RAF1

  • Official Full Name

    v-raf-1 murine leukemia viral oncogene homolog 1

  • Overview

    This gene is the cellular homolog of viral raf gene (v-raf). The encoded protein is a MAP kinase kinase kinase (MAP3K), which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated, the cellular RAF1 protein can phosphorylate to activate the dual specificity protein kinases MEK1 and MEK2, which in turn phosphorylate to activate the serine/threonine specific protein kinases, ERK1 and ERK2. Activated ERKs are pleiotropic effectors of cell physiology and play an important role in the control of gene expression involved in the cell division cycle, apoptosis, cell differentiation and cell migration. Mutations in this gene are associated with Noonan syndrome 5 and LEOPARD syndrome 2. [provided by RefSeq, Jul 2008]
  • Synonyms

    RAF1; v-raf-1 murine leukemia viral oncogene homolog 1; NS5; CRAF; Raf-1; c-Raf; RAF proto-oncogene serine/threonine-protein kinase; Oncogene RAF1; proto-oncogene c-RAF; raf proto-oncogene serine/threonine protein kinase; Craf1; v-Raf; AA990557; BB129353; 6430402F14Rik; D830050J10Rik;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rat
  • Rhesus Macaque
  • E.coli
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Insect Cell
  • Insect Cells
  • Mamanlian cells
  • Mammalian Cell
  • Sf9 Insect Cell
  • Wheat Germ
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • His|MBP
  • SUMO
  • Myc
  • DDK
  • MYC
  • Myc|DDK
  • N/A
  • N
  • 6×His
  • C
  • FLAG
  • The N
  • terminal 6XHis
  • Avi Tag
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human RAF1-16H Active Recombinant Human RAF1, GST-tagged Sf9 Insect Cell GST
Human RAF1-416H Active Recombinant Human RAF1 protein, GST-tagged Insect Cell GST
Human RAF1-551H Active Recombinant Human RAF1, GST-tagged Sf9 Insect Cell GST
Human RAF1-2161H Recombinant Human RAF1, GST-tagged E.coli GST
Human RAF1-29370TH Recombinant Human RAF1 E.coli N/A
Human RAF1-552H Recombinant Human RAF1, MYC/DDK-tagged HEK293 Myc/DDK
Human RAF1-1123H Recombinant Human RAF1 Protein, GST-tagged E.coli GST
Human RAF1-553H Recombinant Human RAF1, GST-tagged Wheat Germ GST
Human RAF1-305H Recombinant Human RAF1 Mammalian Cell His
Human RAF1-352H Recombinant Human RAF1 protein, His/MBP-tagged E.coli His/MBP
Human RAF1-169H Recombinant Human RAF1 protein, His-tagged Insect Cell His
Human RAF1-1122H Recombinant Human V-raf-1 Murine Leukemia Viral Oncogene Homolog 1 E.coli N/A
Human RAF1-1463HCL Recombinant Human RAF1 cell lysate N/A
Human RAF1-428H Recombinant Human RAF1 Protein, His-tagged E.coli His
Human RAF1-413H Recombinant Human RAF1 protein, His&GST-tagged Insect Cells His/GST
Human RAF1-442H Recombinant Human RAF1 Protein, His-tagged Insect Cell His
Human RAF1-3409H Recombinant Human RAF1 protein, His-SUMO-tagged E.coli His-SUMO
Human RAF1-17H Recombinant Human RAF1 Protein, N-terminal 6XHis and Avi Tag E.coli The N-terminal 6XHis and Avi Tag
Human RAF1-4198H Recombinant Human RAF1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human RAF1-9572HFL Recombinant Full Length Human RAF1, Flag-tagged Mamanlian cells Flag
Human RAF1-06H Recombinant Human RAF1 Protein (RBD, 50-140), N-6×His and C-FLAG E.coli N-6×His and C-FLAG
Human RAF1-3964H-B Recombinant Human RAF1 Protein Pre-coupled Magnetic Beads HEK293
Human RAF1-424HF Recombinant Full Length Human RAF1 Protein, GST-tagged In Vitro Cell Free System GST
Human RAF1-6137H Recombinant Human RAF1 Protein (Trp342-Ser619), His tagged E.coli His
Human RAF1-19H Recombinant Human RAF1 Protein, His-tagged E.coli His
Human RAF1-3964H Recombinant Human RAF1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse RAF1-13888M Recombinant Mouse RAF1 Protein Mammalian Cell His
Mouse RAF1-7399M Recombinant Mouse RAF1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Raf1-456M Recombinant Mouse Raf1 Protein, MYC/DDK-tagged HEK293T MYC/DDK
Mouse RAF1-7399M-B Recombinant Mouse RAF1 Protein Pre-coupled Magnetic Beads HEK293
Rat RAF1-4913R Recombinant Rat RAF1 Protein Mammalian Cell His
Rat RAF1-4572R-B Recombinant Rat RAF1 Protein Pre-coupled Magnetic Beads HEK293
Rat RAF1-4572R Recombinant Rat RAF1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque RAF1-3775R Recombinant Rhesus monkey RAF1 Protein, His-tagged Mammalian Cell His
Rhesus Macaque RAF1-3592R-B Recombinant Rhesus Macaque RAF1 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque RAF1-3592R Recombinant Rhesus Macaque RAF1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Chicken RAF1-6859C Recombinant Chicken RAF1 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • RAF1 Related Articles
  • RAF1 Related Research Area
  • RAF1 Related Signal Pathway

