RAF1

  • Official Full Name

    v-raf-1 murine leukemia viral oncogene homolog 1

  • Overview

    This gene is the cellular homolog of viral raf gene (v-raf). The encoded protein is a MAP kinase kinase kinase (MAP3K), which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated, the cellular RAF1 protein can phosphorylate to activate the dual specificity protein kinases MEK1 and MEK2, which in turn phosphorylate to activate the serine/threonine specific protein kinases, ERK1 and ERK2. Activated ERKs are pleiotropic effectors of cell physiology and play an important role in the control of gene expression involved in the cell division cycle, apoptosis, cell differentiation and cell migration. Mutations in this gene are associated with Noonan syndrome 5 and LEOPARD syndrome 2. [provided by RefSeq, Jul 2008]
  • Synonyms

    RAF1; v-raf-1 murine leukemia viral oncogene homolog 1; NS5; CRAF; Raf-1; c-Raf; RAF proto-oncogene serine/threonine-protein kinase; Oncogene RAF1; proto-oncogene c-RAF; raf proto-oncogene serine/threonine protein kinase; Craf1; v-Raf; AA990557; BB129353; 6430402F14Rik; D830050J10Rik;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Human
  • Mouse
  • Rat
  • Rhesus Macaque
  • E.coli
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Insect Cell
  • Insect Cells
  • Mamanlian cells
  • Mammalian Cell
  • Sf21
  • Sf9 Insect Cell
  • Wheat Germ
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • His|MBP
  • SUMO
  • Myc
  • DDK
  • MYC
  • Myc|DDK
  • N/A
  • N
  • 6×His
  • C
  • FLAG
  • The N
  • terminal 6XHis
  • Avi Tag
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human RAF1-16H Active Recombinant Human RAF1, GST-tagged Sf9 Insect Cell GST
Human RAF1-416H Active Recombinant Human RAF1 protein, GST-tagged Insect Cell GST
Human RAF1-551H Active Recombinant Human RAF1, GST-tagged Sf9 Insect Cell GST 306–648
Human RAF1-210H Active Recombinant Human RAF1(Y340D and Y341D)(306-end) Mutation Protein, N-GST-tagged Sf21 GST 306-end
Human RAF1-29370TH Recombinant Human RAF1 E.coli N/A
Human RAF1-2161H Recombinant Human RAF1, GST-tagged E.coli GST C-term-300aa
Human RAF1-1123H Recombinant Human RAF1 Protein, GST-tagged E.coli GST
Human RAF1-552H Recombinant Human RAF1, MYC/DDK-tagged HEK293 Myc/DDK
Human RAF1-305H Recombinant Human RAF1 Mammalian Cell His
Human RAF1-553H Recombinant Human RAF1, GST-tagged Wheat Germ GST 1 a.a. - 648 a.a.
Human RAF1-169H Recombinant Human RAF1 protein, His-tagged Insect Cell His Ser306-Phe648
Human RAF1-352H Recombinant Human RAF1 protein, His/MBP-tagged E.coli His/MBP 492-648 aa
Human RAF1-1122H Recombinant Human V-raf-1 Murine Leukemia Viral Oncogene Homolog 1 E.coli N/A
Human RAF1-1463HCL Recombinant Human RAF1 cell lysate N/A
Human RAF1-428H Recombinant Human RAF1 Protein, His-tagged E.coli His Trp342~Ser619
Human RAF1-413H Recombinant Human RAF1 protein, His&GST-tagged Insect Cells His/GST Ser306-Phe648
Human RAF1-442H Recombinant Human RAF1 Protein, His-tagged Insect Cell His
Human RAF1-3409H Recombinant Human RAF1 protein, His-SUMO-tagged E.coli His-SUMO 1-648aa
Human RAF1-17H Recombinant Human RAF1 Protein, N-terminal 6XHis and Avi Tag E.coli The N-terminal 6XHis and Avi Tag 50-140
Human RAF1-4198H Recombinant Human RAF1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human RAF1-9572HFL Recombinant Full Length Human RAF1, Flag-tagged Mamanlian cells Flag
Human RAF1-06H Recombinant Human RAF1 Protein (RBD, 50-140), N-6×His and C-FLAG E.coli N-6×His and C-FLAG 50-140
Human RAF1-3964H-B Recombinant Human RAF1 Protein Pre-coupled Magnetic Beads HEK293
Human RAF1-424HF Recombinant Full Length Human RAF1 Protein, GST-tagged In Vitro Cell Free System GST 648 amino acids
Human RAF1-6137H Recombinant Human RAF1 Protein (Trp342-Ser619), His tagged E.coli His Trp342-Ser619
Human RAF1-19H Recombinant Human RAF1 Protein, His-tagged E.coli His
Human RAF1-3964H Recombinant Human RAF1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse RAF1-13888M Recombinant Mouse RAF1 Protein Mammalian Cell His
Mouse RAF1-7399M Recombinant Mouse RAF1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Raf1-456M Recombinant Mouse Raf1 Protein, MYC/DDK-tagged HEK293T MYC/DDK
Mouse RAF1-7399M-B Recombinant Mouse RAF1 Protein Pre-coupled Magnetic Beads HEK293
Rat RAF1-4913R Recombinant Rat RAF1 Protein Mammalian Cell His
Rat RAF1-4572R-B Recombinant Rat RAF1 Protein Pre-coupled Magnetic Beads HEK293
Rat RAF1-4572R Recombinant Rat RAF1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque RAF1-3775R Recombinant Rhesus monkey RAF1 Protein, His-tagged Mammalian Cell His
Rhesus Macaque RAF1-3592R-B Recombinant Rhesus Macaque RAF1 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque RAF1-3592R Recombinant Rhesus Macaque RAF1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Chicken RAF1-6859C Recombinant Chicken RAF1 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource
  • RAF1 Related Signal Pathway

