• Official Full Name


  • Overview

    Vitronectin is a cell adhesion and spreading factor found in serum and tissues. Vitronectin interact with glycosaminoglycans and proteoglycans. Is recognized by certain members of the integrin family and serves as a cell-to-substrate adhesion molecule. Inhibitor of the membrane-damaging effect of the terminal cytolytic complement pathway. Somatomedin-B is a growth hormone-dependent serum factor with protease-inhibiting activity. Vitronectin also known as VTN is a protein that in humans is encoded by the VTN gene. The protein encoded by this gene is a member of the pexin family. Vitronectin is an abundant glycoprotein found in serum and the extracellular matrix and promotes cell adhesion and spreading, inhibits the membrane-damaging effect of the terminal cytolytic complement pathway, and binds to several serpin serine protease inhibitors. It is a secreted protein and exists in either a single chain form or a clipped, two chain form held together by a disulfide bond. Vitronectin has been speculated to be involved in hemostasis and tumor malignancy.
  • Synonyms

    VTN; VN; V75; VNT; vitronectin; epibolin; S-protein; somatomedin B; OTTHUMP00000163323; complement S-protein; serum spreading factor; serum-spreading factor;

  • Recombinant Proteins
  • Native Proteins
  • GMP Proteins
  • Antibody
  • Protein Pre-coupled Magnetic Beads
  • Cell & Tissue Lysates
  • Bovine
  • Chicken
  • Human
  • Mouse
  • Pig
  • Rabbit
  • Rat
  • Bovine Plasma
  • E.coli
  • HEK293
  • HEK293T
  • Human Cell
  • Human cells
  • human plasma
  • Human plasma
  • Insect Cell
  • Mammalian Cell
  • Mammalian cells
  • Mouse
  • Mouse Plasma
  • Pig Plasma
  • Porcine plasma
  • Rabbit Plasma
  • rat plasma
  • Rat plasma
  • C
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • Myc|DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human VTN-239H Active Recombinant Human VTN protein E.coli N/A
Human VTN-892H Active Recombinant Human VTN protein HEK293 N/A
Human VTN-2709H Active Recombinant Human Vitronectin Human Cell N/A
Human VTN-295H Active Recombinant Human VTN Mammalian cells N/A
Human VTN-220H Recombinant Human VTN protein(Met1-Leu478), His-tagged HEK293 C-His Met1-Leu478
Human VTN-95H Active Recombinant Human VTN/TMSB4X protein E.coli N/A
Human VTN-675H Active Recombinant Human VTN Protein, His-tagged Insect Cell His 20-478 aa
Human VTN-891H Recombinant Human VTN, His tagged Human Cell His
Human VTN-062H Recombinant Human VTN Protein, His-tagged HEK293 His
Human VTN-31131TH Recombinant Human VTN N/A
Human VTN-248H Recombinant Human VTN, His-tagged E.coli His 20-478aa
Human VTN-5410H Native Human Vitronectin Human plasma N/A
Human VTN-599HG Active GMP Recombinant Human VTN protein HEK293 DNA sequence encoding Human Vitronectin(NP_000629.3) was expressed with His tag at the C-terminal.
Human VTN-569H Recombinant Human VTN Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human CAB11624MH Mouse Monoclonal Antibody to Human Vitronectin Mouse N/A
Human VTN-31737TH Native Human VTN N/A
Human VTN-221H Recombinant Human VTN(Val62-Leu478) Protein, C-6*His-tagged HEK293 His
Human VTN-2H Native Human monomeric vitronectin, Biotin labeled human plasma N/A
Human VTN-3682H Recombinant Human VTN Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human VTN-1179H Recombinant Human VTN protein E.coli N/A 20-478aa
Human VTN-4507H-B Recombinant Human VTN Protein Pre-coupled Magnetic Beads HEK293
Human VTN-54H Active Recombinant Human VTN Protein, Animal Free Human cells
Human VTN-53H Active Recombinant Human VTN Protein, His-tagged E.coli His
Human VTN-6567H Recombinant Human VTN Protein (Glu126-Leu478), N-His tagged E.coli N-His Glu126-Leu478
Human VTN-0825H Active Recombinant Human VTN protein, Biotinylated E.coli N/A Asp20-Arg398
Human VTN-4507H Recombinant Human VTN Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human VTN-3H Native Human multimeric vitronectin, Biotin labeled human plasma N/A
Human VTN-31735TH Native Human VTN N/A
Human VTN-31736TH Native Human VTN N/A
Mouse Vtn-4054M Active Recombinant Mouse Vtn protein(Met1-Lys478), His-tagged HEK293 C-His Met1-Lys478
Mouse VTN-2062MCL Recombinant Mouse VTN cell lysate Human Cell N/A
Mouse Vtn-694M Native Mouse Vitronectin Mouse Plasma N/A
Mouse Vtn-6957M Recombinant Mouse Vtn Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse Vtn-576M Recombinant Mouse Vtn Protein, His-tagged E.coli N-His Asp20-Lys478
Mouse Vtn-1767M Recombinant Mouse Vtn protein, His-tagged E.coli His Pro250~Lys478
Rat Vtn-5769R Recombinant Rat Vtn protein, His-tagged E.coli His Gln21~Arg400
Rat Vtn-683R Native Rat Vitronectin Rat plasma N/A
Rat Vtn -70R Native Rat multimeric vitronectin rat plasma N/A
Rabbit VTN-386R Native Rabbit Vitronectin Rabbit Plasma N/A
Rabbit VTN -61R Native Rabbit multimeric vitronectin Rabbit Plasma N/A
Bovine VTN -33B Native Bovine multimeric vitronectin Bovine Plasma N/A
Bovine VTN-384B Native Bovine Vitronectin Bovine Plasma N/A
Pig VTN-385P Native Pig Vitronectin Pig Plasma N/A
Pig VTN -51P Native Porcine multimeric vitronectin Porcine plasma N/A
Chicken VTN-6618C Recombinant Chicken VTN Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