RAF1 involved in several pathways and played different roles in them. We selected most pathways RAF1 participated on our site, such as MAPK signaling pathway, ErbB signaling pathway, Ras signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with RAF1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
MAPK signaling pathwayPAK2;MAP2K4B;CDC25B;ARRB2;FGF8;CACNA1D;MAP4K4;MAP3K1;FGF7
ErbB signaling pathwayRPS6KB1;AKT1;MYCB;HRAS;CAMK2B1;EREG;HBEGFB;AKT2;NRAS
Ras signaling pathwayINS;NGF;PLA2G5;PLA2G12B;GNB4;GNG10;Pdgfa&Pdgfb;PLD2;FGF13
Rap signaling pathwayLCP2;KRAS;GNAS;NRAS;FARP2;PARD6A;MAPK12;GRIN1;MET
cGMP-PKG signaling pathwayPLCB3;MEF2C;PDE3A;ATP1B3;PPP3R2;SLC8A2;INS2;GNAI3;MAPK1
cAMP signaling pathwaySOX9;HTR1F;HHIP;HCN2;VIPR2;RAC1;FSHB;FSHR;PDE4C
Chemokine signaling pathwayCCL21;GM10591;ROCK2;MAP2K1;CXCL1;PTK2B;CCR8;KRAS;Cxcl15
FoxO signaling pathwayFBXO25;SMAD3;PIK3R3A;NLK;S1PR4;IGF1RA;STK4;PLK1;TGFB3
Sphingolipid signaling pathwayPLCB1;GNA12;RELA;PLD2;SGMS1;SGPP2;SPTLC1;HRAS;DEGS2
Phospholipase D signaling pathwayRHOA;PIP5K1C;PDGFRB;DGKE;PLD1;PIK3CD;HRAS;PIP5K1A;GRM3
PIK-Akt signaling pathwayPRL;FGF13;IL3;KRAS;LAMB1;PPP2CA;GNG5;G6PC3;FGF22
Vascular smooth muscle contractionPPP1R12B;PPP1R12C;PLA2G6;ADORA2AB;CACNA1SA;PRKACBB;PPP1CB;ACTA2;PRKCBA
VEGF signaling pathwayMAPKAPK3;PLA2G4C;MAPK14A;PPP3CCA;MAP2K1;SPHK1;PLCG2;SPHK2;MAPK12B
Focal adhesionARHGAP35;MYL9A;PARVB;PTEN;ITGA6;COL11A2;COL27A1B;RAPGEF1B;FLNB
Gap junctionPRKACBA;TUBA2;ITPR3;TUBA3D;PRKG1A;TUBB;PRKACBB;GUCY1A3;HRAS
Signaling pathways regulating pluripotency of stem cellsNODAL;ZFHX3;WNT2;ACVR1;Fzd4;APC;ACVR1C;SMAD3;MAPK13
Jak-STAT signaling pathwayJAK2A;IL15RA;IL10RA;STAT1;IL17D;HRASB;M17;SOCS3B;IL6
Natural killer cell mediated cytotoxicityIFNA16;MAP2K1;IFNA17;Fasl;PRKCB;RAC1;IFNA6;KLRD1;KLRC4-KLRK1
T cell receptor signaling pathwayIL5;CD40LG;NFKBIB;PIK3CA;MAP2K1;CARD11;SHB;NFKBIA;PAK6
B cell receptor signaling pathwayBANK1;PILRB;IKBKG;CSK;CD72;PIK3AP1;TTC6;AKT2;ARPC2
Fc epsilon RI signaling pathwayMAPK12;NRAS;VAV2;MAP2K3;MAPK13;SYK;MAPK10;PIK3CG;RAC2
Fc gamma R-mediated phagocytosisAKT1;FCGR3A;WASF2;PIK3CA;SYK;WAS;BIN1;SPHK2;PLA2G6
Long-term potentiationPRKACA;CAMK2A;MAPK3;CAMK4;GRIN2A;PPP3CC;PPP3R2;PLCB2;PPP1CC
Neurotrophin signaling pathwaySH2B1;IRAK1;NFKBIA;MAPK12;CAMK2D;MAP2K7;MAP3K5;PDPK1;MAPK8
Serotonergic synapseALOX5;ALOX15;TRPC1;ITPR3;PRKACA;GNG8;MAPK3;GABRB2;KCND2
