RPS6KA1

  • Official Full Name

    ribosomal protein S6 kinase, 90kDa, polypeptide 1

  • Background

    RSK 1 (p90-RSK 1) is a member of a family of 90 kDa ribosomal protein S6 kinases, which includes RSK 1, RSK 2 and RSK 3. These are broadly expressed serine/threonine protein kinases (1) activated in response to mitogenic stimuli, including extracellular signal-regulated protein kinases Erk1 and Erk2 (2). p90-RSK 1 is activated by MAPK in vitro and in vivo via phosphorylation (3). Active RSKs appear to play a major role in transcriptional regulation by translocating to the nucleus and phosphorylating c-Fos and CREB (2,4).
  • Synonyms

    RPS6KA1; ribosomal protein S6 kinase, 90kDa, polypeptide 1; ribosomal protein S6 kinase, 90kD, polypeptide 1; ribosomal protein S6 kinase alpha-1; HU 1; RSK; RSK1; RSK-1; p90S6K; p90RSK1; p90-RSK 1; MAPKAPK-1a; S6K-alpha 1; S6K-alpha-1; MAPKAP kinase 1a; ribosomal S6 kinase 1; MAPK-activated protein kinase 1a; ribosomal protein S6 kinase alpha 1; 90 kDa ribosomal protein S6 kinase 1; MAP kinase-activated protein kinase 1a; dJ590P13.1 (ribosomal protein S6 kinase, 90kD, polypeptide 1); HU-1; MAPKAPK1A;
    • Type:
    • Recombinant Proteins
    • Cell & Tissue Lysates
    • Protein Pre-coupled Magnetic Beads
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rat
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Insect (sf21)
    • Insect Cell
    • Mammalian Cell
    • Sf9 Insect Cell
    • Tag :
    • GST
    • His
    • His (Fc)
    • Avi
    • His|T7
    • Myc
    • DDK
    • N/A
    • No tag
    Species Cat.# Product name Source (Host) Tag Price
    Human RPS6KA1-555H Active Recombinant Human RPS6KA1, GST-tagged Sf9 Insect Cell GST
    Human RPS6KA1-550H Recombinant Human RPS6KA1 Mammalian Cell His
    Human RPS6KA1-30110TH Recombinant Human RPS6KA1 N/A
    Human RPS6KA1-2432H Recombinant Human RPS6KA1, GST-tagged E.coli GST
    Human RPS6KA1-424H Recombinant Human RPS6KA1, GST-tagged, Active Sf9 Insect Cell GST
    Human RPS6KA1-2162HCL Recombinant Human RPS6KA1 293 Cell Lysate HEK293 N/A
    Human RPS6KA1-3984H Recombinant Human RPS6KA1 protein, His-tagged E.coli His
    Human RPS6KA1-1934H Recombinant Human RPS6KA1 protein, His & T7-tagged E.coli His/T7
    Human RPS6KA1-4414H Recombinant Human RPS6KA1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human RPS6KA1-1148H Recombinant Human RPS6KA1 Protein (Q33-T353), Tag Free Insect Cell No tag
    Human RPS6KA1-8403HF Active Recombinant Full Length Human RPS6KA1 Protein, GST-tagged Insect (sf21) GST
    Human RPS6KA1-4010H Recombinant Human RPS6KA1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
    Human RPS6KA1-1149H Recombinant Human RPS6KA1 Protein (Q33-T353), His tagged Insect Cell His
    Human RPS6KA1-4010H-B Recombinant Human RPS6KA1 Protein Pre-coupled Magnetic Beads HEK293
    Mouse Rps6ka1-5609M Recombinant Mouse Rps6ka1 Protein, Myc/DDK-tagged HEK293T Myc/DDK
    Rat RPS6KA1-5172R Recombinant Rat RPS6KA1 Protein Mammalian Cell His
    Rat RPS6KA1-4831R-B Recombinant Rat RPS6KA1 Protein Pre-coupled Magnetic Beads HEK293
    Rat RPS6KA1-4831R Recombinant Rat RPS6KA1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
    Zebrafish RPS6KA1-4852Z Recombinant Zebrafish RPS6KA1 Mammalian Cell His
    Chicken RPS6KA1-3760C Recombinant Chicken RPS6KA1 Mammalian Cell His
    • Involved Pathway
    • Protein Function
    • Interacting Protein
    • RPS6KA1 Related Research Area
    • RPS6KA1 Related Signal Pathway

