VAMP2
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Official Full Name
vesicle-associated membrane protein 2
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Overview
plays a role in membrane fusion in neuronal exocytosis [RGD, Feb 2006] -
Synonyms
VAMP2; vesicle-associated membrane protein 2; SYB; Syb2; RATVAMPB; RATVAMPIR; VAMP-2; synaptobrevin-2; Vesicle-associated membrane protein (synaptobrevin 2); Synaptobrevin 2 (vesicle-associated membrane protein VAMP-2);
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- Interacting Protein
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VAMP2 involved in several pathways and played different roles in them. We selected most pathways VAMP2 participated on our site, such as SNARE interactions in vesicular transport, Synaptic vesicle cycle, Insulin secretion, which may be useful for your reference. Also, other proteins which involved in the same pathway with VAMP2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| SNARE interactions in vesicular transport | STX1A;SEC22BB;BET1L;VAMP4;STX4;STX7;YKT6;SEC22BA;SNAP23.1 |
| Synaptic vesicle cycle | CPLX4;ATP6V1E1;ATP6V0D2;ATP6V1A;RAB3A;DNM3;ATP6V0D1;ATP6V0C;ATP6V1G1 |
| Insulin secretion | PLCB1;TRPM4;CAMK2A;KCNN2;PDX1;KCNN4;INS1;ATP1A1;CREB3L1 |
| Salivary secretion | CALML3;PLCB3;ATP1B4;CST1;ATP1B2;LPO;CST4;HTN1;NOS1 |
VAMP2 has several biochemical functions, for example, SNAP receptor activity, SNARE binding, calcium-dependent protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by VAMP2 itself. We selected most functions VAMP2 had, and list some proteins which have the same functions with VAMP2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| SNAP receptor activity | SNAP23.2;STX11B.1;BET1L;SNAP25A;STX7;SNAP47;STX2;VAMP1;SNAP25 |
| SNARE binding | SEC22BA;GABARAPL2;STX11B.1;MYO5A;STX4A;SYT1;VAMP3;STX11B.2;VAMP7 |
| calcium-dependent protein binding | STMN2;MASP2;SELP;RBM22;S100PBP;SYT1;PDCD6IP;KOP;A2M |
| calmodulin binding | PLCB3;SLC9A1;PPP3CB;MYH11;MYH1E;ASPM;PHKG2;ADCY3;PATE4 |
| identical protein binding | TOPBP1;ORAI1;STXBP1;SETX;RNF4;RIPK3;VEGFA;SCAND1;TLE1 |
| myosin binding | STX4A;SLC6A4;SMYD1B;CALD1;NPHS1;ACTC1;USH2A;RHOA;FXYD1 |
| phospholipid binding | APOA1;SYT14;SEC14L2;APOA2;Defa4;LPAR3;FABP1;BPIFC;PLA2G15 |
| protein C-terminus binding | PDZD3;HESX1;SLC9A3R2;PEX26;PPP1R9B;PPM1A;VPS4B;PLEKHB1;VTA1 |
| protein binding | RPS11;AMFR;HPS1;AKT2;ERC1;SLC4A1AP;EPO;CNOT7;C7orf59 |
| protein complex binding | CDK2;PEX1;CTSL2;LRRC16A;STRN;SHANK1;C8G;NFYB;ARRB2 |
| protein self-association | ABCD3;AGTR1A;PROSAPIP1;SVIP;TRIM32;RSAD2;VAMP2;CCDC88C;ZNF496 |
| syntaxin binding | RAB11A;ABCA1;SYT16;VAMP2;STX16;CAV1;NAPB;STXBP3;NAPA |
| syntaxin-1 binding | SYT1;CCDC167;DAPK1;UNC13A;SNAP25A;STXBP2;SYBU;CPLX1;GOLSYN |
VAMP2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with VAMP2 here. Most of them are supplied by our site. Hope this information will be useful for your research of VAMP2.
PRKD3; Picalm; SNAP29; STX4; F; d2khq9_clobo; g3hx91_crigr
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