Long-term depressionPPP2CB;MAP2K1;GNAI2;MAPK1;GRIA2;LYN;ARAF;PPP2CA;GNA12
Regulation of actin cytoskeletonACTB1;ARPC5L;FN1;WAS;ITGB4;INSB;RAC1;ITGA3B;PIP4K2C
Insulin signaling pathwayMAP2K2;RHOQ;PDE3B;EIF4E1B;BADB;SLC2A4;SHC1;PPP1R3A;IRS2
GnRH signaling pathwayPTK2B;PRKACAA;GNA15.4;GNA15.1;HBEGFA;CAMK2B;CAMK2B1;PRKACG;CALM3
Progesterone-mediated oocyte maturationPLK1;PIK3R5;CDC16;PIK3R3B;IGF1;AKT2L;MAPK3;ANAPC13;BRAF
Estrogen signaling pathwayPIK3CD;PIK3CA;AKT1;KCNJ9;CALML5;KCNJ3;CREB3L2;GNAI3;SOS1
MelanogenesisCALM2;MITFA;GNAO1A;FZD3;EDNRB2;WNT4A;Fzd4;Kitl;GNAQ
Prolactin signaling pathwayMAPK11;PIK3R1;MAPK3;STAT3;SOCS7;PRL;RELA;MAPK1;MAPK8
Thyroid hormone signaling pathwayNOTCH3;PFKFB2;ATP1B2;PFKP;PIK3CD;SLC2A1;TP53;TBC1D4;DIO1
Oxytocin signaling pathwayPIK3R2;CCND1;PPP1R12A;PLA2G4F;ITPR1;RAF1;PLA2G4A;PLCB2;PPP3R2
AlcoholismHIST1H2BC;GNG8;H3F3C;HIST1H4G;HIST2H2BE;DRD1;PDYN;HIST1H3G;BDNF
TuberculosisTRAF6;KSR1;IFNA21;TGFB1;AKT2;CORO1A;CD209B;CALM1;PLK3
Hepatitis CPPP2R2C;IFIT1;STAT2;AKT1;SCARB1;PPP2CB;IKBKG;GSK3B;TYK2
Hepatitis BTGFB2;MAP2K1;ATF4;IRF7;BAX;CREB5;TP53;PIK3CD;CASP9
Influenza AMAP2K3;BLB1;FDPS;HLA-DMB;IRAK4;BLA;NFKBIB;HLA-DPB1;EIF2AK1
Pathways in cancerGSK3B;KRAS;PTGER3;CCNA1;CCDC6;TGFBR2;NCOA4;MITF;HDAC2
Proteoglycans in cancerPRKCG;EZR;TWIST2;WNT9A;WNT10B;FGFR1;WNT11;CAMK2G;NANOG
MicroRNAs in cancerRECK;SLC45A3;MMP16;Pdgfa&Pdgfb;SOX4;TRP53;TIMP3;TNXB;NOTCH4
Colorectal cancerDCC;CASP9;BCL2;BAD;MAPK9;ARAF;AXIN2;TGFB2;PIK3CG
Renal cell carcinomaPIK3R2;PIK3R3;KRAS;ETS1;CUL2;HIF1A;PIK3CG;MAP2K2;GAB1
Pancreatic cancerPIK3CB;RAD51;PIK3R5;ARHGEF6;AKT2;TRP53;RALB;ERBB2;SMAD2
Endometrial cancerMAP2K2;AKT2;CTNNA2;PIK3R2;ARAF;APC2;PDPK1;PIK3R1;PIK3CD
GliomaSHC4;PLCG2;MAPK1;CAMK2G;PIK3R1;PIK3CB;PRKCB;MAPK3;TRP53
Prostate cancerCREB3L1;HSP90AB1;PIK3R3;AKT2;CREB3L2;CPN1;MAP4K1;TGFA;RAF1
MelanomaFGF22;FGF4;MITF;PIK3CD;FGF21;FGF8;PIK3R1;PIK3CG;FGF19
Bladder cancerMAPK1;MAPK3;FGFR3;MDM2;MMP1;UPK3A;E2F3;MMP9;KRAS
Chronic myeloid leukemiaAKT2;BCL2L1;SHC1;RUNX1;KRAS;GAB2;RAF1;PIK3CD;CDK6
Acute myeloid leukemiaPIM2;NRAS;FLT3;SPI1;RARA;CHUK;PIK3CD;PIK3R2;PPARD
Non-small cell lung cancerCASP9;PRKCA;SOS1;ERBB2;RASSF1;FOXO3;PIK3CB;TRP53;HRAS
Central carbon metabolism in cancerG6PD;RAF1;MAP2K2;PDHA1;PDK1;AKT2;KIT;PDHA2;PKM
Choline metabolism in cancerPLA2G4A;PLD2;MAP2K2;TSC1;KRAS;DGKE;PDGFA;PDPK1;PIK3CG