RAF1 involved in several pathways and played different roles in them. We selected most pathways RAF1 participated on our site, such as MAPK signaling pathway, ErbB signaling pathway, Ras signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with RAF1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
MAPK signaling pathwayLAMTOR3;HSP70L;PPM1BB;FGFR3;MAP2K3;FGF14;GNG12;MAP3K7;PLA2G4A
ErbB signaling pathwayCAMK2B1;BADB;RAF1A;ERBB3;GAB1;CDKN1BB;PIK3R3B;HBEGFA;GRB2
Ras signaling pathwaySHC3;FASLG;FGF21;FLT1;ABL1;GNG8;PLCE1;PAK7;KIT
Rap signaling pathwayPFN3;NGF;RAF1;PGF;SRC;PFN2;MAP2K6;BCAR1;MAP2K1
cGMP-PKG signaling pathwayPPIF;CREB5;GTF2IRD1;MYLK3;GUCY1A3;PIK3CD;GNAI1;PIK3CA;ATP1B4
cAMP signaling pathwayGRIN2B;ATP1B3;VAV3;NFATC1;PPP1CC;ROCK1;CREB3L1;CALM1;PRKACA
Chemokine signaling pathwayRAP1B;CXCR5;GSK3B;GSK3A;PIK3CA;GNAI1;CXCR2;ITK;CCR10
FoxO signaling pathwayHRASA;CCND2A;PCK1;IGF1R;MAPK12A;PRKAG3B;PTENA;BRAF;FOXO3
Sphingolipid signaling pathwayCERS2;PRKCA;PPP2R1A;PLD1;PPP2R2A;PLCB3;SPHK1;BAX;PPP2R5E
Phospholipase D signaling pathwayGRM4;RRAS2;AGPAT5;PDGFC;PIP5K1C;AGTR1B;INS2;PDGFB;LPAR3
PIK-Akt signaling pathwayLAMA1;ITGB3;RPS6KB2;LAMC2;PPP2R1A;GNG5;NOS3;IFNA16;PPP2CB
Vascular smooth muscle contractionADCY2B;PLA2G6;PLCB4;CALM1B;PRKACG;NPR2;ARHGEF1;ITPR1;PLA2G2A
VEGF signaling pathwayHSPB1;PIK3R1;PTK2AA;MAPK12;SHC2;AKT2L;AKT3A;CDC42L;RAF1
Focal adhesionROCK2A;PDPK1B;FIGF;FN1;MYLPFA;ERBB2;PPP1CB;COL24A1;ACTN2
Gap junctionGRB2A;TUBA1L;ADRB3A;TUBA7L;HTR2A;PRKG1A;Pdgfa&Pdgfb;MAP3K2;DRD1A
Signaling pathways regulating pluripotency of stem cellsMAPK1;WNT6;AKT1;PIK3CD;FGFR3;FZD9;SMARCAD1;SKIL;SMAD1
Jak-STAT signaling pathwayIFNB1;STAM;SOCS7;STAT2;PIK3R3A;GHRA;IL2RGA;PTPN2A;CSH1
Natural killer cell mediated cytotoxicityLCP2;RAC3;KIR2DS5;KLRK1;VAV3;KRAS;IFNGR2;PPP3R2;SYK
T cell receptor signaling pathwayPTPRC;PTPN6;IFNG;KRAS;FOS;CBLB;NFKB1;CD3E; CD3D;PDCD1
B cell receptor signaling pathwayCDK7;CDK6;ARPC4;DOK3;PDPK1A;GSK3AB;DOK1;PLEKHA1;FCGR2B
Fc epsilon RI signaling pathwayMAPK8;PDPK1;MAPK10;PLA2G4C;PLA2G4A;MAPK9;FCER1A;AKT1;PLA2G4D
Fc gamma R-mediated phagocytosisBIN1;PLD2;RAC1;PRKCG;PPAP2B;PIK3R3;SPHK2;PPAP2C;WASL
Long-term potentiationCALM4;GRIA1;PLCB2;MAPK3;CAMK2D;RPS6KA3;NRAS;CAMK4;ITPR3
Neurotrophin signaling pathwayARHGDIA;MAP3K1;RAF1;KRAS;NTF3;YWHAE;RPS6KA5;NGF;MAPK12
Serotonergic synapseCYP2J6;TRPC1;GNB2;CYP2C37;GNGT1;MAOB;MAPK3;GNAI1;CYP2C39
