RPS6KA2

  • Official Full Name

    ribosomal protein S6 kinase, 90kDa, polypeptide 2

  • Overview

    This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 non-identical kinase catalytic domains and phosphorylates various substrates, including members of the mitogen-activated kinase (MAPK) signalling pathway. The activity of this protein has been implicated in controlling cell growth and differentiation. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
  • Synonyms

    RPS6KA2; ribosomal protein S6 kinase, 90kDa, polypeptide 2; RSK; HU-2; RSK3; p90-RSK3; pp90RSK3; MAPKAPK1C; S6K-alpha; S6K-alpha2; ribosomal protein S6 kinase alpha-2; RSK-3; p90RSK2; p90-RSK 2; MAPKAPK-1c; S6K-alpha-2; MAPKAP kinase 1c; ribosomal S6 kinase 3; MAPK-activated protein kinase 1c; ribosomal protein S6 kinase alpha 2; 90 kDa ribosomal protein S6 kinase 2; MAP kinase-activated protein kinase 1c; ribosomal protein S6 kinase 90kDa polypeptide 2;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Cynomolgus Monkey
  • Human
  • Human
  • E.coli
  • HEK293
  • HEK293T
  • Insect (sf21)
  • Insect Cell
  • Insect Cells
  • Mammalian Cell
  • Sf21
  • Sf9 Insect Cell
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • N/A
  • No tag
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human RPS6KA2-168HFL Active Recombinant Full Length Human RPS6KA2 Protein, N-His-tagged Sf21 His Full Length
Human RPS6KA2-961H Active Recombinant Human RPS6KA2 protein, GST-tagged Insect Cells GST Met1-Leu733
Human RPS6KA2-426H Recombinant Human RPS6KA2, GST-tagged, Active Sf9 Insect Cell GST
Human RPS6KA2-2433H Recombinant Human RPS6KA2, His-tagged E.coli His 66-311aa
Human RPS6KA2-610HCL Recombinant Human RPS6KA2 cell lysate Insect Cell N/A
Human RPS6KA2-5400HF Active Recombinant Full Length Human RPS6KA2 Protein, GST-tagged Insect (sf21) GST 1-733
Human RPS6KA2-3740H Recombinant Human RPS6KA2 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human RPS6KA2-1150H Recombinant Human RPS6KA2 Protein (M1-L733), Tag Free Insect Cell No tag M1-L733
Human RPS6KA2-1151H Recombinant Human RPS6KA2 Protein (M1-L733), GST tagged Insect Cell GST M1-L733
Cynomolgus Monkey RPS6KA2-887C Recombinant Cynomolgus RPS6KA2 Protein, His-tagged Mammalian Cell His
Cynomolgus Monkey RPS6KA2-630C-B Recombinant Cynomolgus Monkey RPS6KA2 Protein Pre-coupled Magnetic Beads HEK293
Cynomolgus Monkey RPS6KA2-630C Recombinant Cynomolgus Monkey RPS6KA2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
  • Involved Pathway
  • Protein Function
  • Interacting Protein

RPS6KA2 involved in several pathways and played different roles in them. We selected most pathways RPS6KA2 participated on our site, such as MAPK signaling pathway, Oocyte meiosis, mTOR signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with RPS6KA2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
MAPK signaling pathwayAKT3A;C11orf52;PPM1B;ECSIT;MAP2K3;CACNG2A;PLA2G4D;RPS6KA4;CACNA1DA
Oocyte meiosisINS;YWHABA;PLK1;MAD2L2;IGF1RB;PPP1CB;CALM2;CALM3;YWHAZ
mTOR signaling pathwayTSC2;AKT3A;STRADA;PIK3R3A;EIF4E1C;ULK2;IGF1;RPS6KA1;TSC1
Long-term potentiationPRKACA;MAPK3;CALM1;CAMK2B;PRKACB;CALM3;GRIN2A;PPP3CC;MAPK1
Neurotrophin signaling pathwayKIDINS220;ZFP110;SORT1;MAPK12;SOS1;RAP1A;ARHGDIA;SHC2;NGFR
Progesterone-mediated oocyte maturationINS;CPEB2;BUB1;CCNB2;RPS6KA3;PRKACA;CDC25A;FZR1A;RPS6KAL
Insulin resistanceG6PC3;PRKCD;GSK3AA;PTPRF;NFKB1;IRS1;SLC2A2;INSR;NFKBIA

RPS6KA2 has several biochemical functions, for example, ATP binding, magnesium ion binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by RPS6KA2 itself. We selected most functions RPS6KA2 had, and list some proteins which have the same functions with RPS6KA2. You can find most of the proteins on our site.

Function Related Protein
ATP bindingCSNK1DB;MAP3K9;SIK3;STRC;C10orf2;IARS2;CCT8;UBE2C;YTHDC2
magnesium ion bindingSERPINB1A;TDP2B;PKMB;NLRC4;MAST2;IDH3A;FAN1;PPA2;ATP11A
protein bindingMECP2;ZNF750;TAF1;NAPG;TAF10;CPSF7;ZNF346;CNGA1;CENPO
protein serine/threonine kinase activityAKT1;MLKL;PAK4;FASTK;PDPK1;PDK3;NIM1K;ALPK1;SNRK
protein serine/threonine/tyrosine kinase activityTESK2;DYRK1B;MAP2K2;DYRK1AA;CLK4;AKT1;DYRK4;PRKCG;CLK3
ribosomal protein S6 kinase activityRPS6KA2;RPS6KB1;RPS6KA3A;RPS6KA3;RPS6KA4;RPS6KB1B;RPS6KA3B;ALPK2;RPS6KB2

RPS6KA2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RPS6KA2 here. Most of them are supplied by our site. Hope this information will be useful for your research of RPS6KA2.

MAPK3; MAPK1; saicar; PKM; RPS6; HSP90AB1; BRAF; PRKCA; PRKCE; CSNK2B; FLNC; 15-deoxy-delta(12,14; bosutinib; imatinib; GRSF1; FAT1

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