RAF1 has several biochemical functions, for example, ATP binding, MAP kinase kinase kinase activity, identical protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by RAF1 itself. We selected most functions RAF1 had, and list some proteins which have the same functions with RAF1. You can find most of the proteins on our site.

Function Related Protein
ATP bindingRTCD1;OAS1B;MYHZ1.1;SEPHS2;SARS;PKZ;MAPK15;MAP4K5;GALK1
MAP kinase kinase kinase activityMAP3K4;MOS;STK3;YSK4;MAP3K2;EGFR;TAOK2;RAF1;ALPK2
identical protein bindingCOL1A1;GRIN3A;SRI;NDE1;NME1;INS;MUL1A;DESI1;HSPB8
metal ion bindingPICK1;IRF2BP2A;TDO2A;GLI2A;GEN1;WBP7;THAP10;PDE3A;ZNF469
mitogen-activated protein kinase kinase bindingTRIB3;TRIB2;MAP3K11;ACE;KSR1;TAOK2;ARRB1;BRAF;IGBP1
protein bindingTMEM66;CXXC1;SCG2;NAT9;FOXO4;CCDC135;DCC;KLB;USHBP1
protein heterodimerization activityIKZF2;Fzd4;TTR;MYO5A;VOX;BMP7A;F11R.1;CHRNB4;SYT10
protein kinase activityPDPK1B;EPHA4;RIPK1L;SBK1;CDK13;MYO3A;IGF1RB;Fert2;PDPK1A
protein serine/threonine kinase activityCDK14;MAPK14A;PRKCQ;AURKB;HIPK4;RPS6KA2;GM4922;CSNK2A1;SQSTM1
NOT small GTPase bindingBRAF;RAF1

RAF1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RAF1 here. Most of them are supplied by our site. Hope this information will be useful for your research of RAF1.

HRAS; YWHAZ

Feiz, L; Williams-Carrier, R; et al. A protein with an inactive pterin-4a-carbinolamine dehydratase domain is required for Rubisco biogenesis in plants. PLANT JOURNAL 80:862-869(2014).
Lou, Q; Zhang, W; et al. The C-Type Lectin OCILRP2 Costimulates EL4 T Cell Activation via the DAP12-Raf-MAP Kinase Pathway. PLOS ONE 9:-(2014).
  • Q&As
  • Reviews

Q&As (5)

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How is the RAF1 protein studied in a clinical context? 01/21/2023

The RAF1 protein is studied through a combination of molecular biology techniques, such as immunohistochemistry, Western blotting, and genetic sequencing, in both clinical and research settings.

Is RAF1 protein expression routinely tested in cancer diagnostics? 06/11/2019

RAF1 protein expression is not typically included in routine cancer diagnostics. Instead, mutations and expression levels of other genes, like BRAF, are often analyzed in cancer patients.

Are there any clinical trials focused on RAF1 protein for disease treatment or research? 01/14/2019

Clinical trials involving RAF1 protein are ongoing for conditions like Noonan syndrome and certain cancers. These trials aim to develop new therapies and better understand its role in disease.

How does the RAF1 protein influence cardiac health, and what clinical implications does this have? 02/28/2018

RAF1 mutations can affect cardiac development, leading to congenital heart defects and other cardiac issues in patients with Noonan syndrome. This has important clinical implications for cardiologists and genetic counselors.

Can RAF1 mutations be inherited, and if so, how does this affect patients and their families? 01/31/2016

Yes, RAF1 mutations can be inherited, and they can lead to Noonan syndrome. This can have a significant impact on affected individuals and their families, necessitating specialized medical care and genetic counseling.

Customer Reviews (3)

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Reviews
04/18/2020

    They understand that each research project may have unique requirements, and they are more than willing to address these specific needs.

    11/01/2017

      The manufacturer's commitment to providing excellent technical support is truly impressive.

      02/25/2016

        Their prompt and insightful responses to inquiries and troubleshooting requests enable me to tackle experimental obstacles with confidence and efficiency.

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