Long-term depressionRYR1;PLA2G4D;PPP2R1A;GRIA1;GNAQ;GNAI2;MAP2K1;MAPK3;GNAO1
Regulation of actin cytoskeletonCDC42;ARHGAP35;DIAPH1;PIK3R2;MYL1;IQGAP2;GNA13A;DIAP3;ACTN2
Insulin signaling pathwayG6PCA.2;PPP1R3D;PHKG2;HKDC1;FOXO1B;FASN;RAPGEF1B;PPARGC1A;PDPK1B
GnRH signaling pathwayCALM4;KRAS;GNRH2;CAMK2D;PTK2BB;HBEGFA;GNRHR4;CAMK2B1;MAPK1
Progesterone-mediated oocyte maturationMAPK14B;CPEB3;GNAI2;PRKACA;MAD2L1;PRKACG;CCNA1;INS1;Adcy4
Estrogen signaling pathwayPRKACA;PIK3R1;GPR30;PIK3R2;NRAS;GNAI2;KCNJ3;ESR1;GNAQ
MelanogenesisCREB3L1;WNT8A;GNAI1;CALML3;WNT7B;FZD9B;WNT2B;FZD8A;CAMK2G
Prolactin signaling pathwayCCND1;INS;SHC4;PIK3CG;SOCS7;NFKB1;SOCS5;CCND2;SHC2
Thyroid hormone signaling pathwaySLC9A1;ACTB;PIK3CB;RXRA;MED12L;NOTCH3;CASP9;TP53;ATP1B3
Oxytocin signaling pathwayPRKAA2;GUCY1B3;GNAI1;CACNA2D1;PPP3CB;CAMKK2;PPP1R12C;CAMK2A;CAMK2B
AlcoholismHDAC5;HIST1H2BQ;CALM3;MAOB;HIST1H3C;HIST2H3C1;CAMKK1;KRAS;GNB3
TuberculosisCORO1A;CD209;RFXAP;CALML3;IFNA5;HSPA9;RIPK2;CASP10;HSPD1
Hepatitis CTNF;LDLR;IRF3;CLDN10;IFNA13;DDX58;MAPK9;BRAF;IFNA10
Hepatitis BMAPK3;IL-8;NFATC1;PTEN;Fasl;PCNA;TIRAP;STAT6;RB1
Influenza AH2-AA;Ifna15;CCL2;EIF2AK1;IL8L1;KPNA1;HLA-DQB1;PIK3R3;IFNA6
Pathways in cancerRXRB;MAPK9;EP300;CSF1R;RAC3;HSP90B1;CBLC;FIGF;EPAS1
Proteoglycans in cancerPIK3CB;Ctsl;ARHGEF1;Casp3;PRKCB;CAMK2G;RPS6;MDM2;ACTB
MicroRNAs in cancerPLCG1;PRKCG;TIMP3;APC2;IGF2BP1;SOCS1;DDIT4;SOS1;FZD3
Colorectal cancerBRAF;PIK3R5;TRP53;PIK3R1;TGFB3;SMAD4;BIRC5;ARAF;FOS
Renal cell carcinomaGAB1;TGFB1;PIK3R1;RAPGEF1;PAK2;PTPN11;HGF;PAK7;AKT2
Pancreatic cancerMAPK3;CDC42;TRP53;CCND1;RALBP1;MAPK8;IKBKG;AKT1;MAPK10
Endometrial cancerPTEN;AKT1;CTNNA2;RAF1;MAP2K2;PIK3R1;CDH1;PIK3R2;PDPK1
GliomaRAF1;AKT1;MDM2;PIK3R5;PIK3CA;AKT2;PLCG2;PRKCA;CAMK2G
Prostate cancerPDGFC;CCNE2;BCL2;KRAS;TRP53;NOXA1;IKBKB;ATF4;GRB2
MelanomaPDGFA;MAP2K1;CCND1;FGF9;FGF19;FGFR1;PIK3R1;MAPK3;FGF6
Bladder cancerHRAS;E2F2;RB1;ERBB2;MAPK3;THBS1;E2F3;KRAS;DAPK1
Chronic myeloid leukemiaMDM2;BCL2L1;CRKL;CCND1;TGFBR1;SMAD4;CDK6;BCR;SMAD3
Acute myeloid leukemiaKIT;MAP2K1;SOS1;RPS6KB2;AKT1;HRAS;ZBTB16;ARAF;RUNX1T1
Non-small cell lung cancerPRKCG;BRAF;PIK3CA;RB1;MAPK1;MAPK3;RXRG;MAP2K1;HRAS
Central carbon metabolism in cancerKIT;PDK1;HK1;FGFR1;PIK3CG;ERBB2;PIK3R1;PFKM;SIRT3
Choline metabolism in cancerPLD2;DGKE;PIK3CB;RHEB;PLA2G4D;MAPK3;TAE1;TSC1;DGKB

