01/2018

RAD51 is recruited to sites of DNA damage through interactions with various mediator proteins, including BRCA2, which helps load RAD51 onto single-stranded DNA regions.

Can RAD51 activity be targeted therapeutically in cancer treatments? 06/01/2018

Yes, RAD51's activity can be targeted therapeutically. Inhibiting RAD51 can sensitize cancer cells to DNA-damaging agents, making it a potential target in combination cancer therapies, especially for tumors with defective DNA repair pathways.

How does RAD51's function compare to that of its paralogs, like RAD51B, RAD51C, etc.? 05/09/2018

RAD51 has several paralogs, including RAD51B, RAD51C, RAD51D, XRCC2, and XRCC3. While they all play roles in HR, each has distinct functions and interactions, with some acting as mediators or stabilizers of RAD51's nucleoprotein filament.

Customer Reviews (3)

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Reviews
09/05/2022

    User-friendly protocol included.

    03/14/2022

      Affordable price, great value.

      01/03/2022

        Product met all specifications.

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