RPS6KA1
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Official Full Name
ribosomal protein S6 kinase, 90kDa, polypeptide 1
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Background
RSK 1 (p90-RSK 1) is a member of a family of 90 kDa ribosomal protein S6 kinases, which includes RSK 1, RSK 2 and RSK 3. These are broadly expressed serine/threonine protein kinases (1) activated in response to mitogenic stimuli, including extracellular signal-regulated protein kinases Erk1 and Erk2 (2). p90-RSK 1 is activated by MAPK in vitro and in vivo via phosphorylation (3). Active RSKs appear to play a major role in transcriptional regulation by translocating to the nucleus and phosphorylating c-Fos and CREB (2,4). -
Synonyms
RPS6KA1; ribosomal protein S6 kinase, 90kDa, polypeptide 1; ribosomal protein S6 kinase, 90kD, polypeptide 1; ribosomal protein S6 kinase alpha-1; HU 1; RSK; RSK1; RSK-1; p90S6K; p90RSK1; p90-RSK 1; MAPKAPK-1a; S6K-alpha 1; S6K-alpha-1; MAPKAP kinase 1a; ribosomal S6 kinase 1; MAPK-activated protein kinase 1a; ribosomal protein S6 kinase alpha 1; 90 kDa ribosomal protein S6 kinase 1; MAP kinase-activated protein kinase 1a; dJ590P13.1 (ribosomal protein S6 kinase, 90kD, polypeptide 1); HU-1; MAPKAPK1A;
- Involved Pathway
- Protein Function
- Interacting Protein
- RPS6KA1 Related Research Area
- RPS6KA1 Related Signal Pathway
RPS6KA1 involved in several pathways and played different roles in them. We selected most pathways RPS6KA1 participated on our site, such as MAPK signaling pathway, Oocyte meiosis, mTOR signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with RPS6KA1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| MAPK signaling pathway | FGF9;FGF12;MAPK3;CACNA1B;MAP2K1;FGFR3;RELA;RPS6KA4;CACNA1G |
| Oocyte meiosis | PGR;CALML5;CDK1;MAPK12B;YWHAZ;PPP1CA;PPP1CB;YWHAB;PPP1CAA |
| mTOR signaling pathway | RPS6;TSC2;AKT3A;PRKCBB;INS;RPS6KA3;PTENA;DDIT4;VEGFA |
| Long-term potentiation | MAP2K1;GRIN2B;BRAF;PPP3R2;PLCB2;GRIN1;GNAQ;GRIN2A;MAP2K2 |
| Neurotrophin signaling pathway | MAPK1;ABL1;TP73;ARHGDIB;SHC4;BDNF;MAPK3;CAMK2G;KRAS |
| Progesterone-mediated oocyte maturation | PIK3CD;GNAI2;MAPK14A;PKMYT1;FZR1A;ANAPC11;PIK3CA;CDC25A;MAD1L1 |
| Insulin resistance | INSRA;PIK3CA;INSR;PPP1R3B;GYS1;SLC27A2;FOXO1B;RPS6KA2;G6PC2 |
RPS6KA1 has several biochemical functions, for example, ATP binding, cysteine-type endopeptidase inhibitor activity involved in apoptotic process, magnesium ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by RPS6KA1 itself. We selected most functions RPS6KA1 had, and list some proteins which have the same functions with RPS6KA1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ATP binding | TESK2;ADCY7;PFKM;CHUK;RECQL4;CSNK1D;UBE2IB;ACSL1;RAD54L |
| cysteine-type endopeptidase inhibitor activity involved in apoptotic process | SERPINB1A;LEF1;MT3;GAS6;IGF1RA;PRDX5;C1QL4L;PRDX3;BIRC5 |
| magnesium ion binding | IMPAD1;ERN2;NUAK2;NUDT3;PPM1A;EYA2;FDXACB1;RPS6KA3B;PGP |
| protein binding | RFFL;PROCR;SLC16A3;BCS1L;SLC9A1;CDK11B;STAT4;PTCH1;NGLY1 |
| protein serine/threonine kinase activity | DMPK;IRAK4;PRKCHB;BUB1B;ALPK1;CAMK2D1;CDK11B;MAPK4;TTK |
| protein serine/threonine/tyrosine kinase activity | DYRK3;RPS6KB1;TNK2;TESK1;CLK2;DYRK2;MAP2K2;PRKCG;SGK1 |
| ribosomal protein S6 kinase activity | RPS6KB1B;RPS6KA3B;RPS6KA4;RPS6KA3;RPS6KB2;RPS6KA3A;RPS6KA1;ALPK2;RPS6KB1 |
RPS6KA1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RPS6KA1 here. Most of them are supplied by our site. Hope this information will be useful for your research of RPS6KA1.
HSP90AB1; VASP; MAPT; CREB1; EIF4B; RPS6; xmd8-92; biotin_acyl-p_probe; YWHAB; ENAH; PPM1G; DDAH2; CFL1; GBP2; TTK; CCT4
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