VTN involved in several pathways and played different roles in them. We selected most pathways VTN participated on our site, such as PIK-Akt signaling pathway, Focal adhesion, ECM-receptor interaction, which may be useful for your reference. Also, other proteins which involved in the same pathway with VTN were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
ECM-receptor interactionVTNA;SV2A;ITGB3B;LAMB1A;GP9;COL2A1A;COL2A1;SDC1;COL4A3

VTN has several biochemical functions, for example, extracellular matrix binding, heparin binding, integrin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by VTN itself. We selected most functions VTN had, and list some proteins which have the same functions with VTN. You can find most of the proteins on our site.

Function Related Protein
extracellular matrix bindingFBLN2;ITGA2B;DCN;SPOCK2;SID4;SPARC;ITGB3;TGFBI;ITGAV
integrin bindingLAMB1;EGFL6;CYR61;LYN;FCER2;CIB2;Npnt;SEMA7A;IGF1
polysaccharide bindingC8orf84;VTN;VTNA;CD209B;TINAGL1;VTNB;MBL1;CLEC18A;TINAG
protein bindingC18orf56;RAB3A;SHANK3;ZNF232;Clec4n;EDARADD;UNC119;SIRPG;CRY1
scavenger receptor activityENPP1;TMPRSS4;PRG4;ENPP2;PRG4B;VTN;CD163;ABHD1;CD6

VTN has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with VTN here. Most of them are supplied by our site. Hope this information will be useful for your research of VTN.

C1QBP; GOPC; SERPINE1; PASK; ganglioside_gm1; ITGAV; ITGB5; GLUD1; f_hcvh; ADH5

Research Area

Related articles

Lee, YS; Ryu, SW; et al. Cross-platform meta-analysis of multiple gene expression profiles identifies novel expression signatures in acquired anthracycline-resistant breast cancer. ONCOLOGY REPORTS 33:1985-1993(2015).
Horner, SM; Wilkins, C; et al. Proteomic Analysis of Mitochondrial-Associated ER Membranes (MAM) during RNA Virus Infection Reveals Dynamic Changes in Protein and Organelle Trafficking. PLOS ONE 10:-(2015).
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