VPS36
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Official Full Name
vacuolar protein sorting 36 homolog (S. cerevisiae) -
Overview
VPS36, VPS22 (SNF8; MIM 610904), and VPS25 (MIM 610907) form ESCRT-II (endosomal sorting complex required for transport II), a complex involved in endocytosis of ubiquitinated membrane proteins. VPS36, VPS22, and VPS25 are also associated in a multiprotein complex with RNA polymerase II elongation factor (ELL; MIM 600284) (Slagsvold et al., 2005 -
Synonyms
VPS36;vacuolar protein sorting 36 homolog (S. cerevisiae);C13orf9, chromosome 13 open reading frame 9 , vacuolar protein sorting 36 homolog (yeast);vacuolar protein-sorting-associated protein 36;CGI 145;Eap45;C13orf9;ELL associated protein of 45 kDa;ELL-associated protein of 45 kDa;ESCRT-II complex subunit VPS36;Vacuolar protein sorting associated protein 36;VPS36_HUMAN;ELL-associated protein, 45 kDa;CGI-145
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| VPS36-3679H | Recombinant Human VPS36, His-tagged | E.coli | Human | His | 1-386aa | |
| VPS36-10340Z | Recombinant Zebrafish VPS36 | Mammalian Cells | Zebrafish | His |
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| VPS36-388HCL | Recombinant Human VPS36 293 Cell Lysate | HEK293 | Human | Non |
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| VPS36-1808H | Recombinant Human VPS36 Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293 | Human | DDK&Myc |
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| Vps36-6939M | Recombinant Mouse Vps36 Protein, Myc/DDK-tagged | HEK293 | Mouse | DDK&Myc |
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Involved Pathway
VPS36 involved in several pathways and played different roles in them. We selected most pathways VPS36 participated on our site, such as Endocytosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with VPS36 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Endocytosis | PLD2,VPS26B,CYTH4,USP8,DDL-2,SPG21,PIP5KL1,EHD2,ARFGEF2,ARF6B |
Protein Function
VPS36 has several biochemical functions, for example, phosphatidylinositol-3-phosphate binding,protein C-terminus binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by VPS36 itself. We selected most functions VPS36 had, and list some proteins which have the same functions with VPS36. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ubiquitin binding | CRY1,OTUB1,MARK4,RNF168,NEDD4,SQSTM1,UCHL3,NUP62,IDE,NPLOC4 |
| protein C-terminus binding | ITGB3BP,TJP2,AP2A1,PPP2CA,TAE1,VIM,STIP1,PEX12,PDZD11,IFT52 |
| protein binding | UBA1,RPS18,TAF2,HCST,CD72,ARHGEF10,CXCL14,PEX10,ITGA6,DTX1 |
| phosphatidylinositol-3-phosphate binding | WDR45B,SNX3,FAM21C,NCF4,SNX20,ZFYVE19,ZFYVE28,SNX13,WIPI2,WIPI1 |
Interacting Protein
VPS36 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with VPS36 here. Most of them are supplied by our site. Hope this information will be useful for your research of VPS36.
GCNT1;pi3p;CDC5L;Vps25;Snf8
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References
- Herdegen, S; Conte, C; et al. Immediate and Persistent Transcriptional Correlates of Long-Term Sensitization Training at Different CNS Loci in Aplysia californica. PLOS ONE 9:-(2014).
- Herdegen, S; Holmes, G; et al. Characterization of the rapid transcriptional response to long-term sensitization training in Aplysia californica. NEUROBIOLOGY OF LEARNING AND MEMORY 116:27-35(2014).