    RPS6KA1 involved in several pathways and played different roles in them. We selected most pathways RPS6KA1 participated on our site, such as MAPK signaling pathway, Oocyte meiosis, mTOR signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with RPS6KA1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    MAPK signaling pathwayFGF9;FGF12;MAPK3;CACNA1B;MAP2K1;FGFR3;RELA;RPS6KA4;CACNA1G
    Oocyte meiosisPGR;CALML5;CDK1;MAPK12B;YWHAZ;PPP1CA;PPP1CB;YWHAB;PPP1CAA
    mTOR signaling pathwayRPS6;TSC2;AKT3A;PRKCBB;INS;RPS6KA3;PTENA;DDIT4;VEGFA
    Long-term potentiationMAP2K1;GRIN2B;BRAF;PPP3R2;PLCB2;GRIN1;GNAQ;GRIN2A;MAP2K2
    Neurotrophin signaling pathwayMAPK1;ABL1;TP73;ARHGDIB;SHC4;BDNF;MAPK3;CAMK2G;KRAS
    Progesterone-mediated oocyte maturationPIK3CD;GNAI2;MAPK14A;PKMYT1;FZR1A;ANAPC11;PIK3CA;CDC25A;MAD1L1
    Insulin resistanceINSRA;PIK3CA;INSR;PPP1R3B;GYS1;SLC27A2;FOXO1B;RPS6KA2;G6PC2

    RPS6KA1 has several biochemical functions, for example, ATP binding, cysteine-type endopeptidase inhibitor activity involved in apoptotic process, magnesium ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by RPS6KA1 itself. We selected most functions RPS6KA1 had, and list some proteins which have the same functions with RPS6KA1. You can find most of the proteins on our site.

    Function Related Protein
    ATP bindingTESK2;ADCY7;PFKM;CHUK;RECQL4;CSNK1D;UBE2IB;ACSL1;RAD54L
    cysteine-type endopeptidase inhibitor activity involved in apoptotic processSERPINB1A;LEF1;MT3;GAS6;IGF1RA;PRDX5;C1QL4L;PRDX3;BIRC5
    magnesium ion bindingIMPAD1;ERN2;NUAK2;NUDT3;PPM1A;EYA2;FDXACB1;RPS6KA3B;PGP
    protein bindingRFFL;PROCR;SLC16A3;BCS1L;SLC9A1;CDK11B;STAT4;PTCH1;NGLY1
    protein serine/threonine kinase activityDMPK;IRAK4;PRKCHB;BUB1B;ALPK1;CAMK2D1;CDK11B;MAPK4;TTK
    protein serine/threonine/tyrosine kinase activityDYRK3;RPS6KB1;TNK2;TESK1;CLK2;DYRK2;MAP2K2;PRKCG;SGK1
    ribosomal protein S6 kinase activityRPS6KB1B;RPS6KA3B;RPS6KA4;RPS6KA3;RPS6KB2;RPS6KA3A;RPS6KA1;ALPK2;RPS6KB1

    RPS6KA1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RPS6KA1 here. Most of them are supplied by our site. Hope this information will be useful for your research of RPS6KA1.

    HSP90AB1; VASP; MAPT; CREB1; EIF4B; RPS6; xmd8-92; biotin_acyl-p_probe; YWHAB; ENAH; PPM1G; DDAH2; CFL1; GBP2; TTK; CCT4

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