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Official Full Name vitronectin
Background Vitronectin is a cell adhesion and spreading factor found in serum and tissues. Vitronectin interact with glycosaminoglycans and proteoglycans. Is recognized by certain members of the integrin family and serves as a cell-to-substrate adhesion molecule. Inhibitor of the membrane-damaging effect of the terminal cytolytic complement pathway. Somatomedin-B is a growth hormone-dependent serum factor with protease-inhibiting activity. Vitronectin also known as VTN is a protein that in humans is encoded by the VTN gene. The protein encoded by this gene is a member of the pexin family. Vitronectin is an abundant glycoprotein found in serum and the extracellular matrix and promotes cell adhesion and spreading, inhibits the membrane-damaging effect of the terminal cytolytic complement pathway, and binds to several serpin serine protease inhibitors. It is a secreted protein and exists in either a single chain form or a clipped, two chain form held together by a disulfide bond. Vitronectin has been speculated to be involved in hemostasis and tumor malignancy.
Synonyms VTN; VN; V75; VNT; vitronectin; epibolin; S-protein; somatomedin B; OTTHUMP00000163323; complement S-protein; serum spreading factor; serum-spreading factor
    • Species :
    • Bovine
    • Chicken
    • Human
    • Mouse
    • Pig
    • Rabbit
    • Rat
    • Source :
    • Bovine Plasma
    • E.coli
    • HEK293
    • HEK293T
    • Human Cell
    • Human plasma
    • Insect Cell
    • Mammalian Cell
    • Mouse
    • Mouse Plasma
    • NS0
    • Pig Plasma
    • Porcine plasma
    • Rabbit Plasma
    • Rat plasma
    • Tag :
    • His
    • Myc/DDK
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human CAB11624MH Mouse Monoclonal Antibody to Human Vitronectin Mouse N/A
    Human VTN-062H Recombinant Human VTN Protein, His-tagged HEK293 His
    Human VTN-220H Recombinant Human VTN Protein, His-tagged HEK293 His
    Human VTN-239H Recombinant Human VTN protein E.coli N/A
    Human VTN-248H Recombinant Human VTN, His-tagged E.coli His
    Human VTN-2709H Recombinant Human Vitronectin Human Cell N/A
    Human VTN-295H Recombinant Human VTN NS0 N/A
    Human VTN-2H Native Human monomeric vitronectin, Biotin labeled human plasma N/A
    Human VTN-31131TH Recombinant Human VTN N/A
    Human VTN-31735TH Native Human VTN N/A
    Human VTN-31736TH Native Human VTN N/A
    Human VTN-31737TH Native Human VTN N/A
    Human VTN-3682H Recombinant Human VTN Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human VTN-3H Native Human multimeric vitronectin, Biotin labeled human plasma N/A
    Human VTN-5410H Native Human Vitronectin Human plasma N/A
    Human VTN-569H Recombinant Human VTN Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human VTN-599HG GMP Recombinant Human VTN protein, His-tagged HEK293 His
    Human VTN-675H Recombinant Human VTN Protein, His-tagged Insect Cell His
    Human VTN-891H Recombinant Human VTN, His tagged Human Cell His
    Human VTN-892H Recombinant Human VTN protein HEK293 N/A
    Human VTN-95H Recombinant Human VTN/TMSB4X protein E.coli N/A
    Mouse Vtn-1767M Recombinant Mouse Vtn protein, His-tagged E.coli His
    Mouse VTN-2062MCL Recombinant Mouse VTN cell lysate Human Cell N/A
    Mouse Vtn-4054M Recombinant Mouse Vtn, His tagged Human Cell His
    Mouse Vtn-694M Native Mouse Vitronectin Mouse Plasma N/A
    Mouse Vtn-6957M Recombinant Mouse Vtn Protein, Myc/DDK-tagged HEK293T Myc/DDK
    Rat Vtn -70R Native Rat multimeric vitronectin rat plasma N/A
    Rat Vtn-5769R Recombinant Rat Vtn protein, His-tagged E.coli His
    Rat Vtn-683R Native Rat Vitronectin Rat plasma N/A
    Bovine VTN -33B Native Bovine multimeric vitronectin Bovine Plasma N/A
    Bovine VTN-384B Native Bovine Vitronectin Bovine Plasma N/A
    Rabbit VTN -61R Native Rabbit multimeric vitronectin Rabbit Plasma N/A
    Rabbit VTN-386R Native Rabbit Vitronectin Rabbit Plasma N/A
    Chicken VTN-6618C Recombinant Chicken VTN Mammalian Cell His
    Pig VTN -51P Native Porcine multimeric vitronectin Porcine plasma N/A
    Pig VTN-385P Native Pig Vitronectin Pig Plasma N/A

    vtn involved in several pathways and played different roles in them. We selected most pathways vtn participated on our site, such as PIK-Akt signaling pathway, Focal adhesion, ECM-receptor interaction, which may be useful for your reference. Also, other proteins which involved in the same pathway with vtn were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    PIK-Akt signaling pathway FGF5; IFNAR1; IFNA7; FLT4; ITGA3; GNG3; FGF14; ITGA4; GNG4; INSR
    Focal adhesion CCND2A; MAPK8; ACTN2B; PPP1R12B; ITGA10; SHC2; PTEN; BADB; ILK; DIAP1
    ECM-receptor interaction ITGA7; IBSP; VTNA; COL4A1; LAMC1; COL1A1; SV2A; COL2A1B; ITGB1A; HMMR
    Proteoglycans in cancer EZR; PRKCA; Ctsl; Casp3; COL21A1; CD44; IL12B; Fzd4; TWIST1; CBL

    vtn has several biochemical functions, for example, extracellular matrix binding, heparin binding, integrin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by vtn itself. We selected most functions vtn had, and list some proteins which have the same functions with vtn. You can find most of the proteins on our site.

    Function Related Protein
    extracellular matrix binding VEGFA; BGN; GPR56; SPARC; ITGA2B; ITGB3; SID4; VTN; SPOCK2; CD248
    heparin binding FGF1; PLA2G2D; PCSK6; CTGF; ZFP207; PGF; APLP2; THBS1; RSPO1; Epy
    integrin binding FAP; WISP2; MMP14; ADAM23; FBLN1; CIB2; CD226; SRC; NISCH; ITGB5
    polysaccharide binding AGL; PRG4A; VTNB; PRG4B; ENDOU; PRG4; CLEC18A; C8orf84; GM106; VTNA
    protein binding DHX40; EIF3B; GM885; KCNA2; SPRY2; TSSK1; RAB11FIP2; PRKCZ; MCC; POLR2E
    scavenger receptor activity LOXL3A; TMPRSS4; ABHD1; SCARA3; LOXL2; CD5; PGBD1; LGALS3BPA; TMPRSS2; MSR1

    vtn has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with vtn here. Most of them are supplied by our site. Hope this information will be useful for your research of vtn.

    C1QBP; GOPC; SERPINE1; PASK; ganglioside_gm1; ITGAV; ITGB5; GLUD1; f_hcvh; ADH5

    Lee, YS; Ryu, SW; et al. Cross-platform meta-analysis of multiple gene expression profiles identifies novel expression signatures in acquired anthracycline-resistant breast cancer. ONCOLOGY REPORTS 33:1985-1993(2015).
    Horner, SM; Wilkins, C; et al. Proteomic Analysis of Mitochondrial-Associated ER Membranes (MAM) during RNA Virus Infection Reveals Dynamic Changes in Protein and Organelle Trafficking. PLOS ONE 10:-(2015).

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