Recombinant Human RAF1, GST-tagged

• Cat.No.: RAF1-2161H
• Product Overview: Recombinant Human RAF1 protein, fused to GST-tag, was expressed in E.coli and purified by GSH-sepharose.

Specification

• Source: E.coli
• Species: Human
• Tag: GST
• Protein length: C-term-300aa
• Storage: The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles.
• Storage Buffer: 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 100mM GSH and 1% Triton X-100,15%glycerol.

Gene Information

• Gene Name: RAF1 v-raf-1 murine leukemia viral oncogene homolog 1 [ Homo sapiens ]
• Official Symbol: RAF1
• Synonyms: RAF1; v-raf-1 murine leukemia viral oncogene homolog 1; RAF proto-oncogene serine/threonine-protein kinase; c Raf; CRAF; Raf 1; Oncogene RAF1; proto-oncogene c-RAF; raf proto-oncogene serine/threonine protein kinase; NS5; Raf-1; c-Raf
• Gene ID: 5894
• mRNA Refseq: NM_002880
• Protein Refseq: NP_002871
• MIM: 164760
• UniProt ID: P04049
• Chromosome Location: 3p25
• Pathway: ARMS-mediated activation, organism-specific biosystem; Activation of NMDA receptor upon glutamate binding and postsynaptic events, organism-specific biosystem; Acute myeloid leukemia, organism-specific biosystem; Acute myeloid leukemia, conserved biosyste
• Function: ATP binding; MAP kinase kinase kinase activity; Ras GTPase binding; metal ion binding; mitogen-activated protein kinase kinase binding; nucleotide binding; protein binding; protein heterodimerization activity; protein kinase activity; protein serine/threo

Reviews

04/18/2020

They understand that each research project may have unique requirements, and they are more than willing to address these specific needs.

11/01/2017

The manufacturer's commitment to providing excellent technical support is truly impressive.

02/25/2016

Their prompt and insightful responses to inquiries and troubleshooting requests enable me to tackle experimental obstacles with confidence and efficiency.

Q&As

How is the RAF1 protein studied in a clinical context?

The RAF1 protein is studied through a combination of molecular biology techniques, such as immunohistochemistry, Western blotting, and genetic sequencing, in both clinical and research settings.

Is RAF1 protein expression routinely tested in cancer diagnostics?

RAF1 protein expression is not typically included in routine cancer diagnostics. Instead, mutations and expression levels of other genes, like BRAF, are often analyzed in cancer patients.

Are there any clinical trials focused on RAF1 protein for disease treatment or research?

Clinical trials involving RAF1 protein are ongoing for conditions like Noonan syndrome and certain cancers. These trials aim to develop new therapies and better understand its role in disease.

How does the RAF1 protein influence cardiac health, and what clinical implications does this have?

RAF1 mutations can affect cardiac development, leading to congenital heart defects and other cardiac issues in patients with Noonan syndrome. This has important clinical implications for cardiologists and genetic counselors.

Can RAF1 mutations be inherited, and if so, how does this affect patients and their families?

Yes, RAF1 mutations can be inherited, and they can lead to Noonan syndrome. This can have a significant impact on affected individuals and their families, necessitating specialized medical care and genetic counseling.