RAF1 has several biochemical functions, for example, ATP binding, MAP kinase kinase kinase activity, identical protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by RAF1 itself. We selected most functions RAF1 had, and list some proteins which have the same functions with RAF1. You can find most of the proteins on our site.

Function Related Protein
ATP bindingKIF6;TBK1;KCNJ10;PAN3;DDX19A;TP53RK;GLULC;ABCA6;ACTR1B
MAP kinase kinase kinase activitySTK4;MAP3K2;MAP3K3;MAP3K5;YSK4;MAP3K4;MAP3K14;EGFR;BRAF
identical protein bindingMAP3K13;RASSF3;DDX58;SIAH1A;ROBO2;CST3;GAPDH;NEFL;EWSR1
metal ion bindingAOX3;ZMYND17;ZNF76;EBF3A;ZBTB37;TRIM35-29;RPL37A;NRD1B;DSG1A
mitogen-activated protein kinase kinase bindingTRIB3;DLG1;TRIB2;TRIB1;IGBP1;BRAF;PIN1;TAOK2;KSR1
protein bindingFASLG;SUPT6H;RPS11;KLF12;ZNF385C;TMBIM6;BLNK;INTS10;GCM1
protein heterodimerization activityH2-AA;BAXA;DRD1A;ADD2;H2AFJ;RRAGA;AXL;HIST1H4E;KCNH5
protein kinase activityTGFBR1B;EPHB3A;DYRK1A;CLK2A;SRC;CSNK1G2A;NRBP1;MAPKAPK2B;RLN1
protein serine/threonine kinase activityMAP4K4;STK16;MAP2K1;PAK2A;LMTK3;SQSTM1;SMOK3B;DYRK3;FAM20C
NOT small GTPase bindingBRAF;RAF1

RAF1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RAF1 here. Most of them are supplied by our site. Hope this information will be useful for your research of RAF1.

HRAS; YWHAZ

Research Area

Related articles

Feiz, L; Williams-Carrier, R; et al. A protein with an inactive pterin-4a-carbinolamine dehydratase domain is required for Rubisco biogenesis in plants. PLANT JOURNAL 80:862-869(2014).
Lou, Q; Zhang, W; et al. The C-Type Lectin OCILRP2 Costimulates EL4 T Cell Activation via the DAP12-Raf-MAP Kinase Pathway. PLOS ONE 9:-(2014).
  • Reviews
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Customer Reviews (3)

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Reviews
04/18/2020

    They understand that each research project may have unique requirements, and they are more than willing to address these specific needs.

    11/01/2017

      The manufacturer's commitment to providing excellent technical support is truly impressive.

      02/25/2016

        Their prompt and insightful responses to inquiries and troubleshooting requests enable me to tackle experimental obstacles with confidence and efficiency.

        Q&As (5)

        Ask a question
        How is the RAF1 protein studied in a clinical context? 01/21/2023

        The RAF1 protein is studied through a combination of molecular biology techniques, such as immunohistochemistry, Western blotting, and genetic sequencing, in both clinical and research settings.

        Is RAF1 protein expression routinely tested in cancer diagnostics? 06/11/2019

        RAF1 protein expression is not typically included in routine cancer diagnostics. Instead, mutations and expression levels of other genes, like BRAF, are often analyzed in cancer patients.

        Are there any clinical trials focused on RAF1 protein for disease treatment or research? 01/14/2019

        Clinical trials involving RAF1 protein are ongoing for conditions like Noonan syndrome and certain cancers. These trials aim to develop new therapies and better understand its role in disease.

        How does the RAF1 protein influence cardiac health, and what clinical implications does this have? 02/28/2018

        RAF1 mutations can affect cardiac development, leading to congenital heart defects and other cardiac issues in patients with Noonan syndrome. This has important clinical implications for cardiologists and genetic counselors.

        Can RAF1 mutations be inherited, and if so, how does this affect patients and their families? 01/31/2016

        Yes, RAF1 mutations can be inherited, and they can lead to Noonan syndrome. This can have a significant impact on affected individuals and their families, necessitating specialized medical care and genetic counseling.

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