Recombinant Human RPS6KA1 Protein, Myc/DDK-tagged, C13 and N15-labeled

Cat.No. : RPS6KA1-4414H
Product Overview : RPS6KA1 MS Standard C13 and N15-labeled recombinant protein (NP_002944) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells.
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Description : This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 nonidentical kinase catalytic domains and phosphorylates various substrates, including members of the mitogen-activated kinase (MAPK) signalling pathway. The activity of this protein has been implicated in controlling cell growth and differentiation. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
Source : HEK293
Species : Human
Tag : Myc/DDK
Molecular Mass : 82.7 kDa
AA Sequence : MPLAQLKEPWPLMELVPLDPENGQT SGEEAGLQPSKDEGVLKEISITHHV KAGSEKADPSHFELLKVLGQGSFGK VFLVRKVTRPDSGHLYAMKVLKKAT LKVRDRVRTKMERDILADVNHPFVV KLHYAFQTEGKLYLILDFLRGGDLF TRLSKEVMFTEEDVKFYLAELALGL DHLHSLGIIYRDLKPENILLDEEGH IKLTDFGLSKEAIDHEKKAYSFCGT VEYMAPEVVNRQGHSHSADWWSYGV LMFEMLTGSLPFQGKDRKETMTLIL KAKLGMPQFLSTEAQSLLRALFKRN PANRLGSGPDGAEEIKRHVFYSTID WNKLYRREIKPPFKPAVAQPDDTFY FDTEFTSRTPKDSPGIPPSAGAHQL FRGFSFVATGLMEDDGKPRAPQAPL HSVVQQLHGKNLVFSDGYVVKETIG VGSYSECKRCVHKATNMEYAVKVID KSKRDPSEEIEILLRYGQHPNIITL KDVYDDGKHVYLVTELMRGGELLDK ILRQKFFSEREASFVLHTIGKTVEY LHSQGVVHRDLKPSNILYVDESGNP ECLRICDFGFAKQLRAENGLLMTPC YTANFVAPEVLKRQGYDEGCDIWSL GILLYTMLAGYTPFANGPSDTPEEI LTRIGSGKFTLSGGNWNTVSETAKD LVSKMLHVDPHQRLTAKQVLQHPWV TQKDKLPQSQLSHQDLQLVKGAMAA TYSALNSSKPTPQLKPIESSILAQR RVRKLPSTTLTRTRPLEQKLISEED LAANDILDYKDDDDKV
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Stability : Stable for 3 months from receipt of products under proper storage and handling conditions.
Storage : Store at -80 centigrade. Avoid repeated freeze-thaw cycles.
Concentration : 50 μg/mL as determined by BCA
Storage Buffer : 100 mM glycine, 25 mM Tris-HCl, pH 7.3.
Gene Name : RPS6KA1 ribosomal protein S6 kinase A1 [ Homo sapiens (human) ]
Official Symbol : RPS6KA1
Synonyms : RPS6KA1; ribosomal protein S6 kinase, 90kDa, polypeptide 1; ribosomal protein S6 kinase, 90kD, polypeptide 1; ribosomal protein S6 kinase alpha-1; HU 1; RSK; RSK1; RSK-1; p90S6K; p90RSK1; p90-RSK 1; MAPKAPK-1a; S6K-alpha 1; S6K-alpha-1; MAPKAP kinase 1a; ribosomal S6 kinase 1; MAPK-activated protein kinase 1a; ribosomal protein S6 kinase alpha 1; 90 kDa ribosomal protein S6 kinase 1; MAP kinase-activated protein kinase 1a; dJ590P13.1 (ribosomal protein S6 kinase, 90kD, polypeptide 1); HU-1; MAPKAPK1A;
Gene ID : 6195
mRNA Refseq : NM_002953
Protein Refseq : NP_002944
MIM : 601684
UniProt ID : Q15418

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (7)

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What is the impact of RPS6KA1 dysregulation on metabolic disorders, such as diabetes and obesity? 10/29/2020

Dysregulation of RPS6KA1 impacts metabolic processes, influencing conditions like diabetes and obesity.

What are the mechanisms by which RPS6KA1 modulates the cell cycle and apoptosis? 01/27/2020

RPS6KA1 modulates the cell cycle and apoptosis, playing a role in cell proliferation and programmed cell death.

How does RPS6KA1 influence neuronal development and function, especially in learning and memory processes? 07/20/2019

RPS6KA1 is involved in neuronal development and function, affecting processes like learning and memory.

How do genetic mutations in RPS6KA1 contribute to the development of certain cancers and other diseases? 06/24/2019

Genetic mutations in RPS6KA1 are linked to certain cancers and diseases, affecting its kinase activity and signaling functions.

How does RPS6KA1 interact with other kinases and signaling molecules in cellular signaling networks? 03/25/2019

RPS6KA1 interacts with various kinases and signaling molecules, integrating multiple cellular signaling pathways.

What role does RPS6KA1 play in cellular responses to stress, particularly in cancer cells? 09/16/2018

RPS6KA1 plays a crucial role in stress responses in cancer cells, influencing cell survival and adaptation mechanisms.

How does RPS6KA1 regulate protein synthesis and cell growth through the mTOR signaling pathway? 01/06/2018

RPS6KA1 regulates protein synthesis and cell growth by modulating the mTOR pathway, affecting ribosomal protein activity.

Customer Reviews (3)

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Reviews
07/10/2022

    Exceptional protein purification, highly recommended for research.

    06/02/2022

      Dependable mass spectrometry analysis; enhances our proteomics research.

      05/26/2020

        Quick and precise protein expression, a valuable service.

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