Active Recombinant Full Length Human RPS6KA1 Protein, GST-tagged

• Cat.No.: RPS6KA1-8403HF
• Product Overview: Full-length human RSK1 [1-735(end) amino acids of accession number NP_002944.2] was expressed as N-terminal GST-fusion protein (110 kDa) using baculovirus expression system. GST-RSK1 was purified by using glutathione sepharose chromatography.

Specification

• Source: Insect (sf21)
• Species: Human
• Tag: GST
• Form: 50 mM Tris-HCl, 150 mM NaCl, 0.05% Brij35, 1 mM DTT, 10% glycerol, pH7.5
• Bio-activity: The activity was measured by off-chip mobility shift assay. The enzyme was incubated with fluorecence-labeled substrate and Mg(or Mn)/ATP. The phosphorylated and unphosphorylated substrates were separated and detected by LabChip™3000.
• Protein length: 1-735
• Purity: 72%
• Applications: SDS-PAGE
• Storage: Store at -80C. Avoid repeating freeze-thaws.

Gene Information

• Gene Name: ribosomal protein S6 kinase, 90kDa, polypeptide 1
• Official Symbol: RPS6KA1
• Synonyms: RPS6KA1;HU-1;MAPKAPK1;MAPKAPK1A;RSK;RSK1;p90Rsk
• Protein Refseq: NP_002944.2
• UniProt ID: Q15418

Reviews

07/10/2022

Exceptional protein purification, highly recommended for research.

06/02/2022

Dependable mass spectrometry analysis; enhances our proteomics research.

05/26/2020

Quick and precise protein expression, a valuable service.

Q&As

What is the impact of RPS6KA1 dysregulation on metabolic disorders, such as diabetes and obesity?

Dysregulation of RPS6KA1 impacts metabolic processes, influencing conditions like diabetes and obesity.

What are the mechanisms by which RPS6KA1 modulates the cell cycle and apoptosis?

RPS6KA1 modulates the cell cycle and apoptosis, playing a role in cell proliferation and programmed cell death.

How does RPS6KA1 influence neuronal development and function, especially in learning and memory processes?

RPS6KA1 is involved in neuronal development and function, affecting processes like learning and memory.

How do genetic mutations in RPS6KA1 contribute to the development of certain cancers and other diseases?

Genetic mutations in RPS6KA1 are linked to certain cancers and diseases, affecting its kinase activity and signaling functions.

How does RPS6KA1 interact with other kinases and signaling molecules in cellular signaling networks?

RPS6KA1 interacts with various kinases and signaling molecules, integrating multiple cellular signaling pathways.

What role does RPS6KA1 play in cellular responses to stress, particularly in cancer cells?

RPS6KA1 plays a crucial role in stress responses in cancer cells, influencing cell survival and adaptation mechanisms.

How does RPS6KA1 regulate protein synthesis and cell growth through the mTOR signaling pathway?

RPS6KA1 regulates protein synthesis and cell growth by modulating the mTOR pathway, affecting ribosomal protein activity.