Recombinant Human RPS6KA1, GST-tagged, Active

Cat.No. : RPS6KA1-424H
Product Overview : Recombinant full-length human RPS6KA1 was expressed bybaculovirusinSf9 insect cellsusing an N-terminal GST tag. MW=108kDa.
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Cat. No. : RPS6KA1-424H
Description : RSK1 is a member of the RSK (ribosomal S6 kinase) family that are growth factor-regulated serine/threonine kinases. RSK1 contains 2 nonidentical kinase catalytic domains and phosphorylates various substrates, including members of the mitogen-activated kinase (MAPK) signalling pathway. RSK1 encodes a predicted 735-amino acid protein containing 2 distinct consensus ATP-binding site sequences. RSK1 transcript is present in lymphocytes, skeletal muscle, liver, and adipose tissue. RSKs are implicated in the activation of the mitogen-activated kinase (MAPK) cascade and the stimulation of cell proliferation and differentiation.
Source : Sf9 insect cells using baculovirus.
Sequence : Full-length.
Applications : Kinase Assay, Western Blot.
Storage And Stability : Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
nullValue_other : Long-term potentiation; MAPK signaling pathway; Neurotrophin signaling pathway; Progesterone-mediated oocyte maturation; mTOR signaling pathway; Signalling by NGF
Gene Name : RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1 [ Homo sapiens ]
Synonyms : RPS6KA1; ribosomal protein S6 kinase, 90kDa, polypeptide 1; S6K-alpha 1; dJ590P13.1 (ribosomal protein S6 kinase, 90kD, polypeptide 1); p90-RSK 1; ribosomal protein S6 kinase alpha 1; RSK; HU-1; RSK1; MAPKAPK1A; EC 2.7.11.1
Gene ID : 6195
mRNA Refseq : NM_001006665
Protein Refseq : NP_001006666
MIM : 601684
UniProt ID : Q15418
Chromosome Location : 1p
Function : ATP binding; magnesium ion binding; nucleotide binding; protein binding; transferase activity; protein serine/threonine kinase activity

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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What is the impact of RPS6KA1 dysregulation on metabolic disorders, such as diabetes and obesity? 10/29/2020

Dysregulation of RPS6KA1 impacts metabolic processes, influencing conditions like diabetes and obesity.

What are the mechanisms by which RPS6KA1 modulates the cell cycle and apoptosis? 01/27/2020

RPS6KA1 modulates the cell cycle and apoptosis, playing a role in cell proliferation and programmed cell death.

How does RPS6KA1 influence neuronal development and function, especially in learning and memory processes? 07/20/2019

RPS6KA1 is involved in neuronal development and function, affecting processes like learning and memory.

How do genetic mutations in RPS6KA1 contribute to the development of certain cancers and other diseases? 06/24/2019

Genetic mutations in RPS6KA1 are linked to certain cancers and diseases, affecting its kinase activity and signaling functions.

How does RPS6KA1 interact with other kinases and signaling molecules in cellular signaling networks? 03/25/2019

RPS6KA1 interacts with various kinases and signaling molecules, integrating multiple cellular signaling pathways.

What role does RPS6KA1 play in cellular responses to stress, particularly in cancer cells? 09/16/2018

RPS6KA1 plays a crucial role in stress responses in cancer cells, influencing cell survival and adaptation mechanisms.

How does RPS6KA1 regulate protein synthesis and cell growth through the mTOR signaling pathway? 01/06/2018

RPS6KA1 regulates protein synthesis and cell growth by modulating the mTOR pathway, affecting ribosomal protein activity.

Customer Reviews (3)

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Reviews
07/10/2022

    Exceptional protein purification, highly recommended for research.

    06/02/2022

      Dependable mass spectrometry analysis; enhances our proteomics research.

      05/26/2020

        Quick and precise protein expression, a valuable service.

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